CN113939310A - 用于制备t细胞组合物的组合物和方法及其用途 - Google Patents

用于制备t细胞组合物的组合物和方法及其用途 Download PDF

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Publication number
CN113939310A
CN113939310A CN202080040129.9A CN202080040129A CN113939310A CN 113939310 A CN113939310 A CN 113939310A CN 202080040129 A CN202080040129 A CN 202080040129A CN 113939310 A CN113939310 A CN 113939310A
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cells
epitope
cell
subject
peptide
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罗伯特·安格
维克拉姆·朱内贾
理查德·盖诺
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Aetna Usa Inc
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Aetna Usa Inc
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/42—Cancer antigens
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    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/4214—Receptors for cytokines
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/42—Cancer antigens
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4244—Enzymes
    • A61K40/4247—Proteinases
    • A61K40/4249—Serine proteases, e.g. kallikrein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4244—Enzymes
    • A61K40/4251—Kinases, e.g. Raf or Src
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4244—Enzymes
    • A61K40/4253—GTPases, e.g. Ras or Rho
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
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CN202080040129.9A 2019-03-30 2020-03-30 用于制备t细胞组合物的组合物和方法及其用途 Pending CN113939310A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962827018P 2019-03-30 2019-03-30
US62/827,018 2019-03-30
PCT/US2020/025796 WO2020205778A1 (en) 2019-03-30 2020-03-30 Compositions and methods for preparing t cell compositions and uses thereof

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CN113939310A true CN113939310A (zh) 2022-01-14

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US (1) US20220282217A1 (https=)
EP (1) EP3946439A4 (https=)
JP (1) JP7668226B2 (https=)
KR (1) KR20220030208A (https=)
CN (1) CN113939310A (https=)
AU (1) AU2020253368A1 (https=)
BR (1) BR112021019558A2 (https=)
CA (1) CA3132028A1 (https=)
IL (1) IL286776A (https=)
MX (1) MX2021012004A (https=)
PH (1) PH12021552476A1 (https=)
SG (1) SG11202110879PA (https=)
TW (1) TW202102531A (https=)
WO (1) WO2020205778A1 (https=)

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GB201505305D0 (en) 2015-03-27 2015-05-13 Immatics Biotechnologies Gmbh Novel Peptides and combination of peptides for use in immunotherapy against various tumors
ES2973548T3 (es) 2016-12-22 2024-06-20 Cue Biopharma Inc Polipéptidos multiméricos moduladores de linfocitos T y métodos para su uso
CN112584852A (zh) * 2018-06-19 2021-03-30 百欧恩泰美国公司 新抗原及其用途
US12421557B2 (en) * 2019-08-16 2025-09-23 The Broad Institute, Inc. Methods for predicting outcomes and treating colorectal cancer using a cell atlas
WO2021231376A2 (en) 2020-05-12 2021-11-18 Cue Biopharma, Inc. Multimeric t-cell modulatory polypeptides and methods of use thereof
WO2022047325A1 (en) * 2020-08-31 2022-03-03 The Trustees Of Columbia University In The City Of New York Targeting of tgm4 to treat prostate cancer
US20240000834A1 (en) * 2020-11-24 2024-01-04 Shanghai GenBase Biotechnology Co., Ltd. Ras mutant epitope peptide and t cell receptor recognizing ras mutant
WO2022115641A2 (en) * 2020-11-25 2022-06-02 Geneius Biotechnology, Inc. Antigen specific t cells and methods of making and using same
AU2022238389A1 (en) * 2021-03-19 2023-10-05 Cue Biopharma, Inc. T-cell modulatory polypeptides and methods of use thereof
WO2022226055A1 (en) * 2021-04-22 2022-10-27 Iogenetics, Llc Personalized allogeneic immunotherapy
US20240287456A1 (en) * 2021-06-22 2024-08-29 Achilles Therapeutics Uk Limited A method for producing antigen-specific t cells
US20250195659A1 (en) * 2021-10-15 2025-06-19 Biontech Us Inc. T cell manufacturing compositions and methods
WO2025208068A2 (en) * 2024-03-29 2025-10-02 Biontech Us Inc. T cell receptor constructs and uses thereof

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WO2018005556A1 (en) * 2016-06-27 2018-01-04 Juno Therapeutics, Inc. Mhc-e restricted epitopes, binding molecules and related methods and uses
WO2018026914A1 (en) * 2016-08-02 2018-02-08 Nantcell, Inc. Transfection of dendritic cells and methods therefor
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US7276478B2 (en) * 2003-09-25 2007-10-02 Zymogenetics, Inc. Methods of treating autoimmune diseases using IL-21
US20110274723A1 (en) * 2009-10-23 2011-11-10 Mannkind Corporation Cancer immunotherapy and method of treatment
US20180052176A1 (en) * 2014-03-27 2018-02-22 British Columbia Cancer Agency T-cell epitope identification
US20180043003A1 (en) * 2014-09-17 2018-02-15 The Johns Hopkins University Reagents and methods for identifying, enriching, and/or expanding antigen-specific t cells
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WO2018026914A1 (en) * 2016-08-02 2018-02-08 Nantcell, Inc. Transfection of dendritic cells and methods therefor

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SG11202110879PA (en) 2021-10-28
JP7668226B2 (ja) 2025-04-24
BR112021019558A2 (pt) 2021-12-21
IL286776A (en) 2021-10-31
PH12021552476A1 (en) 2022-07-18
WO2020205778A1 (en) 2020-10-08
MX2021012004A (es) 2021-11-04
JP2022550649A (ja) 2022-12-05
TW202102531A (zh) 2021-01-16
US20220282217A1 (en) 2022-09-08
CA3132028A1 (en) 2020-10-08
AU2020253368A1 (en) 2021-11-18
KR20220030208A (ko) 2022-03-10
EP3946439A4 (en) 2023-08-02
EP3946439A1 (en) 2022-02-09

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