CN113973820A - Application of bactericidal composition containing flutolanil and chlorothalonil - Google Patents
Application of bactericidal composition containing flutolanil and chlorothalonil Download PDFInfo
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- CN113973820A CN113973820A CN202111324277.6A CN202111324277A CN113973820A CN 113973820 A CN113973820 A CN 113973820A CN 202111324277 A CN202111324277 A CN 202111324277A CN 113973820 A CN113973820 A CN 113973820A
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- chlorothalonil
- flutolanil
- root rot
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/34—Nitriles
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
- A01N37/22—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof the nitrogen atom being directly attached to an aromatic ring system, e.g. anilides
- A01N37/24—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof the nitrogen atom being directly attached to an aromatic ring system, e.g. anilides containing at least one oxygen or sulfur atom being directly attached to the same aromatic ring system
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to an application of a bactericidal composition containing flutolanil and chlorothalonil, wherein the composition contains the flutolanil and the chlorothalonil in a weight ratio of 1:15 to 15: 1. The composition is used for preventing and treating root rot of crops.
Description
(I) technical field
The invention relates to application of a bactericidal composition with a synergistic effect to prevention and treatment of crop root rot, in particular to application of a bactericidal composition containing flutolanil and chlorothalonil to prevention and treatment of crop root rot.
(II) background of the invention
Chlorothalonil (Chlorothalonil) is a low-toxicity broad-spectrum protective fungicide. It destroys the activity of enzyme by reacting with glyceraldehyde-3-phosphate dehydrogenase in fungal cells, thereby destroying the metabolism of fungal cells and losing vitality.
Fluoramide (Flutolanil) belongs to anilide bactericides, and the action mechanism of the flutolanilide is used as a succinate dehydrogenase inhibitor in an electron transfer chain of respiration to inhibit the synthesis of aspartate and glutamate. The flutolanil has extremely high activity, has protection and furuncle treatment activity, can be used for preventing and treating diseases of ornamental plants, rice, cereals, potatoes, beet, vegetables, peanuts, fruits and the like, and is safe to the ornamental plants, the cereals, the rice, the vegetables and the fruits under recommended dosage.
Chinese patent CN102524256A discloses a composition containing chlorothalonil and flutolanil and discloses that the composition has a synergistic effect in preventing and treating anthracnose, leaf spot, sooty mould and alternaria mali.
The root rot of the crops is a common crop disease, can cause the root to rot, gradually weakens the function of absorbing water and nutrients, and finally dies the whole plant. The prevention and control of the root rot of the crops are always difficult problems of the prevention and control of the diseases of the crops, and the prevention and control are difficult.
Disclosure of the invention
The invention aims to screen a pesticide composition with excellent control effect on crop root rot, and solves the problem of difficult control of root rot in the prior art.
The purpose of the invention is realized as follows:
the composition contains the flutolanil and the chlorothalonil in a weight ratio of 1:15 to 15: 1.
Preferably, the weight ratio of flutolanil to chlorothalonil is from 1:10 to 10:1, more preferably from 1:5 to 5:1, such as 1:5, 1:4, 1:3, 1:2, 1:1, 2:1, 3:1, 4:1, 5: 1.
In one embodiment of the invention, the crop root rot disease comprises root rot diseases of panax notoginseng, tobacco, watermelon, melon, pumpkin, peanut, beet, tobacco, soybean, strawberry and other crops; preferably radix Notoginseng, tobacco, Cucurbita pepo fruit, and beet root rot; preferably, the root rot of the crop is caused by pathogenic bacteria such as Fusarium solani, Fusarium culmorum, Fusarium oxysporum, and the like.
The mode of application of the compositions of the invention is well known to those skilled in the art and may be, for example, applied by seed dressing, seed coating, soil spraying, root irrigation, and the like. When the seed dressing or the seed coating is applied, the dosage of the seed dressing or the seed coating is 10-100 g of the effective component per 100kg of seeds; when the soil is sprayed and irrigated with roots, the dosage of the active ingredients is 20-100 g per mu.
In one embodiment of the present invention, the composition may be prepared in any formulation that is agriculturally acceptable, such as wettable powder, water dispersible granules, suspension, or seed treatment suspension.
In specific application, the mass percentage of the flutolanil and the chlorothalonil in the preparation is 5-80%.
The preparation of the above dosage forms is well known to those skilled in the art, and adjuvants and/or carriers used in the preparation of the formulations include: solvent, emulsifier, dispersant, wetting agent, binder, disintegrant, thickener, antifreeze, defoamer, warning color, film forming agent, preservative, stabilizer, pH regulator, filler and/or carrier. For example:
the dispersing agent can be one or more of lignosulfonate, styrene-maleic acid copolymer, glycerol fatty acid polyoxyethylene ether, fatty alcohol polyoxyethylene ether sulfate, alkyl naphthalene sulfonate, naphthalene sulfonate formaldehyde condensate sodium salt, fatty alcohol polyoxyethylene ether phosphate, nonylphenol polyoxyethylene ether, polyoxyethylene alkyl aryl ether and polyoxyethylene lanolin alcohol;
the wetting agent can be one or more of trisiloxane polyoxyethylene ether, sodium dodecyl sulfate, polyoxyethylene lauryl ether carboxylic acid sodium, calcium dodecyl benzene sulfonate, isooctyl ester succinate sodium sulfonate, oleoyl methyl taurate, sodium lauroyl sarcosinate, dioctyl sulfosuccinate, polyoxyethylene alkyl aryl ether phosphate, sorbitan fatty acid ester, castor oil polyoxyethylene ether, fatty alcohol polyoxyethylene ether and alkylphenol polyoxyethylene ether phosphate;
the binder can be one or more of acacia, xanthan gum, carboxyethyl cellulose, gelatin, starch and carboxymethyl cellulose;
the thickener can be one or more of magnesium aluminum silicate, sodium alginate, sodium carboxymethylcellulose, acacia, xanthan gum and polyvinyl alcohol;
the antifreezing agent can be one or more selected from ethylene glycol, propylene glycol, glycerol, etc.;
the defoaming agent can be one or more of isobutyl phosphate, n-octanol and silicone;
the film forming agent can be one or more of polyvinyl alcohol, polyvinyl acetate, carboxymethyl cellulose, chitosan and sodium alginate;
the carrier can be one or more of water, diatomite, kaolin, attapulgite, white carbon black and bentonite;
(IV) detailed description of the preferred embodiments
The present invention is further illustrated by the following examples, which are not intended to limit the present invention, but the present invention is within the scope of the present application by simply modifying the above-described embodiments.
Indoor bioassay example:
indoor bioassay example 1: toxicity determination of flutolanil and chlorothalonil compound on cucurbita pepo root rot
Test subjects: root rot of cucurbita pepo [ Fusarium solani (Mart.). app. et wollenw. fortma cucurbitae ].
The test method comprises the following steps: referring to the indoor bioassay test criteria for pesticides NY/T1156.2-2006, a drug-containing culture medium method is adopted.
3. Data statistics and effect evaluation: calculating the hypha growth inhibition rate (%) according to the test data, solving a toxicity regression equation, and calculating EC50. Evaluation of synergy of pharmaceutical compositions by co-toxicity coefficient (CTC)The CTC is less than or equal to 80 and is antagonistic, 80<CTC<120 is additive effect, and CTC is more than or equal to 120, and is synergistic effect.
The toxicity test results of the flutolanil and the chlorothalonil and the mixed combination of the two in different proportions on the root rot of cucurbita pepo are shown in table 1, wherein ' fluorine: hundred ' in the table 1 is ' flutolanil: chlorothalonil "is shorthand.
TABLE 1 toxicity test results of blending of flutolanil and chlorothalonil to Cucurbita pepo root rot
Indoor bioassay results show that: the flutolanil and the chlorothalonil are mixed according to the proportion of 1:15, 1:10, 1:5, 1:1, 5:1, 10:1 and 15:1, and the mixture shows additive or synergistic effect on the zucchini rhizoctonia rot, and has synergistic effect when mixed according to the proportion of 1: 15-10: 1.
Indoor bioassay example 2: toxicity determination of flutolanil and chlorothalonil compound on beet root rot
Test subjects: beet root rot [ Fusarium culmorum Sacc ].
The test method comprises the following steps: referring to the pesticide bioassay test guideline NY/T1156.2-2006, a drug-containing culture medium method is adopted.
Data statistics and effect evaluation: calculating the hypha growth inhibition rate (%) according to the test data, solving a toxicity regression equation, and calculating EC50. The synergistic effect of the mixed medicament is evaluated by adopting a co-toxicity coefficient (CTC) method, wherein the CTC is not more than 80 and is antagonistic, and 80<CTC<120 is additive effect, and CTC is more than or equal to 120, and is synergistic effect.
The toxicity test results of the flutolanil and the chlorothalonil and the mixed combination of the flutolanil and the chlorothalonil in different proportions on the beet root rot disease are shown in the table 2, wherein ' fluorine: hundred ' in the table 2 is ' flutolanil: chlorothalonil "is shorthand.
TABLE 2 toxicity test results of flutolanil and chlorothalonil mixture against Betula bassiana
Indoor bioassay results show that: the flutolanil and the chlorothalonil are mixed according to the proportion of 1:15, 1:10, 1:5, 1:1, 5:1, 10:1 and 15:1, and the mixture shows additive or synergistic effect on the beet root rot germs and has synergistic effect when mixed according to the proportion of 1: 10-10: 1.
Indoor bioassay example 3: and (3) testing the toxicity of the flutolanil and chlorothalonil compound on the tobacco root rot pathogen.
1. Test subjects: root rot of tobacco [ Fusarium oxysporum ].
The test method comprises the following steps: referring to the pesticide bioassay test guideline NY/T1156.2-2006, a drug-containing culture medium method is adopted.
Data statistics and effect evaluation: calculating the hypha growth inhibition rate (%) according to the test data, solving a toxicity regression equation, and calculating EC50. The synergistic effect of the mixed medicament is evaluated by adopting a co-toxicity coefficient (CTC) method, wherein the CTC is not more than 80 and is antagonistic, and 80<CTC<120 is additive effect, and CTC is more than or equal to 120, and is synergistic effect. The toxicity test results of the mixed combination of flutolanil and chlorothalonil in different proportions on tobacco root rot fungi are shown in table 3, wherein ' fluorine: hundred ' in the table 3 is ' flutolanil: chlorothalonil "is shorthand.
TABLE 3 toxicity test results of mixture of flutolanil and chlorothalonil to Nicotiana tabacum
Indoor bioassay results show that: the chlorothalonil and the flutolanil are mixed according to the proportion of 1:15, 1:10, 1:5, 1:1, 5:1, 10:1 and 15:1, and the mixture shows additive or synergistic effect on the tobacco root rot disease and has synergistic effect when mixed according to the proportion of 1: 10-15: 1.
Formulation examples:
the composition of the present invention can be prepared into a suspension, a water dispersible granule, a wettable powder, a seed treatment suspension, etc. by a known method, and the following specific examples are given.
Formulation example 1:
3g of flutolanil, 15g of chlorothalonil, 3g of fatty alcohol-polyoxyethylene ether sodium sulfate, 6g of castor oil polyoxyethylene ether, 0.5g of sodium carboxymethylcellulose, 4g of glycol and water which are complemented to 100 g. Mixing, pre-crushing, uniformly mixing, wet grinding and homogenizing to obtain the 18 percent suspending agent of the composition.
Formulation example 2:
20g of flutolanil, 20g of chlorothalonil, 7g of isooctyl alcohol succinate sodium sulfonate, 7g of polyoxyethylene lanolin alcohol, 5g of ammonium sulfate, 1.5g of carboxyethyl cellulose and 100g of diatomite. The water dispersible granule of the composition of the invention with the concentration of 40 percent is prepared by pre-crushing and uniformly mixing, and then carrying out air flow crushing and granulation.
Formulation example 3:
5g of flutolanil, 25g of chlorothalonil, 8g of sodium naphthalenesulfonate formaldehyde condensate, 2g of trisiloxane polyoxyethylene ether, 0.5g of sodium carboxymethylcellulose, 5g of propylene glycol and the balance of water to 100 g. Mixing, pre-crushing, wet grinding and homogenizing to obtain the 30% suspension of the composition.
Formulation example 4:
30g of flutolanil, 6g of chlorothalonil, 4g of oil fatty acid polyoxyethylene ether, 5g of sodium lauroyl sarcosinate and 100g of attapulgite. Evenly mixing and carrying out ultrafine grinding to obtain 36 percent wettable powder of the composition.
Formulation example 5:
5g of flutolanil, 5g of chlorothalonil, 3g of fatty alcohol-polyoxyethylene ether phosphate, 4g of calcium dodecyl benzene sulfonate, 5g of propylene glycol, 4g of warning color, 7g of polyvinyl alcohol, 0.5g of Arabic gum and water which are added to make up to 100 g. Mixing, pre-crushing, wet grinding and homogenizing to obtain the 10% seed treating suspending agent of the composition.
Formulation example 6:
2g of flutolanil, 10g of chlorothalonil, 2g of sodium lignosulfonate, 4g of fatty alcohol-polyoxyethylene ether, 5g of glycerol, 4g of warning color, 7g of polyvinyl alcohol, 0.5g of xanthan gum and water which are supplemented to 100 g. Mixing, pre-crushing, wet grinding and homogenizing to obtain the 12% seed treating suspending agent of the composition.
The above description is not meant to be limiting, it being noted that: it will be apparent to those skilled in the art that various changes, modifications, additions and substitutions can be made without departing from the true scope of the invention, and these improvements and modifications should also be construed as within the scope of the invention.
Claims (8)
1. The application of a bactericidal composition containing flutolanil and chlorothalonil in preventing and treating root rot of crops is characterized in that: the composition contains flutolanil and chlorothalonil in a weight ratio of 1:15 to 15: 1.
2. Use according to claim 1, characterized in that: the weight ratio of the flutolanil to the chlorothalonil is 1:10 to 10: 1.
3. Use according to claim 1 or 2, characterized in that: the composition is prepared into any one of pesticide allowable dosage forms.
4. Use according to claim 3, characterized in that: the composition is prepared into wettable powder, water dispersible granules, suspending agents or seed treatment suspending agents.
5. Use according to claim 3 or 4, characterized in that: the composition is 5-80% by mass of the dosage form.
6. Use according to any one of claims 1 to 5, wherein the crop root rot comprises root rot of Panax notoginseng, tobacco, watermelon, melon, Cucurbita pepo, peanut, sugar beet, tobacco, soybean, strawberry.
7. Use according to claim 6, characterized in that the crop root rot is preferably pseudo-ginseng, tobacco, zucchini, beetroot root rot.
8. Use according to claim 6 or 7, characterized in that the root rot disease is caused by the pathogenic bacteria Fusarium solani, Fusarium culmorum or Fusarium oxysporum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111324277.6A CN113973820B (en) | 2021-11-10 | 2021-11-10 | Application of sterilization composition containing fluoroamide and chlorothalonil |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111324277.6A CN113973820B (en) | 2021-11-10 | 2021-11-10 | Application of sterilization composition containing fluoroamide and chlorothalonil |
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| CN113973820A true CN113973820A (en) | 2022-01-28 |
| CN113973820B CN113973820B (en) | 2023-05-16 |
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| CN202111324277.6A Active CN113973820B (en) | 2021-11-10 | 2021-11-10 | Application of sterilization composition containing fluoroamide and chlorothalonil |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102524256A (en) * | 2011-12-23 | 2012-07-04 | 江阴苏利化学有限公司 | Pesticide composition containing flutolanil and chlorothalonil |
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- 2021-11-10 CN CN202111324277.6A patent/CN113973820B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102524256A (en) * | 2011-12-23 | 2012-07-04 | 江阴苏利化学有限公司 | Pesticide composition containing flutolanil and chlorothalonil |
Non-Patent Citations (1)
| Title |
|---|
| 程伯瑛: "《无公害蔬菜农药使用指南》", 31 October 2010, 金盾出版社 * |
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| CN113973820B (en) | 2023-05-16 |
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