CN217766074U - Fresh lung cancer tissue detection clamp suitable for transmission-type terahertz detection - Google Patents

Abstract

The utility model discloses a fresh lung cancer tissue detects anchor clamps suitable for transmission-type terahertz detects now, include: the clamping and moving mechanism comprises an clamp moving rail and a tray moving rail, a driving motor is fixedly mounted at one end of the tray moving rail, the output end of the driving motor is fixedly connected with a ball screw which is located inside the tray moving rail, and a tray moving dragging block is sleeved on the surface thread of the ball screw. The utility model discloses in, through setting up semiconductor refrigeration subassembly structure and automatic centre gripping transfer structure, utilize centre gripping motion and motion fixture mechanism to carry out the non-contact removal of section sample, stop the influence of the handheld body temperature of detection and operation personnel, and utilize heat radiation layer board and semiconductor refrigeration piece to carry out the heat conduction of radiation to the section sample, control section sample low temperature environment around to keep freezing sliced normal state, improve the accuracy that detects.

Description

Fresh lung cancer tissue detection clamp suitable for transmission-type terahertz detection

Technical Field

The utility model relates to a biological detection technical field specifically is a fresh lung cancer tissue detection anchor clamps suitable for transmission-type terahertz detects now.

Background

The traditional tumor cell separation and enrichment technology based on physical properties is often adopted in the circulating tumor cell detection technology, and the technology is mainly used for separating cancer cells according to the size difference between the cancer cells and normal blood cells, namely circulating tumor cells (10-30 mu m), white blood cells (8-10 mu m) and red blood cells (less than 7 mu m). The method has the advantages of simple operation, better maintenance of cell integrity and activity and the like, but has the defects of poor specificity, easy loss of tumor cells with other than specific sizes and the like, is difficult to realize high-efficiency and specific separation and enrichment of circulating tumor cells, has the limitations of large traumaticity, difficult sampling, limited sampling window period, possible increase of metastasis risk and the like, and has very limited effects on early diagnosis, metastasis, prognosis evaluation and the like of cancers. In the aspect of a test method for detecting a frozen living body sample by adopting terahertz, the requirements of an experiment on the practicability and stability of the detection are mainly considered, so that a frozen section is generally flatly attached to the surface of a fused quartz window or a sapphire window for experimental detection.

In the mode in the prior art, because the frozen section is thin (generally only 20 micrometers) and is exposed outside, the temperature of the frozen section can be assimilated by indoor temperature quickly, so that the frozen fresh brain tissue to be detected is melted or the external properties of the frozen fresh brain tissue are changed, an automatic detection clamp is required for sample movement to isolate the interference of the human hand temperature on the sample section, the low-temperature state of the section cannot be continuously maintained by the conventional clamping tool in the section movement process and is still easily influenced by room temperature assimilation, the level of the section cannot be accurately adjusted in the section clamping process, the gravity offset of a culture medium liquid in the low-temperature section is easily generated in the movement process, the influence is further influenced on the accuracy and the stability of the detection effect, and the section in the non-horizontal state cannot be used for the direct measurement operation of a vertical-light terahertz quantum cascade laser, and certain defects exist.

SUMMERY OF THE UTILITY MODEL

The utility model discloses aim at solving one of the technical problem that exists among the prior art or the correlation technique.

Therefore, the utility model discloses the technical scheme who adopts does: fresh lung cancer tissue detection anchor clamps suitable for transmission-type terahertz detects now includes: the clamping motion mechanism comprises a clamp motion rail and a tray motion rail, a driving motor is fixedly mounted at one end of the tray motion rail, the output end of the driving motor is fixedly connected with a ball screw rod positioned in the tray motion rail, a tray motion drag block is sleeved on the surface of the ball screw rod in a threaded manner, the tray motion drag block is slidably mounted on the surface of the tray motion rail, the cooling tray assembly is placed on the surface of the tray motion drag block, and the horizontal supporting mechanism is fixedly mounted on the surface of the cooling tray assembly; the cooling tray assembly comprises a heat radiation supporting plate and a semiconductor refrigerating plate, a refrigerating surface of the semiconductor refrigerating plate is fixedly adhered to the bottom surface of the heat radiation supporting plate, and a plurality of heat radiation guide grooves are formed in the top surface of the heat radiation supporting plate; the horizontal supporting mechanism comprises a fixed ring seat and a slicing supporting plate, the bottom surface of the fixed ring seat is fixedly connected with the surface of the heat radiation supporting plate, a first deflection ring is installed on the inner side of the fixed ring seat in a rotating mode, a second deflection ring is installed on the inner side of the first deflection ring in a rotating mode, the slicing supporting plate is installed on the inner side of the second deflection ring in a rotating mode, and a heavy hammer block is arranged on the bottom surface of the slicing supporting plate.

The present invention may be further configured in a preferred embodiment as: the clamp moving rail and the tray moving rail are arranged on the same plane, the clamp moving rail is of an electromagnetic slide rail structure, the surface of the clamp moving rail is movably provided with an electromagnetic slider, and the input ends of the clamp moving rail, the tray moving rail and the moving clamp mechanism are electrically connected with a controller.

Through adopting above-mentioned technical scheme, utilize the horizontal transverse motion of electromagnetism slide rail technique drive motion fixture mechanism and cooling tray subassembly, can carry out remote isolation and control, avoid human contact, or carry out automated control through control structure.

The present invention may be further configured in a preferred embodiment as: the motion fixture mechanism comprises a lifting motion rail, a telescopic motion cylinder and a driving motor power chuck rod, one end of the lifting motion rail is slidably mounted on the surface of a battery sliding block of the fixture motion rail and is perpendicularly arranged with the fixture motion rail, the lifting motion rail is of an electromagnetic sliding rail structure, an electromagnetic sliding block matched with the lifting motion rail is fixedly mounted at one end of the telescopic motion cylinder, the lifting motion rail is used for lifting the lifting motion cylinder, and longitudinal translation motion of a sample is achieved.

The present invention may be further configured in a preferred embodiment as: the end part of the driving motor power chuck rod is movably hinged with the output end of the telescopic moving cylinder, the inner side of the driving motor power chuck rod is movably provided with a driving rod, and the telescopic moving cylinder and the driving rod are of an electric telescopic rod structure.

By adopting the technical scheme, the power chuck rod of the driving motor is driven to carry out clamping and releasing movement operations through the stretching of the driving rod, and the stretching of the stretching movement cylinder is utilized to carry out transverse translation on a sample, so that a whole set of three-dimensional movement system is built.

The present invention may be further configured in a preferred embodiment as: the heat radiation supporting plate is of a disc-shaped structure, the surface area of the heat radiation supporting plate is larger than the area of the bottom surface of the horizontal supporting mechanism, the heat radiation supporting plate and the horizontal supporting mechanism are made of metal aluminum or copper materials, and the heat radiation guide groove is of a step-shaped groove surface structure.

Through adopting above-mentioned technical scheme, utilize some thermal radiation guide slots to set up on thermal radiation layer board surface to improve thermal radiation layer board and air area of contact, thereby improve the heat conduction volume and absorb the ambient air heat fast, carry out the heat absorption cooling to the air around the sample and handle.

The present invention in a preferred embodiment can be further configured to: the input electric connection of semiconductor refrigeration piece has the independent power of fixed mounting in heat radiation layer board bottom surface, lasts for the power supply of semiconductor refrigeration piece in the motion of cooling tray subassembly, keeps the refrigeration effect, the heat conduction silicone grease has been smeared with the pasting surface coating of heat radiation layer board to the semiconductor refrigeration piece, improves the heat conduction efficiency between heat radiation layer board and the semiconductor refrigeration piece.

The present invention may be further configured in a preferred embodiment as: the both sides fixed mounting of section support ware has the first round pin that is located collinear, and rotates through first round pin and install in the inboard of second deflection ring, the both sides fixed mounting of first deflection ring has the second that is located collinear to rotate the round pin, and rotates through the second and install in the inboard of first deflection ring, first round pin and second are changeed the round pin and are the space vertical direction and arrange.

By adopting the technical scheme, the dynamic level of the slice supporting surface of the slice supporting dish is kept by utilizing the heavy hammer effect of the slice supporting dish in the first deflection ring and the second deflection ring, and the slice is always kept in a horizontal state.

The present invention in a preferred embodiment can be further configured to: the gravity center of the gravity block and the gravity center of the slice tray are located on the same vertical line, and the gravity center height of the gravity block is lower than the horizontal position of the gravity center of the slice tray.

By adopting the technical scheme, the method has the advantages that,

the utility model discloses the beneficial effect who gains does:

1. the utility model discloses in, through setting up semiconductor refrigeration subassembly structure and automatic centre gripping transfer structure, utilize centre gripping motion and motion anchor clamps mechanism to carry out the non-contact removal of section sample, stop the influence of the handheld body temperature of detection operating personnel, and utilize heat radiation layer board and semiconductor refrigeration piece to carry out the heat-conduction of radiation to the section sample, control low temperature environment around the section sample to keep freezing sliced normal condition, improve the accuracy that detects.

2. The utility model discloses in, hold in the palm the structure through setting up the free standing level, utilize the section to hold in the palm the weight effect of ware in first deflection ring and second deflection ring inside, keep the section to hold in the palm the dynamic level that the ware section held in the palm the face, keep the section all the time and be in the horizontality, avoid culture medium liquid ease to and be applicable to the perpendicular light detection of terahertz quantum cascade laser instrument now.

Drawings

Fig. 1 is a schematic overall structure diagram of an embodiment of the present invention;

fig. 2 is a schematic structural view of a motion clamp mechanism according to an embodiment of the present invention;

fig. 3 is a schematic structural view of a slice tray according to an embodiment of the present invention;

fig. 4 is a schematic structural view of a horizontal supporting mechanism according to an embodiment of the present invention;

fig. 5 is a schematic view of a mounting structure of the slice tray according to an embodiment of the present invention.

Reference numerals:

100. a clamping movement mechanism; 110. a clamp moving rail; 120. a tray motion rail; 130. a tray motion drag block; 121. a ball screw; 122. a drive motor;

200. a moving clamp mechanism; 210. lifting the moving rail; 220. a telescopic motion cylinder; 230. a power chuck lever; 240. a drive rod;

300. a cooling tray assembly; 310. a heat radiation pallet; 320. a semiconductor refrigeration sheet; 311. A heat radiation guide groove;

400. a horizontal supporting mechanism; 410. a stationary ring seat; 420. slicing and holding in a dish; 430. a first deflection ring; 440. a second deflector ring; 421. and a weight block.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in detail with reference to the accompanying drawings. It should be noted that the embodiments and features of the embodiments of the present invention may be combined with each other without conflict.

It is to be understood that such description is merely exemplary and is not intended to limit the scope of the present invention.

Some embodiments of the present invention provide a fresh lung cancer tissue detection clamp suitable for transmission-type terahertz detection, which is described below with reference to the accompanying drawings.

Combine fig. 1-5 to show, the utility model provides a fresh lung cancer tissue detects anchor clamps suitable for transmission-type terahertz detects now, include: the clamping movement mechanism 100 comprises a clamp movement rail 110 and a tray movement rail 120, a driving motor 122 is fixedly installed at one end of the tray movement rail 120, the output end of the driving motor 122 is fixedly connected with a ball screw 121 located inside the tray movement rail 120, a tray movement dragging block 130 is sleeved on the surface of the ball screw 121 in a threaded manner, the tray movement dragging block 130 is slidably installed on the surface of the tray movement rail 120, the cooling tray assembly 300 is placed on the surface of the tray movement dragging block 130, and the horizontal supporting mechanism 400 is fixedly installed on the surface of the cooling tray assembly 300; the cooling tray assembly 300 comprises a heat radiation supporting plate 310 and a semiconductor refrigerating plate 320, a refrigerating surface of the semiconductor refrigerating plate 320 is fixedly adhered to a bottom surface of the heat radiation supporting plate 310, and a plurality of heat radiation guide grooves 311 are formed in the top surface of the heat radiation supporting plate 310; the horizontal supporting mechanism 400 comprises a fixed ring seat 410 and a slice supporting plate 420, the bottom surface of the fixed ring seat 410 is fixedly connected with the surface of the heat radiation supporting plate 310, a first deflection ring 430 is rotatably installed on the inner side of the fixed ring seat 410, a second deflection ring 440 is rotatably installed on the inner side of the first deflection ring 430, the slice supporting plate 420 is rotatably installed on the inner side of the second deflection ring 440, and a weight block 421 is arranged on the bottom surface of the slice supporting plate 420.

In this embodiment, the clamp moving rail 110 and the tray moving rail 120 are disposed on the same plane, the clamp moving rail 110 is an electromagnetic slide rail structure and has an electromagnetic slider movably mounted on the surface thereof, and the input ends of the clamp moving rail 110, the tray moving rail 120 and the moving clamp mechanism 200 are electrically connected to a controller. The horizontal transverse movement of the moving clamp mechanism 200 and the cooling tray assembly 300 is driven by the electromagnetic slide rail technology, so that remote isolation control can be performed, the contact of a human body is avoided, or automatic control is performed through a control structure.

Further, the moving clamp mechanism 200 includes a lifting moving rail 210, a telescopic moving cylinder 220 and a driving motor power chuck rod 230, one end of the lifting moving rail 210 is slidably mounted on the surface of a battery slider of the clamp moving rail 110 and is arranged in a vertical direction with the clamp moving rail 110, the lifting moving rail 210 is of an electromagnetic slide rail structure, one end of the telescopic moving cylinder 220 is fixedly mounted with an electromagnetic slider matched with the lifting moving rail 210, and the lifting moving rail 210 is utilized to perform lifting movement of the telescopic moving cylinder 220, so as to realize longitudinal translational movement of the sample.

In this embodiment, the end of the driving motor power clamp rod 230 is movably hinged to the output end of the telescopic moving cylinder 220, the driving rod 240 is movably mounted inside the driving motor power clamp rod 230, and both the telescopic moving cylinder 220 and the driving rod 240 are of electric telescopic rod structures.

Specifically, the driving motor is driven by the extension and contraction of the driving rod 240 to drive the power chuck rod 230 to perform clamping and releasing movement operations, and the extension and contraction of the extension and contraction moving cylinder 220 is utilized to perform transverse translation of the sample, so that a whole set of three-dimensional movement system is constructed.

In this embodiment, the heat radiation support plate 310 is a disc-shaped structure, the surface area of the heat radiation support plate 310 is larger than the bottom surface area of the horizontal support mechanism 400, the heat radiation support plate 310 and the horizontal support mechanism 400 are metal aluminum or copper members, so as to improve the heat conduction between the cooling support plate assembly 300 and the horizontal support mechanism 400, the heat of the sample is absorbed through the contact heat conduction between the horizontal support mechanism 400 and the sample, the sample is kept at a low temperature, the heat radiation guide slot 311 is a stepped groove surface structure, the heat radiation guide slot 311 formed on the surface of the heat radiation support plate 310 is used to improve the contact area between the heat radiation support plate 310 and the air, the heat conduction amount is increased, thereby rapidly absorbing the heat of the surrounding air, and the heat absorption and cooling treatment is performed on the surrounding air of the sample.

In this embodiment, the input end electric connection of semiconductor refrigeration piece 320 has the independent power supply of fixed mounting in heat radiation layer board 310 bottom surface, continues to supply power for semiconductor refrigeration piece 320 in cooling tray subassembly 300 motion, keeps the refrigeration effect, and the heat conduction silicone grease has been smeared to the sticky surface of semiconductor refrigeration piece 320 and heat radiation layer board 310, improves the heat conduction efficiency between heat radiation layer board 310 and the semiconductor refrigeration piece 320.

In this embodiment, the two sides of the slicing tray 420 are fixedly installed with first rotating pins located on the same straight line, and are rotatably installed on the inner side of the second deflecting ring 440 through the first rotating pins, the two sides of the first deflecting ring 430 are fixedly installed with second rotating pins located on the same straight line, and are rotatably installed on the inner side of the first deflecting ring 430 through the second rotating pins, the first rotating pins and the second rotating pins are arranged in the spatial vertical direction, and freely deflect in the three-dimensional multi-directional direction, the weight block 421 is of a metal spherical structure, the gravity center of the weight block 421 and the gravity center of the slicing tray 420 are located on the same vertical line, and the gravity center height of the weight block 421 is lower than the horizontal position of the gravity center of the slicing tray 420, and gravity is used for providing power for the automatic deflection of the slicing tray 420.

Specifically, the slice tray 420 is deflected at any angle inside the first deflection ring 430 and the second deflection ring 440 by the weight of the weight block 421 to keep the port of the slice tray 420 horizontal upwards, and the slice is kept in a horizontal state, so that the escape of the culture medium is avoided, and the vertical light detection device is suitable for the terahertz quantum cascade laser.

The utility model discloses a theory of operation and use flow:

firstly, a power supply of a semiconductor refrigerating sheet 320 is turned on, a heat radiation supporting plate 310 is refrigerated through the Peltier effect of the semiconductor refrigerating sheet 320, the surface temperature of the heat radiation supporting plate 310 is lower than-4 ℃, a sliced sample is taken out from a storage cabinet and is rapidly placed in a sliced plate tray 420, a detection cabinet body is closed, the whole detection fixture is isolated from the contact with the outside air, and the work control of a clamping movement mechanism 100, a movement fixture mechanism 200 and a cooling tray assembly 300 is controlled outside the detection cabinet body through a controller; the motion clamping operation is carried out on the motion clamp mechanism 200, the cooling tray assembly 300 and the horizontal supporting mechanism 400 by utilizing the clamping motion mechanism 100 and the motion clamp mechanism 200, the motion clamping operation is carried out to the terahertz quantum cascade laser detection end, in the moving process, the slice supporting plate 420 is enabled to deflect at any angle in the first deflection ring 430 and the second deflection ring 440 under the action of the weight block 421, the port of the slice supporting plate 420 is always kept to be horizontally upward, the level of a slice sample is kept, until the slice supporting plate moves to the lower side of the vertical light of the terahertz quantum cascade laser, in the process of slow slice transfer motion, the self low temperature of the heat radiation supporting plate 310 is contacted with the ambient air, the air heat is absorbed and is continuously cooled through the semiconductor refrigeration piece 320, the low temperature of the ambient air of the heat radiation supporting plate 310 and the horizontal supporting mechanism 400 is kept, the temperature assimilation of the air and the slice sample is avoided, the slice sample is kept at the low temperature, and the stability of physicochemical properties is ensured.

In the present application, the term "plurality" means two or more unless expressly defined otherwise. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items. The terms "mounted," "connected," "fixed," and the like are to be construed broadly, and for example, "connected" may be a fixed connection, a removable connection, or an integral connection; "connected" may be directly connected or indirectly connected through an intermediate. The specific meaning of the above terms in the present invention can be understood according to specific situations by those skilled in the art.

It will be understood that when an element is referred to as being "mounted to," "secured to" or "disposed on" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. As used herein, the terms "vertical," "horizontal," "upper," "lower," "left," "right," and the like are for purposes of illustration only and do not denote a single embodiment.

In the description of the present specification, the description of the terms "one embodiment," "some embodiments," "specific embodiments," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the claims and their equivalents.

Claims (8)

1. Fresh lung cancer tissue detection anchor clamps suitable for transmission-type terahertz detects now, its characterized in that includes: the clamping mechanism (100), the moving clamp mechanism (200), the cooling tray assembly (300) and the horizontal supporting mechanism (400), wherein the clamping mechanism (100) comprises a clamp moving rail (110) and a tray moving rail (120), a driving motor (122) is fixedly installed at one end of the tray moving rail (120), the output end of the driving motor (122) is fixedly connected with a ball screw (121) located inside the tray moving rail (120), a tray moving dragging block (130) is sleeved on the surface of the ball screw (121) in a threaded manner, the tray moving dragging block (130) is slidably installed on the surface of the tray moving rail (120), the cooling tray assembly (300) is placed on the surface of the tray moving dragging block (130), and the horizontal supporting mechanism (400) is fixedly installed on the surface of the cooling tray assembly (300);

the cooling tray assembly (300) comprises a heat radiation supporting plate (310) and a semiconductor refrigerating plate (320), a refrigerating surface of the semiconductor refrigerating plate (320) is fixedly adhered to the bottom surface of the heat radiation supporting plate (310), and a plurality of heat radiation guide grooves (311) are formed in the top surface of the heat radiation supporting plate (310);

horizontal supporting mechanism (400) includes fixed ring seat (410) and section support dish (420), the bottom surface of fixed ring seat (410) is connected with the fixed surface of heat radiation layer board (310), first deflection ring (430) are installed in the inboard rotation of fixed ring seat (410), second deflection ring (440) are installed in the inboard rotation of first deflection ring (430), section support dish (420) rotate install in the inboard of second deflection ring (440), the bottom surface of section support dish (420) is equipped with counter weight piece (421).

2. The fresh lung cancer tissue detection clamp suitable for transmission-type terahertz detection according to claim 1, wherein the clamp moving rail (110) and the tray moving rail (120) are arranged on the same plane, the clamp moving rail (110) is of an electromagnetic slide rail structure, the surface of the clamp moving rail (110) is movably provided with an electromagnetic slider, and the input ends of the clamp moving rail (110), the tray moving rail (120) and the moving clamp mechanism (200) are electrically connected with a controller.

3. The fresh lung cancer tissue detection clamp suitable for transmission-type terahertz detection according to claim 1, wherein the moving clamp mechanism (200) comprises a lifting moving rail (210), a telescopic moving cylinder (220) and a driving motor power clamp rod (230), one end of the lifting moving rail (210) is slidably mounted on the surface of a battery slide block of the clamp moving rail (110) and is arranged perpendicular to the clamp moving rail (110), the lifting moving rail (210) is of an electromagnetic slide rail structure, and one end of the telescopic moving cylinder (220) is fixedly mounted with an electromagnetic slide block matched with the lifting moving rail (210).

4. The fresh lung cancer tissue detection clamp suitable for transmission-type terahertz detection according to claim 3, wherein an end of the driving motor power clamp rod (230) is movably hinged to an output end of a telescopic moving cylinder (220), a driving rod (240) is movably mounted on the inner side of the driving motor power clamp rod (230), and the telescopic moving cylinder (220) and the driving rod (240) are both of electric telescopic rod structures.

5. The fresh lung cancer tissue detection clamp suitable for transmission-type terahertz detection according to claim 1, wherein the heat radiation supporting plate (310) is of a disc-shaped structure, the surface area of the heat radiation supporting plate (310) is larger than the area of the bottom surface of the horizontal supporting mechanism (400), the heat radiation supporting plate (310) and the horizontal supporting mechanism (400) are made of metal aluminum or copper material, and the heat radiation guide groove (311) is of a stepped groove surface structure.

6. The fresh lung cancer tissue detection clamp suitable for transmission-type terahertz detection according to claim 1, wherein an input end of the semiconductor refrigeration sheet (320) is electrically connected with an independent power supply fixedly mounted on the bottom surface of the heat radiation supporting plate (310), and a heat-conducting silicone grease is coated on the adhering surface of the semiconductor refrigeration sheet (320) and the heat radiation supporting plate (310).

7. The fresh lung cancer tissue detection clamp suitable for transmission-type terahertz detection according to claim 1, wherein the slicing tray (420) is fixedly provided with first rotating pins on the same straight line at two sides and is rotatably arranged at the inner side of the second deflection ring (440) through the first rotating pins, the first deflection ring (430) is fixedly provided with second rotating pins on the same straight line at two sides and is rotatably arranged at the inner side of the first deflection ring (430) through the second rotating pins, and the first rotating pins and the second rotating pins are arranged in a space vertical direction.

8. The fresh lung cancer tissue detection clamp suitable for transmission-type terahertz detection according to claim 1, wherein the weight block (421) is a metal sphere-shaped structure, the center of gravity of the weight block (421) and the center of gravity of the slicing tray (420) are located on the same vertical line, and the height of the center of gravity of the weight block (421) is lower than the horizontal position of the center of gravity of the slicing tray (420).

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