CN114025845A - 心肌肌钙蛋白活化剂的多晶型物 - Google Patents

心肌肌钙蛋白活化剂的多晶型物 Download PDF

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Publication number
CN114025845A
CN114025845A CN202080034295.8A CN202080034295A CN114025845A CN 114025845 A CN114025845 A CN 114025845A CN 202080034295 A CN202080034295 A CN 202080034295A CN 114025845 A CN114025845 A CN 114025845A
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CN
China
Prior art keywords
crystalline form
radiation
peaks
xrpd
compound
Prior art date
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Pending
Application number
CN202080034295.8A
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English (en)
Chinese (zh)
Inventor
S.阿扎利
M.查韦斯
J.马林诺夫斯基
S.M.门嫩
D.L.里德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Cytokinetics Inc
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Amgen Inc
Cytokinetics Inc
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Publication date
Application filed by Amgen Inc, Cytokinetics Inc filed Critical Amgen Inc
Publication of CN114025845A publication Critical patent/CN114025845A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN202080034295.8A 2019-03-12 2020-03-12 心肌肌钙蛋白活化剂的多晶型物 Pending CN114025845A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962817194P 2019-03-12 2019-03-12
US62/817,194 2019-03-12
PCT/US2020/022221 WO2020185983A1 (en) 2019-03-12 2020-03-12 Polymorphs of a cardiac troponin activator

Publications (1)

Publication Number Publication Date
CN114025845A true CN114025845A (zh) 2022-02-08

Family

ID=70190163

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080034295.8A Pending CN114025845A (zh) 2019-03-12 2020-03-12 心肌肌钙蛋白活化剂的多晶型物

Country Status (6)

Country Link
US (1) US20220185791A1 (enExample)
EP (1) EP3938042A1 (enExample)
JP (1) JP2022525102A (enExample)
CN (1) CN114025845A (enExample)
TW (1) TWI857027B (enExample)
WO (1) WO2020185983A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20200924A1 (es) 2017-09-13 2020-09-14 Amgen Inc Compuestos de bisamida sustituida que activan el sarcomero cardiaco
SG11202109891WA (en) 2019-03-12 2021-10-28 Amgen Inc Polymorphs and cocrystals of a cardiac troponin activator
AU2022239717A1 (en) 2021-03-15 2023-11-02 Maze Therapeutics, Inc. Inhibitors of glycogen synthase 1 (gys1) and methods of use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014152236A1 (en) * 2013-03-14 2014-09-25 Amgen Inc. Heterocyclic compounds and their uses
US20190077793A1 (en) * 2017-09-13 2019-03-14 Amgen Inc. Bisamide sarcomere activating compounds and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
AU3192500A (en) * 1999-03-16 2000-10-04 C & C Research Laboratories Substituted proline derivatives and medicinal compositions containing the same
TW200911787A (en) * 2007-07-03 2009-03-16 Astrazeneca Ab New aza-bicyclohexane compounds useful as inhibitors of thrombin

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014152236A1 (en) * 2013-03-14 2014-09-25 Amgen Inc. Heterocyclic compounds and their uses
US20190077793A1 (en) * 2017-09-13 2019-03-14 Amgen Inc. Bisamide sarcomere activating compounds and uses thereof
WO2019055590A1 (en) * 2017-09-13 2019-03-21 Amgen Inc. SARCOMERIC BISAMIDE ACTIVATOR COMPOUNDS AND USES THEREOF

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANNA KARAGIANNI: "pharmaceutical cocrystals new solid phase modification approaches for the formulation of APIS", PHARMA CELLTICS, vol. 10, no. 1, pages 18 *
BASTIN R J: "salt selection and optimisation for pharmaceutical new chemical entities", ORGANIC PROCESS RESEARCH AND DEVELOPMENT, vol. 4, no. 5, pages 427 - 435, XP008154792, DOI: 10.1021/op000018u *
STEPHEN BYRN: "pharmaceutical solid；s: a strategic approach to regulatory consideration", PHARMACEUTICAL RESEARCH, vol. 12, no. 7, pages 945 - 954, XP055395840 *

Also Published As

Publication number Publication date
JP2022525102A (ja) 2022-05-11
TW202100517A (zh) 2021-01-01
TWI857027B (zh) 2024-10-01
EP3938042A1 (en) 2022-01-19
WO2020185983A1 (en) 2020-09-17
US20220185791A1 (en) 2022-06-16

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