CN114007633A - 作为治疗前列腺癌的新型标志物的ephb4-肝配蛋白b2受体配体对 - Google Patents

作为治疗前列腺癌的新型标志物的ephb4-肝配蛋白b2受体配体对 Download PDF

Info

Publication number
CN114007633A
CN114007633A CN202080028627.1A CN202080028627A CN114007633A CN 114007633 A CN114007633 A CN 114007633A CN 202080028627 A CN202080028627 A CN 202080028627A CN 114007633 A CN114007633 A CN 114007633A
Authority
CN
China
Prior art keywords
treatment
cancer
therapy
ephb4
refractory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080028627.1A
Other languages
English (en)
Chinese (zh)
Inventor
V·卡拉斯诺佩洛夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vascular Gene Therapy Co
Original Assignee
Vascular Gene Therapy Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vascular Gene Therapy Co filed Critical Vascular Gene Therapy Co
Publication of CN114007633A publication Critical patent/CN114007633A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4703Inhibitors; Suppressors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN202080028627.1A 2019-02-13 2020-02-13 作为治疗前列腺癌的新型标志物的ephb4-肝配蛋白b2受体配体对 Pending CN114007633A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962805291P 2019-02-13 2019-02-13
US62/805,291 2019-02-13
PCT/US2020/018160 WO2020168110A1 (en) 2019-02-13 2020-02-13 Ephb4-ephrin b2 receptor ligand pair as a novel marker for the treatment of prostate cancer

Publications (1)

Publication Number Publication Date
CN114007633A true CN114007633A (zh) 2022-02-01

Family

ID=72045655

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080028627.1A Pending CN114007633A (zh) 2019-02-13 2020-02-13 作为治疗前列腺癌的新型标志物的ephb4-肝配蛋白b2受体配体对

Country Status (8)

Country Link
US (1) US20220153791A1 (https=)
EP (1) EP3923969A4 (https=)
JP (1) JP2022520596A (https=)
KR (1) KR20220010469A (https=)
CN (1) CN114007633A (https=)
AU (1) AU2020221276A1 (https=)
CA (1) CA3139416A1 (https=)
WO (1) WO2020168110A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113939309A (zh) * 2019-03-17 2022-01-14 血管基因治疗公司 使用sEphB4-HSA融合蛋白治疗癌症
CN118290563A (zh) * 2024-06-03 2024-07-05 磐如生物科技(天津)有限公司 一种前列腺癌抗原肽和免疫佐剂组合物及其在抗肿瘤中的应用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2021012208A (es) 2013-10-04 2023-01-19 Infinity Pharmaceuticals Inc Compuestos heterocíclicos y usos de los mismos.
NZ724368A (en) 2014-03-19 2023-07-28 Infinity Pharmaceuticals Inc Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
EP4585268A3 (en) 2015-09-14 2025-10-15 Twelve Therapeutics, Inc. Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
CA3211742A1 (en) * 2021-03-18 2022-09-22 Valery Krasnoperov Use of sephb4-hsa fusion protein as a first-line therapy in cancer treatment

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060040325A1 (en) * 2004-08-16 2006-02-23 Medimmune, Inc. Integrin antagonists with enhanced antibody dependent cell-mediated cytoxicity activity
US20060204512A1 (en) * 2004-09-23 2006-09-14 Vasgene Therapeutics, Inc. Polypeptide compounds for inhibiting angiogenesis and tumor growth
WO2012068477A1 (en) * 2010-11-19 2012-05-24 Vasgene Therapeutics, Inc. Methods and compositions for inhibiting angiogenesis and tumor growth
US20150301058A1 (en) * 2012-11-26 2015-10-22 Caris Science, Inc. Biomarker compositions and methods
CN113939309A (zh) * 2019-03-17 2022-01-14 血管基因治疗公司 使用sEphB4-HSA融合蛋白治疗癌症

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7381410B2 (en) * 2003-03-12 2008-06-03 Vasgene Therapeutics, Inc. Polypeptide compounds for inhibiting angiogenesis and tumor growth

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060040325A1 (en) * 2004-08-16 2006-02-23 Medimmune, Inc. Integrin antagonists with enhanced antibody dependent cell-mediated cytoxicity activity
US20060204512A1 (en) * 2004-09-23 2006-09-14 Vasgene Therapeutics, Inc. Polypeptide compounds for inhibiting angiogenesis and tumor growth
US20100261653A1 (en) * 2004-09-23 2010-10-14 Vasgene Therapeutics, Inc. Polypeptide compounds for inhibiting angiogenesis and tumor growth
WO2012068477A1 (en) * 2010-11-19 2012-05-24 Vasgene Therapeutics, Inc. Methods and compositions for inhibiting angiogenesis and tumor growth
US20150301058A1 (en) * 2012-11-26 2015-10-22 Caris Science, Inc. Biomarker compositions and methods
CN113939309A (zh) * 2019-03-17 2022-01-14 血管基因治疗公司 使用sEphB4-HSA融合蛋白治疗癌症

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LI C.等: "Inhibition of the erythropoietin-producing receptor EPHB4 antagonizes androgen receptor overexpression and reduces enzalutamide resistance", 《J BIOL CHEM》, vol. 295, no. 16, 17 April 2020 (2020-04-17), pages 5470 - 5483 *
SARMAD SADEGHI等: "EphB4-EphrinB2 receptor-ligand pair as a novel target in prostate cancer (PC).", 《JOURNAL OF CLINICAL ONCOLOGY》, vol. 37, no. 7, 26 February 2019 (2019-02-26) *
傅明杰;邢雪;: "Eph受体家族与肿瘤及肿瘤血管的相关性研究进展", 临床普外科电子杂志, no. 02, 1 April 2014 (2014-04-01) *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113939309A (zh) * 2019-03-17 2022-01-14 血管基因治疗公司 使用sEphB4-HSA融合蛋白治疗癌症
CN118290563A (zh) * 2024-06-03 2024-07-05 磐如生物科技(天津)有限公司 一种前列腺癌抗原肽和免疫佐剂组合物及其在抗肿瘤中的应用
CN118290563B (zh) * 2024-06-03 2024-08-02 磐如生物科技(天津)有限公司 一种前列腺癌抗原肽和免疫佐剂组合物及其在抗肿瘤中的应用

Also Published As

Publication number Publication date
KR20220010469A (ko) 2022-01-25
CA3139416A1 (en) 2020-08-20
US20220153791A1 (en) 2022-05-19
WO2020168110A1 (en) 2020-08-20
EP3923969A1 (en) 2021-12-22
JP2022520596A (ja) 2022-03-31
AU2020221276A1 (en) 2021-10-07
EP3923969A4 (en) 2022-10-19

Similar Documents

Publication Publication Date Title
CN114007633A (zh) 作为治疗前列腺癌的新型标志物的ephb4-肝配蛋白b2受体配体对
ES2564794T5 (es) R-espondinas como moduladores de angiogénesis y vasculogénesis
US10786545B2 (en) Use of peptides that block metadherin-SND1 interaction as treatment for cancer
EP3398966A1 (en) Methods and compositions for modulating angiogenesis and pericyte composition
US9452197B2 (en) Antagonists of BMP9, BMP10, ALK1 and other ALK1 ligands, and uses thereof
US20130202594A1 (en) ALK1 Antagonists and Their Uses in Treating Renal Cell Carcinoma
AU2016261770B2 (en) Compounds and compositions useful for treating or preventing cancer metastasis, and methods using same
KR20220015375A (ko) Sephb4-hsa 융합 단백질을 이용한 암의 치료
US10195166B2 (en) Methods for treating hepatitis C virus infectious disease
HK40068256A (en) Ephb4-ephrin b2 receptor ligand pair as a novel marker for the treatment of prostate cancer
US20120121589A1 (en) Modified egfr ectodomain
US20260053891A1 (en) Methods and compositions for treating cancer
US20250134975A1 (en) Cancer vaccine comprising epitope of c-met and use thereof
JP2008525050A (ja) ゼブラフィッシュのヘテロ三量体Gタンパク質γ2サブユニット(GNG2)
AU2015337859B2 (en) Use of therapeutic agents
JP2025516174A (ja) T細胞疲弊を防止するための組成物及び方法
TW202529780A (zh) 包含抗steap2嵌合抗原受體t細胞之治療組合
Moscoso 22nd Annual Meeting of the American Society of Gene and Cell Therapy (ASGCT). Washington, DC, USA-April 29-May 2, 2019
JP2016501856A (ja) 乳癌を処置するためのcd44v6由来ペプチド

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40068256

Country of ref document: HK

WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20220201

WD01 Invention patent application deemed withdrawn after publication