CN114008458A - 用于检测头颈部表皮样癌的唾液生物标志物 - Google Patents

用于检测头颈部表皮样癌的唾液生物标志物 Download PDF

Info

Publication number
CN114008458A
CN114008458A CN202080041403.4A CN202080041403A CN114008458A CN 114008458 A CN114008458 A CN 114008458A CN 202080041403 A CN202080041403 A CN 202080041403A CN 114008458 A CN114008458 A CN 114008458A
Authority
CN
China
Prior art keywords
saliva
concentration
genus
cancer
level
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080041403.4A
Other languages
English (en)
Chinese (zh)
Inventor
V·M·纳瓦罗·洛佩兹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bainiu R&d Co ltd
Original Assignee
Bainiu R&d Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bainiu R&d Co ltd filed Critical Bainiu R&d Co ltd
Publication of CN114008458A publication Critical patent/CN114008458A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56955—Bacteria involved in periodontal diseases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57557—Immunoassay; Biospecific binding assay; Materials therefor for cancer of other specific parts of the body, e.g. brain
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/205—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Campylobacter (G)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN202080041403.4A 2019-04-05 2020-04-06 用于检测头颈部表皮样癌的唾液生物标志物 Pending CN114008458A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19382253.3A EP3719498A1 (en) 2019-04-05 2019-04-05 Salivary biomarkers for the detection of head and neck epidermoid cancer (cecc)
EP19382253.3 2019-04-05
PCT/EP2020/059761 WO2020201575A1 (en) 2019-04-05 2020-04-06 Salivary biomarkers for the detection of epidermoid cancer of the head and neck

Publications (1)

Publication Number Publication Date
CN114008458A true CN114008458A (zh) 2022-02-01

Family

ID=67437232

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080041403.4A Pending CN114008458A (zh) 2019-04-05 2020-04-06 用于检测头颈部表皮样癌的唾液生物标志物

Country Status (10)

Country Link
US (1) US12584178B2 (enExample)
EP (2) EP3719498A1 (enExample)
JP (1) JP7557789B2 (enExample)
KR (1) KR20210149144A (enExample)
CN (1) CN114008458A (enExample)
AU (1) AU2020252417B2 (enExample)
CA (1) CA3135976A1 (enExample)
ES (1) ES3053185T3 (enExample)
PL (1) PL3948285T3 (enExample)
WO (1) WO2020201575A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12334375B2 (en) 2019-08-08 2025-06-17 Lam Research Corporation Spindle assembly for wafer transfer in a multi-station process module
KR20240052707A (ko) * 2022-10-14 2024-04-23 국립암센터 구강 미생물총 기반 구강암의 진단

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180003348A (ko) * 2016-06-30 2018-01-09 연세대학교 산학협력단 폐암의 진단 또는 폐암의 병기에 관한 정보를 제공하는 방법 및 이를 이용하는 키트
US20180010171A1 (en) * 2016-06-23 2018-01-11 The Charlotte Mecklenburg Hospital Authority D/B/A Carolinas Healthcare System Compositions and methods for oral microbiome signatures

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180010171A1 (en) * 2016-06-23 2018-01-11 The Charlotte Mecklenburg Hospital Authority D/B/A Carolinas Healthcare System Compositions and methods for oral microbiome signatures
KR20180003348A (ko) * 2016-06-30 2018-01-09 연세대학교 산학협력단 폐암의 진단 또는 폐암의 병기에 관한 정보를 제공하는 방법 및 이를 이용하는 키트

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ABDRAZAK AMER ET AL.: ""The Microbiome of Potentially Malignant Oral Leukoplakia Exhibits Enrichment for Fusobacterium, Leptotrichia, Campylobacter, and Rothia Species"", 《FRONTIERS IN MICROBIOLOGY》, vol. 8, 1 December 2017 (2017-12-01), pages 1 - 9 *
HONGLI GONG ET AL.: ""Microbiota in the Throat and Risk Factors for Laryngeal Carcinoma"", 《APPLIED AND ENVIRONMENTAL MICROBIOLOGY》, vol. 80, no. 23, 19 September 2014 (2014-09-19), pages 7356 - 7363 *
IAN GANLY ET AL.: ""Periodontal pathogens are a risk factor of oral cavity squamous cell carcinoma, inde pendent of tobacco and alcohol and human papillomavirus"", 《INTERNATIONAL JOURNAL OF CANCER》, vol. 145, 22 January 2019 (2019-01-22), pages 775 - 784 *
IAN GANLY ET AL.: ""Periodontal pathogens are a risk factor of oral cavity squamous cell carcinoma, independent of tobacco and alcohol and human papillomavirus"", 《INTERNATIONAL JOURNAL OF CANCER》, vol. 145, 22 January 2019 (2019-01-22), pages 775 - 784, XP055653573, DOI: 10.1002/ijc.32152 *
JENN-REN HSIAO ET AL.: ""The interplay between oral microbiome, lifestyle factors and genetic polymorphisms in the risk of oral squamous cell carcinoma"", 《CARCINOGENESIS》, vol. 39, no. 6, 13 April 2018 (2018-04-13), pages 778 - 787, XP055653798, DOI: 10.1093/carcin/bgy053 *
MOK SHAO FENG ET AL.: ""The oral microbiome community variations associated with normal, potentially malignant disorders and malignant lesions of the oral cavity"", 《MALAYSIAN J PATHOL》, 30 April 2017 (2017-04-30), pages 1 - 15 *
SMRUTI PUSHALKAR ET AL.: ""Comparison of oral microbiota in tumor and non-tumor tissues of patients with oral squamous cell carcinoma"", 《BMC MICROBIOLOGY》, vol. 12, 20 July 2012 (2012-07-20), pages 1 - 15 *
吴芳 等: ""16S rRNA基因克隆文库分析比较牙周炎患者和健康人口腔唾液微生物多样性"", 《微生物学通报》, vol. 43, no. 6, 20 June 2016 (2016-06-20), pages 1295 *

Also Published As

Publication number Publication date
EP3948285C0 (en) 2025-09-03
US20220170111A1 (en) 2022-06-02
US12584178B2 (en) 2026-03-24
ES3053185T3 (en) 2026-01-20
AU2020252417B2 (en) 2025-12-18
EP3719498A1 (en) 2020-10-07
KR20210149144A (ko) 2021-12-08
EP3948285B1 (en) 2025-09-03
EP3948285A1 (en) 2022-02-09
WO2020201575A1 (en) 2020-10-08
JP7557789B2 (ja) 2024-09-30
AU2020252417A1 (en) 2021-12-02
PL3948285T3 (pl) 2025-12-01
CA3135976A1 (en) 2020-10-08
JP2022529909A (ja) 2022-06-27

Similar Documents

Publication Publication Date Title
KR102930361B1 (ko) 암의 평가 및/또는 치료를 위한 무 세포 dna
US8673555B2 (en) Detecting neoplasm
CN114736968A (zh) 血浆游离dna甲基化标志物在肺癌早筛中的用途以及肺癌早筛装置
CN112609015A (zh) 一种预测结直肠癌风险的微生物标志物及其应用
CN114008458A (zh) 用于检测头颈部表皮样癌的唾液生物标志物
Lin et al. Analysis of the triage value of multigene methylation testing for CIN2+ in hrHPV-positive patients
TWI881732B (zh) 預測結直腸癌或結直腸腺瘤風險的新型微生物標誌物
CN114231648B (zh) 牙周梭杆菌作为食管鳞状细胞癌生物标志物及其应用
CN118460724A (zh) 一种早期胃癌淋巴结转移的甲基化标志物及应用
CN114480636B (zh) 胆汁细菌作为肝门部胆管癌诊断及预后标志物的用途
CN118006815A (zh) 具核梭杆菌特异性dna序列及其应用和检测方法
CN113667757B (zh) 用于前列腺癌早期筛查的生物标志物组合、试剂盒及应用
CN117106918A (zh) 基因甲基化鉴别诊断肺良性结节和恶性肿瘤方法及其试剂盒
CN114854855A (zh) 食管癌的生物标志物、核酸产品和试剂盒
KR102954588B1 (ko) 기관지폐포세척액의 마이크로바이옴을 포함하는 폐암 진단용 바이오마커 조성물
Qin et al. Noninvasive detection of early nasopharyngeal carcinoma based on three gene methylation analysis in bilateral nasal swab samples processed automatically
WO2019095541A1 (zh) 一种诊断预示乳腺癌骨转移的组合物及诊断预示方法
JP7558511B2 (ja) 被験者の脳微小出血の重症化リスクを予測するための方法、脳微小出血の重症化リスクの高い被験者をスクリーニングするための方法、及びそれらに用いるキット
HK1223986A1 (zh) 结直肠癌的检测引物、方法及试剂盒
WO2026090778A1 (zh) 用于检测胃癌的标志物、试剂盒及其应用
CN120484063A (zh) 一种多肽作为标志物在诊断绝经后骨质疏松症中的应用
KR20240176856A (ko) 기관지폐포세척액의 마이크로바이옴을 포함하는 폐암 진단용 바이오마커 조성물
CN117402962A (zh) 膀胱癌尿液微生物标志物及其应用
CN119433057A (zh) 一种基于粪便中幽门螺旋杆菌单核苷酸位点的应用
HK40089228A (zh) 预测结直肠癌风险的新型微生物标志物

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination