CN113854963B - Prostate cancer photoacoustic spectrum database and construction method thereof - Google Patents
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Abstract
The invention relates to a prostate cancer photoacoustic spectrum database and a construction method thereof, wherein the database comprises: an input module: to input sample clinical data of prostate cancer patients into the storage module; a storage module: storing sample clinical data of prostate cancer patients; a database query module: to enable data queries of prostate cancer patient databases. Compared with the prior art, the method has the advantages that the management and acquisition processes of the sample clinical data of the prostate cancer patient are streamlined and standardized, the photoacoustic spectrum information with pathological significance is integrated, the chemical component content of the prostate tissue and the cluster size change information of the prostate tissue can be provided, and accurate support is provided for subsequent noninvasive detection and malignancy grading of the prostate tissue.
Description
Technical Field
The invention relates to the technical field of biomedicine and computer storage, in particular to a prostate cancer photoacoustic spectrum database and a construction method thereof.
Background
Prostate puncture biopsy is the gold standard for prostate cancer diagnosis, puncture is mostly performed under the guidance of ultrasound, clear images of the cross section and sagittal plane of the prostate can be obtained through rectal ultrasound, and the whole puncture process is monitored in real time. However, the existing ultrasonic system has low diagnosis sensitivity on early prostate cancer, and false negative puncture results are easy to occur. Magnetic resonance-ultrasound imaging fusion prostate aspiration biopsy is a recently developed prostate aspiration technique. According to the method, the magnetic resonance image shot previously and the real-time ultrasonic image are overlapped and fused, and the original two-dimensional ultrasonic image is upgraded through three-dimensional reconstruction, so that the suspicious target is more visual and clear, and the targeted puncture biopsy can be guided. Although the puncture precision can be improved through prostate targeted puncture under the guidance of magnetic resonance-ultrasonic imaging, the cost is high and the time is consumed, and the magnetic resonance not only needs to be prepared on instruments, but also needs doctors to accurately read the prostate color Doppler ultrasound and magnetic resonance results through further professional learning, and master the use skills of related equipment, so that the labor cost is increased. In addition, the current clinical data of the prostate cancer patient usually includes paper pathology collected in a medical record room, which consumes manpower and material resources, and the obtained clinical data information is not collected and processed in a standardized manner, so that the relation between the clinical data information is not obtained, and the clinical data information cannot be fully utilized.
Chinese patent CN110136787a discloses a method, a database and a device for constructing a clinical database of an elderly puerpera, which only collects and stores clinical data of the elderly puerpera, does not analyze the relationship among the clinical data, and does not provide more information.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a prostate cancer photoacoustic spectrometry database and a construction method thereof.
The purpose of the invention can be realized by the following technical scheme:
a prostate cancer photoacoustic spectroscopy database, the database comprising:
an input module: the system is used for inputting sample clinical data of a prostate cancer patient into a storage module;
a storage module: storing sample clinical data of a prostate cancer patient;
a database query module: to enable data queries of prostate cancer patient databases.
The sample clinical data of the prostate cancer patient comprises personal information, prostate tissue test examination information, tissue biopsy pathological information and photoacoustic spectrum detection information.
The pathological information of the tissue biopsy comprises pathological section staining information and a Gleason score of a focus of a patient, the pathological section staining information comprises HE staining, immunohistochemistry, masson staining and Nile red staining experiments, good and malignant judgment of prostate tissues and change information of collagen fiber and fat content of tissues are respectively provided, and the Gleason score provides grading and prognosis judgment information of the prostate cancer according to the cell differentiation degree and is used for carrying out pathological diagnosis on a small amount of living tissues taken from the body of the patient.
The photoacoustic spectrum detection information is obtained by acquiring photoacoustic information of the prostate tissue by the same standard and performing standardized processing, and is used for credibly reflecting pathological significance and information of the prostate tissue.
The method for acquiring the photoacoustic information of the prostate tissue by the same standard specifically comprises the following steps:
the laser beam which is vertically incident is split by adopting a splitting piece with the ratio of the transmissivity to the reflectivity of 9:1, the transmitted light is vertically irradiated and coupled to the optical fiber and uniformly irradiated on the prostate tissue, the reflected light is vertically irradiated on a black body which can completely absorb the light, and the photoacoustic signal generated by the black body is corrected on each wavelength of the photoacoustic signal generated by the prostate tissue.
The optical fiber side opening is used for generating uniform strip laser to irradiate prostate tissues to be detected and further generate photoacoustic signals, and other positions of the optical fiber do not emit light, so that surrounding tissues and a coupling agent cannot be irradiated by the light, further the photoacoustic signals cannot be generated, and the certainty of the source of the photoacoustic signals is ensured.
The prostate tissue comprises an independent in-vitro puncture tissue strip, an in-vitro full-cutting tissue and an in-vivo tissue, and when the independent in-vitro puncture tissue strip is detected, the tissue strip is directly attached to one side of an optical fiber opening, so that laser irradiates the tissue strip to be detected to generate a photoacoustic signal; when the isolated total-section tissue and the in-vivo tissue are detected, the optical fiber is rotated by 360 degrees, so that the light-emitting side of the optical fiber opening irradiates the whole prostate tissue to be detected to generate photoacoustic signals, the photoacoustic signals generated by the prostate tissue are received by the broadband ultrasonic sensors with the same model, the received photoacoustic signals are subjected to signal processing according to the unified standard, and the photoacoustic spectrum detection information of the prostate tissue is obtained.
The photoacoustic spectrum detection information comprises a light wavelength-sound frequency two-dimensional spectrogram and a photoacoustic spectrum quantification parameter, wherein the light wavelength-sound frequency two-dimensional spectrogram is used for providing content information of each chemical component, the light wavelength spectrum comprises chemical component type information of the prostate tissue, the sound frequency spectrum comprises cluster structure information of each chemical component of the prostate tissue, and the photoacoustic spectrum quantification parameter comprises linear fitting parameters of a sound power spectrum, including intercept, median and slope, and is used for reflecting the uniformity, content and size information of the chemical component clusters in the prostate tissue.
The prostate cancer photoacoustic spectrum database is used for realizing accurate discrimination and grading of benign and malignant prostate tissues through the mapping relation between photoacoustic spectrum detection information and laboratory test information and tissue biopsy pathological information.
The construction method of the prostate cancer photoacoustic spectrometry database specifically comprises the following steps:
the method comprises the steps of collecting sample clinical data of a prostate cancer patient in advance, inputting the sample clinical data into a storage module for storage through an input module in an automatic or manual input mode, constructing a database query module to realize data query of a prostate cancer patient database, and establishing a mapping relation between photoacoustic spectrum detection information and test examination information and tissue biopsy pathological information in the database.
Compared with the prior art, the invention has the following advantages:
1. the invention creatively establishes the clinical database of the sample of the prostate cancer patient, and the database acquires the information of the sample clinical data of the prostate cancer patient and processes and standardizes the management process, thereby saving manpower and material resources and improving timeliness and accuracy.
2. The database integrates photoacoustic spectrum information, can provide the chemical component content of the prostate tissue and the size change information of clusters of different chemical components caused by cell differentiation, and the photoacoustic signals are collected in a standardized manner and processed in a unified manner, so that the pathological information of the prostate tissue can be accurately reflected.
Drawings
FIG. 1 is a flow chart of the method of the present invention.
Fig. 2 is a diagram illustrating a photoacoustic time spectrum acquired by the present invention.
Fig. 3 is a diagram of photoacoustic power spectra collected by the present invention.
Detailed Description
The invention is described in detail below with reference to the figures and specific embodiments.
Examples
The photoacoustic technology combines the high sensitivity of optical imaging and the high resolution of ultrasonic imaging because it is "light in and out". The photoacoustic signal carries optical, thermodynamic and microstructure information of the tissue, and can express multi-dimensional information of molecules, chemistry, functions and the like of biological tissues. The change of a photoacoustic signal of a detected object is researched by changing the wavelength of light waves, and the signal response on the dimension of the light wavelengths represents the molecular chemical information of the tissue to be detected, so that the photoacoustic signal can be used for analyzing related to molecular content; the size distribution of the light-absorbing molecular clusters is characterized by the expansion in the acoustic frequency dimension, the light-absorbing molecular clusters can be used for quantitative micro-structural evaluation of biomacromolecules, and the research of the photoacoustic prostatic cancer diseases mainly focuses on the differentiation of single normal tissues and tumor tissues, and the differentiation of prostatic cancers with different degrees of malignancy can be realized without research.
Therefore, the invention establishes the prostate photoacoustic spectrum database based on the photoacoustic technology, and realizes early noninvasive diagnosis and malignancy rating of prostate cancer.
The embodiment of the invention provides a method for constructing a photoacoustic spectrum database of a prostate cancer patient, which comprises the following steps as shown in figure 1:
s1, collecting sample clinical data of a prostate cancer patient; wherein the sample clinical data of prostate cancer patients comprises: personal information, prostate tissue examination information, tissue biopsy pathology information, and photoacoustic spectroscopy detection information.
And S2, constructing a prostate cancer patient database, wherein the prostate cancer patient database is used for inputting and storing sample clinical data of the prostate cancer patient. It should be noted that, the method further includes:
and S3, constructing a database query module, wherein the database query module is used for querying data of the database from the prostate cancer patient database.
Wherein, the constructed prostate cancer patient database comprises:
a storage module: for storing sample clinical data of prostate cancer patients;
an input module: for inputting sample clinical data of prostate cancer patients into the storage module.
A database query module: data for querying a database from a prostate cancer patient database.
Further, the input mode of the input module is automatic input and automatically matches the data format of the storage module or manual input.
According to the database construction method, a prostate cancer patient photoacoustic spectrum database is constructed, and is used for inputting and storing collected sample clinical data of prostate cancer patients; wherein, the sample clinical data of the prostate cancer patient is collected in advance; sample clinical data for prostate cancer patients include: personal information, prostate tissue examination information, tissue biopsy pathology information, and photoacoustic spectroscopy detection information.
The tissue biopsy pathological information comprises but is not limited to pathological section staining information and Gleason score of a focus of a patient, wherein the pathological section staining information comprises HE staining, immunohistochemistry and massson staining, and Nile red staining experiments, and can respectively provide benign and malignant judgment of prostate tissue and change information such as tissue collagen fiber and fat content; the Gleason score provides information on the grade and prognosis of prostate cancer based on the degree of cell differentiation, and is used for pathological diagnosis of a small amount of biopsy taken from a patient.
The photoacoustic spectrum detection information includes, but is not limited to, a light wavelength-sound frequency two-dimensional spectrogram and a photoacoustic spectrum quantification parameter; the optical wavelength-acoustic frequency two-dimensional spectrogram comprises the types and the contents of chemical components of the skin and cluster structure information of each chemical component, and the optical acoustic spectrum quantification parameters can carry out quantitative analysis on the types and the contents of the chemical components in the skin and the cluster structures of each chemical component, correspond to the test information and the tissue biopsy pathological information one by one, and realize the diagnosis of skin tumors.
The prostate cancer patient database query module is used for querying data from a prostate cancer patient database, and the prostate cancer patient database further comprises: the storage module is used for storing sample clinical data of a prostate cancer patient; and the input module is used for inputting the sample clinical data of the prostate cancer patient into the storage module.
Claims (6)
1. A prostate cancer photoacoustic spectroscopy database, comprising:
an input module: to input sample clinical data of prostate cancer patients into the storage module;
a storage module: storing sample clinical data of prostate cancer patients;
a database query module: a data query to implement a prostate cancer patient database;
the sample clinical data of the prostate cancer patient comprises personal information, prostate tissue test examination information, tissue biopsy pathological information and photoacoustic spectrum detection information;
the photoacoustic spectrum detection information is obtained by acquiring photoacoustic information of the prostate tissue by the same standard and carrying out standardized processing so as to truthfully reflect the pathological significance and information of the prostate tissue;
the method for acquiring the photoacoustic information of the prostate tissue by the same standard specifically comprises the following steps:
the laser beam which is vertically incident is split by adopting a splitting piece with the transmittance and reflectivity ratio of 9:1, the transmitted light is vertically irradiated and coupled to the optical fiber and uniformly irradiated on the prostate tissue, the reflected light is vertically irradiated on a black body which can fully absorb the light, and the photoacoustic signal generated by the black body is corrected on each wavelength of the photoacoustic signal generated by the prostate tissue;
the prostate tissue comprises an independent in-vitro puncture tissue strip, an in-vitro full-cutting tissue and an in-vivo tissue, and when the independent in-vitro puncture tissue strip is detected, the tissue strip is directly attached to one side of an optical fiber opening, so that the laser irradiates the tissue strip to be detected to generate a photoacoustic signal; when the isolated total-section tissue and the in-vivo tissue are detected, the optical fiber is rotated by 360 degrees, so that the light-emitting side of the optical fiber opening irradiates the whole prostate tissue to be detected to generate photoacoustic signals, the photoacoustic signals generated by the prostate tissue are received by the broadband ultrasonic sensors with the same model, the received photoacoustic signals are subjected to signal processing according to the unified standard, and the photoacoustic spectrum detection information of the prostate tissue is obtained.
2. The database of claim 1, wherein the pathological information of the biopsy includes pathological section staining information and Gleason score at the focus of the patient, the pathological section staining information includes HE staining, immunohistochemistry and masson staining, and nile red staining test, which respectively provide information on benign and malignant diagnosis of the prostate tissue and change of collagen fiber and fat content of the tissue, and the Gleason score provides information on grade and prognosis of the prostate cancer according to the degree of cell differentiation, which is used for pathological diagnosis of a small amount of biopsy taken from the patient.
3. The database according to claim 1, wherein the optical fiber is open at the side to generate uniform laser beam to irradiate the prostate tissue to be detected and further generate the photoacoustic signal, and other positions of the optical fiber do not emit light, so that the light cannot irradiate the surrounding tissue and the coupling agent and further cannot generate the photoacoustic signal, thereby ensuring the certainty of the source of the photoacoustic signal.
4. The database according to claim 1, wherein the photoacoustic spectroscopy detection information comprises a two-dimensional spectrum of light wavelength-sound frequency for providing content information of each chemical component, and a photoacoustic spectroscopy quantification parameter, wherein the light wavelength spectrum comprises the chemical component type information of prostate tissue, the sound frequency spectrum comprises the cluster structure information of each chemical component of prostate tissue, and the photoacoustic spectroscopy quantification parameter comprises linear fitting parameters of sound power spectrum, including intercept, median and slope, for reflecting the uniformity, content and size information of chemical component clusters in prostate tissue.
5. The database of claim 1, wherein the database of photoacoustic spectra of prostate cancer is used to accurately identify and grade the benign or malignant prostate tissue by mapping the information detected by the photoacoustic spectra with the information detected by the laboratory tests and the pathological information of tissue biopsy.
6. The database of photoacoustic spectra of prostate cancer according to claim 1, wherein the method for constructing the database of photoacoustic spectra of prostate cancer comprises:
the method comprises the steps of collecting sample clinical data of a prostate cancer patient in advance, inputting the sample clinical data into a storage module for storage through an input module in an automatic or manual input mode, constructing a database query module to realize data query of a prostate cancer patient database, and establishing a mapping relation between photoacoustic spectrum detection information and test examination information and tissue biopsy pathological information in the database.
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| CN102138809A (en) * | 2011-02-15 | 2011-08-03 | 福建师范大学 | Opto-acoustic scan imaging method and device for detecting prostate |
| CN106691391A (en) * | 2017-02-09 | 2017-05-24 | 集美大学 | Lateral scanning photoacoustic imaging method and device for prostate glands |
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| CN103393409A (en) * | 2013-08-22 | 2013-11-20 | 南京大学 | Comprehensive analysis method of multi-dimensional biology opto-acoustic image spectra |
| JP6873924B2 (en) * | 2015-06-04 | 2021-05-19 | コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． | Systems and methods for precision diagnosis and treatment extended by cancer grade maps |
| US10441250B2 (en) * | 2015-10-08 | 2019-10-15 | Zmk Medical Technologies Inc. | 3D multi-parametric ultrasound imaging |
| CN111341423A (en) * | 2020-02-24 | 2020-06-26 | 杭州憶盛医疗科技有限公司 | Medical data sharing system based on Internet of things and applying 5G technology |
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| CN102138809A (en) * | 2011-02-15 | 2011-08-03 | 福建师范大学 | Opto-acoustic scan imaging method and device for detecting prostate |
| CN106691391A (en) * | 2017-02-09 | 2017-05-24 | 集美大学 | Lateral scanning photoacoustic imaging method and device for prostate glands |
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