CN113862300A - 具有共同轻链的转基因兔 - Google Patents
具有共同轻链的转基因兔 Download PDFInfo
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- CN113862300A CN113862300A CN202111174951.7A CN202111174951A CN113862300A CN 113862300 A CN113862300 A CN 113862300A CN 202111174951 A CN202111174951 A CN 202111174951A CN 113862300 A CN113862300 A CN 113862300A
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| EP16162580 | 2016-03-29 | ||
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| CN201680063211.7A CN108347906A (zh) | 2015-10-29 | 2016-10-27 | 具有共同轻链的转基因兔 |
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| AU2019233523A1 (en) | 2018-03-12 | 2020-10-01 | Genmab A/S | Antibodies |
| WO2020132557A1 (en) * | 2018-12-21 | 2020-06-25 | Compass Therapeutics Llc | Transgenic mouse expressing common human light chain |
| IL298632A (en) * | 2020-06-02 | 2023-01-01 | Biocytogen Pharmaceuticals Beijing Co Ltd | Non-human animals genetically modified with a common light chain immunoglobulin locus |
| EP4242232A4 (en) * | 2020-11-06 | 2024-09-11 | Bio-Thera Solutions, Ltd. | BISPECIFIC ANTIBODY AND ITS USE |
| CN115702931A (zh) * | 2021-08-06 | 2023-02-17 | 百奥泰生物制药股份有限公司 | 抗pd-l1/cd47双特异抗体在治疗疾病中的应用 |
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| AU751659B2 (en) * | 1997-05-02 | 2002-08-22 | Genentech Inc. | A method for making multispecific antibodies having heteromultimeric and common components |
| WO2000046251A2 (en) * | 1999-02-05 | 2000-08-10 | Buelow Jens Ulrich | Human polyclonal antibodies from transgenic nonhuman animals |
| AU8470301A (en) * | 2000-08-03 | 2002-02-18 | Wim-Van Schooten | Production of humanized antibodies in transgenic animals |
| MXPA06000562A (es) * | 2003-07-15 | 2006-03-30 | Therapeutic Human Polyclonals | Loci de inmunoglobulina humanizada. |
| US20060117398A1 (en) * | 2004-10-22 | 2006-06-01 | Roland Buelow | Suppression of endogenous immunoglobulin expression |
| CN101263158B (zh) * | 2005-08-03 | 2011-12-28 | 人类多克隆治疗股份有限公司 | 表达人源化免疫球蛋白的转基因动物中b细胞凋亡的抑制 |
| CA2661848C (en) * | 2006-09-01 | 2015-02-03 | Therapeutic Human Polyclonals, Inc. | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
| WO2009082624A2 (en) * | 2007-12-10 | 2009-07-02 | Zymogenetics, Inc. | Antagonists of il-17a, il-17f, and il-23 and methods of using the same |
| EA201001691A1 (ru) * | 2008-04-28 | 2011-10-31 | Калобайос Фармасьютикалз, Инк. | Антитела к гранулоцитарно-макрофагальному колониестимулирующему фактору |
| US20110152173A1 (en) * | 2008-07-02 | 2011-06-23 | Emergent Product Development Seattle ,LLC | TNF-a ANTAGONIST MULTI-TARGET BINDING PROTEINS |
| PT3211005T (pt) * | 2008-07-08 | 2021-06-15 | Geneuro Sa | Utilização terapêutica de ligandos específicos nas doenças associadas a msrv |
| KR20110057245A (ko) * | 2008-09-19 | 2011-05-31 | 메디뮨 엘엘씨 | Ｃｄ105에 대해 지시된 항체 및 그의 용도 |
| US20130045492A1 (en) * | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| CN105884896A (zh) * | 2010-12-15 | 2016-08-24 | 惠氏有限责任公司 | 抗缺刻蛋白1抗体 |
| CN120383672A (zh) * | 2012-04-20 | 2025-07-29 | 美勒斯公司 | 用于产生免疫球蛋白样分子的方法和手段 |
| US20150203591A1 (en) * | 2012-08-02 | 2015-07-23 | Regeneron Pharmaceuticals, Inc. | Mutivalent antigen-binding proteins |
| PT2900694T (pt) * | 2012-09-27 | 2018-11-13 | Merus Nv | Anticorpos de igg biespecíficos como ativadores de células t |
| WO2014209384A1 (en) * | 2013-06-28 | 2014-12-31 | Amgen Inc. | Methods for treating homozygous familial hypercholesterolema |
| PL3081576T3 (pl) * | 2013-12-12 | 2020-03-31 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Przeciwciało anty pd-1, jego fragment wiążący antygen i ich zastosowanie medyczne |
| EP3110846B1 (en) * | 2014-02-28 | 2020-08-19 | Merus N.V. | Antibodies that bind egfr and erbb3 |
| EP3126384B1 (en) * | 2014-04-01 | 2020-12-02 | Adimab, LLC | Multispecific antibody analogs comprising a common light chain, and methods of their preparation and use |
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| CN108347906A (zh) | 2018-07-31 |
| JP2018537968A (ja) | 2018-12-27 |
| JP7085992B2 (ja) | 2022-06-17 |
| EP3367786A1 (en) | 2018-09-05 |
| CN113897371A (zh) | 2022-01-07 |
| US20230332175A1 (en) | 2023-10-19 |
| SG10202006332PA (en) | 2020-08-28 |
| WO2017072208A1 (en) | 2017-05-04 |
| SG11201802698XA (en) | 2018-05-30 |
| HK1258306A1 (zh) | 2019-11-08 |
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