CN113917095A - Pancreatic cancer liver metastasis chemotherapy drug-resistant in-vitro drug sensitivity detection device - Google Patents
Pancreatic cancer liver metastasis chemotherapy drug-resistant in-vitro drug sensitivity detection device Download PDFInfo
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- CN113917095A CN113917095A CN202111153919.0A CN202111153919A CN113917095A CN 113917095 A CN113917095 A CN 113917095A CN 202111153919 A CN202111153919 A CN 202111153919A CN 113917095 A CN113917095 A CN 113917095A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
Abstract
The invention discloses an in-vitro drug sensitivity detection device for pancreatic cancer and liver metastasis chemotherapy drug resistance, which belongs to the technical field of external drug sensitivity detection devices.
Description
Technical Field
The invention relates to an external drug sensitivity detection device, in particular to an external drug sensitivity detection device for pancreatic cancer liver metastasis chemotherapy drug resistance, and belongs to the technical field of external drug sensitivity detection devices.
Background
Pancreatic cancer is a malignant tumor of the digestive tract, the disease condition is rapidly developed, the degree of deterioration is high, and metastasis easily occurs in the late stage.
The most important thing is that patients need to be prepared in the aspect of the mood and the life quality of the patients can be improved to a certain extent through active and effective treatment.
Gemcitabine is commonly adopted in the existing chemotherapy for treating the liver metastasis of pancreatic cancer;
gemcitabine, a novel cytosine nucleoside derivative, is activated by deoxycytidine kinase and metabolized by cytosine nucleoside deaminase after entering the human body, as does cytarabine.
The product is a pyrimidine antitumor drug, has the same action mechanism as cytarabine, and the main metabolite of the product is doped with DNA in cells and mainly acts on G1/S phase.
But the difference is that the difluorine can inhibit nucleotide reductase besides being doped into DNA, so that the intracellular deoxynucleoside triphosphate is reduced, and the difference is that the difluorine can inhibit the degradation of intracellular metabolites by deoxycytidine deaminase, so that the difluorine has the self-synergistic effect.
Clinically, the product has different anti-tumor spectrum from cytarabine and is effective on various solid tumors.
In the prior art, each group of cells are not respectively exposed to gemcitabine with different concentrations to carry out a sensitivity detection device, the first method cannot carry out simultaneous measurement, the second method cannot pack gemcitabine in the adding process, the quantification of the gemcitabine is uniform, the temperature and humidity maintenance is difficult, the problem of dripping is easy to occur in the adding process of the gemcitabine, and therefore the pancreatic cancer liver metastasis chemotherapy drug-resistant in-vitro drug sensitivity detection device is designed to optimize the problems.
Disclosure of Invention
The invention mainly aims to provide an in vitro drug sensitivity detection device for chemotherapy and drug resistance in pancreatic cancer liver transfer, gemcitabine with different concentrations is placed in a gemcitabine classified storage tank and is separated by a separation support plate, a refrigeration component and a refrigerant liquid conveying and refluxing component are started to enable refrigerant liquid to refrigerate the gemcitabine classified storage tank in a cooling pipe, meanwhile, the flowing of the liquid drives a hydraulic drive component to move during refrigeration, a rotating rod is driven by the hydraulic drive component to move, a stirring component is driven by the rotating rod to move, gemcitabine with different concentrations is stirred, the problem that gemcitabine solution is not uniform enough after being placed for a long time is avoided, a transparent sealing cover is opened by a hand-held handle to place a culture dish inside a culture dish clamping component for clamping, then the hand-held handle is loosened to limit through a buffer limiting component so that the transparent sealing cover can be tightly pressed on the top of a base, and take a breath through starting the subassembly of taking a breath, keep the culture dish under the same and suitable temperature through the thermostatic assembly, start the location lifter subassembly with the accurate alignment culture dish top of drain pipe subassembly, then start corresponding electronic adjusting part and drive the operation of T type piston rod subassembly, lead in liquid to the piston cavity earlier through T type piston rod subassembly cooperation check valve subassembly, then flow into to the culture dish through T type piston rod subassembly cooperation drain pipe subassembly and carry out ration and accurate liquid feeding, it is regularly through the timer simultaneously, remind after reaching the survey time.
The purpose of the invention can be achieved by adopting the following technical scheme:
a pancreatic cancer liver transfer chemotherapy drug-resistant in-vitro drug sensitivity detection device comprises a base, wherein a constant temperature component is arranged at the top of the base, side L-shaped support frames are arranged on two sides of the top of the base, gemcitabine classified storage tanks are arranged at the other ends of the side L-shaped support frames, a plurality of groups of separation support plates are arranged in the gemcitabine classified storage tanks at equal intervals, the separation support plates divide the gemcitabine classified storage tanks into a plurality of empty bins, the tops of the empty bins are communicated with liquid feeding pipes, cooling pipes are laid around interlayer meals of the gemcitabine classified storage tanks, a refrigeration component is arranged on one side of the tops of the gemcitabine classified storage tanks, the refrigeration component is communicated with the cooling pipes through a refrigeration liquid conveying backflow component, a stirring component is arranged in each group of empty bins and is arranged along the axial direction of gemcitabine classified storage tanks, rotating rods are arranged at the axial positions of the gemcitabine classified storage tanks in a penetrating manner through the separation support plates, the stirring assembly is fixed on the outer side of the rotating rod, the other end of the rotating rod penetrates through the gemcitabine classified storage tank and is provided with a hydraulic driving assembly, the hydraulic driving assembly is positioned at a refrigerant liquid output part of the refrigerant liquid conveying backflow assembly, a group of quantitative liquid adding bins are arranged at the bottom of the gemcitabine classified storage tank and below each group of empty bins, piston cavities communicated with the gemcitabine classified storage tank are arranged in the quantitative liquid adding bins, a check valve assembly is arranged between the piston cavities and the gemcitabine classified storage tank, a T-shaped piston rod assembly is arranged below the inner side of each piston cavity, an electric adjusting assembly for driving the T-shaped piston rod assembly is arranged at the top in each quantitative liquid adding bin, a second air guide hole is arranged at the bottom of each piston cavity, a first air guide hole is arranged at the bottom of the quantitative liquid adding bin, the output end of the T-shaped piston rod assembly is connected with a liquid guide pipe assembly, and side limiting plates are arranged at two sides of the top of the base close to the L-shaped support frames, and lie in the inboard of side spacing board and seted up the side spacing groove, the spacing subassembly of buffering is installed to the interior bottom in side spacing groove, the second lift fixed plate is installed at the top of the spacing subassembly of buffering, transparent sealing cover is installed to the inboard of second lift fixed plate, and a plurality of through-holes have been seted up at transparent sealing cover top, the catheter subassembly runs through this through-hole, the top middle part department of base installs the location lifter subassembly, the end fixing of catheter subassembly is on the location lifter subassembly, be equipped with culture dish centre gripping subassembly under the top of base and being located the catheter subassembly, one side of side L type support frame is equipped with the subassembly of taking a breath with transparent sealing cover side top intercommunication, the timer is installed to side L type support frame top lateral part.
Preferably, the thermostatic assembly comprises an electric heater and an electric heating plate, the electric heating plate is installed at the inner top of the base, and the electric heater is installed inside the base and is electrically connected with the electric heating plate;
the refrigeration assembly comprises a refrigeration bin, a semiconductor refrigerator, an aluminum alloy temperature guide plate and an aluminum alloy temperature guide rod, the refrigeration bin is installed on one side of the top of the gemcitabine classified storage tank, a plurality of groups of semiconductor refrigerators are arranged on the inner top of the refrigeration bin in a penetrating mode, the refrigeration end of each semiconductor refrigerator is located inside the refrigeration bin, the refrigeration end is provided with the aluminum alloy temperature guide plate, and the bottom of the aluminum alloy temperature guide plate is paved with the plurality of groups of aluminum alloy temperature guide rods.
Preferably, the refrigeration liquid is carried the backward flow subassembly and is included the refrigeration liquid recovery pipe, the bow type heat exchange tube, the refrigeration liquid connecting pipe, first carry the refrigeration pipe, the refrigeration pipe is carried to water pump and second, the water pump is installed at the top of the categorised storage jar of gemcitabine, and the one end intercommunication of water pump has first transport refrigeration pipe, the other end intercommunication hydraulic drive subassembly of first transport refrigeration pipe, the output intercommunication of hydraulic drive subassembly has the second to carry the refrigeration pipe, the other end and the cooling pipe intercommunication of the categorised storage jar inlayer below of gemcitabine of refrigeration pipe are carried to the second, the other end intercommunication of water pump has the bow type heat exchange tube, the bow type heat exchange tube is located the inside in refrigeration storehouse, the other end intercommunication of bow type heat exchange tube has the refrigeration liquid recovery pipe, and the cooling pipe intercommunication at the categorised storage jar inlayer top of gemcitabine.
Preferably, the hydraulic drive assembly comprises a hydraulic drive bin and fan blades, the hydraulic drive bin is installed at the side end of the gemcitabine classifying storage tank, the fan blades are arranged inside the hydraulic drive bin, the rotating rod penetrates through the gemcitabine classifying storage tank and is inserted into the hydraulic drive bin to be fixed with the middle of the side of the fan blades, the top of the hydraulic drive bin is communicated with the first conveying refrigeration pipe, and the bottom of the hydraulic drive bin is communicated with the second conveying refrigeration pipe.
Preferably, the stirring assembly comprises a sleeve, an arc-shaped stirring rod and a side fixing rod, the sleeve is sleeved on the outer side of the rotating rod, the side fixing rod is installed on the outer side of the sleeve at equal intervals, and the arc-shaped stirring rod is installed at the end part of the side fixing rod.
Preferably, check valve subassembly includes feed liquor pipe, check valve and first spacing spring, and the piston chamber passes through the inside intercommunication of feed liquor pipe and the categorised storage jar of gemcitabine, and the check valve has been filled in to the inboard bottom of feed liquor pipe, and is equipped with first spacing spring between the interior top in check valve and piston chamber.
Preferably, the T-shaped piston rod assembly comprises a lifting piston and a liquid outlet piston pipe, the lifting piston capable of sliding up and down in the piston cavity is arranged in the piston cavity, the bottom of the lifting piston is communicated with the liquid outlet piston pipe, and the liquid outlet piston pipe penetrates through the piston cavity and the quantitative liquid adding bin to be communicated with the liquid guide pipe assembly;
the electric adjusting assembly comprises a second electric lifting rod and a first lifting fixing plate, the second electric lifting rod is installed at the inner top side part of the quantitative liquid adding bin, the first lifting fixing plate is installed at the output end of the second electric lifting rod, and one side of the first lifting fixing plate is fixed with the outer wall of the liquid outlet piston pipe.
Preferably, the liquid guide pipe assembly comprises an electromagnetic valve, a liquid guide hose and a liquid dropping head, the bottom of the liquid outlet piston pipe is communicated with the electromagnetic valve, the bottom of the electromagnetic valve is communicated with the liquid guide hose, the other end of the liquid guide hose is communicated with the liquid dropping head, and the liquid dropping head is fixed on the positioning lifting frame assembly.
Preferably, the buffering limiting assembly comprises an outer limiting barrel, a second limiting spring and an inner limiting barrel, the outer limiting barrel is mounted at the inner bottom of the side limiting groove, the second limiting spring is mounted at the inner bottom of the outer limiting barrel, the inner limiting barrel is mounted at the top of the second limiting spring, the bottom of the outer side of the inner limiting barrel is inserted into the outer limiting barrel, and a second lifting fixing plate is mounted at the top of the inner limiting barrel;
the positioning lifting frame assembly comprises a first electric lifting rod, a positioning frame and fixing holes, the first electric lifting rod is installed in the middle of the top of the base, the positioning frame is installed at the output end of the first electric lifting rod, a plurality of groups of fixing holes are formed in the top of the positioning frame, and the liquid dropping head is fixed on the inner wall of the fixing hole.
Preferably, the culture dish clamping assembly comprises a U-shaped frame, a third limiting spring, a clamping plate and a protective sponge layer, the U-shaped frame is installed at the top of the base and located right below the liquid dropper, the third limiting spring is paved on the inner side of the U-shaped frame, the clamping plate is installed at the end part of the third limiting spring, and the protective sponge layer is paved on the outer side of the clamping plate;
the subassembly of taking a breath includes the scavenging pump and the hose of taking a breath, and the scavenging pump is installed to side L type support frame side bottom, and the one end of scavenging pump is through the hose of taking a breath and transparent sealing cover side top intercommunication, and the picture peg is installed to the both sides of transparent sealing cover, and the slot of mutually supporting with the picture peg is seted up to the top both sides of base.
The invention has the beneficial technical effects that:
the invention provides a pancreatic cancer liver transfer chemotherapy drug-resistant in-vitro drug sensitivity detection device, gemcitabine with different concentrations is placed in a gemcitabine classified storage tank and is separated by a separation support plate, a refrigeration component and a refrigerant liquid conveying backflow component are started to enable refrigerant liquid to refrigerate the gemcitabine classified storage tank in a cooling pipe, meanwhile, the flowing of the liquid drives a hydraulic drive component to move during refrigeration, the hydraulic drive component drives a rotating rod to move, the rotating rod drives a stirring component to move, gemcitabine with different concentrations is stirred, the problem that gemcitabine solution is not uniform enough after being placed for a long time is avoided, a handheld handle opens a transparent sealing cover to place a culture dish inside a culture dish clamping component for clamping, then the handheld handle is loosened to limit through a buffer limiting component so that the transparent sealing cover can be tightly pressed on the top of a base, and take a breath through starting the subassembly of taking a breath, keep the culture dish under the same and suitable temperature through the thermostatic assembly, start the location lifter subassembly with the accurate alignment culture dish top of drain pipe subassembly, then start corresponding electronic adjusting part and drive the operation of T type piston rod subassembly, lead in liquid to the piston cavity earlier through T type piston rod subassembly cooperation check valve subassembly, then flow into to the culture dish through T type piston rod subassembly cooperation drain pipe subassembly and carry out ration and accurate liquid feeding, it is regularly through the timer simultaneously, remind after reaching the survey time.
Drawings
FIG. 1 is a side cross-sectional view of the whole device of a preferred embodiment of the apparatus for detecting drug sensitivity of pancreatic cancer in vitro in liver metastasis chemotherapy for drug resistance according to the present invention;
FIG. 2 is a schematic diagram of a holder structure of a preferred embodiment of an apparatus for detecting drug sensitivity of pancreatic cancer in vitro in liver metastasis chemotherapy;
FIG. 3 is a schematic diagram of a quantitative dropping assembly of a preferred embodiment of an apparatus for detecting drug sensitivity of pancreatic cancer in vitro in liver metastasis chemotherapy in accordance with the present invention;
FIG. 4 is an enlarged view of the structure at the position c of a preferred embodiment of the in vitro drug sensitivity detection device for pancreatic cancer liver metastasis chemotherapy drug resistance according to the present invention;
FIG. 5 is an enlarged view of the structure at the position b of a preferred embodiment of the in vitro drug sensitivity testing device for the drug resistance in the pancreatic cancer liver metastasis chemotherapy according to the present invention;
FIG. 6 is an enlarged view of the structure at the position a of a preferred embodiment of the device for detecting drug sensitivity in vitro for liver metastasis chemotherapy of pancreatic cancer according to the present invention;
FIG. 7 is a diagram of a gemcitabine drug solution storage box of a preferred embodiment of an in vitro drug sensitivity testing device for liver metastasis chemotherapy of pancreatic cancer in accordance with the present invention;
FIG. 8 is an enlarged view of the structure at position d of a preferred embodiment of the in vitro drug sensitivity testing device for the chemotherapy resistance of pancreatic cancer liver metastasis according to the present invention;
FIG. 9 is an enlarged view of the structure at the position e of a preferred embodiment of the in vitro drug sensitivity testing device for the chemotherapy resistance of pancreatic cancer liver metastasis according to the present invention;
fig. 10 is a schematic perspective view of a fixing plate of a preferred embodiment of the apparatus for detecting drug sensitivity of pancreatic cancer in vitro in liver metastasis chemotherapy.
In the figure: 1-base, 2-side L-shaped support frame, 3-gemcitabine classified storage tank, 4-cooling pipe, 5-locating frame, 6-liquid dropping head, 7-transparent sealing cover, 9-liquid guide hose, 10-air exchange pump, 11-air exchange hose, 12-first electric lifting rod, 13-electric heater, 14-electric heating plate, 15-quantitative liquid adding bin, 17-side limiting plate, 18-U-shaped frame, 19-third limiting spring, 20-clamping plate, 21-protective sponge layer, 22-water pump, 23-piston cavity, 24-second electric lifting rod, 25-liquid inlet pipe, 26-one-way valve, 27-first limiting spring, 28-liquid outlet piston pipe, 29-first lifting fixing plate and 30-lifting piston, 31-an electromagnetic valve, 32-a first air guide hole, 33-a second air guide hole, 34-a side limiting groove, 35-a second lifting fixing plate, 36-an inner limiting cylinder, 37-a second limiting spring, 38-an outer limiting cylinder, 39-a slot, 40-an inserting plate, 41-a first conveying refrigerating fluid pipe, 42-a second conveying refrigerating fluid pipe, 43-a refrigerating fluid connecting pipe, 44-a separating supporting plate, 45-a sleeve, 46-an arc-shaped stirring rod, 47-a hydraulic driving bin, 48-a fan blade, 49-a rotating rod, 50-a side fixing rod, 51-a semiconductor refrigerator, 52-an aluminum alloy heat guide plate, 53-an aluminum alloy heat guide rod, 54-an arch-shaped heat exchange tube, 55-a refrigerating fluid recovery tube, 56-a liquid feeding tube and 57-a refrigerating bin, 58-fixed hole, 59-timer.
Detailed Description
In order to make the technical solutions of the present invention more clear and definite for those skilled in the art, the present invention is further described in detail below with reference to the examples and the accompanying drawings, but the embodiments of the present invention are not limited thereto.
As shown in fig. 1-10, the present embodiment provides an external drug sensitivity detection device for chemotherapy for pancreatic cancer liver metastasis, which includes a base 1, a constant temperature component is disposed at the top of the base 1, side L-shaped support frames 2 are mounted on two sides of the top of the base 1, a gemcitabine classification storage tank 3 is mounted at the other end of the side L-shaped support frame 2, a plurality of sets of partition support plates 44 are disposed at equal intervals inside the gemcitabine classification storage tank 3, the partition support plates 44 partition the gemcitabine classification storage tank 3 into a plurality of empty bins, a liquid feeding pipe 56 is communicated with the top of each empty bin, a cooling pipe 4 is laid around an inner layer of the gemcitabine classification storage tank 3, a refrigeration component is mounted on one side of the top of the gemcitabine classification storage tank 3, the refrigeration component is communicated with the cooling pipe 4 through a refrigeration liquid conveying backflow component, and a stirring component is disposed in each empty bin, the stirring assembly is axially arranged along the gemcitabine classified storage tank 3, a rotating rod 49 is arranged at the axial position of the gemcitabine classified storage tank 3 through a partition support plate 44, the stirring assembly is fixed at the outer side of the rotating rod 49, the other end of the rotating rod 49 is provided with a hydraulic driving assembly through the gemcitabine classified storage tank 3, the hydraulic driving assembly is positioned at a refrigerating fluid output part of a refrigerating fluid conveying and returning assembly, a group of quantitative liquid adding bins 15 are arranged at the bottom of the gemcitabine classified storage tank 3 and below each group of empty bins, a piston cavity 23 communicated with the gemcitabine classified storage tank 3 is arranged inside the quantitative liquid adding bins 15, a check valve assembly is arranged between the piston cavity 23 and the gemcitabine classified storage tank 3, a T-shaped piston rod assembly is arranged inside the piston cavity 23, and an electric adjusting assembly for driving the T-shaped piston rod assembly is arranged at the top part in the quantitative liquid adding bin 15, a second air guide hole 33 is arranged at the bottom of the piston cavity 23, a first air guide hole 32 is arranged at the bottom of the quantitative liquid feeding bin 15, the output end of the T-shaped piston rod component is connected with a liquid guide pipe component, side limiting plates 17 are arranged at two sides of the top of the base 1 close to the side L-shaped supporting frame 2, side limiting grooves 34 are arranged at the inner sides of the side limiting plates 17, a buffering limiting component is arranged at the inner bottom of each side limiting groove 34, a second lifting fixing plate 35 is arranged at the top of the buffering limiting component, a transparent sealing cover 7 is arranged at the inner side of each second lifting fixing plate 35, a plurality of through holes are arranged at the top of the transparent sealing cover 7, the liquid guide pipe component penetrates through the through holes, a positioning lifting frame component is arranged at the middle part of the top of the base 1, the end part of the liquid guide pipe component is fixed on the positioning lifting frame component, a culture dish clamping component is arranged at the top of the base 1 and under the liquid guide pipe component, one side of the side L-shaped support frame 2 is provided with an air exchange assembly communicated with the top of the side of the transparent sealing cover 7, and the top of the side L-shaped support frame 2 is provided with a timer 59.
Gemcitabine with different concentrations is placed in the gemcitabine classified storage tank 3 and is separated by the separation supporting plate 44, the refrigeration component and the refrigerant liquid conveying and returning component are started to enable refrigerant liquid to refrigerate the gemcitabine classified storage tank 3 in the cooling pipe 4, meanwhile, the flowing of the liquid drives the hydraulic drive component to move during refrigeration, the hydraulic drive component drives the rotating rod 49 to move, the rotating rod 49 drives the stirring component to move, gemcitabine with different concentrations is stirred, the problem that gemcitabine solution is not uniform enough after being placed for a long time is avoided, the transparent sealing cover 7 is opened by the hand handle to place a culture dish on the inner side of the culture dish clamping component for clamping, then the hand handle is loosened to limit through the buffering limiting component so that the transparent sealing cover 7 can be tightly pressed on the top of the base 1 and air exchange is carried out by starting the air exchange component, keep the culture dish under the same and suitable temperature through the constant temperature subassembly, start the location lift frame subassembly with the accurate alignment culture dish top of drain pipe subassembly, then start corresponding electric adjusting part and drive T type piston rod subassembly operation, lead to liquid earlier to piston cavity 23 in through T type piston rod subassembly cooperation check valve subassembly, then flow into to the culture dish through T type piston rod subassembly cooperation drain pipe subassembly and carry out ration and accurate liquid feeding, it is regularly through timer 59 simultaneously, remind after reaching the measuring time.
In the present embodiment, the thermostatic assembly includes an electric heater 13 and an electric heating plate 14, the electric heating plate 14 is installed at the inner top of the base 1, and the electric heater 13 is installed inside the base 1 and electrically connected with the electric heating plate 14;
the electric heater 13 is started to heat the electric heating plate 14, and the culture dish on the top of the base 1 is kept at a proper temperature through the electric heating plate 14.
The refrigeration assembly comprises a refrigeration bin 57, a semiconductor refrigerator 51, an aluminum alloy temperature guide plate 52 and an aluminum alloy temperature guide rod 53, the refrigeration bin 57 is installed on one side of the top of the gemcitabine classified storage tank 3, a plurality of groups of semiconductor refrigerators 51 are arranged on the inner top of the refrigeration bin 57 in a penetrating manner, the refrigeration end of each semiconductor refrigerator 51 is positioned in the refrigeration bin 57 and is provided with the aluminum alloy temperature guide plate 52, a plurality of groups of aluminum alloy temperature guide rods 53 are paved at the bottom of the aluminum alloy temperature guide plate 52, the refrigerant liquid conveying and refluxing assembly comprises a refrigerant liquid recovery pipe 55, an arched heat exchange pipe 54, a refrigerant liquid connecting pipe 43, a first conveying refrigeration pipe 41, a water pump 22 and a second conveying refrigeration pipe 42, the water pump 22 is installed on the top of the gemcitabine classified storage tank 3, one end of the water pump 22 is communicated with the first conveying refrigeration pipe 41, the other end of the first conveying refrigeration pipe 41 is communicated with the hydraulic drive assembly, the output end of the hydraulic drive assembly is communicated with the second conveying refrigeration pipe 42, the other end of second transport refrigeration pipe 42 and cooling pipe 4 intercommunication of gemcitabine classification storage jar 3 inlayer below, the other end intercommunication of water pump 22 has bow type heat exchange tube 54, and bow type heat exchange tube 54 is located the inside of refrigeration storehouse 57, and the other end intercommunication of bow type heat exchange tube 54 has refrigerant liquid recovery pipe 55, and the other end of refrigerant liquid recovery pipe 55 and cooling pipe 4 intercommunication at gemcitabine classification storage jar 3 inlayer top.
The semiconductor refrigerator 51 and the water pump 22 are started, the refrigerating fluid circularly moves in the refrigerating fluid recovery pipe 55, the arch-shaped heat exchange pipe 54, the refrigerating fluid connecting pipe 43, the first conveying refrigerating pipe 41, the water pump 22, the second conveying refrigerating pipe 42 and the cooling pipe 4, the refrigerating fluid is positioned in the arch-shaped heat exchange pipe 54 when passing through the refrigerating bin 57, meanwhile, the semiconductor refrigerator 51, the aluminum alloy temperature guide plate 52 and the aluminum alloy temperature guide rod 53 rapidly cool, heat exchange is carried out on the refrigerating fluid, and the function of circular refrigeration is realized.
In this embodiment, the hydraulic drive assembly includes hydraulic drive bin 47 and flabellum 48, hydraulic drive bin 47 is installed to the side end of gemcitabine classified storage jar 3, and be equipped with flabellum 48 in hydraulic drive bin 47's inside, bull stick 49 runs through gemcitabine classified storage jar 3 and inserts in hydraulic drive bin 47 with the side middle part of flabellum 48 is fixed, the top of hydraulic drive bin 47 and first transport refrigeration pipe 41 intercommunication, the bottom of hydraulic drive bin 47 and second transport refrigeration pipe 42 intercommunication, the stirring subassembly includes sleeve 45, arc puddler 46 and side dead lever 50, sleeve 45 overlaps the outside department at bull stick 49, and the side dead lever 50 is installed to the outside of sleeve 45 equidistant, and install arc puddler 46 at the tip of side dead lever 50.
During the circulating refrigeration, the refrigerating fluid drives the bin 47 through water power and strikes the fan blades 48 to rotate the fan blades 48, so as to drive the rotating rod 49 to move, and further drive the sleeve 45, the arc-shaped stirring rod 46 and the side fixing rod 50 which are arranged outside the rotating rod 49 to rotate and stir.
In this embodiment, the check valve assembly includes a liquid inlet pipe 25, a check valve 26 and a first limiting spring 27, the piston chamber 23 is communicated with the inside of the gemcitabine classification storage tank 3 through the liquid inlet pipe 25, the check valve 26 is inserted into the bottom of the inner side of the liquid inlet pipe 25, a first limiting spring 27 is disposed between the check valve 26 and the inner top of the piston chamber 23, the T-shaped piston rod assembly includes a lifting piston 30 and a liquid outlet piston pipe 28, a lifting piston 30 capable of sliding up and down inside the piston chamber 23 is disposed inside the piston chamber 23, the bottom of the lifting piston 30 is communicated with the liquid outlet piston pipe 28, the liquid outlet piston pipe 28 penetrates through the piston chamber 23 and the quantitative liquid feeding chamber 15 to be communicated with the liquid guiding pipe assembly, the electric adjusting assembly includes a second electric lifting rod 24 and a first lifting fixing plate 29, the second electric lifting rod 24 is mounted at the inner top side portion of the quantitative liquid feeding chamber 15, the first lifting fixing plate 29 is mounted at the output end of the second electric lifting rod 24, one side of first lift fixed plate 29 is fixed with the outer wall of play liquid piston tube 28, the catheter subassembly includes solenoid valve 31, drain hose 9 and dripper 6, the bottom intercommunication of play liquid piston tube 28 has solenoid valve 31, and the bottom intercommunication of solenoid valve 31 has drain hose 9, the other end intercommunication of drain hose 9 has dripper 6, and dripper 6 fixes on location lifter frame subassembly, location lifter frame subassembly includes first electric lift rod 12, locating rack 5 and fixed orifices 58, base 1 top mid-mounting has first electric lift rod 12, and locating rack 5 is installed to the output of first electric lift rod 12, multiunit fixed orifices 58 have been seted up at the top of locating rack 5, and dripper 6 fixes the inner wall at fixed orifices 58.
The second electric lifting rod 24 is started to drive the first lifting fixing plate 29 to move, the liquid outlet piston tube 28 is driven to move through the first lifting fixing plate 29, the lifting piston 30 is driven to move downwards through the liquid outlet piston tube 28, the one-way valve 26 of the liquid outlet piston tube is enabled to open the liquid inlet tube 25 under negative pressure, the solution flows into the piston cavity 23 and flows out through the liquid outlet piston tube 28, the second electric lifting rod 24 can be adjusted to ensure the adjustment of the liquid adding amount, the liquid passes through the electromagnetic valve 31, the liquid guide hose 9 and the liquid dropper 6 enter the culture dish, and meanwhile the liquid dropper 6 is matched with the positioning frame 5 and the first electric lifting rod 12 to enable the liquid dropper to be added accurately.
In this embodiment, the buffering limiting assembly comprises an outer limiting barrel 38, a second limiting spring 37 and an inner limiting barrel 36, the outer limiting barrel 38 is installed at the inner bottom of the side limiting groove 34, the second limiting spring 37 is installed at the inner bottom of the outer limiting barrel 38, the inner limiting barrel 36 is installed at the top of the second limiting spring 37, the bottom of the outer side of the inner limiting barrel 36 is inserted into the outer limiting barrel 38, and the second lifting fixing plate 35 is installed at the top of the inner limiting barrel 36.
In the embodiment, the culture dish clamping assembly comprises a U-shaped frame 18, a third limiting spring 19, a clamping plate 20 and a protective sponge layer 21, wherein the U-shaped frame 18 is installed at the top of the base 1 and is located right below the liquid dropper 6, the third limiting spring 19 is laid on the inner side of the U-shaped frame 18, the clamping plate 20 is installed at the end part of the third limiting spring 19, and the protective sponge layer 21 is laid on the outer side of the clamping plate 20;
the subassembly of taking a breath includes scavenging pump 10 and ventilation hose 11, and scavenging pump 10 is installed to 2 side bottoms of side L type support frame, and scavenging pump 10's one end is through ventilation hose 11 and transparent sealed cowling 7 side top intercommunication, and picture peg 40 is installed to the both sides of transparent sealed cowling 7, and the slot 39 of mutually supporting with picture peg 40 is seted up to the top both sides of base 1.
The above are only further embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can substitute or change the technical solution of the present invention and its concept within the scope of the present invention.
Claims (10)
1. A pancreas cancer liver metastasis chemotherapy drug-resistant external drug sensitivity detection device, characterized by: comprises a base (1), a constant temperature component is arranged at the top of the base (1), side L-shaped supporting frames (2) are arranged at two sides of the top of the base (1), gemcitabine classified storage tanks (3) are arranged at the other ends of the side L-shaped supporting frames (2), a plurality of groups of partition supporting plates (44) are arranged in the gemcitabine classified storage tanks (3) at equal intervals, the partition supporting plates (44) divide the gemcitabine classified storage tanks (3) into a plurality of empty bins, a liquid adding pipe (56) is communicated with the top of each empty bin, cooling pipes (4) are laid around an inner sandwich meal of the gemcitabine classified storage tanks (3), a refrigeration component is arranged at one side of the top of the gemcitabine classified storage tanks (3) and communicated with the cooling pipes (4) through refrigeration liquid conveying backflow components, stirring components are arranged in each group of empty bin, and are axially arranged along the gemcitabine classified storage tanks (3), the axial position of the gemcitabine classifying storage tank (3) penetrates through the separating support plate (44) and is provided with a rotating rod (49), a stirring assembly is fixed on the outer side of the rotating rod (49), the other end of the rotating rod (49) penetrates through the gemcitabine classifying storage tank (3) and is provided with a hydraulic driving assembly, the hydraulic driving assembly is positioned at a refrigerating fluid output part of a refrigerating fluid conveying and returning assembly, the bottom of the gemcitabine classifying storage tank (3) is positioned below each group of empty bins and is provided with a group of quantitative liquid adding bins (15), a piston cavity (23) communicated with the gemcitabine classifying storage tank (3) is arranged inside the quantitative liquid adding bins (15), a check valve assembly is arranged between the piston cavity (23) and the gemcitabine classifying storage tank (3), a T-shaped piston rod assembly is arranged inside the piston cavity (23), and an electric adjusting assembly for driving the T-shaped piston rod assembly is arranged at the top in the quantitative liquid adding bins (15), a second air guide hole (33) is arranged at the bottom of the piston cavity (23), a first air guide hole (32) is arranged at the bottom of the quantitative liquid adding bin (15), the output end of the T-shaped piston rod component is connected with a liquid guide pipe component, side limiting plates (17) are arranged at two sides of the top of the base (1) close to the L-shaped support frame (2), side limiting grooves (34) are arranged at the inner sides of the side limiting plates (17), a buffering limiting component is arranged at the inner bottom of each side limiting groove (34), a second lifting fixing plate (35) is arranged at the top of each buffering limiting component, a transparent sealing cover (7) is arranged at the inner side of each second lifting fixing plate (35), a plurality of through holes are arranged at the top of the transparent sealing cover (7), the liquid guide pipe component penetrates through the through holes, a positioning lifting frame component is arranged at the middle of the top of the base (1), and the end part of the liquid guide pipe component is fixed on the positioning lifting frame component, the top of base (1) just is located and is equipped with culture dish centre gripping subassembly under the catheter subassembly, and one side of side L type support frame (2) is equipped with the subassembly of taking a breath with transparent sealed cowling (7) side top intercommunication, and timer (59) are installed to side L type support frame (2) top side.
2. The apparatus for detecting drug sensitivity of pancreatic cancer in vitro in liver metastasis chemotherapy as claimed in claim 1, wherein: the constant temperature component comprises an electric heater (13) and an electric heating plate (14), the electric heating plate (14) is installed at the inner top of the base (1), and the electric heater (13) is installed inside the base (1) and is electrically connected with the electric heating plate (14);
refrigeration subassembly leads warm pole (53) including refrigeration storehouse (57), semiconductor cooler (51), aluminium alloy, and temperature guide plate (52) and aluminium alloy, refrigeration storehouse (57) are installed in the one side at gemcitabine classification storage jar (3) top, the interior top in refrigeration storehouse (57) is run through and is equipped with multiunit semiconductor cooler (51), the refrigeration end of semiconductor cooler (51) is located the inside in refrigeration storehouse (57), and this refrigeration end is installed the aluminium alloy and is led warm board (52), multiunit aluminium alloy is laid to the bottom that aluminium alloy led warm board (52) and is led warm pole (53).
3. The apparatus for detecting drug sensitivity of pancreatic cancer in vitro in liver metastasis chemotherapy as claimed in claim 2, wherein: the refrigerant liquid conveying and refluxing assembly comprises a refrigerant liquid recovery pipe (55), an arch-shaped heat exchange pipe (54), a refrigerant liquid connecting pipe (43), a first conveying refrigerant pipe (41), a water pump (22) and a second conveying refrigerant pipe (42), the top of the gemcitabine classified storage tank (3) is provided with the water pump (22), one end of the water pump (22) is communicated with the first conveying refrigerant pipe (41), the other end of the first conveying refrigerant pipe (41) is communicated with the hydraulic drive assembly, the output end of the hydraulic drive assembly is communicated with the second conveying refrigerant pipe (42), the other end of the second conveying refrigerant pipe (42) is communicated with the cooling pipe (4) below the inner layer of the gemcitabine classified storage tank (3), the other end of the water pump (22) is communicated with the arch-shaped heat exchange pipe (54), the arch-shaped heat exchange pipe (54) is positioned in the refrigeration bin (57), the other end of the arch-shaped heat exchange pipe (54) is communicated with the refrigerant liquid recovery pipe (55), and the other end of the refrigerant liquid recovery pipe (55) is communicated with a cooling pipe (4) at the top of an inner interlayer of the gemcitabine classification storage tank (3).
4. The apparatus for detecting drug sensitivity of pancreatic cancer in vitro in liver metastasis chemotherapy as claimed in claim 3, wherein: the hydraulic drive assembly comprises a hydraulic drive bin (47) and fan blades (48), the hydraulic drive bin (47) is installed at the side end part of the gemcitabine classifying storage tank (3), the fan blades (48) are arranged inside the hydraulic drive bin (47), a rotating rod (49) penetrates through the gemcitabine classifying storage tank (3) and is inserted into the hydraulic drive bin (47) to be fixed with the side middle part of the fan blades (48), the top of the hydraulic drive bin (47) is communicated with the first conveying refrigeration pipe (41), and the bottom of the hydraulic drive bin (47) is communicated with the second conveying refrigeration pipe (42).
5. The apparatus for detecting drug sensitivity of pancreatic cancer in vitro in liver metastasis chemotherapy as claimed in claim 4, wherein: the stirring assembly comprises a sleeve (45), an arc-shaped stirring rod (46) and a side fixing rod (50), wherein the sleeve (45) is sleeved at the outer side of the rotating rod (49), the side fixing rod (50) is installed on the outer side of the sleeve (45) at equal intervals, and the arc-shaped stirring rod (46) is installed at the end part of the side fixing rod (50).
6. The apparatus for detecting drug sensitivity of pancreatic cancer in vitro in liver metastasis chemotherapy as claimed in claim 5, wherein: check valve subassembly includes feed liquor pipe (25), check valve (26) and first spacing spring (27), and piston chamber (23) are through the inside intercommunication of feed liquor pipe (25) with the categorised storage jar of gemcitabine (3), and check valve (26) have been filled in to the inboard bottom of feed liquor pipe (25), and is equipped with first spacing spring (27) between the interior top of check valve (26) and piston chamber (23).
7. The apparatus for detecting drug sensitivity of pancreatic cancer in vitro in liver metastasis chemotherapy as claimed in claim 6, wherein: the T-shaped piston rod assembly comprises a lifting piston (30) and a liquid outlet piston pipe (28), the lifting piston (30) capable of sliding up and down in the piston cavity (23) is arranged in the piston cavity (23), the bottom of the lifting piston (30) is communicated with the liquid outlet piston pipe (28), and the liquid outlet piston pipe (28) penetrates through the piston cavity (23) and the quantitative liquid adding bin (15) to be communicated with the liquid guide pipe assembly;
the electric adjusting assembly comprises a second electric lifting rod (24) and a first lifting fixing plate (29), the second electric lifting rod (24) is installed at the inner top side part of the quantitative liquid adding bin (15), the first lifting fixing plate (29) is installed at the output end of the second electric lifting rod (24), and one side of the first lifting fixing plate (29) is fixed with the outer wall of the liquid outlet piston pipe (28).
8. The apparatus for detecting drug sensitivity of pancreatic cancer in vitro in liver metastasis chemotherapy as claimed in claim 7, wherein: the liquid guide pipe assembly comprises an electromagnetic valve (31), a liquid guide hose (9) and a liquid dropping head (6), the bottom of the liquid outlet piston pipe (28) is communicated with the electromagnetic valve (31), the bottom of the electromagnetic valve (31) is communicated with the liquid guide hose (9), the other end of the liquid guide hose (9) is communicated with the liquid dropping head (6), and the liquid dropping head (6) is fixed on the positioning lifting frame assembly.
9. The apparatus for detecting drug sensitivity of pancreatic cancer in vitro in liver metastasis chemotherapy as claimed in claim 8, wherein: the buffering limiting assembly comprises an outer limiting barrel (38), a second limiting spring (37) and an inner limiting barrel (36), the outer limiting barrel (38) is installed at the inner bottom of the side limiting groove (34), the second limiting spring (37) is installed at the inner bottom of the outer limiting barrel (38), the inner limiting barrel (36) is installed at the top of the second limiting spring (37), the bottom of the outer side of the inner limiting barrel (36) is inserted into the outer limiting barrel (38), and a second lifting fixing plate (35) is installed at the top of the inner limiting barrel (36);
the positioning lifting frame assembly comprises a first electric lifting rod (12), a positioning frame (5) and fixing holes (58), the first electric lifting rod (12) is installed in the middle of the top of the base (1), the positioning frame (5) is installed at the output end of the first electric lifting rod (12), multiple groups of fixing holes (58) are formed in the top of the positioning frame (5), and the liquid dropper (6) is fixed on the inner wall of the fixing holes (58).
10. The apparatus for detecting drug sensitivity of pancreatic cancer in vitro in liver metastasis chemotherapy as claimed in claim 9, wherein: the culture dish clamping assembly comprises a U-shaped frame (18), a third limiting spring (19), a clamping plate (20) and a protective sponge layer (21), the U-shaped frame (18) is installed at the top of the base (1) and located right below the liquid dropper (6), the third limiting spring (19) is laid on the inner side of the U-shaped frame (18), the clamping plate (20) is installed at the end portion of the third limiting spring (19), and the protective sponge layer (21) is laid on the outer side of the clamping plate (20);
the subassembly of taking a breath includes scavenging pump (10) and ventilation hose (11), and scavenging pump (10) are installed to side L type support frame (2) side bottom, and the one end of scavenging pump (10) is through ventilation hose (11) and transparent sealed cowling (7) side top intercommunication, and picture peg (40) are installed to the both sides of transparent sealed cowling (7), and slot (39) of mutually supporting with picture peg (40) are seted up to the top both sides of base (1).
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