CN1140284C - Chinese-medicinal pill for treating rheumatoid arthritis - Google Patents

Abstract

The present invention relates to a Chinese patent pill for treating rheumatoid arthritis, which is prepared by compounding dried gecko, pberetima, syngnathus, thunder god vine root, cassia twig, radices paeoniae alba, rhizoma anemarrhenae, glycyrrhiza, ephedra, largehead atractylodes rhizome, aconite, ledebouriella seseloides, menispermaceae, astragali, tuckahoe, angelica, chuanxiong rhizome, scorpion, centipede, sweet cistanche, notoginseng root, ground beetle, Chinese taxillus herb, large-flowered euonymus root, cyathula root, tall gastrodis tuber, black-striped snake, barbary wolfberry fruit, leech and semen brassicae albae. The Chinese patent pill has the functions of enriching and nourishing blood, invigorating the liver and the kidney, dispelling pathogenic wind, promoting blood circulation for removing obstructions in the collaterals, dispelling cold and eliminating dampness; besides, the Chinese patent pill has the advantages of treating both the manifestation and the root cause of diseases and conspicuous and stable curative effect.

Description

The Chinese patent medicine ball of treatment rheumatoid arthritis

The present invention relates to Chinese patent medicine, relate to a kind of Chinese patent medicine ball that is used for the treatment of rheumatoid arthritis specifically.

Rheumatoid arthritis is the disease based on chronic general arthralgia.Have clinically multiple, the characteristics of symmetry arthralgia, swelling, but acute attack, but also spontaneous remission, but tend to cause the irreversible stiff and ossified sex deviation in joint, the disability rate height does not still have specific short at present.Belong in Chinese medicine " arthromyodynia ", because its course of disease is long, touching difficulty heals, so be called " insensitive impediment ".Though many pharmaceutical trials are arranged in this disease of treatment both at home and abroad, be not because curative effect is not good enough recent decades, can not be accepted by the patient too greatly because of side effect exactly.

Motherland's tcm theory is thought, rheumatoid is because the Liver and kidney weakness, wind-cold damp pathogen is invaded joint, meridians in an opponent's defence, cause the QI and blood retardance, move not smooth, cause that pain, tingle, arthroncus, joint stuffiness take place at position such as muscle BJM, belong to the disease of deficiency in origin and excess in superficiality, sharply outbreak during often because of climate change.Modern medicine thinks that rheumatoid arthritis is a kind of autoimmune disease of non-special originality, and companion's blood flow is learned and changed and the microcirculation change, and in stage of attack, hemorheological indexes is worth height than the normal person.The inventor of present patent application finds through further investigation, " gold is deficient " Ramulus Cinnamomi paeoniae and Anemarrhenae Decoction can improve hemorheology, make whole blood viscosity (ratio), plasma viscosity (ratio), erythrocyte electrophoretic time (second) that obvious decline be arranged, can make above-mentioned three indexs be tending towards recovering normal, microcirculation improvement.And insect medicine has the effect of stronger dispelling wind and removing obstruction in the collateral pain relieving, and utilization is appropriate, can play brave husband's merit.Radix Tripterygii Wilfordii is that Chinese medicine is used for the treatment of the medicine that rheumatoid first-selection must be used, and this medicine has had that prostaglandin generates inhibitory action and onset is very fast, and stronger humoral immunization inhibitory action is arranged.

Purpose of the present invention just is to overcome above-mentioned weak point of the prior art, and based on above-mentioned tcm theory, provides a kind of from setting about with blood-supplementing blood-nourishing, liver and kidney tonifying, reaches the Chinese patent medicine ball of the treatment rheumatoid arthritis for the treatment of both the principal and secondary aspects of a disease.

Purpose of the present invention can realize by following measure:

The Chinese patent medicine ball of treatment rheumatoid arthritis of the present invention is formed by pure Chinese medicine medical material compatibility, and the ratio of weight and number of its medicament composing prescription is as follows: Gekko Swinhonis (Gekko Swinhonis) 6-15g, Pheretima 6-20g, Solenognathus 6-10g, Radix Tripterygii Wilfordii 6-15g, Ramulus Cinnamomi 6-15g, Radix Paeoniae Alba 10-25g, Rhizoma Anemarrhenae 10-15g, Radix Glycyrrhizae 6-10g, Herba Ephedrae 6-10g, Rhizoma Atractylodis Macrocephalae 6-15g, Radix Aconiti Lateralis Preparata 6-10g, Radix Saposhnikoviae 6-10g, Radix Stephaniae Tetrandrae 5-15g, Radix Astragali 10-30g, Radix Angelicae Sinensis 10-15g, Rhizoma Chuanxiong 10-15g, Herba Cistanches (field Herba Cistanches) 10-30g, Radix Notoginseng (Typhonium flagelliforme (Lodd.) Blume) 6-10g, eupolyphoge sinensis (eupolyphaga) 5-10g, the Cortex Eucommiae (black Folium) 6-15g, Zaocys 5-10g, Fructus Lycii 10-20g, Semen Sinapis (Semen Sinapis Albae) 10-20g, Poria 10-15g, Scorpio 6-10g, Scolopendra 2-5g, Herba Taxilli 10-30g, Radix Cyathulae 6-10g, Rhizoma Gastrodiae 6-15g, Hirudo 3-6g.

The preparation method of this Chinese patent medicine ball is conventional preparation method, can be with the common pulverization of said medicine, and making pellets by mixing medical powder with honey is patent medicine.

The present invention adds tonification healthy energy, activating blood circulation to dissipate blood stasis and a large amount of insect medicine and forms with " gold is deficient " Ramulus Cinnamomi paeoniae and Anemarrhenae Decoction.The Radix Astragali, Radix Angelicae Sinensis, Radix Paeoniae Alba benefiting QI and nourishing blood in the side; The Cortex Eucommiae (black Folium), Herba Cistanches (field Herba Cistanches), Herba Taxilli, Fructus Lycii, the Rhizoma Atractylodis Macrocephalae, Radix Aconiti Lateralis Preparata liver and kidney tonifying and spleen invigorating are to fill the source of the five internal organs; Ramulus Cinnamomi, Herba Ephedrae, Radix Saposhnikoviae etc., the letter that dispels the wind is wet, warming the meridian for promoting the flow of YANG QI, with Xie Qibiao; Clearing away heat and nourishing YIN, nourishing blood to suppress the hyperactive liver such as the Radix Paeoniae Alba, the Rhizoma Anemarrhenae, Radix Glycyrrhizae, with its in; Moreover Ramulus Cinnamomi, the Radix Paeoniae Alba, the Rhizoma Anemarrhenae can improve rheology, make whole blood viscosity (ratio), plasma viscosity (ratio), erythrocyte electrophoretic time (second) that obvious decline be arranged, and can make above-mentioned three indexs be tending towards recovering normal, microcirculation improvement.And insect medicine has the effect of stronger dispelling wind and removing obstruction in the collateral pain relieving, and utilization is appropriate, can play brave husband's merit.Zaocys can be searched and pick the wet to remove insensitive impediment of muscles and bones meridians, is that other medicines are irreplaceable; And Semen Sinapis (Semen Sinapis Albae) the outer wet disease of flesh side film that disappears in order to the joint, also is that other medicines are irreplaceable; Rhizoma Chuanxiong, Radix Notoginseng (Typhonium flagelliforme (Lodd.) Blume) are first choice of activating blood circulation to dissipate blood stasis, the removing obstruction in the collateral to relieve pain; Radix Tripterygii Wilfordii then is that Chinese medicine is used for the treatment of the medicine that rheumatoid first-selection must be used, and this medicine has had that prostaglandin generates inhibitory action and onset is very fast, and stronger humoral immunization inhibitory action is arranged.

In sum, Chinese patent medicine ball of the present invention is set about from blood-supplementing blood-nourishing, liver and kidney tonifying, doublely dispels the wind, promoting blood circulation to remove obstruction in the collateral, cold expelling removing dampness, has treating both the principal and secondary aspects of a disease, evident in efficacy, the advantage consolidated.

The Chinese patent medicine ball of treatment rheumatoid arthritis of the present invention generally took effect in the back of taking medicine through the clinical observation to 54 routine patients (course of disease is the shortest 6 months, and is the longest 32 years for wherein male 10 examples, women 44 examples) in 3-10 days; Wherein produce effects 32 examples account for 60%; Effective 21 examples account for 38%; Invalid 1 example accounts for 2%; Total effective rate 98%.For details see attached table:

Table 1: observation index

Observation item (meansigma methods)	Deadlock in morning (branch)	The arthralgia number	The arthroncus number
				The example number	54	54	54
Before the treatment	212	21.24	14.53
				After the treatment	21	8.04	2.94
P	＜0.01	＜0.01	＜0.01
				Improvement %	90	50	72

Table 2: treatment group and contrast therapeutic effect comparison sheet

	Case load	Effective routine number	Invalid routine number	Effective percentage	Differential meaning
						The treatment group	54	53	1	98％	Differ remarkable
Matched group	20	12	8	60％

Annotate: the diagnosis of above-mentioned clinical observation and criterion adopt " rheumatoid arthritis combination of Chinese and Western medicine diagnosis and treatment standard " that the diagnostic criteria of U.S. rheumatism association the 51st ARA meeting revision June in 1987 and first national combination of Chinese and Western medicine rheumatism science that China holds in Kunming in April, 1988 revises after the meeting as the diagnositc decision standard: promptly 1, the swollen joint of getting involved is painful, 2, the function of joint moving obstacle, 3, arthralgia, 4, then be judged to effectively if any two persons of taking effect in four standards of deadlock etc. in morning, wherein three persons of taking effect then are judged to produce effects, take effect or do not see as only there being one that any improver then is judged to is invalid.

Matched group is treated for using other medicines (except hormone, the Radix Tripterygii Wilfordii preparation) in the table 2 curative effect and judgement curative effect, diagnostic criteria is all identical.

The present invention is described in further detail below with reference to embodiment:

Embodiment 1:

Get Gekko Swinhonis (Gekko Swinhonis) 10g, Pheretima 16g, Solenognathus 6g, Radix Tripterygii Wilfordii 8g, Ramulus Cinnamomi 10g, Radix Paeoniae Alba 15g, Rhizoma Anemarrhenae 10g, Radix Glycyrrhizae 6g, Herba Ephedrae 7g, Rhizoma Atractylodis Macrocephalae 15g, Radix Aconiti Lateralis Preparata 10g, Radix Saposhnikoviae 9g, Radix Stephaniae Tetrandrae 12g, Radix Astragali 20g, Poria 10g, Radix Angelicae Sinensis 10g, Rhizoma Chuanxiong 13g, Scorpio 8g, Scolopendra 5g, Herba Cistanches (field Herba Cistanches) 15g, Radix Notoginseng (Typhonium flagelliforme (Lodd.) Blume) 10g, eupolyphoge sinensis (eupolyphaga) 5g, Herba Taxilli 30g, the Cortex Eucommiae (black Folium) 15g, Radix Cyathulae 6g, Rhizoma Gastrodiae 10g, Zaocys 5g, Fructus Lycii 20g, Hirudo 4g, the common pulverization of Semen Sinapis (Semen Sinapis Albae) 10g, making pellets by mixing medical powder with honey, every ball 9g.

Embodiment 2:

Get Gekko Swinhonis (Gekko Swinhonis) 6g, Pheretima 20g, Solenognathus 9g, Radix Tripterygii Wilfordii 6g, Ramulus Cinnamomi 15g, Radix Paeoniae Alba 20g, Rhizoma Anemarrhenae 15g, Radix Glycyrrhizae 8g, Herba Ephedrae 10g, Rhizoma Atractylodis Macrocephalae 6g, Radix Aconiti Lateralis Preparata 7g, Radix Saposhnikoviae 7g, Radix Stephaniae Tetrandrae 10g, Radix Astragali 25g, Poria 15g, Radix Angelicae Sinensis 14g, Rhizoma Chuanxiong 10g, Scorpio 10g, Scolopendra 3g, Herba Cistanches (field Herba Cistanches) 25g, Radix Notoginseng (Typhonium flagelliforme (Lodd.) Blume) 6g, eupolyphoge sinensis (eupolyphaga) 8g, Herba Taxilli 15g, the Cortex Eucommiae (black Folium) 7g, Radix Cyathulae 9g, Rhizoma Gastrodiae 6g, Zaocys 9g, Fructus Lycii 12g, Hirudo 5g, the common pulverization of Semen Sinapis (Semen Sinapis Albae) 18g, making pellets by mixing medical powder with honey, every ball 9g.

Eupolyphoge sinensis in the prescription (eupolyphaga) is also referred to as the worm.

Claims (1)

1, a kind of Chinese patent medicine ball for the treatment of rheumatoid arthritis, it is characterized in that: the ratio of weight and number of its medicament composing prescription is as follows: Gekko Swinhonis 6-15g, Pheretima 6-20g, Solenognathus 6-10g, Radix Tripterygii Wilfordii 6-15g, Ramulus Cinnamomi 6-15g, Radix Paeoniae Alba 10-25g, Rhizoma Anemarrhenae 10-15g, Radix Glycyrrhizae 6-10g, Herba Ephedrae 6-10g, Rhizoma Atractylodis Macrocephalae 6-15g, Radix Aconiti Lateralis Preparata 6-10g, Radix Saposhnikoviae 6-10g, Radix Stephaniae Tetrandrae 5-15g, Radix Astragali 10-30g, Radix Angelicae Sinensis 10-15g, Rhizoma Chuanxiong 10-15g, Herba Cistanches 10-30g, Radix Notoginseng 6-10g, eupolyphoge sinensis 5-10g, Cortex Eucommiae 6-15g, Zaocys 5-10g, Fructus Lycii 10-20g, Semen Sinapis Albae 10-20g, Poria 10-15g, Scorpio 6-10g, Scolopendra 2-5g, Herba Taxilli 10-30g, Radix Cyathulae 6-10g, Rhizoma Gastrodiae 6-15g, Hirudo 3-6g.