CN113993529A - 用于治疗肝脏病症的方法和组合物 - Google Patents

用于治疗肝脏病症的方法和组合物 Download PDF

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Publication number
CN113993529A
CN113993529A CN202080043100.6A CN202080043100A CN113993529A CN 113993529 A CN113993529 A CN 113993529A CN 202080043100 A CN202080043100 A CN 202080043100A CN 113993529 A CN113993529 A CN 113993529A
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China
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subject
composition
liver
microbial
clostridium
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Pending
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CN202080043100.6A
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English (en)
Chinese (zh)
Inventor
奥维尔·科尔特曼
芬妮·佩罗多
詹姆斯·布拉德
约翰·艾德
科琳·卡特克利菲
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Pendulum Therapeutics Inc
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Whole Biome Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Zoology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
CN202080043100.6A 2019-05-21 2020-05-20 用于治疗肝脏病症的方法和组合物 Pending CN113993529A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962850773P 2019-05-21 2019-05-21
US62/850,773 2019-05-21
PCT/US2020/033870 WO2020236979A1 (en) 2019-05-21 2020-05-20 Methods and compositions for treating liver disorders

Publications (1)

Publication Number Publication Date
CN113993529A true CN113993529A (zh) 2022-01-28

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CN202080043100.6A Pending CN113993529A (zh) 2019-05-21 2020-05-20 用于治疗肝脏病症的方法和组合物

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US (1) US20220211780A1 (https=)
EP (1) EP3973047A4 (https=)
JP (1) JP2022533672A (https=)
KR (1) KR20220011683A (https=)
CN (1) CN113993529A (https=)
AU (1) AU2020278703A1 (https=)
CA (1) CA3140096A1 (https=)
SG (1) SG11202112515RA (https=)
WO (1) WO2020236979A1 (https=)
ZA (1) ZA202110111B (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117599092A (zh) * 2024-01-23 2024-02-27 南方医科大学南方医院 生孢梭菌在制备预防和/或治疗肝脏疾病的药物中的应用
CN118526527A (zh) * 2024-03-19 2024-08-23 华中科技大学同济医学院附属协和医院 益生菌混合液在制备预防或治疗apap诱导肝损伤药物中的应用
CN119639633A (zh) * 2025-02-18 2025-03-18 杭州师范大学附属医院(杭州市第二人民医院) 一种治疗非酒精性脂肪肝的酵母菌益生菌复合物及其制备方法和应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201903823QA (en) 2014-10-31 2019-05-30 Whole Biome Inc Methods and compositions relating to microbial treatment and diagnosis of disorders
CN111372596A (zh) 2017-08-30 2020-07-03 潘德勒姆治疗公司 用于治疗微生物组相关病症的方法和组合物
CA3106315A1 (en) 2018-07-19 2020-01-23 Pendulum Therapeutics, Inc. Methods and compositions for microbial engraftment
SG11202112515RA (en) * 2019-05-21 2021-12-30 Pendulum Therapeutics Inc Methods and compositions for treating liver disorders
NL2030011B1 (en) * 2021-12-03 2023-06-20 Caelus Pharmaceuticals B V Prevention or treatment of hepatic steatosis
EP4467148A4 (en) * 2022-01-20 2025-04-23 Korea Institute of Science and Technology Composition for prevention, amelioration or treatment of non-alcoholic fatty liver disease, comprising extracellular vesicles derived from roseburia spp. or bifidobacterium spp
KR102679094B1 (ko) * 2024-04-24 2024-06-27 충남대학교 산학협력단 항비만 효능을 지닌 한국인 마이크로바이옴 유래 클로스트리디움 부티리쿰 균주 및 이의 용도

Citations (6)

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WO2018106844A1 (en) * 2016-12-06 2018-06-14 Whole Biome Inc. Methods and compositions relating to isolated and purified microbes
US20190015424A1 (en) * 2016-01-11 2019-01-17 Pledpharma Ab Methods and formulations for treatment of and/or protection against acute liver failure and other hepatotoxic conditions
WO2019046646A1 (en) * 2017-08-30 2019-03-07 Whole Biome Inc. METHODS AND COMPOSITIONS FOR THE TREATMENT OF MICROBIOMA ASSOCIATED DISORDERS
US20210052674A1 (en) * 2017-09-28 2021-02-25 Kobiolabs, Inc. Composition for diagnosis and treatment of alcoholic liver disease, using change in short-chain fatty acid producing gut bacterial community
CN113730442A (zh) * 2014-10-31 2021-12-03 潘德勒姆治疗公司 与病症的微生物治疗和诊断有关的方法和组合物
US20220211780A1 (en) * 2019-05-21 2022-07-07 Pendulum Therapeutics, Inc. Methods And Compositions For Treating Liver Disorders

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CA3113684A1 (en) * 2018-09-24 2020-04-02 Pendulum Therapeutics, Inc. Microbial compositions and methods of use

Patent Citations (7)

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CN113730442A (zh) * 2014-10-31 2021-12-03 潘德勒姆治疗公司 与病症的微生物治疗和诊断有关的方法和组合物
US20190015424A1 (en) * 2016-01-11 2019-01-17 Pledpharma Ab Methods and formulations for treatment of and/or protection against acute liver failure and other hepatotoxic conditions
WO2018106844A1 (en) * 2016-12-06 2018-06-14 Whole Biome Inc. Methods and compositions relating to isolated and purified microbes
WO2019046646A1 (en) * 2017-08-30 2019-03-07 Whole Biome Inc. METHODS AND COMPOSITIONS FOR THE TREATMENT OF MICROBIOMA ASSOCIATED DISORDERS
CN111372596A (zh) * 2017-08-30 2020-07-03 潘德勒姆治疗公司 用于治疗微生物组相关病症的方法和组合物
US20210052674A1 (en) * 2017-09-28 2021-02-25 Kobiolabs, Inc. Composition for diagnosis and treatment of alcoholic liver disease, using change in short-chain fatty acid producing gut bacterial community
US20220211780A1 (en) * 2019-05-21 2022-07-07 Pendulum Therapeutics, Inc. Methods And Compositions For Treating Liver Disorders

Non-Patent Citations (2)

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HITOSHI ENDO等: "Butyrate-Producing Probiotics Reduce Nonalcoholic Fatty Liver Disease Progression in Rats: New Insight into the Probiotics for the Gut-Liver Axis", PLOS ONE, 16 May 2013 (2013-05-16), pages 1 - 3 *
易中华;: "饲用微生态制剂丁酸梭菌的研究与应用进展", 饲料研究, 7 February 2012 (2012-02-07), pages 14 - 17 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117599092A (zh) * 2024-01-23 2024-02-27 南方医科大学南方医院 生孢梭菌在制备预防和/或治疗肝脏疾病的药物中的应用
CN117599092B (zh) * 2024-01-23 2024-04-26 南方医科大学南方医院 生孢梭菌在制备预防和/或治疗肝脏疾病的药物中的应用
CN118526527A (zh) * 2024-03-19 2024-08-23 华中科技大学同济医学院附属协和医院 益生菌混合液在制备预防或治疗apap诱导肝损伤药物中的应用
CN119639633A (zh) * 2025-02-18 2025-03-18 杭州师范大学附属医院(杭州市第二人民医院) 一种治疗非酒精性脂肪肝的酵母菌益生菌复合物及其制备方法和应用

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CA3140096A1 (en) 2020-11-26
EP3973047A1 (en) 2022-03-30
EP3973047A4 (en) 2023-01-11
US20220211780A1 (en) 2022-07-07
ZA202110111B (en) 2024-04-24
KR20220011683A (ko) 2022-01-28
SG11202112515RA (en) 2021-12-30
WO2020236979A1 (en) 2020-11-26
JP2022533672A (ja) 2022-07-25
AU2020278703A1 (en) 2022-01-27

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