CN113966401A - 用于治疗amd的htra1调节 - Google Patents

用于治疗amd的htra1调节 Download PDF

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Publication number
CN113966401A
CN113966401A CN202080042929.4A CN202080042929A CN113966401A CN 113966401 A CN113966401 A CN 113966401A CN 202080042929 A CN202080042929 A CN 202080042929A CN 113966401 A CN113966401 A CN 113966401A
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htra1
sequence
risk
dna
protein
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Chinese (zh)
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布兰迪·威廉姆斯
格雷戈里·哈格曼
伯特·蒂莫西·理查兹
奥萨马·约瑟夫
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University of Utah Research Foundation Inc
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University of Utah Research Foundation Inc
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    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
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    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2740/10011—Retroviridae
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CN202080042929.4A 2019-04-10 2020-04-10 用于治疗amd的htra1调节 Pending CN113966401A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962832182P 2019-04-10 2019-04-10
US62/832,182 2019-04-10
PCT/US2020/027802 WO2020210724A1 (en) 2019-04-10 2020-04-10 Htra1 modulation for treatment of amd

Publications (1)

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CN113966401A true CN113966401A (zh) 2022-01-21

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US (1) US20230165976A1 (https=)
EP (1) EP3953485A4 (https=)
JP (2) JP2022526429A (https=)
CN (1) CN113966401A (https=)
CA (1) CA3136119A1 (https=)
WO (1) WO2020210724A1 (https=)

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CN113512564A (zh) * 2021-08-05 2021-10-19 呈诺再生医学科技(珠海横琴新区)有限公司 以iPSC来源的细胞为载体、基因治疗湿性年龄相关性黄斑变性
US20240358855A1 (en) * 2021-08-18 2024-10-31 University Of Utah Research Foundation Multigene constructs for treatment of age-related macular degeneration and other complement dysregulation-related conditions
US20250003989A1 (en) * 2021-11-15 2025-01-02 The Children`S Medical Center Corporation Methods for tauopathy diagnosis and treatment

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WO2012125869A1 (en) * 2011-03-15 2012-09-20 University Of Utah Research Foundation Methods of diagnosing and treating vascular associated maculopathy and symptoms thereof
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WO2018169983A1 (en) * 2017-03-13 2018-09-20 President And Fellows Of Harvard College Methods of modulating expression of target nucleic acid sequences in a cell

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EP3953485A1 (en) 2022-02-16
US20230165976A1 (en) 2023-06-01
EP3953485A4 (en) 2023-05-17
CA3136119A1 (en) 2020-10-15
JP2025175283A (ja) 2025-12-01
JP2022526429A (ja) 2022-05-24

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