CN114010724A - Eye ointment for treating eye diseases and preparation method thereof - Google Patents

Eye ointment for treating eye diseases and preparation method thereof Download PDF

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Publication number
CN114010724A
CN114010724A CN202111596123.2A CN202111596123A CN114010724A CN 114010724 A CN114010724 A CN 114010724A CN 202111596123 A CN202111596123 A CN 202111596123A CN 114010724 A CN114010724 A CN 114010724A
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parts
extraction
ointment
traditional chinese
eye diseases
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李艳红
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
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Abstract

The invention discloses an eye ointment for treating eye diseases and a preparation method thereof, belonging to the technical field of medicine preparation, and the eye ointment comprises the following raw material components (by weight): 5-15 parts of radix polygonati officinalis, 5-15 parts of mint, 5-15 parts of mulberry leaf, 10-20 parts of fructus viticis, 5-10 parts of periostracum cicada, 10-20 parts of rhizoma cimicifugae, 15-25 parts of semen cassiae, 15-20 parts of pipewort, 15-25 parts of snake gall, 15-10 parts of buddleja officinalis, 10-20 parts of selfheal, 5-10 parts of prepared rhizome of rehmannia, 5-10 parts of ginseng, 15-25 parts of rhizoma acori graminei, 5-10 parts of salvia miltiorrhiza, 5-10 parts of safflower carthamus, 10-20 parts of glossy privet fruit, 5-15 parts of rhizoma anemarrhenae and 10-20 parts of notopterygium root, and the invention has the beneficial effects that: the whole formula comprises: the externally applied pure traditional Chinese medicine eye ointment has the advantages of promoting blood circulation around eyes, strengthening qi and blood circulation around eyes, relaxing muscles and nerves around eyes and eliminating visual fatigue, can be quickly extracted, has high concentration, is simple and easy to use, and can effectively treat various eye diseases such as dry eyes, itching and pain, visual deterioration, presbyopia, xerophthalmia and the like, and the preparation method thereof.

Description

Eye ointment for treating eye diseases and preparation method thereof
Technical Field
The invention relates to the technical field of medicine preparation, in particular to an eye ointment for treating eye diseases and a preparation method thereof.
Background
At present, eye ointments for treating ophthalmic diseases are divided into two types, namely chemical synthetic drugs and traditional Chinese medicine preparations, and the effects of the chemical synthetic drugs are not ideal due to the limitations of clinical curative effects and toxic and side effects. The traditional Chinese medicine preparation is widely favored due to obvious curative effect and low toxic and side effect, but the traditional extraction method of the compound traditional Chinese medicine has poor absorption of patients and long production period. The Chinese herbal compound is a prescription which is composed of two or more than two medicinal herbs, has a relatively specified processing method and a relatively specified using method and is designed aiming at relatively determined diseases and symptoms, and is a main component of a Chinese herbal prescription.
The traditional extraction method by water decoction or reflux extraction is not good, and the production period is long, so the extraction effect is further improved, the clinical curative effect is enhanced, the cost is saved, and the technical optimization is needed. Microwave-assisted extraction (MAE) a process in which Microwave energy is used to heat a solvent in contact with a sample to separate a desired compound from the sample matrix into the solvent.
Disclosure of Invention
The invention aims to overcome the defects of low extraction concentration and long period of the traditional Chinese medicine compound extraction method, and provides an externally-applied pure Chinese medicine eye ointment which can be extracted according to a formula, is simple and easy to use, and can effectively treat various eye diseases such as dry eyes, acid itching, pain, vision loss, presbyopia, xerophthalmia and the like, and a preparation method thereof. The preparation process is simple, the medicine can be completely absorbed by patients, the bioavailability of the effective components of the medicine is improved, and the curative effect and the medication safety are improved.
To solve the above technical problem, according to an aspect of the present invention, the present invention provides the following technical solutions:
an ophthalmic ointment for treating an ocular disease, comprising: the formula comprises the following raw material components (by weight): 5-15 parts of radix polygonati officinalis, 5-15 parts of mint, 5-15 parts of mulberry leaf, 10-20 parts of fructus viticis, 5-10 parts of periostracum cicada, 10-20 parts of rhizoma cimicifugae, 15-25 parts of semen cassiae, 15-20 parts of pipewort, 15-25 parts of snake gall, 15-10 parts of buddleja officinalis, 10-20 parts of selfheal, 5-10 parts of radix rehmanniae preparata, 5-10 parts of ginseng, 15-25 parts of rhizoma acori graminei, 5-10 parts of radix salviae miltiorrhizae, 5-10 parts of safflower, 10-20 parts of glossy privet fruit, 5-15 parts of rhizoma anemarrhenae and 10-20 parts of notopterygium root.
Preferably: the formula comprises the following raw material components (by weight): 5 parts of polygonatum odoratum, 5 parts of mint, 5 parts of mulberry leaf, 10 parts of chastetree fruit, 5 parts of cicada slough, 10 parts of cimicifuga foetida, 15 parts of cassia seed, 15 parts of pipewort, 15 parts of snake gall, 15 parts of butterflybush flower, 10 parts of selfheal, 5 parts of prepared rhizome of rehmannia, 5 parts of ginseng, 15 parts of rhizoma acori graminei, 5 parts of salvia miltiorrhiza, 5 parts of safflower carthamus, 10 parts of glossy privet fruit, 5 parts of rhizoma anemarrhenae and 10 parts of notopterygium root.
Preferably: the formula comprises the following raw material components (by weight): 10 parts of radix polygonati officinalis, 5 parts of mint, 10 parts of mulberry leaf, 15 parts of fructus viticis, 5 parts of periostracum cicadae, 10 parts of rhizoma cimicifugae, 15 parts of semen cassiae, 20 parts of pipewort, 20 parts of snake gall, 10 parts of butterflybush flower, 15 parts of selfheal, 5 parts of radix rehmanniae preparata, 5 parts of ginseng, 20 parts of rhizoma acori graminei, 5 parts of salvia miltiorrhiza, 5 parts of safflower carthamus, 15 parts of glossy privet fruit, 10 parts of rhizoma anemarrhenae and 12 parts of notopterygium root.
Preferably: the formula comprises the following raw material components (by weight): 15 parts of fragrant solomonseal rhizome, 15 parts of mint, 15 parts of mulberry leaf, 20 parts of chastetree fruit, 10 parts of cicada slough, 20 parts of largetrifolioliolioliolious bugbane rhizome, 25 parts of cassia seed, 20 parts of pipewort flower, 25 parts of snake gall, 10 parts of butterflybush flower, 20 parts of common selfheal fruit-spike, 10 parts of prepared rehmannia root, 10 parts of ginseng, 25 parts of grassleaf sweelflag rhizome, 10 parts of salvia miltiorrhiza, 10 parts of safflower, 20 parts of glossy privet fruit, 15 parts of common anemarrhena rhizome and 20 parts of incised notopterygium rhizome.
A preparation method of an eye ointment for treating eye diseases comprises the following steps:
the method comprises the following steps: the traditional Chinese medicine is extracted by adopting a traditional Chinese medicine compound ultrasonic extraction method, according to the compatibility of traditional Chinese medicines in the components, the dry powder of the traditional Chinese medicines is weighed (the powder is sieved by a No. 2 pharmacopoeia standard sieve), 10 times of water is added into the mixed powder for soaking for 2 hours, an MDS-2002AT microwave digestion device is used for carrying out microwave-assisted extraction on a soaking solution twice, the extraction time is 20min each time, the extraction temperature is 100 ℃, an extraction liquid is centrifugally filtered, then supernatant obtained by two-time extraction is combined, the concentrated medicinal liquid is concentrated to about 0.1g/ml of the concentration of the medicinal materials, the medicinal liquid is added into a D101 macroporous resin column for adsorption, the macroporous resin column is washed by water firstly, then is eluted by water for multiple times by ethanol with gradient concentration, is eluted by 30% of ethanol, finally is eluted by 70% of ethanol twice, the eluent with 70% of concentration is combined, the ethanol is recovered, and the mixed extract of the traditional Chinese medicines is obtained by concentration;
step two: soaking 1% carbomer for 24 hr, adding glycerol, propylene glycol, oleum Armeniacae amarum, and ceramide;
step three: adding the Chinese medicinal extract in the step one to form a solution;
step four: and gradually adding the triethylamine into the solution obtained in the third step, stirring and mixing uniformly to form an ointment, then canning, and sterilizing by using cobalt 60 rays to obtain a finished product.
Preferably: the microwave digestion and extraction conditions in the first step are as follows: the microwave frequency is 2500-3500 MHz, the power is 500-15000W, the extraction temperature is 50-120 ℃, and the extraction time is 5-40 minutes.
Preferably: in the first step, the mixed powder of the traditional Chinese medicinal materials is soaked in 10 times of water for 2 hours, the microwave digestion and extraction time is 20 minutes, and the temperature is 100 ℃.
Compared with the prior art:
1. the whole formula comprises: promoting circulation of qi and blood around eyes, relaxing muscles and nerves around eyes, relieving asthenopia, improving nutrition environment in eyes, refreshing eyes, regulating ability, and improving eyesight;
2. the formula of the invention adopts natural edible plant medicines as raw materials, each component accords with the regulation of the drug administration law and utilizes the comprehensive effect of various traditional Chinese medicines to treat various eye diseases, the toxic and side effects to human bodies are small, the medicine is taken nearby, the traditional Chinese medicines are easier to absorb by the optimized extraction process, the recurrence is not easy, and the cure effect is good;
3. the traditional Chinese medicine composition extracts, the carbomer gel matrix, the vegetable oil and the humectant form a stable ointment, and a breathable and moisture-retaining reticular film is formed on the surface of eyes after application, so that the effect is lasting, and the moisturizing effect is good;
4. the external pure traditional Chinese medicine eye ointment and the preparation method thereof overcome the defects of low extraction concentration and long period of the traditional Chinese medicine compound extraction method, can be used for extracting components, are simple and easy to use, can effectively treat various eye diseases such as dry eyes, acid itching, pain, visual deterioration, presbyopia, xerophthalmia and the like, have simple preparation process, and can be completely absorbed by patients. Improves the bioavailability of the active ingredients of the medicine, and increases the curative effect and the medication safety.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, embodiments of the present invention will be described in further detail below.
Example 1:
an ophthalmic ointment for treating an ocular disease, comprising: the formula comprises the following raw material components (by weight): 5 parts of radix polygonati officinalis, 5 parts of mint, 5 parts of mulberry leaf, 10 parts of fructus viticis, 5 parts of periostracum cicada, 10 parts of rhizoma cimicifugae, 15 parts of semen cassiae, 15 parts of pipewort, 15 parts of snake gall, 15 parts of butterflybush flower, 10 parts of selfheal, 5 parts of radix rehmanniae preparata, 5 parts of ginseng, 15 parts of rhizoma acori graminei, 5 parts of salvia miltiorrhiza, 5 parts of safflower carthamus, 10 parts of glossy privet fruit, 5 parts of rhizoma anemarrhenae and 10 parts of notopterygium root;
a preparation method of an eye ointment for treating eye diseases comprises the following steps:
the method comprises the following steps: the traditional Chinese medicine is extracted by adopting a traditional Chinese medicine compound ultrasonic extraction method, according to the compatibility of traditional Chinese medicines in the components, the dry powder of the traditional Chinese medicines is weighed (the powder is sieved by a No. 2 pharmacopoeia standard sieve), 10 times of water is added into the mixed powder for soaking for 2 hours, an MDS-2002AT microwave digestion device is used for carrying out microwave-assisted extraction on a soaking solution twice, the extraction time is 20min each time, the extraction temperature is 100 ℃, the extraction liquid is centrifugally filtered, the supernatant obtained by two times of extraction is combined, the concentrated solution is concentrated to the concentration of the medicinal materials of about 0.1g/ml, the medicinal materials are added into a D101 macroporous resin column for adsorption, the macroporous resin column is washed by water firstly, then is eluted by water for multiple times by ethanol with gradient concentration, is eluted by 30% of ethanol, finally is eluted by 70% of ethanol twice, the eluent with concentration of 70% is combined, the ethanol is recovered, and the mixed extract of the traditional Chinese medicines is prepared by concentration, wherein:
the microwave digestion and extraction conditions are as follows: the microwave frequency is 2500-3500 MHz, the power is 500-15000W, the extraction temperature is 50-120 ℃, and the extraction time is 5-40 minutes.
Soaking the mixed powder of the traditional Chinese medicinal materials in 10 times of water for 2 hours, and performing microwave digestion and extraction for 20 minutes at the temperature of 100 ℃;
step two: soaking 1% carbomer for 24 hr, adding glycerol, propylene glycol, oleum Armeniacae amarum, and ceramide;
step three: adding the Chinese medicinal extract in the step one to form a solution;
step four: and gradually adding the triethylamine into the solution obtained in the third step, stirring and mixing uniformly to form an ointment, then canning, and sterilizing by using cobalt 60 rays to obtain a finished product.
In summary, the following steps: the eye ointment finished product obtained according to the formula and the preparation method in the embodiment has small toxic and side effects, the absorption rate reaches 94.3%, the recurrence rate is 4%, and the cure rate is 96%.
Example 2:
an ophthalmic ointment for treating an ocular disease, comprising: preferably: the formula comprises the following raw material components (by weight): 10 parts of radix polygonati officinalis, 5 parts of mint, 10 parts of mulberry leaf, 15 parts of fructus viticis, 5 parts of periostracum cicadae, 10 parts of rhizoma cimicifugae, 15 parts of semen cassiae, 20 parts of pipewort, 20 parts of snake gall, 10 parts of butterflybush flower, 15 parts of selfheal, 5 parts of radix rehmanniae preparata, 5 parts of ginseng, 20 parts of rhizoma acori graminei, 5 parts of salvia miltiorrhiza, 5 parts of safflower carthamus, 15 parts of glossy privet fruit, 10 parts of rhizoma anemarrhenae and 12 parts of notopterygium root;
a preparation method of an eye ointment for treating eye diseases comprises the following steps:
the method comprises the following steps: the traditional Chinese medicine is extracted by adopting a traditional Chinese medicine compound ultrasonic extraction method, according to the compatibility of traditional Chinese medicines in the components, the dry powder of the traditional Chinese medicines is weighed (the powder is sieved by a No. 2 pharmacopoeia standard sieve), 10 times of water is added into the mixed powder for soaking for 2 hours, an MDS-2002AT microwave digestion device is used for carrying out microwave-assisted extraction on a soaking solution twice, the extraction time is 20min each time, the extraction temperature is 100 ℃, the extraction liquid is centrifugally filtered, the supernatant obtained by two times of extraction is combined, the concentrated solution is concentrated to the concentration of the medicinal materials of about 0.1g/ml, the medicinal materials are added into a D101 macroporous resin column for adsorption, the macroporous resin column is washed by water firstly, then is eluted by water for multiple times by ethanol with gradient concentration, is eluted by 30% of ethanol, finally is eluted by 70% of ethanol twice, the eluent with concentration of 70% is combined, the ethanol is recovered, and the mixed extract of the traditional Chinese medicines is prepared by concentration, wherein:
the microwave digestion and extraction conditions are as follows: the microwave frequency is 2500-3500 MHz, the power is 500-15000W, the extraction temperature is 50-120 ℃, and the extraction time is 5-40 minutes.
Soaking the mixed powder of the traditional Chinese medicinal materials in 10 times of water for 2 hours, and performing microwave digestion and extraction for 20 minutes at the temperature of 100 ℃;
step two: soaking 1% carbomer for 24 hr, adding glycerol, propylene glycol, oleum Armeniacae amarum, and ceramide;
step three: adding the Chinese medicinal extract in the step one to form a solution;
step four: and gradually adding the triethylamine into the solution obtained in the third step, stirring and mixing uniformly to form an ointment, then canning, and sterilizing by using cobalt 60 rays to obtain a finished product.
In summary, the following steps: the eye ointment finished product obtained according to the formula and the preparation method in the embodiment has the advantages of little toxic and side effect, 97.8% of absorption rate, 1% of recurrence rate and 99% of cure rate.
Example 3:
an ophthalmic ointment for treating an ocular disease, comprising: the formula comprises the following raw material components (by weight): 15 parts of radix polygonati officinalis, 15 parts of mint, 15 parts of mulberry leaf, 20 parts of fructus viticis, 10 parts of periostracum cicadae, 20 parts of rhizoma cimicifugae, 25 parts of semen cassiae, 20 parts of pipewort, 25 parts of snake gall, 10 parts of butterflybush flower, 20 parts of selfheal, 10 parts of radix rehmanniae preparata, 10 parts of ginseng, 25 parts of rhizoma acori graminei, 10 parts of salvia miltiorrhiza, 10 parts of safflower carthamus, 20 parts of glossy privet fruit, 15 parts of rhizoma anemarrhenae and 20 parts of notopterygium root;
a preparation method of an eye ointment for treating eye diseases comprises the following steps:
the method comprises the following steps: the traditional Chinese medicine is extracted by adopting a traditional Chinese medicine compound ultrasonic extraction method, according to the compatibility of traditional Chinese medicines in the components, the dry powder of the traditional Chinese medicines is weighed (the powder is sieved by a No. 2 pharmacopoeia standard sieve), 10 times of water is added into the mixed powder for soaking for 2 hours, an MDS-2002AT microwave digestion device is used for carrying out microwave-assisted extraction on a soaking solution twice, the extraction time is 20min each time, the extraction temperature is 100 ℃, the extraction liquid is centrifugally filtered, the supernatant obtained by two times of extraction is combined, the concentrated solution is concentrated to the concentration of the medicinal materials of about 0.1g/ml, the medicinal materials are added into a D101 macroporous resin column for adsorption, the macroporous resin column is washed by water firstly, then is eluted by water for multiple times by ethanol with gradient concentration, is eluted by 30% of ethanol, finally is eluted by 70% of ethanol twice, the eluent with concentration of 70% is combined, the ethanol is recovered, and the mixed extract of the traditional Chinese medicines is prepared by concentration, wherein:
the microwave digestion and extraction conditions are as follows: the microwave frequency is 2500-3500 MHz, the power is 500-15000W, the extraction temperature is 50-120 ℃, and the extraction time is 5-40 minutes.
Soaking the mixed powder of the traditional Chinese medicinal materials in 10 times of water for 2 hours, and performing microwave digestion and extraction for 20 minutes at the temperature of 100 ℃;
step two: soaking 1% carbomer for 24 hr, adding glycerol, propylene glycol, oleum Armeniacae amarum, and ceramide;
step three: adding the Chinese medicinal extract in the step one to form a solution;
step four: and gradually adding the triethylamine into the solution obtained in the third step, stirring and mixing uniformly to form an ointment, then canning, and sterilizing by using cobalt 60 rays to obtain a finished product.
In summary, the following steps: the eye ointment finished product obtained according to the formula and the preparation method in the embodiment has small toxic and side effects, the absorption rate reaches 95.2%, the recurrence rate is 3%, and the cure rate is 97%.
In order to prove the treatment effect of the medicine on various eye diseases, the invention carries out clinical tracking observation on 200 cases of eye disease patients using the medicine prepared in the embodiment 2, and the observation period is 45 days and five cases are one treatment period.
The using method comprises the following steps: the appropriate amount is taken each time to massage the periphery of the eye orbit 3-5 times a day. The clinical follow-up results were as follows:
the efficacy of the drug of the present invention can also be demonstrated during the treatment of the following typical cases:
typical cases are 1, Wangzhi, female, 38 years old, photophobia of eyes, epiphora induced by wind and muscae volitantes. The left eye is myopic 375 degrees, and the right eye is myopic 325 degrees. After the product is used for the first time, people feel that eyes are cold and tear, people feel that eyes are moistened after using two days, the first product is used for photophobia, the tear flow in the wind is completely improved, children are sent to learn by riding an electric vehicle in the morning and do not tear, the 2 nd product is used for killing mosquitoes, most of mosquitoes are not felt, people who see people beyond 5 meters can see the product, objects are clear, and the time of three months is used, so that the problems of eyes are solved, the wrinkles and the pouches are greatly diluted;
typical cases 2, hairy antler disease, female, age 47, xerophthalmia, lacrimation and photophobia, the eyes feel like being wrapped by a layer of things and are uncomfortable, and the symptoms of using three lacrimation are not existed, the symptoms of dry eyes are good, the symptoms of using three lacrimation are almost not existed, and photophobia is completely improved;
typical case 3, Zhangyi, female, age 69, early cataract, presbyopia, eye pouch and eye pattern are obvious, and the presbyopia is obviously improved after four products are used, so that the words on the television and the mobile phone can be seen clearly. Hospital screening for cataracts is also much reduced.
The pharmacology of each raw material in the formula of the medicine is as follows:
fragrant solomonseal rhizome: has effects in nourishing yin, moistening lung, nourishing stomach, and promoting salivation.
Mint: is rich in menthol and menthone, and has effects of dispelling pathogenic wind heat, promoting eruption, removing toxic substance, dispersing stagnated liver qi, relieving qi stagnation, and relieving itching.
Mulberry leaf: is rich in polysaccharide, alkaloid, flavone, etc., and has effects of dispelling pathogenic wind and heat, clearing lung-heat, moistening dryness, removing liver fire, and improving eyesight.
Chastetree fruit: has the functions of dispelling wind, clearing away heat, refreshing, eliminating wind, relieving pain, etc.
Cicada slough: has the functions of improving eyesight, removing nebula, eliminating conjunctival congestion, dispelling wind and heat, etc.
Cimicifugae foetidae: has the functions of clearing away heat and toxic material, promoting eruption, etc.
Cassia seed: clear heat and improve eyesight. Can be used for treating conjunctival congestion, swelling and pain, photophobia, lacrimation, dim eyesight, headache, vertigo, etc.
Pipewort: disperse wind-heat, improve vision and remove nebula. Can be used for treating conjunctival congestion due to wind-heat, swelling pain, photophobia, and nebula.
Snake bile: korea rich in trace elements has effects of clearing away heat and toxic materials, dispelling pathogenic wind, eliminating dampness, improving eyesight, and clearing away heart-fire.
Butterflybush flower: contains flavonoids, and has antiinflammatory and antioxidant effects.
Selfheal: contains triterpenoid saponin, and has effects of relieving inflammation, relieving swelling, purging liver fire, and improving eyesight.
Prepared rhizome of rehmannia: has effects in nourishing yin, invigorating kidney, nourishing blood, and invigorating qi.
Ginseng: has effects in regulating body resistance and immunity, stimulating hematopoietic organ, relieving fatigue, and repairing eye hemorrhage and retinal detachment.
Grassleaf sweelflag rhizome: has the functions of tonifying liver and kidney, removing nebula and improving eyesight.
Red sage root: promoting blood circulation, removing blood stasis, and improving microcirculation. It has effects of eliminating conjunctival congestion, swelling and pain, heat tearing, improving eyesight, and removing nebula.
Saffron: promoting blood circulation, removing blood stasis, relieving depression, tranquilizing mind, cooling blood, and removing toxic substance.
Glossy privet fruit: clearing heat, improving eyesight, and tonifying liver and kidney, and can be used for treating dizziness, blurred vision, and tinnitus.
Rhizoma anemarrhenae: contains saponin, flavone, etc. and has the functions of clearing away heat, purging fire, promoting fluid production and moistening dryness.
Notopterygium root: contains volatile oil, coumarin and amino acids, and has effects in dispelling pathogenic wind and cold, dispelling pathogenic wind and relieving pain
While the invention has been described above with reference to an embodiment, various modifications may be made and equivalents may be substituted for elements thereof without departing from the scope of the invention. In particular, the various features of the disclosed embodiments of the invention may be used in any combination, provided that no structural conflict exists, and the combinations are not exhaustively described in this specification merely for the sake of brevity and resource conservation. Therefore, it is intended that the invention not be limited to the particular embodiments disclosed, but that the invention will include all embodiments falling within the scope of the appended claims.

Claims (7)

1. An eye ointment for treating eye diseases is characterized by comprising the following raw material components in parts by weight: 5-15 parts of radix polygonati officinalis, 5-15 parts of mint, 5-15 parts of mulberry leaf, 10-20 parts of fructus viticis, 5-10 parts of periostracum cicada, 10-20 parts of rhizoma cimicifugae, 15-25 parts of semen cassiae, 15-20 parts of pipewort, 15-25 parts of snake gall, 15-10 parts of buddleja officinalis, 10-20 parts of selfheal, 5-10 parts of radix rehmanniae preparata, 5-10 parts of ginseng, 15-25 parts of rhizoma acori graminei, 5-10 parts of radix salviae miltiorrhizae, 5-10 parts of safflower, 10-20 parts of glossy privet fruit, 5-15 parts of rhizoma anemarrhenae and 10-20 parts of notopterygium root.
2. The ophthalmic ointment for treating eye diseases according to claim 1, wherein the formulation comprises the following raw material components (by weight): 5 parts of polygonatum odoratum, 5 parts of mint, 5 parts of mulberry leaf, 10 parts of chastetree fruit, 5 parts of cicada slough, 10 parts of cimicifuga foetida, 15 parts of cassia seed, 15 parts of pipewort, 15 parts of snake gall, 15 parts of butterflybush flower, 10 parts of selfheal, 5 parts of prepared rhizome of rehmannia, 5 parts of ginseng, 15 parts of rhizoma acori graminei, 5 parts of salvia miltiorrhiza, 5 parts of safflower carthamus, 10 parts of glossy privet fruit, 5 parts of rhizoma anemarrhenae and 10 parts of notopterygium root.
3. The ophthalmic ointment for treating eye diseases according to claim 1, wherein the formulation comprises the following raw material components (by weight): 10 parts of radix polygonati officinalis, 5 parts of mint, 10 parts of mulberry leaf, 15 parts of fructus viticis, 5 parts of periostracum cicadae, 10 parts of rhizoma cimicifugae, 15 parts of semen cassiae, 20 parts of pipewort, 20 parts of snake gall, 10 parts of butterflybush flower, 15 parts of selfheal, 5 parts of radix rehmanniae preparata, 5 parts of ginseng, 20 parts of rhizoma acori graminei, 5 parts of salvia miltiorrhiza, 5 parts of safflower carthamus, 15 parts of glossy privet fruit, 10 parts of rhizoma anemarrhenae and 12 parts of notopterygium root.
4. The ophthalmic ointment for treating eye diseases according to claim 1, wherein the formulation comprises the following raw material components (by weight): 15 parts of fragrant solomonseal rhizome, 15 parts of mint, 15 parts of mulberry leaf, 20 parts of chastetree fruit, 10 parts of cicada slough, 20 parts of largetrifolioliolioliolious bugbane rhizome, 25 parts of cassia seed, 20 parts of pipewort flower, 25 parts of snake gall, 10 parts of butterflybush flower, 20 parts of common selfheal fruit-spike, 10 parts of prepared rehmannia root, 10 parts of ginseng, 25 parts of grassleaf sweelflag rhizome, 10 parts of salvia miltiorrhiza, 10 parts of safflower, 20 parts of glossy privet fruit, 15 parts of common anemarrhena rhizome and 20 parts of incised notopterygium rhizome.
5. A preparation method of an eye ointment for treating eye diseases is characterized by comprising the following steps:
the method comprises the following steps: the traditional Chinese medicine is extracted by adopting a traditional Chinese medicine compound ultrasonic extraction method, according to the compatibility of traditional Chinese medicines in the components, the dry powder of the traditional Chinese medicines is weighed, the mixed powder is added with 10 times of water for soaking for 2 hours, then an MDS-2002AT microwave digestion device is used for carrying out microwave-assisted extraction on a soaking solution twice, the extraction temperature is 100 ℃, supernatant obtained by the two-time extraction is combined after the extraction liquid is centrifugally filtered, the obtained mixture is concentrated until the concentration of the medicinal materials is about 0.1g/ml, the obtained product is added into a D101 macroporous resin column for adsorption, the macroporous resin column is washed by water firstly, then is eluted by ethanol with gradient concentration for multiple times, is eluted by water firstly, is eluted by 30% ethanol again, is eluted by 70% ethanol twice finally, is combined with ethanol eluent with concentration of 70%, the ethanol is recovered, and is concentrated to obtain a mixed extract of the traditional Chinese medicines;
step two: soaking 1% carbomer for 24 hr, adding glycerol, propylene glycol, oleum Armeniacae amarum, and ceramide;
step three: adding the Chinese medicinal extract in the step one to form a solution;
step four: and gradually adding the triethylamine into the solution obtained in the third step, stirring and mixing uniformly to form an ointment, then canning, and sterilizing by using cobalt 60 rays to obtain a finished product.
6. The ophthalmic ointment for treating eye diseases and the preparation method thereof according to claim 5, wherein the conditions of microwave digestion and extraction in the first step are as follows: the microwave frequency is 2500-3500 MHz, the power is 500-15000W, the extraction temperature is 50-120 ℃, and the extraction time is 5-40 minutes.
7. The eye ointment for treating eye diseases and the preparation method thereof according to claim 5, wherein the mixed powder of the Chinese medicinal materials in the first step is soaked in 10 times of water for 2 hours, and the microwave digestion extraction time is 20 minutes and the temperature is 100 ℃.
CN202111596123.2A 2021-12-24 2021-12-24 Eye ointment for treating eye diseases and preparation method thereof Pending CN114010724A (en)

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CN115261140A (en) * 2022-08-01 2022-11-01 开封御创医学科技有限公司 Extraction device, traditional Chinese medicine eye patch prepared by extraction device and preparation method
CN115252705A (en) * 2022-06-27 2022-11-01 程平 An eye ointment containing flos Chrysanthemi Indici and its preparation method
CN115337378A (en) * 2022-09-20 2022-11-15 尕玛块周 Multi-effect eye protection formula and preparation method thereof

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CN109700928A (en) * 2019-03-05 2019-05-03 傅伟建 A kind of pack and its massage application method of promotion vision restoration
CN110934925A (en) * 2019-12-31 2020-03-31 傅碧池 Traditional Chinese medicine composition of eye patch for relieving asthenopia
CN113813315A (en) * 2021-08-16 2021-12-21 上海市光华中西医结合医院 Traditional Chinese medicine composition for relieving asthenopia and xerophthalmia, application thereof and prepared eye mask

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CN109700928A (en) * 2019-03-05 2019-05-03 傅伟建 A kind of pack and its massage application method of promotion vision restoration
CN110934925A (en) * 2019-12-31 2020-03-31 傅碧池 Traditional Chinese medicine composition of eye patch for relieving asthenopia
CN113813315A (en) * 2021-08-16 2021-12-21 上海市光华中西医结合医院 Traditional Chinese medicine composition for relieving asthenopia and xerophthalmia, application thereof and prepared eye mask

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115252705A (en) * 2022-06-27 2022-11-01 程平 An eye ointment containing flos Chrysanthemi Indici and its preparation method
CN115261140A (en) * 2022-08-01 2022-11-01 开封御创医学科技有限公司 Extraction device, traditional Chinese medicine eye patch prepared by extraction device and preparation method
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CN115337378A (en) * 2022-09-20 2022-11-15 尕玛块周 Multi-effect eye protection formula and preparation method thereof

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