CN114009644A - Stomach-nourishing probiotic solid beverage resistant to gastric acid and preparation method thereof - Google Patents
Stomach-nourishing probiotic solid beverage resistant to gastric acid and preparation method thereof Download PDFInfo
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- CN114009644A CN114009644A CN202111133169.0A CN202111133169A CN114009644A CN 114009644 A CN114009644 A CN 114009644A CN 202111133169 A CN202111133169 A CN 202111133169A CN 114009644 A CN114009644 A CN 114009644A
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- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/19—Dairy proteins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a stomach-nourishing probiotic solid beverage with gastric acid resistance and a preparation method thereof. Comprises embedded probiotic particles; the probiotic embedded particles comprise probiotic cores and embedding layers, and the probiotic embedded particles embed the probiotic cores in the four embedding layers by adopting a four-layer embedding process; the coating layer comprises a protein protective layer, a lipid protective layer and a double-layer polysaccharide protective layer from inside to outside in sequence; the probiotic embedded particle comprises the following components: 100 parts of helicobacter pylori-resistant probiotic composition, 2-6 parts of concentrated whey protein, 3-9 parts of sodium caseinate, 0.1-0.3 part of konjac flour, 5-10 parts of high oleic acid sunflower seed oil, 1-2 parts of trehalose, 1-2 parts of maltodextrin, 5-10 parts of polyfructose, 1-2 parts of inulin and 0.06-0.12 part of phospholipid. The invention has high acid resistance and high survival rate of intestinal tracts.
Description
The technical field is as follows:
the invention belongs to the technical field of probiotic products, and particularly relates to a stomach-nourishing probiotic solid beverage with gastric acid resistance and a preparation method thereof.
Background art:
in recent years, the key role of probiotics in human health has been known and recognized by more and more people, and now the probiotics are widely applied to various products, which becomes a consumption hot tide in the market nowadays.
The probiotics can play the physiological function only by reaching the intestinal tract with a large amount of live bacteria through the gastric environment and colonizing the intestinal mucosa, and can generate beneficial effect on human body by changing the balance of intestinal flora. However, many active probiotics have poor resistance and are sensitive to high acid environment, and after entering the human body, the active probiotics are difficult to smoothly pass through the acid environment of the stomach and the high bile salt environment of the duodenum and reach the small intestine in a live bacterial state, so that the micro-ecological regulation function is exerted. Therefore, the survival rate in the intestinal tract is also an important index of the efficacy of the probiotics.
China is a high-incidence country of stomach cancer, and about half of newly-increased and dead stomach cancer patients all over the world occur in China. Nearly half of the newly discovered stomach cancers are related to helicobacter pylori infection every year, more than 90% of duodenal ulcers and about 80% of gastric ulcers are caused by helicobacter pylori infection, and the helicobacter pylori infection rate in China is up to 60%. Therefore, it is important to fight against helicobacter pylori for people to nourish their stomach daily, and the way in which probiotics are taken to control helicobacter pylori infection becomes a hot spot, and the ability of probiotics to resist gastric acid and bile salt and the survival rate of the probiotics in the intestinal tract are particularly important.
As is well known, the embedding system is the most widely studied technology for protecting probiotics at present, and the embedding materials used at present mainly comprise chitosan, sodium alginate, carrageenan, gelatin, sodium caseinate, whey protein, resistant dextrin, phospholipid and starch. These embedding materials have a certain protective effect on the probiotics. However, this effect is not to the extent that the probiotic exerts the greatest effect. For example, the most commonly used sodium alginate-embedded probiotics are still unable to survive in an environment with a pH < 2.
The common embedding technology mainly adopts double-layer embedding, three embedding layers can be selected for a few probiotic products, but the survival rate of the embedded live bacteria is not ideal, and the survival rate of the embedded live bacteria is only 20% -30%.
The information disclosed in this background section is only for enhancement of understanding of the general background of the invention and should not be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person skilled in the art.
The invention content is as follows:
the invention aims to provide a stomach-nourishing probiotic solid beverage with gastric acid resistance and a preparation method thereof, thereby overcoming the defects in the prior art.
In order to achieve the above object, the present invention provides a stomach nourishing probiotic solid beverage with gastric acid resistance, comprising: embedding the probiotic into particles; the probiotic embedded particles comprise probiotic cores and embedding layers, and the probiotic embedded particles embed the probiotic cores in the four embedding layers by adopting a four-layer embedding process; the coating layer comprises a protein protective layer, a lipid protective layer and a double-layer polysaccharide protective layer from inside to outside in sequence; the protein protective layer has the directional slow-release and controlled-release effects; a lipid protective layer which protects the inner material from bile; the double-layer polysaccharide protective layer is composed of a biomolecule polymer which is insoluble in gastric acid, protects substances embedded inside from being damaged in a low pH value environment, can resist the erosion of gastric acid in vivo, and has high acid resistance and high survival rate of intestinal tracts; the probiotic embedded particle comprises the following components in parts by mass: 100 parts of helicobacter pylori-resistant probiotic composition, 2-6 parts of concentrated whey protein, 3-9 parts of sodium caseinate, 0.1-0.3 part of konjac flour, 5-10 parts of high oleic acid sunflower seed oil, 1-2 parts of trehalose, 1-2 parts of maltodextrin, 5-10 parts of polyfructose, 1-2 parts of inulin and 0.06-0.12 part of phospholipid.
Preferably, in the technical scheme, the anti-helicobacter pylori probiotic composition is selected from at least one of lactobacillus acidophilus, lactobacillus bulgaricus, lactobacillus plantarum, lactobacillus rhamnosus, lactobacillus reuteri, lactobacillus casei, lactobacillus gasseri, lactobacillus johnsonii, lactobacillus salivarius, lactobacillus brevis, streptococcus lactis, bacillus subtilis, bifidobacterium bifidum, bifidobacterium adolescentis, bifidobacterium infantis, bifidobacterium breve, bifidobacterium longum, helicobacter romobacter, bifidobacterium lactis, lactobacillus formative, acetobacter veillanis, gluconacetobacter xylinus, pediococcus cerevisiae, streptococcus thermophilus, aspergillus oryzae, aspergillus ankae and lactococcus lactis.
Preferably, in the technical scheme, the anti-helicobacter pylori probiotic composition is a combination of lactobacillus johnsonii, lactobacillus salivarius and lactobacillus plantarum, and the weight ratio of the lactobacillus johnsonii, the lactobacillus salivarius and the lactobacillus plantarum is 1: 1: 1.
preferably, in the technical scheme, the concentrated whey protein is selected from one of concentrated whey protein WPC70, concentrated whey protein WPC80 and WPI.
Preferably, in the technical scheme, the concentrated whey protein is concentrated whey protein WPC 80.
A preparation method of stomach-nourishing probiotic solid beverage with gastric acid resistance comprises the following steps: (1) taking the helicobacter pylori-resistant probiotic composition as a core material, and mixing concentrated whey protein, sodium caseinate, konjac flour and deionized water in a mass ratio of 0.2: 0.3: 0.01: 1, carrying out fluidized bed spray embedding on the homogeneous liquid obtained by mixing to obtain a protein protective layer, and drying to obtain an embedded substance A, wherein the water content is less than or equal to 8%;
(2) high oleic acid sunflower seed oil, phospholipid and deionized water are mixed according to a mass ratio of 0.5: 0.002: 1, performing fluidized bed spray embedding on the embedded object A obtained in the step (1) by using mixed homogeneous liquid to obtain a lipid protective layer, and drying to obtain an embedded object B with the water content less than or equal to 5 percent;
(3) mixing trehalose, maltodextrin, phospholipid and water in a mass ratio of 0.1: 0.1: 0.002: 1, performing fluidized bed spray embedding on the embedding material B obtained in the step (2) by using a mixed homogeneous solution to obtain a third polysaccharide protective layer, and drying to obtain an embedding material C with the water content less than or equal to 3%;
(4) inulin, polyfructose, phospholipid and water are mixed according to a mass ratio of 0.1:0.5: 0.002: 1, performing fluidized bed spray embedding on the embedded object C obtained in the step (3) by using a mixed homogeneous solution to obtain a fourth polysaccharide protective layer, and drying to obtain an embedded object D, namely probiotic embedded particles, wherein the moisture content is 1.5-2.5%.
A stomach nourishing probiotic solid beverage with gastric acid resistance further comprises: medicinal and edible stomach nourishing granules; the components of the medicine are 5 parts of hericium erinaceus, 10 parts of yellow millet, 10 parts of rice, 5 parts of lotus seeds, 5 parts of Chinese yam, 3 parts of poria cocos, 2 parts of gordon euryale seeds, 40 parts of fructo-oligosaccharide and 20 parts of polydextrose.
A preparation method of stomach-nourishing probiotic solid beverage with gastric acid resistance comprises the following steps: mixing 5 parts of hericium erinaceus, 10 parts of yellow millet, 10 parts of rice, 5 parts of lotus seeds, 5 parts of Chinese yam, 3 parts of poria cocos, 2 parts of gordon euryale seeds, 40 parts of fructo-oligosaccharide and 20 parts of polydextrose, crushing by a crusher, sieving by a 80-mesh sieve, carrying out boiling granulation, and after granulation is finished, sieving a granulation body by a 20-mesh sieve to obtain the medicinal and edible stomach nourishing granules.
Compared with the prior art, the invention has the following beneficial effects:
the stomach-nourishing probiotics are selected from Lactobacillus johnsonii, Lactobacillus salivarius and Lactobacillus plantarum with the helicobacter pylori resistance, and are treated by a four-layer embedding technology to form protein protective layers respectively, so that the protein protective layers have directional slow-release and controlled-release effects; a lipid protective layer protecting the internal substances from bile; the double-layer polysaccharide protective layer is composed of a biomolecule polymer which is insoluble in gastric acid, and has double-effect protection, so that the double-layer polysaccharide protective layer has high acid resistance and high survival rate of intestinal tracts. Meanwhile, a certain amount of medicinal and edible stomach nourishing granules are compounded, so that the compound tea has better mouth melting property and can be drunk directly.
Description of the drawings:
fig. 1 is a schematic structural view of a probiotic embedded particle according to the present invention;
the reference signs are: 1-probiotic core, 2-protein protective layer, 3-lipid protective layer, 4-third polysaccharide protective layer and 5-fourth polysaccharide protective layer.
The specific implementation mode is as follows:
the following detailed description of specific embodiments of the invention is provided, but it should be understood that the scope of the invention is not limited to the specific embodiments.
Throughout the specification and claims, unless explicitly stated otherwise, the word "comprise", or variations such as "comprises" or "comprising", will be understood to imply the inclusion of a stated element or component but not the exclusion of any other element or component.
Example 1
As shown in fig. 1, a stomach nourishing probiotic solid beverage with gastric acid resistance comprises: embedding the probiotic into particles; the probiotic embedded particles comprise probiotic cores 1 and embedding layers, and the probiotic embedded particles embed the probiotic cores 1 in the four embedding layers by adopting a four-layer embedding process; the coating layer comprises a protein protective layer 2, a lipid protective layer 3, a third polysaccharide protective layer 4 and a fourth polysaccharide protective layer 5 from inside to outside in sequence; the protein protective layer 2 has the directional slow-release and controlled-release effects; a lipid protective layer 3, which can protect the inner substances from being damaged by bile; the third polysaccharide protective layer 4 and the fourth polysaccharide protective layer 5 are made of biomolecule polymers which are difficult to dissolve in gastric acid, protect substances embedded inside from being damaged in a low pH value environment, can resist the erosion of gastric acid in vivo, and enable the substances to have high acid resistance and high survival rate of intestinal tracts; the probiotic embedded particle comprises the following components: 100 parts of helicobacter pylori-resistant probiotic composition, 2 parts of concentrated whey protein WPC80, 3 parts of sodium caseinate, 0.1 part of konjac flour, 5 parts of high oleic acid sunflower seed oil, 1 part of trehalose, 1 part of maltodextrin, 5 parts of polyfructose, 1 part of inulin and 0.06 part of phospholipid. The anti-helicobacter pylori probiotic composition is a combination of lactobacillus johnsonii, lactobacillus salivarius and lactobacillus plantarum, and the weight ratio of the lactobacillus johnsonii to the lactobacillus salivarius to the lactobacillus plantarum is 1: 1: 1.
a preparation method of stomach-nourishing probiotic solid beverage with gastric acid resistance comprises the following steps: (1) mixing the components in a weight ratio of 1: 1: 1, taking a composition of lactobacillus johnsonii, lactobacillus salivarius and lactobacillus plantarum as a core material, and mixing concentrated whey protein WPC80, sodium caseinate, konjac flour and deionized water in a mass ratio of 0.2: 0.3: 0.01: 1, carrying out fluidized bed spray embedding on the homogeneous liquid obtained by mixing to obtain a protein protective layer, and drying to obtain an embedded substance A, wherein the water content is less than or equal to 8%;
(2) high oleic acid sunflower seed oil, phospholipid and deionized water are mixed according to a mass ratio of 0.5: 0.002: 1, performing fluidized bed spray embedding on the embedded object A obtained in the step (1) by using mixed homogeneous liquid to obtain a lipid protective layer, and drying to obtain an embedded object B with the water content less than or equal to 5 percent;
(3) mixing trehalose, maltodextrin, phospholipid and water in a mass ratio of 0.1: 0.1: 0.002: 1, performing fluidized bed spray embedding on the embedding material B obtained in the step (2) by using a mixed homogeneous solution to obtain a third polysaccharide protective layer, and drying to obtain an embedding material C with the water content less than or equal to 3%;
(4) inulin, polyfructose, phospholipid and water are mixed according to a mass ratio of 0.1:0.5: 0.002: 1, performing fluidized bed spray embedding on the embedded object C obtained in the step (3) by using a mixed homogeneous solution to obtain a fourth polysaccharide protective layer, and drying to obtain an embedded object D, namely probiotic embedded particles, wherein the moisture content is 1.5-2.5%.
Simulated gastric juice test of probiotic embedded particles:
the test method comprises the following steps: preparing two parts of artificial gastric juice according to a pharmacopoeia method, wherein the pH value is about 2, respectively putting the probiotic embedded particles and the contrast original bacteria powder with equal mass into the corresponding artificial gastric juice, and detecting the viable count result after 2 hours in an artificial gastric juice environment at 37 ℃.
As can be seen from the above table, the survival rate of the embedded probiotic particles is improved by 230% compared with that of the non-embedded probiotic particles after the embedded probiotic particles are treated for 2 hours by simulating gastric acid. The probiotic embedded particles have good acid resistance, and the survival capability of the embedded probiotics passing through the gastrointestinal tract is obviously improved.
Example 2
A stomach nourishing probiotic solid beverage with gastric acid resistance further comprises: medicinal and edible stomach nourishing granules; the components of the medicine are 5 parts of hericium erinaceus, 10 parts of yellow millet, 10 parts of rice, 5 parts of lotus seeds, 5 parts of Chinese yam, 3 parts of poria cocos, 2 parts of gordon euryale seeds, 40 parts of fructo-oligosaccharide and 20 parts of polydextrose.
A preparation method of stomach-nourishing probiotic solid beverage with gastric acid resistance comprises the following steps: mixing 5 parts of hericium erinaceus, 10 parts of yellow millet, 10 parts of rice, 5 parts of lotus seeds, 5 parts of Chinese yam, 3 parts of poria cocos, 2 parts of gordon euryale seeds, 40 parts of fructo-oligosaccharide and 20 parts of polydextrose, crushing by a crusher, sieving by a 80-mesh sieve, carrying out boiling granulation, and after granulation is finished, sieving a granulation body by a 20-mesh sieve to obtain the medicinal and edible stomach nourishing granules.
The compound preparation is a certain amount of medicinal and edible stomach nourishing granules, has better mouth melting property and can be drunk directly.
The foregoing descriptions of specific exemplary embodiments of the present invention have been presented for purposes of illustration and description. It is not intended to limit the invention to the precise form disclosed, and obviously many modifications and variations are possible in light of the above teaching. The exemplary embodiments were chosen and described in order to explain certain principles of the invention and its practical application to enable one skilled in the art to make and use various exemplary embodiments of the invention and various alternatives and modifications as are suited to the particular use contemplated. It is intended that the scope of the invention be defined by the claims and their equivalents.
Claims (8)
1. A stomach nourishing probiotic solid beverage with gastric acid resistance is characterized in that: comprises embedded probiotic particles; the probiotic embedded particles comprise probiotic cores and embedding layers, and the probiotic embedded particles embed the probiotic cores in the four embedding layers by adopting a four-layer embedding process; the coating layer comprises a protein protective layer, a lipid protective layer and a double-layer polysaccharide protective layer from inside to outside in sequence; the probiotic embedded particle comprises the following components: 100 parts of helicobacter pylori-resistant probiotic composition, 2-6 parts of concentrated whey protein, 3-9 parts of sodium caseinate, 0.1-0.3 part of konjac flour, 5-10 parts of high oleic acid sunflower seed oil, 1-2 parts of trehalose, 1-2 parts of maltodextrin, 5-10 parts of polyfructose, 1-2 parts of inulin and 0.06-0.12 part of phospholipid.
2. The stomach nourishing probiotic solid beverage resistant to gastric acid according to claim 1, characterized in that: the probiotic composition for resisting helicobacter pylori is selected from at least one of Lactobacillus acidophilus, Lactobacillus bulgaricus, Lactobacillus plantarum, Lactobacillus rhamnosus, Lactobacillus reuteri, Lactobacillus casei, Lactobacillus gasseri, Lactobacillus johnsonii, Lactobacillus salivarius, Lactobacillus brevis, Streptococcus lactis, Bacillus subtilis, Bifidobacterium bifidum, Bifidobacterium adolescentis, Bifidobacterium infantis, Bifidobacterium breve, Bifidobacterium longum, helicobacter pylori, Bifidobacterium lactis, Lactobacillus formaticus, Acetobacter striatum, Acetobacter xylinum, Pediococcus cerevisiae, Streptococcus thermophilus, Aspergillus oryzae, Aspergillus ankarum and lactococcus lactis.
3. The stomach nourishing probiotic solid beverage resistant to gastric acid according to claim 2, characterized in that: the helicobacter pylori-resisting probiotic composition is a combination of lactobacillus johnsonii, lactobacillus salivarius and lactobacillus plantarum, and the weight ratio of the lactobacillus johnsonii to the lactobacillus salivarius to the lactobacillus plantarum is 1: 1: 1.
4. the stomach nourishing probiotic solid beverage resistant to gastric acid according to claim 1, characterized in that: the concentrated whey protein is selected from concentrated whey protein WPC70, concentrated whey protein WPC80, and WPI.
5. The stomach nourishing probiotic solid beverage resistant to gastric acid according to claim 4, characterized in that: the concentrated whey protein is concentrated whey protein WPC 80.
6. A preparation method of stomach-nourishing probiotic solid beverage with gastric acid resistance comprises the following steps: (1) taking the helicobacter pylori-resistant probiotic composition as a core material, and mixing concentrated whey protein, sodium caseinate, konjac flour and deionized water in a mass ratio of 0.2: 0.3: 0.01: 1, carrying out fluidized bed spray embedding on the homogeneous liquid obtained by mixing to obtain a protein protective layer, and drying to obtain an embedded substance A, wherein the water content is less than or equal to 8%;
(2) high oleic acid sunflower seed oil, phospholipid and deionized water are mixed according to a mass ratio of 0.5: 0.002: 1, performing fluidized bed spray embedding on the embedded object A obtained in the step (1) by using mixed homogeneous liquid to obtain a lipid protective layer, and drying to obtain an embedded object B with the water content less than or equal to 5 percent;
(3) mixing trehalose, maltodextrin, phospholipid and water in a mass ratio of 0.1: 0.1: 0.002: 1, performing fluidized bed spray embedding on the embedding material B obtained in the step (2) by using a mixed homogeneous solution to obtain a third polysaccharide protective layer, and drying to obtain an embedding material C with the water content less than or equal to 3%;
(4) inulin, polyfructose, phospholipid and water are mixed according to a mass ratio of 0.1:0.5: 0.002: 1, performing fluidized bed spray embedding on the embedded object C obtained in the step (3) by using a mixed homogeneous solution to obtain a fourth polysaccharide protective layer, and drying to obtain an embedded object D, namely probiotic embedded particles, wherein the moisture content is 1.5-2.5%.
7. A stomach-nourishing probiotic solid beverage resistant to gastric acid according to any one of claims 1 to 5, characterized in that: comprises medicinal and edible stomach nourishing granules; the components of the medicine are 5 parts of hericium erinaceus, 10 parts of yellow millet, 10 parts of rice, 5 parts of lotus seeds, 5 parts of Chinese yam, 3 parts of poria cocos, 2 parts of gordon euryale seeds, 40 parts of fructo-oligosaccharide and 20 parts of polydextrose.
8. The preparation method of the stomach nourishing probiotic solid beverage with gastric acid resistance according to claim 7 comprises the following steps: mixing 5 parts of hericium erinaceus, 10 parts of yellow millet, 10 parts of rice, 5 parts of lotus seeds, 5 parts of Chinese yam, 3 parts of poria cocos, 2 parts of gordon euryale seeds, 40 parts of fructo-oligosaccharide and 20 parts of polydextrose, crushing by a crusher, sieving by a 80-mesh sieve, carrying out boiling granulation, and after granulation is finished, sieving a granulation body by a 20-mesh sieve to obtain the medicinal and edible stomach nourishing granules.
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