CN113930288A - Exocarpium citri grandis essential oil and application thereof in vehicle-mounted refreshing aroma - Google Patents

Exocarpium citri grandis essential oil and application thereof in vehicle-mounted refreshing aroma Download PDF

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CN113930288A
CN113930288A CN202111096073.1A CN202111096073A CN113930288A CN 113930288 A CN113930288 A CN 113930288A CN 202111096073 A CN202111096073 A CN 202111096073A CN 113930288 A CN113930288 A CN 113930288A
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essential oil
exocarpium citri
pummelo peel
citri grandis
parts
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何勤勤
黄新敏
韩寒冰
王�琦
周艳青
黄依莎
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Guangdong University of Petrochemical Technology
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Guangdong University of Petrochemical Technology
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    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11BPRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00Essential oils; Perfumes
    • C11B9/02Recovery or refining of essential oils from raw materials
    • C11B9/027Recovery of volatiles by distillation or stripping
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534Mentha (mint)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/61Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11BPRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00Essential oils; Perfumes
    • C11B9/02Recovery or refining of essential oils from raw materials
    • C11B9/022Refining

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  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
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Abstract

The invention relates to the technical field of pummelo peel processing, in particular to pummelo peel essential oil and application thereof in vehicle-mounted refreshing aromatherapy; the pummelo peel essential oil is obtained by extracting pummelo peel, and the application method in the vehicle-mounted refreshing aroma comprises the following steps: taking 17-20 parts of exocarpium Citri Grandis essential oil, 10-12 parts of tea tree essential oil, 8-10 parts of lemon essential oil and 5-6 parts of mint essential oil; mixing the above essential oils at a certain proportion, and adding into anhydrous vehicle-mounted aromatherapy machine; according to the invention, the exocarpium citri grandis is dried by using a liquid nitrogen quick freezing and freezing vacuum drying method, so that compared with the traditional heat drying method, the essential oil components of the exocarpium citri grandis can be reserved; meanwhile, the essential oil is extracted by adopting the traditional normal-pressure steam method according to the characteristics of the exocarpium citri grandis essential oil, the extraction effect is good, the cost is low, and the yield of the essential oil by using the method is 0.1-0.3%; by utilizing the functions of eliminating phlegm and relieving cough and refreshing and restoring consciousness of volatile oil in the pummelo peel essential oil and the refreshing and sterilizing functions of tea tree essential oil, lemon essential oil and mint essential oil, the vehicle-mounted aromatherapy can achieve the effects of refreshing and restoring consciousness, preventing carsickness and sterilizing.

Description

Exocarpium citri grandis essential oil and application thereof in vehicle-mounted refreshing aroma
Technical Field
The invention relates to the technical field of pummelo peel processing, in particular to pummelo peel essential oil and application thereof in vehicle-mounted refreshing aromatherapy.
Background
Pummelo peel is commonly used as an oral carsickness medicament, for example, Chinese patent discloses a traditional Chinese medicine formula capable of preventing carsickness, and the patent application number 201610126416.7 describes that: a traditional Chinese medicine formula capable of preventing carsickness is characterized in that: the weight ratio of the raw materials is as follows: 1.0-10.0 parts of birthwort root, 2.0-8.0 parts of apocynum venetum, 3.0-8.0 parts of spina date seed, 10.0-20.0 parts of sandalwood, 1.0-20.0 parts of pummelo peel and the like.
The technical scheme has the following defects that: 1) it is a plaster, and the carsickness prevention effect can be achieved only by taking or applying the plaster, and obviously, the mode is not suitable for operation in a car. 2) Its preparation is rather complicated, and 35 Chinese herbal medicines are required.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides the carsickness prevention essential oil which does not need to be taken or applied.
The technical scheme of the invention is as follows:
the pummelo peel flower essential oil is obtained by extracting pummelo peel flowers, and the extraction method of the pummelo peel flowers comprises the following steps:
step one, collecting fresh red tangerine flowers;
quickly freezing by adopting liquid nitrogen, placing the liquid nitrogen in a freeze dryer for freeze drying, and taking out and crushing after drying;
step three, extracting the crude citrus grandis essential oil by using a normal-pressure steam method;
collecting upper oily liquid of the crude pummelo flower essential oil by adopting a liquid separation method;
and step five, adding anhydrous sodium sulfate into the oily liquid to remove water, and filtering to obtain the pummelo peel essential oil.
Specifically, in the second step, 1kg of the pummelo peel is quickly frozen by using the liquid nitrogen and the pummelo peel according to 1L of the liquid nitrogen.
Specifically, in the second step, the operation flow of the freeze dryer is as follows: firstly, cooling the exocarpium citri grandis flower to-40 ℃, carrying out vacuum drying for 12h, heating to 30 ℃ under the condition of 0.4MPa, taking out after drying, and crushing to obtain exocarpium citri grandis flower powder.
Specifically, in the third step, the weight ratio of the pummelo peel flower powder to the water is 1: 30.
Specifically, in the fifth step, the weight ratio of the anhydrous sodium sulfate to the oily liquid is 1: 20.
The application of the pummelo peel essential oil in the vehicle-mounted refreshing aroma comprises the following steps: taking 17-20 parts of exocarpium Citri Grandis essential oil, 10-12 parts of tea tree essential oil, 8-10 parts of lemon essential oil and 5-6 parts of mint essential oil; and (3) uniformly mixing the essential oil according to a proportion, and adding the mixture into an anhydrous vehicle-mounted aromatherapy machine.
The invention has the beneficial effects that: according to the invention, the exocarpium citri grandis is dried by using a liquid nitrogen quick freezing and freezing vacuum drying method, so that compared with the traditional heat drying method, the essential oil components of the exocarpium citri grandis can be reserved; meanwhile, the essential oil is extracted by adopting the traditional normal-pressure steam method according to the characteristics of the exocarpium citri grandis essential oil, the extraction effect is good, the cost is low, and the yield of the essential oil by using the method is 0.1-0.3%. The vehicle-mounted aromatherapy component mainly comprises the exocarpium citri grandis essential oil, the tea tree essential oil, the lemon essential oil and the mint essential oil, the characteristics of various essential oils are comprehensively exerted, the effects of eliminating phlegm and relieving cough and refreshing and restoring consciousness in the exocarpium citri grandis essential oil are utilized, and the refreshing and sterilizing effects of the tea tree essential oil, the lemon essential oil and the mint essential oil are utilized, so that the vehicle-mounted aromatherapy component can achieve the effects of refreshing and restoring consciousness, preventing carsickness and sterilizing.
Detailed Description
The following is further described in conjunction with the detailed description:
example 1
Picking fresh exocarpium Citri Grandis, adding liquid nitrogen at a ratio of 1kg exocarpium Citri Grandis to 1L liquid nitrogen, rapidly freezing, and storing at low temperature. Placing frozen exocarpium Citri Grandis in a freeze dryer, cooling to-40 deg.C, vacuum drying for 12 hr, heating to 30 deg.C under 0.4MPa, drying, taking out, and pulverizing. Adding purified water into the crushed exocarpium Citri Grandis powder at a ratio of 1: 30 (namely adding 30 parts by weight of purified water into 1 part by weight of exocarpium Citri Grandis powder, the same below), and extracting exocarpium Citri Grandis essential oil by normal pressure water vapor method. Collecting the condensed liquid, collecting the upper oily liquid by adopting a liquid separation method, and adding anhydrous sodium sulfate according to the proportion of 20: 1 to remove water (namely adding 1 part by weight of anhydrous sodium sulfate into every 20 parts by weight of oily liquid, the same below), so as to obtain the pummelo flower essential oil. Taking 17 parts of exocarpium Citri Grandis essential oil, 10 parts of tea tree essential oil, 8 parts of lemon essential oil and 5 parts of mint essential oil; and (3) uniformly mixing the essential oil according to a proportion, and adding the mixture into an anhydrous vehicle-mounted aromatherapy machine to obtain the vehicle-mounted refreshing aromatherapy.
Example 2
Picking fresh exocarpium Citri Grandis, adding liquid nitrogen at a ratio of 1kg exocarpium Citri Grandis to 1L liquid nitrogen, rapidly freezing, and storing at low temperature. Placing frozen exocarpium Citri Grandis in a freeze dryer, cooling to-40 deg.C, vacuum drying for 12 hr, heating to 30 deg.C under 0.4MPa, drying, taking out, and pulverizing. Adding purified water into the crushed exocarpium citri grandis pollen powder according to the proportion of 1: 30, and extracting the exocarpium citri grandis essential oil by adopting a normal pressure water vapor method. Collecting the condensed liquid, collecting the upper oily liquid by adopting a liquid separation method, and adding anhydrous sodium sulfate according to the proportion of 20: 1 to remove water to obtain the pummelo peel essential oil. Taking 20 parts of exocarpium Citri Grandis essential oil, 12 parts of tea tree essential oil, 10 parts of lemon essential oil and 6 parts of mint essential oil; and (3) uniformly mixing the essential oil according to a proportion, and adding the mixture into an anhydrous vehicle-mounted aromatherapy machine to obtain the vehicle-mounted refreshing aromatherapy.
Example 3
Picking fresh exocarpium Citri Grandis, adding liquid nitrogen at a ratio of 1kg exocarpium Citri Grandis to 1L liquid nitrogen, rapidly freezing, and storing at low temperature. Placing frozen exocarpium Citri Grandis in a freeze dryer, cooling to-40 deg.C, vacuum drying for 12 hr, heating to 30 deg.C under 0.4MPa, drying, taking out, and pulverizing. Adding purified water into the crushed exocarpium citri grandis pollen powder according to the proportion of 1: 30, and extracting the exocarpium citri grandis essential oil by adopting a normal pressure water vapor method. Collecting the condensed liquid, collecting the upper oily liquid by adopting a liquid separation method, and adding anhydrous sodium sulfate according to the proportion of 20: 1 to remove water to obtain the pummelo peel essential oil. Taking 20 parts of exocarpium Citri Grandis essential oil, 12 parts of tea tree essential oil, 10 parts of lemon essential oil and 6 parts of mint essential oil; and (3) uniformly mixing the essential oil according to a proportion, and adding the mixture into an anhydrous vehicle-mounted aromatherapy machine to obtain the vehicle-mounted refreshing aromatherapy.
To verify the effectiveness of the invention, 300 carsickness patients (male-female ratio 1: 1, age stage 20-50 years) were randomly selected to take taxis with the vehicle-mounted refreshing aromatherapy obtained in example 3, each trip exceeding 30 minutes. The experimental results are as follows:
Figure BDA0003268966710000031
the above table shows that the present invention can effectively inhibit car sickness and reduce the incidence of vomiting caused by car sickness. However, the effective rate of the product is still lower than that of oral medicines because the product is the aromatherapy.
The foregoing embodiments and description have been presented only to illustrate the principles and preferred embodiments of the invention, and various changes and modifications may be made therein without departing from the spirit and scope of the invention as hereinafter claimed.

Claims (6)

1. The pummelo peel flower essential oil is characterized by being obtained by extracting pummelo peel flower, and the extraction method of the pummelo peel flower comprises the following steps:
step one, collecting fresh red tangerine flowers;
quickly freezing by adopting liquid nitrogen, placing the liquid nitrogen in a freeze dryer for freeze drying, and taking out and crushing after drying;
step three, extracting the crude citrus grandis essential oil by using a normal-pressure steam method;
collecting upper oily liquid of the crude pummelo flower essential oil by adopting a liquid separation method;
and step five, adding anhydrous sodium sulfate into the oily liquid to remove water, and filtering to obtain the pummelo peel essential oil.
2. The pummelo peel essential oil according to claim 1, which is characterized in that: in the second step, 1kg of the pummelo peel is quickly frozen by the liquid nitrogen and the pummelo peel according to 1L of the liquid nitrogen.
3. The pummelo peel essential oil according to claim 1, which is characterized in that: in the second step, the operation flow of the freeze dryer is as follows: firstly, cooling the exocarpium citri grandis flower to-40 ℃, carrying out vacuum drying for 12h, heating to 30 ℃ under the condition of 0.4MPa, taking out after drying, and crushing to obtain exocarpium citri grandis flower powder.
4. The pummelo peel essential oil according to claim 1, which is characterized in that: in the third step, the weight ratio of the exocarpium citri grandis powder to the water is 1: 30.
5. The pummelo peel essential oil according to claim 1, which is characterized in that: in the fifth step, the weight ratio of the anhydrous sodium sulfate to the oily liquid is 1: 20.
6. Use of an essential oil of exocarpium Citri Grandis obtained according to any one of claims 1-5 in vehicle-mounted refreshing aromatherapy, which comprises: taking 17-20 parts of exocarpium Citri Grandis essential oil, 10-12 parts of tea tree essential oil, 8-10 parts of lemon essential oil and 5-6 parts of mint essential oil; and (3) uniformly mixing the essential oil according to a proportion, and adding the mixture into an anhydrous vehicle-mounted aromatherapy machine.
CN202111096073.1A 2021-09-17 2021-09-17 Exocarpium citri grandis essential oil and application thereof in vehicle-mounted refreshing aroma Pending CN113930288A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104324404A (en) * 2014-11-04 2015-02-04 重庆市日用化学工业研究所 Aromatic essential oil composition for vehicle and preparation method thereof
CN104711121A (en) * 2015-02-28 2015-06-17 湖北中烟工业有限责任公司 Method for extracting chrysanthemum indicum essential oil in ultrasonic-assisted solvent-free microwave extraction manner
CN108659957A (en) * 2018-06-20 2018-10-16 吕梁学院 The method that jujube extracts essential oil
CN109675081A (en) * 2019-03-05 2019-04-26 云南中烟新材料科技有限公司 A kind of Fruity type natural plants Vehicular aromatherapy essential oil and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104324404A (en) * 2014-11-04 2015-02-04 重庆市日用化学工业研究所 Aromatic essential oil composition for vehicle and preparation method thereof
CN104711121A (en) * 2015-02-28 2015-06-17 湖北中烟工业有限责任公司 Method for extracting chrysanthemum indicum essential oil in ultrasonic-assisted solvent-free microwave extraction manner
CN108659957A (en) * 2018-06-20 2018-10-16 吕梁学院 The method that jujube extracts essential oil
CN109675081A (en) * 2019-03-05 2019-04-26 云南中烟新材料科技有限公司 A kind of Fruity type natural plants Vehicular aromatherapy essential oil and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
李武国,等: "化州柚花挥发油的GC-MS分析及其对肺癌细胞A549增殖、迁移的影响研究", 中国药房, vol. 29, no. 22, 31 December 2018 (2018-12-31), pages 3093 - 3097 *

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