CN113876886A - 治疗痤疮的口服药物及其制备方法 - Google Patents
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Abstract
本发明公开了治疗痤疮的口服药物及其制备方法，治疗痤疮的口服药物按重量份计算，成分包括：地黄10‑30份，全蝎3‑6份，僵蚕5‑10份，蜂房5‑10份，甘草5‑10份，当归10‑30份，黄芪10‑30份，知母10‑30份，天冬10‑30份，麦冬10‑30份，熟地10‑30份。本发明制备的药物具有主治养血祛风,清热凉血之功效，从根本上治疗痤疮。为众多痤疮患者提供了一个安全、有效、可靠、价廉的药物，和其他同类药品相比，具有一定的综合优势。
Description
技术领域
本发明涉及药品技术领域。更具体地说，本发明涉及治疗痤疮药物及其制备方法。
背景技术
痤疮是临床常见的多发性毛囊皮脂腺的慢性炎症性皮肤病，主要发生在青春期，发病率很高，易反复发作，可持续多年，严重者可留有疤痕及色素沉着，损坏患者容颜、影响患者身心健康。现代医学认为座疮是一种多因素的皮肤病，发病机理尚未完全清楚，主要与内分泌失调尤其是雄性激素失调、毛囊皮脂腺导管异常角化、微生物感染以及免疫、炎症等因素有关。
痤疮属中医“肺风粉刺”、“肺风酒刺”范畴，以颜面、胸背部发生黑头粉刺，压之脂栓排出，或有丘疹，小如粟粒，大若赤豆，孤立散在，或密集成群，或颜有脓疮，其色黄白，破之即出，脓血相兼或生结节，淡红或紫，突出皮面，或半在皮下，触之韧实，或有囊肿，其形卵圆，触之柔韧， 本病可有皮疹病史，可见于青年男女。《医宗金鉴·外科心法要诀》记载:“每发于面鼻，起碎疙瘩，形如黍屑，色赤肿痛破出白粉刺。其病机为青年男女血气方刚，血热内蕴，气火偏旺，致灼血成瘀，郁搏于肌肤，复因过食甘肥厚味，热邪内蕴，郁久化毒，循经生热，结于体肤，热毒郁结，针对本病血热蕴毒，郁结体肤的病机，故治疗宜用养血祛风，清热凉血之法治之”。
现有的中药配方，或成分过于复杂，疗效缓慢，或制备方法繁杂，不易实现，成本高昂。
发明内容
为了解决上述问题，本发明提出一种治疗痤疮的口服药物及其制备方法。该口服药物具有养血祛风，清热凉血之功效。用于血热风燥引起的丘疹性痤疮，症见黑头或白头粉刺伴红色丘疹，颜面潮红，皮肤烘热，痛痒或皮肤油腻，间有结节，或伴有口臭，便秘，尿赤等症状。该治疗痤疮的口服药物，按重量份计算，活性成分包括：地黄10-30份，全蝎3-6份，僵蚕5-10份，蜂房5-10份，甘草5-10份，当归10-30份，黄芪10-30份，知母10-30份，天冬10-30份，麦冬10-30份，熟地10-30份。
本发明的原料特点：配方中的地黄甘苦而寒，清热凉血，滋养阴液。全蝎辛平，解疮肿毒，用于疮疡肿毒，有以毒攻毒之效;僵蚕咸辛，化痰散结。蜂房甘平，善祛风攻毒，除瘾疹瘙痒，甘草补脾益气，清热解毒。当归补血活血，润肠通便。黄芪补气健脾。知母清热泻火，生津润燥，润肠通便。天冬滋阴润燥，清肺降火。麦冬养阴生津，润肠通便。熟地滋阴养血。
本发明的治疗痤疮的口服药物制备成颗粒。颗粒既具有液体制剂吸收迅速完全，易于服用，口感好等优点，又具有固体制剂质量稳定，携带、保存和服用方便等特点。治疗痤疮的口服药物的制备方法，包括以下步骤：
步骤一、地黄10-30份，全蝎3-6份，僵蚕5-10份，蜂房5-10份，甘草5-10份，当归10-30份，黄芪10-30份，知母10-30份，天冬10-30份，麦冬10-30份，熟地10-30份加入到提取罐中，加水煎煮二次，第一次加水10倍量，第二次加水8倍量，每次煎煮8小时，合并滤液，滤过(80目)；
步骤二、将步骤一获得的滤液置于浓缩罐进行浓缩，浓缩至相对密度1.30(80℃)的稠膏；
步骤三、将步骤二获得的稠膏加入10-30份糊精，混匀，经制粒机制成颗粒，干燥(60℃)，备用。
本发明至少包括以下有益效果：本发明以功效确切、作用机理明确的中药成分地黄、全蝎、僵蚕、蜂房、甘草、当归、黄芪、知母、天冬、麦冬、熟地为主要原料，以现代药理学研究结果为研制依据、根据中医对痤疮的发生机理及治则组方，充分挖掘其药用功能，多种成分、综合作用达到治疗痤疮的目的。具有养血祛风，清热凉血之功效。用于血热风燥引起的丘疹性痤疮，症见黑头或白头粉刺伴红色丘疹，颜面潮红，皮肤烘热，痛痒或皮肤油腻，间有结节，或伴有口臭，便秘，尿赤之症状。从而从根本上治疗痤疮。为众多痤疮患者提供了一个安全、有效、可靠、价廉的药物，和其他同类药品相比，具有一定的综合优势。
具体实施方式
下面结合实施例对本发明做进一步的详细说明，以令本领域技术人员参照说明书文字能够据以实施。
需要说明的是，下述实施方案中所述实验方法，如无特殊说明，均为常规方法，所述试剂和材料，如无特殊说明，均可从商业途径获得。
本发明治疗痤疮的口服药物，按重量份计算，成分包括：地黄10-30份，全蝎3-6份，僵蚕5-10份，蜂房5-10份，甘草5-10份，当归10-30份，黄芪10-30份，知母10-30份，天冬10-30份，麦冬10-30份，熟地10-30份。
本发明治疗痤疮的口服药物的制备方法，包括以下步骤：
步骤一、地黄10-30份，全蝎3-6份，僵蚕5-10份，蜂房5-10份，甘草5-10份，当归10-30份，黄芪10-30份，知母10-30份，天冬10-30份，麦冬10-30份，熟地10-30份加入到提取罐中，加水煎煮二次，第一次加水10倍量，第二次加水8倍量，每次煎煮8小时，合并滤液，滤过(80目)；
步骤二、将步骤一获得的滤液置于浓缩罐进行浓缩，浓缩至相对密度1.30(80℃)的稠膏；
步骤三、将步骤二获得的稠膏加入10-30份糊精，混匀，经制粒机制成颗粒， 干燥(60℃)，备用。
尽管本发明的实施方案已公开如上，但其并不仅仅限于说明书和实施方式中所列运用，它完全可以被适用于各种适合本发明的领域，对于熟悉本领域的人员而言，可容易地实现另外的修改，因此在不背离权利要求及等同范围所限定的一般概念下，本发明并不限于特定的细节和这里示出与描述的实施例。
Claims (2)
1.治疗痤疮的口服药物，其特征在于，按重量份计算，成分包括：地黄10-30份，全蝎3-6份，僵蚕5-10份，蜂房5-10份，甘草5-10份，当归10-30份，黄芪10-30份，知母10-30份，天冬10-30份，麦冬10-30份，熟地10-30份。
2.如权利要求1所述的治疗痤疮的口服药物的制备方法，其特征在于，包括以下步骤：
步骤一、地黄10-30份，全蝎3-6份，僵蚕5-10份，蜂房5-10份，甘草5-10份，当归10-30份，黄芪10-30份，知母10-30份，天冬10-30份，麦冬10-30份，熟地10-30份加入到提取罐中，加水煎煮二次，第一次加水10倍量，第二次加水8倍量，每次煎煮8小时，合并滤液，滤过(80目)；
步骤二、将步骤一获得的滤液置于浓缩罐进行浓缩，浓缩至相对密度1.30(80℃)的稠膏；
步骤三、将步骤二获得的稠膏加入10-30份糊精，混匀，经制粒机制成颗粒，干燥(60℃)，备用。
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