CN113855757A - Formula for regulating constipation and preparation process thereof - Google Patents
Formula for regulating constipation and preparation process thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/64—Orobanchaceae (Broom-rape family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention relates to a formula for regulating constipation and a preparation process thereof, wherein the formula comprises the following components in percentage by mass: 11 to 14 percent of bunge cherry seed, 11 to 14 percent of purple perilla, 36 to 40 percent of yam, 12 to 14 percent of cistanche, 18 to 20 percent of cassia seed and the balance of auxiliary materials. The invention also provides a preparation process of the formula. The decoction prepared by the formula can be used for adjusting excess heat, yin deficiency and yang deficiency type constipation.
Description
Technical Field
The invention relates to a formula for regulating constipation and a preparation process thereof, belonging to the field of medicine and food homology.
Background
Functional constipation is manifested by constipation, prolonged defecation period, dry and hard feces, etc. Epidemiological investigations have shown that the incidence of functional constipation is generally higher in the elderly than in the young. Constipation, a common clinical symptom, can be accompanied by various acute and chronic diseases, which brings great inconvenience to patients, especially the elderly patients, and can induce or aggravate the original intestinal tract and cardiovascular and cerebrovascular diseases. The clinical symptoms of functional constipation can be temporarily relieved by conventional medicament treatment, hydrotherapy enema and operation treatment of western medicine, and the problems of high recurrence rate and obvious medicament side effect after medicament withdrawal exist. The unique and diverse treatment modes of the traditional Chinese medicine play an irreplaceable role in treating the functional constipation, and have the advantages of obvious curative effect, small side effect and the like.
The semen Pruni is dry mature seed of Prunus humilis Bunge, Prunus japonica Linn or Prunus amygdalus Membrananas gracilis of Rosaceae, the former two are called "small semen Pruni", and the latter one is called "big semen Pruni". The bunge cherry seed is pungent, bitter and sweet in flavor and mild in nature. It enters spleen, large intestine and small intestine meridians. Has the functions of moistening dryness, smoothing intestine, descending qi and promoting diuresis. Can be used for treating consumption of body fluid, intestinal dryness, food stagnation, abdominal distention, constipation, dysuria, etc. The perilla leaf has pungent and warm nature and has the effects of relieving exterior syndrome, dispelling cold, regulating qi and harmonizing nutrient. It can be used for treating common cold, fever, cough, asthma, and abdominal distention. The compendium of materia medica carries the actions of promoting the circulation of qi, relieving epigastric distention, clearing phlegm, benefiting lung, harmonizing blood, warming middle energizer, alleviating pain, relieving asthma and preventing abortion. Cassia seed, semen Cassiae is sweet, bitter, salty and slightly cold. It enters liver and large intestine meridians. Mainly used for clearing heat, improving eyesight, moistening intestines and relaxing bowels. Can be used for treating conjunctival congestion, photophobia, lacrimation, headache, vertigo, dim eyesight, and constipation. Yam can tonify spleen and stomach, and treat deficiency of qi, asthenia and dyspepsia.
Disclosure of Invention
The invention aims to provide a formula for regulating constipation.
Yet another object of the present invention is to: provides a preparation process of the formula for regulating constipation.
The purpose of the invention is realized by the following scheme: a formula for regulating constipation comprises the following components in percentage by mass: 11 to 14 percent of bunge cherry seed, 11 to 14 percent of purple perilla, 36 to 40 percent of yam, 12 to 14 percent of cistanche, 18 to 20 percent of cassia seed and 0 to 9 percent of auxiliary materials.
Wherein the auxiliary materials are used for preparing stable decoction and comprise thickener sodium carboxymethyl cellulose and/or emulsifier sucrose fatty acid ester and/or preservative potassium sorbate.
The invention also provides a preparation process of the formula for regulating constipation, which comprises the following steps:
(1) 11-14% of bunge cherry seeds, 11-14% of purple perilla, 36-40% of Chinese yam, 12-14% of cistanche and 18-20% of cassia seeds are mixed and then added with 2 times of pure water to be soaked for 30 minutes; boiling with strong fire, decocting with medium fire for 30 min, and collecting decoction; adding water and decocting for 20 minutes to obtain a later decoction; finally, the front decoction and the rear decoction are combined to obtain decoction for later use;
(2) adding sodium carboxymethyl cellulose as a thickening agent into pure water according to the dosage, dissolving and uniformly mixing to obtain sodium carboxymethyl cellulose solution;
(3) dissolving an emulsifier sucrose fatty acid ester into the decoction prepared in the step (1) according to the dosage, and fully and uniformly mixing to obtain a solution;
(4) dissolving a preservative potassium sorbate into the solution prepared in the step (3) according to the dosage;
(5) and (3) uniformly mixing the sodium carboxymethyl cellulose solution prepared in the step (2) and the solution prepared in the step (4), adding water to dilute into decoction, and sterilizing.
The invention relates to a compound for regulating constipation and decoction prepared by the compound, which can regulate constipation of excess heat, yin deficiency and yang deficiency. The obtained compound decoction has long shelf life and good stability. Can be used for relieving constipation due to yin deficiency and yang deficiency.
Detailed Description
Example 1:
a formula for regulating constipation comprises:
the Chinese dwarf cherry seeds: 10g
Purple perilla: 10g
Chinese yam: 30g of
Cistanche deserticola: 10g
Cassia seed: 15g of
Sodium carboxymethylcellulose (thickener): 1.8-2.2g
Sucrose fatty acid ester (emulsifier): 1.8-2.2g
Potassium sorbate (preservative): 1.8-2.2 g;
the preparation process of the formula for regulating constipation comprises the following steps:
(1) mixing 10g of bunge cherry seeds, 10g of purple perilla, 30g of Chinese yam, 10g of cistanche and 15g of cassia seeds, and adding 2 times of pure water for soaking for 30 minutes; boiling with strong fire, decocting with medium fire for 30 min, and collecting the decoction; adding water to submerge the liquid medicine surface and decocting for 20 minutes to obtain a second decoction; finally, combining the two decoctions;
(2) 1.8-2.2g of sodium carboxymethylcellulose is added into 10-30ml of pure water and evenly mixed to obtain sodium carboxymethylcellulose solution for later use;
(3) adding 1.8-2.2g of sucrose fatty acid ester and 1.8-2.2g of potassium sorbate, uniformly mixing, fully dissolving, adding the sodium carboxymethylcellulose solution obtained in the step (2), uniformly mixing, diluting with pure water to 1000ml, uniformly mixing, sealing and subpackaging into 10-20 parts, and sterilizing.
Example 2
The formulation was otherwise the same as in example 1 except that the emulsifiers were respectively selected from the group consisting of HLB15 sucrose fatty acid ester, HLB13 sucrose fatty acid ester, and HLB11 sucrose fatty acid ester, and the stability was observed.
1, preparation of aqueous solution-1:
(1) mixing semen Pruni 10g, Perillae herba 10g, rhizoma Dioscoreae 30g, Cistanchis herba 10g, and semen Cassiae 15g, adding 2 times of pure water, soaking for 30 min, boiling with strong fire, turning to middle fire, decocting for 30 min, pouring out decoction, adding water, decocting for 20 min, and mixing the decoctions;
(2) taking 1.8-2.2g of sodium carboxymethylcellulose, adding into 10-30ml of pure water, and uniformly mixing to obtain sodium carboxymethylcellulose solution for later use;
(3) adding 1.8-2.2g of HLB15 sucrose fatty acid ester and 1.8-2.2g of potassium sorbate into the decoction obtained in the step (1), fully mixing uniformly and dissolving, adding the sodium carboxymethylcellulose solution obtained in the step (2), mixing uniformly, diluting with pure water to 950-; subpackaging and sterilizing to obtain the formula water solution-1.
The aqueous solution is allowed to stand at room temperature for 1 week, and then it is visually checked whether the solution is in a stable state and has a "phase transition" process, such as the solution turns into colloid, becomes clear and turbid, and if so, the solution is regarded as unstable.
2. Preparation of aqueous solution-2:
(1) mixing semen Pruni 10g, Perillae herba 10g, rhizoma Dioscoreae 30g, Cistanchis herba 10g, and semen Cassiae 15g, soaking in 2 times of pure water for 30 min, boiling with strong fire, turning to middle fire, and decocting for 30 min. The decoction is poured out and added with water to be decocted for 20 minutes. And finally, combining the two decoction liquids.
(2) Taking 1.8-2.2g of sodium carboxymethylcellulose in the formula, adding into 10-30ml of pure water, and uniformly mixing for later use;
(3) adding 1.8-2.2g of HLB13 sucrose fatty acid ester and 1.8-2.2g of potassium sorbate into the step (1), fully mixing and dissolving, adding the sodium carboxymethylcellulose solution obtained in the step (2), mixing uniformly, diluting with pure water to 950-1050ml, and mixing uniformly; subpackaging and sterilizing to obtain the formula water solution-2.
The aqueous solution is allowed to stand at room temperature for 1 week, and then it is visually checked whether the solution is in a stable state and has a "phase transition" process, such as the solution turns into colloid, becomes clear and turbid, and if so, the solution is regarded as unstable.
3. Preparation of aqueous solution-3:
(1) mixing semen Pruni 10g, Perillae herba 10g, rhizoma Dioscoreae 30g, Cistanchis herba 10g, and semen Cassiae 15g, adding 2 times of pure water, soaking for 30 min, boiling with strong fire, turning to middle fire, decocting for 30 min, pouring out decoction, adding water, decocting for 20 min, and mixing the decoctions.
(2) Taking 1.8-2.2g of sodium carboxymethylcellulose, adding into 10-30ml of pure water, and uniformly mixing for later use;
(3) adding 1.8-2.2g of HLB11 sucrose fatty acid ester and 1.8-2.2g of potassium sorbate into the solution obtained in the step (1), dissolving and uniformly mixing, adding the sodium carboxymethylcellulose solution obtained in the step (2), uniformly mixing, diluting with pure water to 950-1050ml, uniformly mixing, subpackaging, and sterilizing to obtain the formula aqueous solution-3.
Standing the aqueous solution at room temperature for 1 week, and observing whether there is a phase change process in the stable state of the solution, such as the solution turns into colloid, becomes clear and turbid, and if so, it is regarded as unstable
Example 3.
The other steps are the same as example 1, except that the thickening agents are respectively selected from sodium carboxymethylcellulose, xanthan gum and resistant dextrin for testing, and the viscosity is observed.
Visually observing whether the solution stability is good, if the solution is clear and transparent and does not have a phase change phenomenon after standing for 7 days, the stability is good; standing for 7 days, observing the softening property, and if the mixture is solid after 7 days and cannot be stirred or weighed, determining that the rheological property is poor or the viscosity is high; if the liquid is still in a liquid state, the rheological property is considered to be good if the container such as a dropper and the like is convenient to measure.
1. Preparation of aqueous solution-4:
(1) mixing semen Pruni 10g, Perillae herba 10g, rhizoma Dioscoreae 30g, Cistanchis herba 10g, and semen Cassiae 15g, adding 2 times of pure water, soaking for 30 min, boiling with strong fire, turning to middle fire, decocting for 30 min, and pouring out the decoction; adding water and decocting for 20 minutes; finally, combining the two decoctions;
(2) taking 1.8-2.2g of sodium carboxymethylcellulose, adding into 10-30ml of pure water, and uniformly mixing for later use;
(3) and (2) adding 1.8-2.2g of sucrose fatty acid ester and 1.8-2.2g of potassium sorbate into the decoction obtained in the step (1), dissolving and uniformly mixing, adding the sodium carboxymethylcellulose solution obtained in the step (2), uniformly mixing, diluting with pure water to 950 plus 1050ml, uniformly mixing, subpackaging and sterilizing to obtain the formula aqueous solution-4.
The stability and rheological property of the compound aqueous solution-4 are visually checked to determine whether the stability and rheological property are good or not.
2. Preparation of aqueous solution-5:
(1) mixing semen Pruni 10g, Perillae herba 10g, rhizoma Dioscoreae 30g, Cistanchis herba 10g, and semen Cassiae 15g, adding 2 times of pure water, soaking for 30 min, boiling with strong fire, turning to middle fire, decocting for 30 min, and pouring out the decoction; decocting in water for 20 min, and mixing the decoctions;
(2) adding 1.8-2.2g of xanthan gum into 10-30ml of pure water, and uniformly mixing to obtain a xanthan gum solution for later use;
(3) adding 1.8-2.2g of sucrose fatty acid ester and 1.8-2.2g of potassium sorbate into the decoction obtained in the step (1), dissolving and uniformly mixing, adding the xanthan gum solution obtained in the step (2), uniformly mixing, diluting with pure water to 950 plus 1050ml, uniformly mixing, subpackaging and sterilizing to obtain the compound aqueous solution-5.
The aqueous solution-5 was visually inspected for good solution stability and rheology.
3. Preparation of aqueous solution-6:
(1) mixing semen Pruni 10g, Perillae herba 10g, rhizoma Dioscoreae 30g, Cistanchis herba 10g, and semen Cassiae 15g, adding 2 times of pure water, soaking for 30 min, boiling with strong fire, turning to middle fire, decocting for 30 min, and pouring out the decoction; decocting in water for 20 min, and mixing the decoctions;
(2) adding 1.8-2.2g of resistant dextrin into 10-30ml of pure water, and uniformly mixing for later use;
(3) and (2) adding 1.8-2.2g of sucrose fatty acid ester and 1.8-2.2g of potassium sorbate into the decoction obtained in the step (1), dissolving and uniformly mixing, adding the resistant dextrin solution obtained in the step (2), uniformly mixing, diluting with pure water to 950 plus 1050ml, uniformly mixing, subpackaging and sterilizing to obtain the compound aqueous solution-6.
Visual inspection of the aqueous solution-6 for good stability and rheology
Analyzing the using effect of the compound preparation:
case 1 Qianzhi, Man, 1983 years old, orthopedist
The patient has difficulty in defecating for more than 2 years, defecating every 4-6 days, and needs to struggle every effort to get in a small quantity of forest toilet every time. The stool is formed and not dry, and the limbs are weak, the appetite is not good, and the stool is intolerant to cold. Pale with little coating and thready and soft pulse. The diagnosis is caused by spleen-qi deficiency, kidney-yang deficiency and intestinal cloud loss. The formula is taken twice a day for 2 weeks. The symptoms of the patients are obviously improved, and the patients are defecated once in 1 to 2 days and formed in proper amount. One month of follow-up visit, the patient defecates smoothly and the symptoms basically disappear.
Case 2 Chen-Yi, woman, 1985 old, medical skilled doctor
The patient has difficulty in defecation for more than 1 year, and has the disadvantages of difficulty in defecation every 2-3 days, labor waste in defecation every time, feeling of incomplete defecation and long defecation time. Little tongue fluid, pale tongue without coating, thready and weak pulse, dizziness, tinnitus and insomnia. Constipation due to yin deficiency can be diagnosed. The formula is taken twice a day for 3 weeks. The symptoms of the patient are obviously improved, the defecation frequency is increased and the defecation time is shortened by 1-2 times a day. One month of follow-up visit, the patient defecates smoothly and the symptoms basically disappear.
The compound aqueous solution obtained by the invention can be stored for a long time and has good stability performance. Can be used for relieving constipation of yin deficiency type and yang deficiency type, but not limited to the above two types.
Claims (4)
1. The formula for regulating constipation is characterized by comprising the following components in percentage by mass: 11 to 14 percent of bunge cherry seed, 11 to 14 percent of purple perilla, 36 to 40 percent of yam, 12 to 14 percent of cistanche, 18 to 20 percent of cassia seed and 0 to 9 percent of auxiliary materials.
2. The formulation for regulating constipation according to claim 1, wherein the adjuvant is an adjuvant for preparing a stable decoction, and comprises carboxymethyl cellulose sodium as a thickener, and/or sucrose fatty acid ester as an emulsifier, and/or potassium sorbate as a preservative.
3. A preparation process of a formula for regulating constipation is characterized by comprising the following steps:
(1) 11-14% of bunge cherry seeds, 11-14% of purple perilla, 36-40% of Chinese yam, 12-14% of cistanche and 18-20% of cassia seeds are mixed and then added with 2 times of pure water to be soaked for 30 minutes; boiling with strong fire, decocting with medium fire for 30 min, and collecting decoction; adding water and decocting for 20 minutes to obtain a later decoction; finally, the front decoction and the rear decoction are combined to obtain decoction for later use;
(2) adding sodium carboxymethyl cellulose as a thickening agent into pure water according to the dosage, dissolving and uniformly mixing to obtain sodium carboxymethyl cellulose solution;
(3) dissolving an emulsifier sucrose fatty acid ester into the decoction prepared in the step (1) according to the dosage, and fully and uniformly mixing to obtain a solution;
(4) dissolving a preservative potassium sorbate into the solution prepared in the step (3) according to the dosage;
(5) and (3) uniformly mixing the sodium carboxymethyl cellulose solution prepared in the step (2) and the solution prepared in the step (4), adding water to dilute into decoction, and sterilizing.
4. The process for preparing the formula for regulating constipation according to claim 3, which comprises the following steps:
(1) mixing 10g of bunge cherry seeds, 10g of purple perilla, 30g of Chinese yam, 10g of cistanche and 15g of cassia seeds, and adding 2 times of pure water for soaking for 30 minutes; boiling with strong fire, decocting with medium fire for 30 min, and collecting the decoction; adding water and decocting for 20 minutes to obtain a later decoction; finally, combining the first decoction and the second decoction to obtain decoction for later use;
(2) adding 1.8-2.2gg thickener sodium carboxymethylcellulose into 10-30ml pure water, dissolving and mixing uniformly to obtain sodium carboxymethylcellulose solution;
(3) dissolving 1.8-2.2g of emulsifier sucrose fatty acid ester in the decoction prepared in the step (1), and fully and uniformly mixing to obtain a solution;
(4) dissolving 1.8-2.2g of preservative potassium sorbate in the solution prepared in the step (3);
(5) and (3) uniformly mixing the sodium carboxymethylcellulose solution prepared in the step (2) and the solution prepared in the step (4), adding water to dilute the mixture to 1000-1500 ml, and sterilizing.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1915300A (en) * | 2006-08-25 | 2007-02-21 | 胡彩芳 | Medication of medical broth for treating atonic constipation, and preparation method |
| CN104971216A (en) * | 2015-07-29 | 2015-10-14 | 张光泉 | Tea substitute drink for treating constipation and preparation method thereof |
-
2021
- 2021-10-27 CN CN202111255766.0A patent/CN113855757A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1915300A (en) * | 2006-08-25 | 2007-02-21 | 胡彩芳 | Medication of medical broth for treating atonic constipation, and preparation method |
| CN104971216A (en) * | 2015-07-29 | 2015-10-14 | 张光泉 | Tea substitute drink for treating constipation and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 央视网: "[健康之路]便秘良方：山药", 《CCTV.节目官网》 * |
| 田燕 等: "《中药临床新用途》", 30 June 2016, 金盾出版社 * |
| 胡琼力 等: "《实用临床中药学》", 30 June 2020, 河南科学技术出版社 * |
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Application publication date: 20211231 |