CN113996448A - Hyaluronic acid dressing centrifugal purification device and use method - Google Patents
Hyaluronic acid dressing centrifugal purification device and use method Download PDFInfo
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- CN113996448A CN113996448A CN202111242815.7A CN202111242815A CN113996448A CN 113996448 A CN113996448 A CN 113996448A CN 202111242815 A CN202111242815 A CN 202111242815A CN 113996448 A CN113996448 A CN 113996448A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/02—Centrifuges consisting of a plurality of separate bowls rotating round an axis situated between the bowls
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/16—Rotary, reciprocated or vibrated modules
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B11/00—Feeding, charging, or discharging bowls
- B04B11/04—Periodical feeding or discharging; Control arrangements therefor
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B7/00—Elements of centrifuges
- B04B7/08—Rotary bowls
- B04B7/12—Inserts, e.g. armouring plates
- B04B7/16—Sieves or filters
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B9/00—Drives specially designed for centrifuges; Arrangement or disposition of transmission gearing; Suspending or balancing rotary bowls
- B04B9/02—Electric motor drives
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B9/00—Drives specially designed for centrifuges; Arrangement or disposition of transmission gearing; Suspending or balancing rotary bowls
- B04B9/08—Arrangement or disposition of transmission gearing ; Couplings; Brakes
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The invention provides a hyaluronic acid dressing centrifugal purification device and a use method thereof, wherein the device comprises a centrifugal mechanism, a driving mechanism, a locking mechanism, a supporting mechanism and a supporting tray; the locking mechanism is used for driving the centrifugal mechanism to rotate; the centrifugal mechanism is used for centrifugally purifying the hyaluronic acid dressing with different centrifugal degrees; the device has a reasonable structure, adopts a brand-new grading centrifugal cylinder, can debug out hyaluronic acid dressing with proper centrifugal degree according to centrifugal cylinders with different radiuses, can quickly separate out hyaluronic acid dressing with different centrifugal degrees, saves a complex material guide assembly, is convenient for the derivation of the hyaluronic acid dressing, and is convenient and efficient to use.
Description
Technical Field
The invention discloses a hyaluronic acid dressing centrifugal purification device and a using method thereof, and relates to the field of hyaluronic acid dressing centrifugal purification.
Background
Hyaluronic acid, also known as hyaluronic acid, is a disaccharide glycosaminoglycan composed of D-glucuronic acid and N-acetylglucosamine. Hyaluronic acid is an acidic mucopolysaccharide, which was first isolated from bovine vitreous humor by Meyer et al, university of Columbia, 1934. Hyaluronic acid has biochemical drugs with high clinical value, and is widely applied to various ophthalmic surgeries, such as crystal implantation, corneal transplantation, anti-glaucoma surgeries and the like. It can also be used for treating arthritis and promoting wound healing. The skin care cosmetic has unique skin protection effect, can keep skin moist, smooth, fine, tender and elastic, and has the effects of preventing wrinkles, resisting wrinkles, beautifying, protecting health and recovering physiological functions of the skin.
There are three methods for refining hyaluronic acid:
1. animal tissue: the main raw materials are cockscomb, bulls-eye vitreous body and the like. Defatting raw materials with acetone or ethanol, dehydrating, soaking in distilled water, filtering, treating with sodium chloride water solution and chloroform solution, adding trypsin, keeping temperature to obtain mixed solution, treating with ion exchanger, and purifying to obtain refined hyaluronic acid. The method has extremely low extraction rate of only about 1 percent and complicated separation process, so that the hyaluronic acid is expensive and reaches $ 5000/kg, and the method limits the use of the hyaluronic acid in large amount in cosmetics.
2. And (3) microbial fermentation: glucose is used as carbon source fermentation liquor and is fermented in a culture medium for 48 hours, mycelium and impurities are removed by filtration after the fermentation is finished, and then a high-purity product is obtained by simple operations such as an alcohol precipitation method and the like. The hyaluronic acid prepared by the fermentation method has the advantages that the molecular weight can be set according to the commodity design, and the key point of the fermentation method is the selection of strains, and the selection of streptococcus, lactic acid bacteria and the like is performed.
3. Chemical synthesis: the hyaluronic acid is synthesized by a natural enzyme polymerization reaction, synthesizing a hyaluronic acid oxazepine derivative by using a polysaccharide polymer, adding a water-splitting enzyme to prepare a complex of the derivative and the enzyme, and removing the enzyme in a reaction solution at 90 ℃. The artificial synthesis method can greatly reduce the manufacturing cost of the hyaluronic acid, but the structure is not pure.
In the prior art, no matter which of the above refining methods is used, the purity of the hyaluronic acid is low, so centrifugal purification is required, the higher the centrifugal degree is, the higher the purity is, but the lower the yield is, and the traditional hyaluronic acid centrifugal purification device cannot adjust the proper centrifugal degree according to the purity requirement; in addition, the centrifuged hyaluronic acid needs to be filtered and exported, and the conventional devices need to be distributed and finished, so that the structure is complicated, and therefore, a centrifugal purification device for hyaluronic acid dressing and a use method thereof are urgently needed to solve the problems.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a hyaluronic acid dressing centrifugal purification device and a use method, so as to solve the problems in the background technology, the hyaluronic acid dressing centrifugal purification device is reasonable in structure, adopts a brand-new grading centrifugal cylinder, can be used for debugging hyaluronic acid dressings with proper centrifugal degrees according to centrifugal cylinders with different radiuses, can be used for quickly separating hyaluronic acid dressings with different centrifugal degrees, and is convenient to use and high in efficiency due to the fact that a complex material guide assembly is omitted.
In order to achieve the purpose, the invention is realized by the following technical scheme: a hyaluronic acid dressing centrifugal purification device comprises a centrifugal mechanism, a driving mechanism, a locking mechanism, a supporting mechanism and a supporting tray;
the locking mechanism is used for driving the centrifugal mechanism to rotate and comprises a motor and a guide shaft, the motor is arranged on the supporting tray, a magnetic limiting disc is arranged on a power shaft of the motor, and the guide shaft is connected to the power shaft of the motor;
the centrifugal mechanism is used for centrifugally purifying hyaluronic acid dressings with different centrifugation degrees and comprises a centrifugal cylinder and a centrifugal filter membrane, the centrifugal cylinder is sleeved on a guide shaft, the centrifugal filter membrane is arranged in the centrifugal cylinder, and a liquid level meter is arranged on the centrifugal cylinder in a penetrating manner;
the supporting mechanism is used for supporting and moving the centrifugal cylinder up and down, and the supporting mechanism is an electric telescopic rod.
Furthermore, a plurality of centrifugal cylinders are arranged, the diameters of the centrifugal cylinders are different, and the centrifugal cylinders are overlapped and sleeved in a concentric circle mode.
Further, the injection mouth has been seted up at the top of centrifuge bowl, and the injection mouth runs through and is provided with the injection stopper, the medicine outlet has been seted up to the bottom of centrifuge bowl, and goes out the medicine outlet and run through and be provided with solenoid valve or go out the medicine stopper, the inside of centrifuge bowl is provided with the balancing weight, and the balancing weight is used for balancing the centrifugal force when centrifuge bowl is rotatory.
Further, the centrifugal filter membrane is of a circular truncated cone structure with two hollow end faces, and the centrifugal filter membrane is fixedly arranged in the centrifugal cylinder.
Furthermore, the magnetic limiting disc is magnetically attracted with the bottom of the centrifugal cylinder.
Further, be provided with a plurality of on the support tray and be used for receiving the silo that connects of liquid in the different centrifuge bowl, be provided with the locking mechanism who is used for centrifuge bowl location to stop on the support tray, the locking includes electro-magnet and iron sheet, the electro-magnet sets up on the support tray, the iron sheet is attached at the centrifuge bowl lower surface, the rotating surface of iron sheet and the coincidence of the central line of electro-magnet.
Furthermore, the number of the electric telescopic rods is at least three, and each electric telescopic rod is distributed on the upper surface of the support tray at equal intervals.
Furthermore, the surface of the guide shaft is provided with teeth, the inner side of the centrifugal cylinder at the innermost side is provided with a tooth sleeve, and the tooth sleeve is matched with the teeth.
Further, the use method of the hyaluronic acid dressing centrifugal purification device comprises the following steps:
the method comprises the following steps that (1) a supporting tray is placed on a designated supporting plane, a plurality of centrifugal cylinders with different diameters are overlapped and sleeved according to a concentric circle pattern, and finally, an integral structure is formed in a sleeved mode;
step (1-1), inserting the integral structure in the step (1) into a guide shaft, and magnetically attaching the bottom of a centrifugal cylinder to a magnetic limiting disc;
opening a medicine injection port on the centrifugal cylinder, pouring hyaluronic acid dressing to be centrifugally treated into the centrifugal cylinder, injecting hyaluronic acid dressing with a specified volume into the centrifugal cylinder by continuously observing the reading of a liquid level meter, and tightly covering the medicine injection port after the liquid level meter reaches the reading of the specified volume;
step (3), a motor is electrified, the motor drives a centrifugal cylinder to rotate at a high speed in a centrifugal mode through a guide shaft for a period of time, after the centrifugal cylinder rotates at a high speed, hyaluronic acid dressing materials in the centrifugal cylinder are layered under the action of centrifugal force, the centrifuged hyaluronic acid dressing materials are filtered out through a centrifugal filter membrane, the filtered hyaluronic acid dressing materials enter the bottom of the centrifugal cylinder, and after the motor is electrified for a period of time, the motor is powered off;
step (4), when the motor is powered off, the electromagnet is powered on, the rotating iron sheet is continuously adsorbed after the electromagnet is powered on, finally the iron sheet is adsorbed at the top of the electromagnet, the centrifugal cylinder is stopped, and at the moment, the medicine outlet of the centrifugal cylinder is just aligned to the material receiving groove;
step (5), when the centrifuge finally stops, the electric telescopic rod is powered on, and the electric telescopic rod supports the centrifuge tube to move upwards for a certain distance;
step (5-1), opening an electromagnetic valve at the medicine outlet or a medicine outlet plug at the moment, and pouring the hyaluronic acid dressing after centrifugation in the centrifugal cylinder into a corresponding material receiving groove;
step (6), finally, taking out the material receiving groove, electrifying the electric telescopic rod to descend to the lowest position, enabling the bottom of the centrifugal cylinder to be magnetically adsorbed with the magnetic limiting disc again, completing a centrifugal cycle, and centrifugally processing another batch of hyaluronic acid dressing according to the steps (1) to (6);
step (6-1), after the centrifugation is finished, the electric telescopic rod can be continuously electrified, and the electric telescopic rod supports the centrifugal cylinder to leave the magnetic limiting disc; and then taking the centrifugal cylinder out of the guide shaft, opening the medicine injection port and the medicine outlet port on the upper side and the lower side of the centrifugal cylinder, and cleaning the magnetic limiting disc in the centrifugal cylinder to be magnetically attracted with the bottom of the centrifugal cylinder.
Further, in the step (2), the hyaluronic acid dressing with high centrifugal degree and needing large centrifugal force is placed in a large-diameter centrifugal cylinder, and the hyaluronic acid dressing with low centrifugal degree and needing small centrifugal force is placed in a small-diameter centrifugal cylinder; in the step (3), the power-on time of the motor is set according to the centrifugal time of the hyaluronic acid dressing.
The invention has the beneficial effects that:
1. the centrifugal mechanism is used for centrifugally purifying hyaluronic acid dressings with different centrifugation degrees, and comprises a centrifugal cylinder and a centrifugal filter membrane, wherein the centrifugal cylinder is sleeved on a guide shaft, the centrifugal filter membrane is arranged in the centrifugal cylinder, and the hyaluronic acid dressings after centrifugation are filtered and layered again by adding the centrifugal filter membrane so as to play a role in purifying and filtering impurities in the hyaluronic acid dressings;
2. the centrifugal cylinder is provided with a plurality of centrifugal cylinders, the diameters of the centrifugal cylinders are different, and the plurality of centrifugal cylinders are overlapped and sleeved in a concentric circle manner; the design is that at the same rotating speed, the formula of the centrifugal force F = m omega2r where ω denotes the angular velocity of the rotation of the non-inertial system itself, r denotes the radius of rotation, and m denotes the mass of the object, it can be seen that under the same mass m and angular velocity ω, the centrifugal force F is in positive linear correlation with the radius of rotation r, and therefore, different centrifugal forces can be obtained for centrifuges of different radii;
3. the locking mechanism is used for driving the centrifugal mechanism to rotate; the motor drives the centrifugal cylinder to rotate at high speed, and the design of the guide shaft is convenient for the disassembly of the centrifugal cylinder;
4. the supporting mechanism is used for supporting and moving the centrifugal cylinder up and down, the supporting mechanism is at least three electric telescopic rods, each electric telescopic rod is distributed on the upper surface of the supporting tray at equal intervals, and the centrifugal cylinder is supported to move up and down through the up-and-down movement of the electric telescopic rods, so that the hyaluronic acid dressing in the centrifugal cylinder can be conveniently led out;
5. the hyaluronic acid dressing separation device is reasonable in structure, adopts a brand-new grading centrifugal cylinder, can be used for debugging hyaluronic acid dressings with proper centrifugal degrees according to centrifugal cylinders with different radiuses, and can be used for quickly separating hyaluronic acid dressings with different centrifugal degrees.
Drawings
Other features, objects and advantages of the invention will become more apparent upon reading of the detailed description of non-limiting embodiments with reference to the following drawings:
FIG. 1 is a schematic structural diagram of a hyaluronic acid dressing centrifugal purification device of the invention;
FIG. 2 is a front sectional view of a hyaluronic acid dressing centrifugal purification device of the present invention;
FIG. 3 is a left sectional view of a hyaluronic acid dressing centrifugal purification device of the present invention;
FIG. 4 is a schematic structural diagram of a centrifugal filter membrane in the centrifugal purification device for hyaluronic acid dressing according to the present invention;
FIG. 5 is a schematic structural diagram of a guide shaft in the centrifugal purification device for hyaluronic acid dressing;
in the figure: 1 centrifugal mechanism, 11 centrifugal cylinder, 12 medicine injection port, 13 liquid level meter, 14 centrifugal filter membrane, 15 medicine outlet, 16 balancing weight, 21 supporting tray, 22 material receiving groove, 3 driving mechanism, 31 motor, 32 magnetic limiting disc, 33 guide shaft, 4 locking mechanism, 41 electromagnet, 42 iron sheet and 5 supporting mechanism.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
Referring to fig. 1-5, the present invention provides a technical solution: a hyaluronic acid dressing centrifugal purification device comprises a centrifugal mechanism 1, a driving mechanism 3, a locking mechanism 4, a supporting mechanism 5 and a supporting tray 21; the problem that the hyaluronic acid dressing in the past can not be purified in a grading way according to the requirement of the centrifugation degree, and the derivation process of the centrifuged hyaluronic acid dressing is complex is solved.
The locking mechanism 4 is used for driving the centrifugal mechanism 1 to rotate, the locking mechanism 4 comprises a motor 31 and a guide shaft 33, the motor 31 is arranged on the supporting tray 21, a magnetic limiting disc 32 is arranged on a power shaft of the motor 31, the guide shaft 33 is connected to the power shaft of the motor 31, teeth are arranged on the surface of the guide shaft 33, a tooth sleeve is arranged on the inner side of the centrifugal cylinder 11 at the innermost side, and the tooth sleeve is matched with the teeth; the motor 31 drives the centrifugal cylinder 11 to rotate at high speed, and the design of the guide shaft 33 facilitates the disassembly of the centrifugal cylinder 11.
The centrifugal mechanism 1 is used for centrifugally purifying hyaluronic acid dressings with different centrifugation degrees, the centrifugal mechanism 1 comprises a centrifugal cylinder 11 and a centrifugal filter membrane 14, the centrifugal cylinder 11 is sleeved on a guide shaft 33, the centrifugal filter membrane 14 is arranged in the centrifugal cylinder 11, and the centrifugal filter membrane 14 is added to enable the centrifuged hyaluronic acid dressings to be filtered and layered again so as to achieve the effect of purifying and filtering impurities in the hyaluronic acid dressings;
a plurality of centrifugal cylinders 11 are arranged, the diameter of each centrifugal cylinder 11 is different, and the plurality of centrifugal cylinders 11 are overlapped and sleeved in a concentric circle manner; the design is that at the same rotating speed, the formula of the centrifugal force F = m omega2r where ω denotes the angular velocity at which the non-inertial system itself rotates, r denotes the radius of rotation, and m denotes the mass of the object, it can be seen that the centrifugal force F is positively linearly related to the radius of rotation r for the same mass m and angular velocity ω, and thus different centrifugal forces can be obtained for different radii of the centrifuge bowl 11.
The supporting mechanism 5 is used for supporting and moving the centrifugal cylinder 11 up and down, the supporting mechanism 5 is at least three electric telescopic rods, each electric telescopic rod is distributed on the upper surface of the supporting tray 21 at equal intervals, and the centrifugal cylinder 11 is supported to move up and down through the up-and-down movement of the electric telescopic rods, so that the hyaluronic acid dressing in the centrifugal cylinder 11 can be conveniently led out.
The top of the centrifugal cylinder 11 of the invention is provided with a medicine injection port 12, the medicine injection port 12 is provided with a medicine injection plug in a penetrating way, the bottom of the centrifugal cylinder 11 is provided with a medicine outlet 15, the medicine outlet 15 is provided with an electromagnetic valve or a medicine outlet plug in a penetrating way, the interior of the centrifugal cylinder 11 is provided with a balancing weight 16, the balancing weight 16 is used for balancing the centrifugal force when the centrifugal cylinder 11 rotates, and the normal rotation of the centrifugal cylinder 11 is prevented from being influenced by the unbalance in hand and the eccentric rotation in the high-speed rotation process of the centrifugal cylinder 11.
The centrifugal filter membrane 14 is in a truncated cone structure with two hollow end faces, is fixedly arranged in the centrifugal cylinder 11, and is designed to enable hyaluronic acid dressing rotating at a high speed to pass through the centrifugal filter membrane 14 under the action of centrifugal force for filtration, so that the purity of the hyaluronic acid dressing is further improved.
The magnetic limiting disc 32 of the present invention is magnetically attracted to the bottom of the centrifugal cylinder 11 to prevent the centrifugal cylinder 11 from moving upwards and jumping up when rotating at high speed.
The supporting tray 21 of the invention is provided with a plurality of material receiving grooves 22 for receiving liquid in different centrifugal cylinders 11;
the supporting tray 21 is provided with a locking mechanism 4 for positioning and stopping the centrifuge tube 11, the locking mechanism comprises an electromagnet 41 and an iron sheet 42, the electromagnet 41 is arranged on the supporting tray 21, the iron sheet 42 is attached to the lower surface of the centrifuge tube 11, the rotating surface of the iron sheet 42 is overlapped with the central line of the electromagnet 41, and the design enables the medicine outlet 15 of the centrifuge tube 11 to be aligned with the material receiving groove 22 to lead out hyaluronic acid dressing when the centrifuge tube 11 stops.
The specific working principle is as follows: firstly, a supporting tray 21 is placed on a designated supporting plane, a plurality of centrifugal cylinders 11 with different diameters are overlapped and sleeved according to a concentric circle pattern, and finally, an integral structure is formed in a sleeved mode; the integral structure is inserted into the guide shaft 33, and the bottom of the centrifugal cylinder 11 is magnetically attached to the magnetic limiting disc 32;
then opening a medicine injection port 12 on the centrifugal cylinder 11, pouring hyaluronic acid dressing to be centrifugally treated into the centrifugal cylinder 11, continuously observing the reading of the liquid level meter 13, injecting the hyaluronic acid dressing with a specified volume into the centrifugal cylinder 11, and tightly covering the medicine injection port 12 after the liquid level meter 13 reaches the reading of the specified volume; the hyaluronic acid dressing with high centrifugal degree and large centrifugal force is placed in the large-diameter centrifugal cylinder 11, and the hyaluronic acid dressing with low centrifugal degree and small centrifugal force is placed in the small-diameter centrifugal cylinder 11;
then the motor 31 is electrified, the motor 31 drives the centrifugal cylinder 11 to rotate at high speed for a period of time in a centrifugal mode through the guide shaft 33, and after the centrifugal cylinder 11 rotates at high speed, the hyaluronic acid dressing in the centrifugal cylinder 11 is layered under the action of centrifugal force; according to the formula of centrifugal force F = m ω2r where ω denotes the angular velocity of the rotation of the non-inertial system itself, r denotes the radius of rotation, and m denotes the mass of the object, it can be seen that under the same mass m and angular velocity ω, the centrifugal force F is in positive linear correlation with the radius of rotation r, and therefore, different centrifugal forces can be obtained for centrifuge bowl 11 of different radii;
then the hyaluronic acid dressing rotating at a high speed is subjected to centrifugal force and passes through a centrifugal filter membrane 14 for filtration, the purity of the hyaluronic acid dressing is further improved, the filtered hyaluronic acid dressing enters the bottom of a centrifugal cylinder 11, after a motor 31 is electrified for a period of time, the electrifying time of the motor 31 is set according to the centrifuging time of the hyaluronic acid dressing, and then the motor 31 is powered off;
then, when the motor 31 is powered off, the electromagnet 41 is powered on, the rotating iron sheet 42 is continuously adsorbed after the electromagnet 41 is powered on, finally the iron sheet 42 is adsorbed at the top of the electromagnet 41, the centrifugal cylinder 11 stops, and at the moment, the medicine outlet 15 of the centrifugal cylinder 11 just aligns with the material receiving groove 22;
when the centrifuge is finally stopped, the electric telescopic rod is powered on, and the electric telescopic rod supports the centrifuge tube 11 to move upwards for a certain distance; at the moment, the electromagnetic valve at the medicine outlet 15 or the medicine outlet plug is opened, and the hyaluronic acid dressing after centrifugation in the centrifuge tube 11 is poured into the corresponding material receiving groove 22; finally, the material receiving groove 22 is taken out, the electric telescopic rod is electrified and descends to the lowest position, the bottom of the centrifugal cylinder 11 is magnetically adsorbed with the magnetic limiting disc 32 again, a centrifugal cycle is completed, and another batch of hyaluronic acid dressing can be centrifugally processed according to the steps;
finally, after the centrifugation is finished, the electric telescopic rod can be continuously electrified, and the electric telescopic rod supports the centrifugal cylinder 11 to leave the magnetic limiting disc 32; then, the centrifuge tube 11 is taken out from the guide shaft 33, and the medicine injection ports 12 on the upper and lower sides of the centrifuge tube 11 are opened. .
While there have been shown and described what are at present considered the fundamental principles and essential features of the invention and its advantages, it will be apparent to those skilled in the art that the invention is not limited to the details of the foregoing exemplary embodiments, but is capable of other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (10)
1. The utility model provides a hyaluronic acid dressing centrifugation purification device which characterized in that: comprises a centrifugal mechanism (1), a driving mechanism (3), a locking mechanism (4), a supporting mechanism (5) and a supporting tray (21);
the locking mechanism (4) is used for driving the centrifugal mechanism (1) to rotate, the locking mechanism (4) comprises a motor (31) and a guide shaft (33), the motor (31) is arranged on the supporting tray (21), a magnetic limiting disc (32) is arranged on a power shaft of the motor (31), and the guide shaft (33) is connected to the power shaft of the motor (31);
the centrifugal mechanism (1) is used for centrifugally purifying hyaluronic acid dressings with different centrifugation degrees, the centrifugal mechanism (1) comprises a centrifugal cylinder (11) and a centrifugal filter membrane (14), the centrifugal cylinder (11) is sleeved on a guide shaft (33), the centrifugal filter membrane (14) is arranged in the centrifugal cylinder (11), and a liquid level meter (13) is arranged on the centrifugal cylinder (11) in a penetrating manner;
the supporting mechanism (5) is used for supporting and moving the centrifugal cylinder (11) up and down, and the supporting mechanism (5) is an electric telescopic rod.
2. The hyaluronic acid dressing centrifugal purification device of claim 1, wherein: the centrifugal cylinder (11) is provided with a plurality of centrifugal cylinders, the diameter of each centrifugal cylinder (11) is different, and the plurality of centrifugal cylinders (11) are overlapped and sleeved in a concentric circle mode.
3. The hyaluronic acid dressing centrifugal purification device of claim 1 or 2, wherein: injection mouth (12) have been seted up at the top of centrifuge tube (11), and injection mouth (12) run through and are provided with the injection stopper, medicine outlet (15) have been seted up to the bottom of centrifuge tube (11), and medicine outlet (15) run through and are provided with solenoid valve or play medicine stopper, the inside of centrifuge tube (11) is provided with balancing weight (16), and balancing weight (16) are used for balancing the centrifugal force when centrifuge tube (11) is rotatory.
4. The hyaluronic acid dressing centrifugal purification device of claim 1, wherein: the centrifugal filter membrane (14) is of a circular truncated cone structure with two hollow end faces, and the centrifugal filter membrane (14) is fixedly arranged in the centrifugal cylinder (11).
5. The hyaluronic acid dressing centrifugal purification device of claim 1, wherein: the magnetic limiting disc (32) is magnetically attracted with the bottom of the centrifugal cylinder (11).
6. The hyaluronic acid dressing centrifugal purification device of claim 1, wherein: support and be provided with a plurality of on tray (21) and be used for receiving connect silo (22) of liquid in different centrifuge bowl (11), be provided with locking mechanism (4) that are used for centrifuge bowl (11) location to stop on support tray (21), the locking includes electro-magnet (41) and iron sheet (42), electro-magnet (41) set up on support tray (21), iron sheet (42) are attached at centrifuge bowl (11) lower surface, the rotating surface of iron sheet (42) and the coincidence of the central line of electro-magnet (41).
7. The hyaluronic acid dressing centrifugal purification device of claim 1, wherein: the number of the electric telescopic rods is at least three, and each electric telescopic rod is distributed on the upper surface of the supporting tray (21) at equal intervals.
8. The hyaluronic acid dressing centrifugal purification device of claim 1, wherein: the surface of the guide shaft (33) is provided with teeth, the inner side of the centrifugal cylinder (11) at the innermost side is provided with a tooth sleeve, and the tooth sleeve is matched with the teeth.
9. The use method of the hyaluronic acid dressing centrifugal purification device according to any one of claims 1-8, characterized by comprising the following steps:
step (1), placing a supporting tray (21) on a designated supporting plane, overlapping and sleeving a plurality of centrifugal cylinders (11) with different diameters according to a concentric circle pattern, and finally sleeving to form an integral structure;
step (1-1), inserting the integral structure in the step (1) into a guide shaft (33), and magnetically attaching the bottom of a centrifugal cylinder (11) to a magnetic limiting disc (32);
step (2), opening a medicine injection port (12) on the centrifugal cylinder (11), pouring hyaluronic acid dressing to be centrifugally treated into the centrifugal cylinder (11), continuously observing the reading of the liquid level meter (13), injecting the hyaluronic acid dressing with a specified volume into the centrifugal cylinder (11), and tightly covering the medicine injection port (12) after the liquid level meter (13) reaches the reading of the specified volume;
step (3), a motor (31) is electrified, the motor (31) drives a centrifugal cylinder (11) to rotate at a high speed in a centrifugal mode through a guide shaft (33) for a period of time, after the centrifugal cylinder (11) rotates at a high speed, hyaluronic acid dressing materials in the centrifugal cylinder (11) are layered under the action of centrifugal force, the centrifuged hyaluronic acid dressing materials are filtered out through a centrifugal filter membrane (14), the filtered hyaluronic acid dressing materials enter the bottom of the centrifugal cylinder (11), and after the motor (31) is electrified for a period of time, the motor (31) is powered off;
step (4), when the motor (31) is powered off, the electromagnet (41) is powered on, the electromagnet (41) continuously adsorbs the rotating iron sheet (42) after being powered on, finally the iron sheet (42) is adsorbed at the uppermost part of the electromagnet (41), the centrifugal cylinder (11) stops, and at the moment, the medicine outlet (15) of the centrifugal cylinder (11) is just aligned to the material receiving groove (22);
step (5), when the centrifuge is finally stopped, the electric telescopic rod is powered on, and the electric telescopic rod supports the centrifuge tube (11) to move upwards for a certain distance;
step (5-1), opening an electromagnetic valve at the medicine outlet (15) or a medicine outlet plug at the moment, and pouring the hyaluronic acid dressing after centrifugation in the centrifugal cylinder (11) into a corresponding material receiving groove (22);
step (6), finally, taking out the material receiving groove (22), electrifying the electric telescopic rod to descend to the lowest position, enabling the bottom of the centrifugal cylinder (11) to be magnetically adsorbed with the magnetic limiting disc (32) again, completing a centrifugal cycle, and centrifugally processing another batch of hyaluronic acid dressing according to the steps (1) to (6);
step (6-1), after the centrifugation is finished, the electric telescopic rod can be continuously electrified, and the electric telescopic rod supports the centrifugal cylinder (11) to leave the magnetic limiting disc (32); then taking the centrifugal cylinder (11) out of the guide shaft (33), opening the medicine injection port (12) and the medicine outlet port (15) on the upper side and the lower side of the centrifugal cylinder (11), and cleaning the interior of the centrifugal cylinder (11).
10. The use method of the hyaluronic acid dressing centrifugal purification device according to claim 9, wherein the hyaluronic acid dressing centrifugal purification device comprises the following steps: in the step (2), the hyaluronic acid dressing with high centrifugal degree and needing large centrifugal force is placed in a large-diameter centrifugal cylinder (11), and the hyaluronic acid dressing with low centrifugal degree and needing small centrifugal force is placed in a small-diameter centrifugal cylinder (11);
in the step (3), the power-on time of the motor (31) is set according to the centrifugation time of the hyaluronic acid dressing.
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