CN106691391A - Lateral scanning photoacoustic imaging method and device for prostate glands - Google Patents
Lateral scanning photoacoustic imaging method and device for prostate glands Download PDFInfo
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- CN106691391A CN106691391A CN201710071221.1A CN201710071221A CN106691391A CN 106691391 A CN106691391 A CN 106691391A CN 201710071221 A CN201710071221 A CN 201710071221A CN 106691391 A CN106691391 A CN 106691391A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
- A61B8/0833—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving detecting or locating foreign bodies or organic structures
- A61B8/085—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving detecting or locating foreign bodies or organic structures for locating body or organic structures, e.g. tumours, calculi, blood vessels, nodules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4483—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
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Abstract
The invention provides a lateral scanning photoacoustic imaging method and device for prostate glands. The device comprises a lateral signal exciting source and a lateral signal receiving device, wherein the lateral signal exciting source comprises an optical fiber, a reflecting mirror, a catheter and a pulse laser light source; the tail end of the catheter is a lateral light transmission light emitting end; the tail end position of the light emitting end is provided with the reflecting mirror; the optical fiber is arranged in a pipe cavity of the catheter; the optical fiber output end is adjacent to the reflecting mirror and points to the reflecting mirror. In a work process, the catheter rotates so that the reflecting mirror faces tissues to be scanned; the light source emits pulse later through the optical fiber and the reflecting mirror, so that the tissues to be scanned generate photoinduced ultrasonic signals; the lateral signal receiving device generates a scanning image according to the signal. The nondestructive inward lateral light outlet type large-range light radiation is performed on prostate gland tissues at better light intensity through the urethra; in addition, the nondestructive ultrasound receiving operation is started through scanning detection of a lateral long-focus region ultrasonic transducer arranged in the rectum; the large-range and great-depth three-dimensional photoacoustic imaging can be realized.
Description
Technical field
The present invention relates to medical diagnostic apparatus, especially a kind of lateral scanning acousto-optic imaging method and dress for prostate
Put.
Background technology
Prostate profile such as it is same before and after slightly flat inversion chestnut, it is deep to ensconce bone positioned between bladder and urethra reproduction diaphragm
In basin, before paste pubic symphysis, behind be installed with urethra according to rectum, centre, determine that prostate position is hidden, be difficult examination spy
Point.Photoacoustic imaging technology will unavoidably be solved two problems in the application of tumor of prostate early detection：It is deep penetration, comprehensive
Non-invasive light sound excite and undamaged supersonic sounding.
Focusing optical acoustic scanning imaging presses certain repetition rate irradiated tissue using short-pulse laser, because light absorbs are adiabatic
The ultrasonic signal for expanding and producing is received by that after the propagation in tissue, can be in the focused transducer of tissue surface.
And focused ultrasonic transducer is due to the characteristic responded with the photoacoustic signal in Zhi Duiqijiao areas, the ultrasonic signal for being gathered
Its Jiao Qu is mainly derived from, therefore by burnt area's point by point scanning organizer of ultrasonic transducer, longitudinal optoacoustic of the multiple positions of combination
Signal can be obtained by the two-dimentional light absorbs figure of organizer.The focal spot that the spatial resolution of this method depends on transducer is big
It is small.When probe of the focused transducer for focal length area, the one-dimensional time resolution optoacoustic on transducers focus axial direction can also be utilized
Signal, the anti-organizer that releases combines plane orthogonal to the axial direction in the upward energy absorption distribution of ultrasonic transducer focal axis
Transversal scanning obtained by multiple longitudinal signals, you can constitute a 3-D view, with imaging algorithm it is simple the characteristics of.This
The lateral resolution of the image of sample is still depending on the focal spot size of transducer；Longitudinal frame is then by the frequency range of photoacoustic signal
Response time with ultrasonic transducer determines.
For prostate, the image quality of optical acoustic scanning imaging depends greatly on radiation modality, such as in gland
In vitro（Belly or rectum）Light irradiation is carried out, is then easily caused light penetration depth not enough by the serious optical attenuation of peripheral organization,
Especially urethra side body of gland is larger with external irradiation light source distance, and its light absorbs energy seriously diminishes, it is difficult to carry out effective light
Sound is excited；It is internal and the interior lights irradiation that per urethra is carried out can allow have more fully energy absorption inside prostata tissue
Light absorbs distribution is larger, in fact, per urethra optical transport mode and the prostate PDT realized have been obtained generally
Use, this inside photo-acoustic excitation for showing per urethra and carrying out has great Clinical feasibility.
The know-why method of tumor of prostate optoacoustic Non-Destructive Testing that the irradiation of per urethra interior lights is carried out is, lateral letter
Number excitaton source per urethra is inserted and irradiates prostate, is produced absorbing weaker normal gland tissue and absorbing stronger tumor region
The ultrasonic signal of raw strength difference, because light spread speed in the tissue is much larger than the velocity of sound in organizer, so in sample
The photoacoustic signal that absorber is produced substantially can be regarded as while being excited.And the absorber of diverse location and the distance popped one's head in
Difference, the photoacoustic signal that it is produced can be received by being popped one's head in after different time delays, therefore, the position of target absorption body can
Determined by the photoacoustic signal propagation time；In addition, the direct phase of energy absorption degree of the amplitude of photoacoustic signal and target absorption body
Close, therefore the energy absorption situation of target absorption body can also be understood from the range value of photoacoustic signal.For tumor of prostate
The photoacoustic signal of generation can then make full use of the adjacent rectal void of rear side, be put by lateral focal length area focused ultrasonic transducer
Non-Destructive Testing is peeped in being carried out in rectum.Transducer axially carrying out on certain position being detected around axle sectoring first, hereafter,
Rotary positioning apparatus rotary guide pipe changes the irradiation orientation of pulse laser, to produce the ultrasonic signal in new orientation；Signal receives dress
Put continuation carries out sectoring detection by rotating stepper motor drive.The electricity containing radially time-resolved ultrasound information for being exported
Oscillograph being input into after the amplified device amplification of signal, filtering and being processed by computer, computer is generated according to multi-faceted ultrasonic signal
Scan image is simultaneously spliced, and realization need to scan the comprehensive two-dimensional imaging of tissue.Connect by electronic control translation stage drive signal
Receiving apparatus produce axial translation, and the covering of the fan rotation that signal receiving device continues to make under multidirectional irradiation on new axial location is swept
Retouch, just can so complete to cover being scanned around axle sector scan and axial translation for prostate and perienchyma, realize whole sample
The collection of three-dimensional light energy deposition distribution data, so as to obtain the function comprising physiology and pathological information of prostata tissue into
As figure.Because the focused transducer based on focal length area detects photoacoustic signal, the feelings of transducer lengthwise position can need not adjusted
Effective imaging region more long is obtained under condition, so as to conveniently realize the photoacoustic imaging of higher depth tissue；So medical worker is just
The hurtless measure external detection to the prostate cancer of hidden focus can be realized.
But the detection of higher depth tissue needs the scanning imaging technology there are enough imaging depths, also imply that receiving is swept
Enough intensities of illumination are must assure that in the target retouched.The photo-acoustic excitation used currently for the photoacoustic imaging system of prostate is more
Be through at belly or rectum irradiate, using dispersion fiber internal mode of excitation due to light path it is discrete so that on target detection face
Light energy it is weaker, unilateral light penetration depth is not enough when causing same energy input, easily the unilateral imaging depth of influence；And
Some such lateral old systems are smaller due to light irradiation area, and cost time multiple rotary light source is needed in experiment to ensure to see
Whole absorbers are observed, scan efficiency has been severely impacted；During additionally, due to prostate photo-acoustic detection, rectal void is first-selected
The place of ultrasound signal receipt device, and arrayed ultrasonic transducer is limited to rectal void and can only carry out the signal of limited angle
Collection, it is difficult to obtain enough data, easily influence imaging depth and precision, extreme difficulties are brought to image reconstruction.If in inspection
Need to carry out receiver during survey greatly apart from lateral displacement to adjust directional bearing for receiving the signal in new orientation, it will cause
The serious discomfort of subject；How to solve these is related to deep penetration, comprehensive non-invasive light sound to excite and not damaged ultrasound spy
The problem of survey, is a significant research direction.
The content of the invention
The present invention proposes a kind of lateral scanning acousto-optic imaging method and device for prostate, can be through per urethram with preferable
Luminous intensity human prostate tissues are carried out with the scan-type light irradiation in a big way of lossless introversive side lighting-out tpye, and by putting
In the ultrasonic waves no-wound scanning probe of the lateral focal length area ultrasonic transducer in human rectum, be capable of achieving on a large scale, big depth
Three-dimensional photoacoustic imaging.
The present invention uses following technical scheme.
A kind of lateral scanning acousto-optic imaging method and device for prostate, the lateral scanning opto-acoustic imaging devices bag
Lateral signal excitation source and lateral signal receiving device are included, the lateral signal excitation source includes optical fiber, speculum, conduit and arteries and veins
Impulse radiant；The conduit is the detection conduit that can be inserted into position to be detected；Catheter tip be can laterally printing opacity light transmitting
End, is provided with the speculum set with conduit bevel at light transmitting terminal tip；Conduit top is connected with rotary positioning apparatus；It is described
Optical fiber is set in conduit cavity, the optic fibre input end is connected with pulsed laser light source；Fiber-optic output is located at light transmitting terminal simultaneously
Adjacent with speculum, fiber-optic output tip is polished to, the light direction sensing reflection of fiber-optic output vertical with optical fiber body
Mirror；The lateral signal receiving device is lateral submerged long-focus area focused ultrasonic probe, ultrasonic receiver；When lateral scanning light
When acoustic imaging apparatus work, rotary positioning apparatus rotary guide pipe makes speculum towards that need to scan tissue, and pulsed laser light source is through light
Fine, speculum to that need to scan tissue emissions pulse laser makes that the tissue photic ultrasonic signal of generation need to be scanned；Set with conduit bevel
The speculum put converts it towards orientation as needed；Signal receiving device is received under each orientation irradiation in sectoring mode
The signal of generation simultaneously delivers to external computer, and computer is according to the folk prescription position of signal generation X/Y plane or comprehensive two being spliced into
Dimension image；The signal receiving end of lateral signal receiving device is located on translation stage, when signal receiving end moves to change on Z axis
During its received bit, external computer is processed the signal of new and old received bit to realize scanning the three-dimensional light on the XYZ axles of target
Acoustic imaging.
The optical fiber is end-fire multimode fibre, be provided with the smooth transmitting terminal tip with conduit into 45 degree of angles set it is anti-
Penetrate mirror.
The catheter outer diameter scope is identical with common Medical urethral catheter external diametrical extent.
The lateral signal receiving device is lateral submerged long-focus area focused transducer.
The translation stage is electronic control translation stage, and electronic control translation stage is loaded with rotating stepper motor, and the lateral signal receives dress
The signal receiving end put is connected with rotating stepper motor, and rotating stepper motor changes the reception direction of signal receiving end, automatically controlled flat
Moving stage carrying signal receiving terminal is moved on Z axis.
The lateral scanning opto-acoustic imaging devices human prostate is laterally scanned the method for work of photoacoustic imaging according to
It is secondary to comprise the following steps；
A1, conduit is inserted or direct per urethra insertion human prostate position through catheter, be located at the light transmitting terminal of conduit
The side of tissue need to be scanned, it is outer noninvasive super body of gland is carried out in the signal receiving end insertion human rectum of lateral signal receiving device
Sound reception operation；
A2, rotary positioning apparatus rotary guide pipe make speculum light direction scan tissue towards the need of conduit light transmitting terminal side；
A3, pulsed laser light source through optical fiber, speculum to tissue emissions pulse laser need to be scanned, make to scan tissue produce it is photic
Ultrasonic signal；
A4, the signal receiving end receive ultrasonic signal, while lateral signal receiving device changes signal and connects under static state
Towards to realize the signal receiving plane of fan-shaped track, the ultrasonic signal data for receiving are reached outside to receiving end by signal receiving device
Computer, computer generates the scan image of folk prescription position according to ultrasonic signal；
A5, rotary positioning apparatus rotary guide pipe change the irradiation orientation of pulse laser, lateral signal receiving device signal receiving end
After the ultrasonic signal that covering of the fan receives the generation of new irradiation orientation is continued in original position, data are reached external computer, computer
The scan image in new orientation is generated according to ultrasonic signal and is spliced until obtaining comprehensive two dimensional image；
A6, lateral signal receiving device are driven after being moved to new position on Z axis by electronic control translation stage, on this XY axial plane
The ultrasonic scanning signal produced under multidirectional irradiation re-starts fan-shaped reception, and computer connects according to lateral signal receiving device signal
After receiving end is generated and is spliced new comprehensive two-dimensional scan image in all ultrasonic signals that new position is received, then with step
The two-dimensional image data merging treatment obtained in rapid A5 need to scan the three-dimensional imaging of the XYZ axles of tissue to generate.
The ultrasonic signal that the transducer is received send after carrying out amplitude limit, shaping, filtering and amplification by ultrasonic pulse receiver
Enter digital oscilloscope, the digital oscilloscope take after multiple averaging is processed through GPIB cards treatment gained to the ultrasonic signal
Data deliver to computer.
The fiber-optic output is 5mm with the spacing of speculum, and the fiber-optic output, speculum are solid with adhesive
It is fixed.
The pulsed laser light source for can output wavelength be 680-1000nm wave band continuously adjustabe pulse lasers or independence
Output 532nm or 1064nm wavelength pulsed lasers, pulsewidth 6-8ns, individual pulse energy are about 4mJ, repetition rate 10Hz and swash
The OPO pulse lasers of light beam, the optically coupled device of pulse laser is input into laser to optical fiber.
In the present invention, lateral signal excitation source includes end-fire end-fire multimode fibre (numerical aperture 0.25, diameter
1.5mm) with one piece of speculum and conduit at 45 degree of inclination angles；Optical fiber connector throws flat and vertical with optical axis, and end has one with speculum
The distance of section about 5mm, because optical fiber output light has certain angle of divergence (29 degree), the hot spot for then reaching speculum is larger, warp
After crossing the further amplification of reflex of oblique angle speculum, light beam is irradiated to tissue sample with being approximately perpendicular to the direction of optical fiber,
Help to realize compared with large spot（Diameter 5mm) lateral irradiation；Due to the lateral Radiation Characteristics of lateral light source, and speculum is anti-
The characteristics of light intensity is preferable, optical energy loss is small is penetrated, the photoacoustce signal intensity for needing emphasis scanning area is improved so that the present invention is more suitable
Substantially understand for tumour orientation, but need the diagnosis occasion for further confirming that.
In the present invention, key area scanning easily can be only carried out, conduit need to be only rotated to predetermined angular,
Without the receiving terminal of overall transverse shifting ultrasonic probe, ultrasonic receiver, so as to improve sweep speed；When doctor is only concerned urethra list
The distribution of side absorber and when be not intended to understand urethra surrounding whole absorber information, unilateral imaging characteristicses of the invention are then more
Such demand that diagnostic scan is carried out to key area can be met, due to sweep speed accelerate and scanning information amount be simplified,
The speed of doctor's examination garbage is improved, so as to improve diagnosis and treatment efficiency.
In the present invention, fiber-optic output tip is polished to, the light direction sensing of fiber-optic output vertical with optical fiber body
Speculum；The design causes that the emergent light of fiber-optic output is more neat, and what reduction concave plane was caused goes out light dispersion, so that
Help to lift output intensity.
In the present invention, the lateral signal receiving device is lateral submerged long-focus area focused transducer；Due to
Focused ultrasonic transducer have the photoacoustic signal in its burnt area is responded, to outside its Jiao Qu photoacoustic signal response be almost
Zero characteristic, the ultrasonic signal for being gathered be mainly derived from its focus where region, therefore by the Jiao Qu of ultrasonic transducer by
Spot scan organizer, the multiple position longitudinal direction photoacoustic signals of combination can be obtained by the two-dimentional light absorbs figure of organizer；Therefore this hair
Bright to be rotated to predetermined angular with conduit first when lateral photoacoustic imaging is carried out to prostata tissue body, lateral focal length area surpasses
Sonic transducer axially carrying out on certain position being detected around axle sectoring, exported containing radially time-resolved ultrasound information
The amplified device of electric signal amplify, be input into oscillograph after filtering and processed by computer；Hereafter, rotary positioning apparatus rotation change is led
The irradiation orientation of pipe, computer continues the sectoring detection for driving lateral signal receiving device to carry out new orientation photoacoustic signal.Electricity
Brain generates scan image and is spliced according to the ultrasonic signal produced under multidirectional irradiation respectively, and realization need to scan tissue
Comprehensive two-dimensional imaging；Lateral signal receiving device can do axial translation via the two-dimension translational of electronic control translation stage, new
Proceed on axial location under multidirectional irradiation around axle scanning probe, can so complete to cover whole prostate samples three-dimensional
Light energy deposition distribution data collection, so as to obtain the functional imaging comprising physiology and pathological information of prostata tissue
Figure, lateral imaging method carried out with the present invention can realize the multi-orientation detection to scanning target, therefore be imaged more reliable；
Additionally due to prostate is one of minimum organ of human body, because output intensity of the invention and scope are ensured, therefore press
When apparatus of the present invention are detected, intrarectal focal length area ultrasonic probe, ultrasonic receiver only needs to be maintained in rectum to be carried out slightly around axle
Displacement can make range of receiving cover whole tissue, and solving can only have been gathered using conventional medical arrayed ultrasonic transducer
Limit angle photoacoustic signal and cause image reconstruction that there is the problem of arduous and complexity, without its horizontal receiving position of change,
The inspection that the personnel of being checked can be greatly reduced is uncomfortable.
Compared with traditional fiber light source, simple easily standby, the low cost of the present invention makes simple, be conducive to irradiation direction compared with
On a large scale with depth in imaging of absorber Embedded, it is possible to resolve the current column lateral light emission rate of dispersion fiber is weaker, is easily caused unilateral light
Penetration depth is not enough and the problem of the unilateral imaging depth of influence；Lateral light source with the existing total reflection principle based on light is compared,
It can be avoided small due to irradiation luminous point, cost time multiple rotary light source is needed in experiment to ensure to observe whole absorbers
Shortcoming.
The present invention design lateral light source be used for internal photo-acoustic excitation when, have to absorber preferable stationkeeping ability and into
As ability, unilateral areas imaging has absolutely proved advantage of the lateral light source in unilateral imaging than larger, and specifically into
As in operation, operating personnel can change the imaging of absorber Embedded in other orientation by the rotation of lateral light source；Before early stage
That is at the rear of prostate, the lateral light source is expected to turn into early stage prostatitis the peripheral zone that row gland cancer mostly occurs in prostate
A kind of new light-source structure in gland cancer photoacoustic imaging technology, with important value.
Brief description of the drawings
The present invention is described in more detail with reference to the accompanying drawings and detailed description：
Accompanying drawing 1 is imaging device principle schematic of the invention；
Accompanying drawing 2 is the light extraction schematic diagram of conduit light transmitting terminal of the invention；
Accompanying drawing 3 is the light extraction schematic diagram on the other direction of conduit light transmitting terminal of the invention；
Accompanying drawing 4 is optical fiber of the invention, the cut-away illustration at speculum；
Accompanying drawing 5 is imaging results schematic diagram of the invention；
Accompanying drawing 6 is another schematic diagram of imaging results of the invention；
In figure：1- pulsed laser light sources；2- conduits；The light transmitting terminal of 3- conduits；The lateral signal receiving devices of 4-（Focusing focal length
Area's ultrasonic probe, ultrasonic receiver）；5- rectum；6- urethras or catheter；7- need to scan tissue（Tumor of prostate）；The automatically controlled translations of 8-
Platform；9- rotating stepper motors；10- computers；11- speculums；12- optical fiber；13- digital oscilloscopes；14- rotating stepper motors turn
Axle；15- rotary positioning apparatus.
Specific embodiment
As shown in figures 1 to 6；A kind of lateral scanning acousto-optic imaging method and device for prostate, the lateral scanning light
Acoustic imaging apparatus include lateral signal excitation source and lateral signal receiving device, the lateral signal excitation source include optical fiber 12,
Speculum 11, conduit 2 and pulsed laser light source 1；The conduit 2 is the detection conduit that can be inserted into position to be detected；The end of conduit 2
For can lateral printing opacity light transmitting terminal 3, the speculum 11 set with conduit bevel is provided with the tip of light transmitting terminal 3；Conduit 2 begins
End is connected with rotary positioning apparatus；Optical fiber 12, the input of the optical fiber 12 and the phase of pulsed laser light source 1 are set in the conduit cavity
Even；Fiber-optic output is at light transmitting terminal and adjacent with speculum 11, and fiber-optic output tip is polished to and the body of optical fiber 12
Vertically, the light direction directional mirror 11 of fiber-optic output；The lateral signal receiving device is lateral submerged long-focus
The focusing ultrasonic probe, ultrasonic receiver 4 in area；When lateral scanning opto-acoustic imaging devices work, rotary positioning apparatus rotary guide pipe 2 makes
Speculum 11 swashs through optical fiber 12, speculum 11 towards that need to scan tissue, pulsed laser light source to that need to scan the transmitting pulse of tissue 7
Light, makes that the photic ultrasonic signal of generation of tissue 7 need to be scanned；The speculum set with conduit bevel converts its direction side as needed
Position；Signal receiving device receives the lower signal for producing of each orientation irradiation and delivers to external computer in sectoring mode, computer
Comprehensive two dimensional image that is folk prescription position or being spliced into according to signal generation X/Y plane；The signal of lateral signal receiving device
On translation stage, when signal receiving end is moved to change its received bit on Z axis, external computer is to new and old reception for receiving terminal
The signal of position is processed to realize scanning the three-dimensional photoacoustic imaging on the XYZ axles of target.
The optical fiber 12 is end-fire multimode fibre, is provided with the tip of smooth transmitting terminal 3 and is set with 2 one-tenth 45 degree of angles of conduit
Speculum 11.
The external diametrical extent of the conduit 2 is identical with the external diametrical extent of common Medical urethral catheter 6.
The lateral signal receiving device is lateral submerged long-focus area focused transducer.
The translation stage is electronic control translation stage, and electronic control translation stage is loaded with rotating stepper motor 9, and the lateral signal receives dress
The signal receiving end put is connected with rotating stepper motor（It is connected with rotating shaft 14）, rotating stepper motor changes signal receiving end and connects
Debit is to electronic control translation stage carrying signal receiving terminal is moved on Z axis.
In this example, electronic control translation stage is fixed in sleeve pipe, is connected with miniature rotating stepper motor by screw mandrel, ultrasonic transduction
Device is fixed on the motor shaft of miniature electric rotating machine, and ultrasonic transducer lower section casing wall is the sound transmitting window of thickness 0.5mm, sound transmitting window
Axial length is 40mm, and sound transmitting window is 60 ° to motor shaft subtended angle.Overall package is in sleeve pipe.
The lateral scanning opto-acoustic imaging devices human prostate is laterally scanned the method for work of photoacoustic imaging according to
It is secondary to comprise the following steps；
A1, conduit 2 is inserted or direct per urethra insertion human prostate position through catheter 6, make the light transmitting terminal position of conduit
It is outer noninvasive body of gland is carried out in the signal receiving end insertion human rectum of lateral signal receiving device in the side that need to scan tissue
Ultrasonic reception operation；
A2, rotary positioning apparatus rotary guide pipe 2 make the light direction of speculum 11 need scanning group towards the side of conduit light transmitting terminal 3
Knit 7；
A3, pulsed laser light source 1, to that need to scan the emission pulse laser of tissue 7, make that tissue 7 need to be scanned through optical fiber 12, speculum 11
Produce ultrasonic signal；
A4, the signal receiving end receive ultrasonic signal, while lateral signal receiving device changes signal and connects under static state
Receiving end is towards realizing the signal receiving plane of fan-shaped track（Sector is fan-shaped around axle）, signal receiving device is the ultrasound for receiving
Signal data reaches external computer, and computer generates the scan image of folk prescription position according to ultrasonic signal；
A5, rotary positioning apparatus rotary guide pipe change the irradiation orientation of pulse laser, lateral signal receiving device signal receiving end
After the ultrasonic signal that covering of the fan receives the generation of new irradiation orientation is continued in original position, data are reached external computer, computer
The scan image in new orientation is generated according to ultrasonic signal and is spliced until obtaining comprehensive two dimensional image；
A6, lateral signal receiving device are driven after being moved to new position on Z axis by electronic control translation stage, on this XY axial plane
The ultrasonic scanning signal produced under multidirectional irradiation re-starts fan-shaped reception, and computer connects according to lateral signal receiving device signal
After receiving end is generated and is spliced new comprehensive two-dimensional scan image in all ultrasonic signals that new position is received, then with step
The two-dimensional image data merging treatment obtained in rapid A5 need to scan the three-dimensional imaging of the XYZ axles of tissue to generate.
The ultrasonic signal that the transducer is received send after carrying out amplitude limit, shaping, filtering and amplification by ultrasonic pulse receiver
Enter digital oscilloscope 13,13 pairs of ultrasonic signals of the digital oscilloscope take after multiple averaging is processed through GPIB cards treatment
The data obtained delivers to computer.
The output end of the optical fiber 12 is 5mm with the spacing of speculum 11, and the output end of the optical fiber 12, speculum 11 are with viscous
Mixture is fixed.
The pulsed laser light source for can output wavelength be 680-1000nm wave band continuously adjustabe pulse lasers or independence
Output 532nm or 1064nm wavelength pulsed lasers, pulsewidth 6-8ns, individual pulse energy are about 4mJ, repetition rate 10Hz and swash
The OPO pulse lasers of light beam, the optically coupled device of pulse laser is input into laser to optical fiber.
The optical fiber is numerical aperture 0.25, the end-fire multimode fibre of diameter 1.5mm.
In this example, when human prostate's scanning photoacoustic imaging is carried out, mobile performance of the signal receiving end on Z axis
It is signal receiving end in the motion of retreating at human rectum position.
Pulse laser is taken in this example for synchronous triggering signal trigger data acquisition computer operation realizes adopting for photoacoustic signal
Collection record.
In this example, because prostate volume is small（Upper end transverse diameter about 4cm, vertical diameter about 3cm, anteroposterior diameter about 2cm）, and it is lateral
Signal excitation source is larger to irradiation range（2-3cm）, it is only necessary to the lateral irradiation of four direction just can cover global tissue.And
The signal receiving device being connected with rotating stepper motor rotating shaft need to only be driven by rotating stepper motor and done in four times in rectal void
Low-angle just can completely be received around axle sectoring and be related to the ultrasonic scanning signal of whole body of gland.
Conventional adult's catheter has tetra- kinds of models of 12F, 14F, 16F, 18F, and its external diameter is 4-6mm.The catheter outer diameter
Catheter external diametrical extent in commonly using.
When the present apparatus is tested, human prostate can be simulated using simulated tissue, its preparation method is, analog sample base
Bottom is by agar powder（2g）, distilled water (100ml), Fat Emulsion 20ml（Concentration 20%）Heating is poured into column glassware and is condensed into, greatly
It is small to be（4.5*4.5*5cm）, centre is reserved with 6mm through holes simulation urethra, and simulates tumour with carbon-point.
Claims (9)
1. a kind of lateral scanning acousto-optic imaging method and device for prostate, it is characterised in that：The lateral scanning optoacoustic
Imaging device includes lateral signal excitation source and lateral signal receiving device, and the lateral signal excitation source includes optical fiber, reflection
Mirror, conduit and pulsed laser light source；The conduit is the detection conduit that can be inserted into position to be detected；Catheter tip is can be laterally saturating
The light transmitting terminal of light, is provided with the speculum set with conduit bevel at light transmitting terminal tip；Conduit top is filled with rotational positioning
Put connected；Optical fiber is set in the conduit cavity, the optic fibre input end is connected with pulsed laser light source；Fiber-optic output is located at light
At transmitting terminal and adjacent with speculum, fiber-optic output tip is polished to, the light extraction side of fiber-optic output vertical with optical fiber body
To directional mirror；The lateral signal receiving device is lateral submerged long-focus area focused ultrasonic probe, ultrasonic receiver；When
When lateral scanning opto-acoustic imaging devices work, rotary positioning apparatus rotary guide pipe makes speculum swash towards that need to scan tissue, pulse
Radiant, to that need to scan tissue emissions pulse laser, makes that the tissue photic ultrasonic signal of generation need to be scanned through optical fiber, speculum；With lead
The speculum that pipe bevel is set converts it towards orientation as needed；Signal receiving device is received respectively in sectoring mode
The irradiation lower signal for producing in orientation simultaneously delivers to external computer, and computer is according to signal generation X/Y plane folk prescription position or is spliced into
Comprehensive two dimensional image；The signal receiving end of lateral signal receiving device is located on translation stage, when signal receiving end is on Z axis
To change during its received bit, external computer is processed the signal of new and old received bit to realize scanning the XYZ axles of target for movement
On three-dimensional photoacoustic imaging.
2. a kind of lateral scanning acousto-optic imaging method and device for prostate according to claim 1, its feature exists
In：The optical fiber is end-fire multimode fibre, and the speculum set into 45 degree of angles with conduit is provided with the smooth transmitting terminal tip.
3. a kind of lateral scanning acousto-optic imaging method and device for prostate according to claim 2, its feature exists
In：The catheter outer diameter scope is identical with common Medical urethral catheter external diametrical extent.
4. a kind of lateral scanning acousto-optic imaging method and device for prostate according to claim 3, its feature exists
In：The lateral signal receiving device is lateral submerged long-focus area focused transducer.
5. a kind of lateral scanning acousto-optic imaging method and device for prostate according to claim 4, its feature exists
In：The translation stage is electronic control translation stage, and electronic control translation stage is loaded with rotating stepper motor, the letter of the lateral signal receiving device
Number receiving terminal is connected with rotating stepper motor, and rotating stepper motor changes the reception direction of signal receiving end, and electronic control translation stage holds
Signal receiving end is carried to be moved on Z axis.
6. a kind of lateral scanning acousto-optic imaging method and device for prostate according to claim 5, its feature exists
In：The method of work that the lateral scanning opto-acoustic imaging devices are laterally scanned photoacoustic imaging to human prostate includes successively
Following steps；
A1, conduit is inserted or direct per urethra insertion human prostate position through catheter, be located at the light transmitting terminal of conduit
The side of tissue need to be scanned, it is outer noninvasive super body of gland is carried out in the signal receiving end insertion human rectum of lateral signal receiving device
Sound reception operation；
A2, rotary positioning apparatus rotary guide pipe make speculum light direction scan tissue towards the need of conduit light transmitting terminal side；
A3, pulsed laser light source through optical fiber, speculum to tissue emissions pulse laser need to be scanned, make to scan tissue produce it is photic
Ultrasonic signal；
A4, the signal receiving end receive ultrasonic signal, while lateral signal receiving device changes signal and connects under static state
Towards to realize the signal receiving plane of fan-shaped track, the ultrasonic signal data for receiving are reached outside to receiving end by signal receiving device
Computer, computer generates the scan image of folk prescription position according to ultrasonic signal；
A5, rotary positioning apparatus rotary guide pipe change the irradiation orientation of pulse laser, lateral signal receiving device signal receiving end
After the ultrasonic signal that covering of the fan receives the generation of new irradiation orientation is continued in original position, data are reached external computer, computer
The scan image in new orientation is generated according to ultrasonic signal and is spliced until obtaining comprehensive two dimensional image；
A6, lateral signal receiving device are driven after being moved to new position on Z axis by electronic control translation stage, on this XY axial plane
The ultrasonic scanning signal produced under multidirectional irradiation re-starts fan-shaped reception, and computer connects according to lateral signal receiving device signal
After receiving end is generated and is spliced new comprehensive two-dimensional scan image in all ultrasonic signals that new position is received, then with step
The two-dimensional image data merging treatment obtained in rapid A5 need to scan the three-dimensional imaging of the XYZ axles of tissue to generate.
7. a kind of lateral scanning acousto-optic imaging method and device for prostate according to claim 6, its feature exists
In：Feeding is digital after the ultrasonic signal that the transducer is received is carried out amplitude limit, shaping, filtering and amplified by ultrasonic pulse receiver
Oscillograph, the digital oscilloscope carries out sending treatment the data obtained through GPIB cards after taking multiple averaging treatment to the ultrasonic signal
To computer.
8. a kind of lateral scanning acousto-optic imaging method and device for prostate according to claim 1, its feature exists
In：The fiber-optic output is 5mm with the spacing of speculum, and the fiber-optic output, speculum are fixed with adhesive.
9. a kind of lateral scanning acousto-optic imaging method and device for prostate according to claim 1, its feature exists
In：The pulsed laser light source for can output wavelength be 680-1000nm wave band continuously adjustabe pulse lasers or independent output
532nm or 1064nm wavelength pulsed lasers, pulsewidth 6-8ns, individual pulse energy are about 4mJ, the laser beam of repetition rate 10Hz
OPO pulse lasers, the optically coupled device of pulse laser to optical fiber be input into laser.
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| CN107822595A (en) * | 2017-09-28 | 2018-03-23 | 华南师范大学 | The per urethra optoacoustic prostate developing method and device received based on ring battle array |
| CN109507117A (en) * | 2018-11-12 | 2019-03-22 | 中国科学技术大学 | A kind of micro-nano image checking experimental provision based on optoacoustic beam shaping |
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| CN113854963B (en) * | 2021-09-15 | 2022-12-16 | 同济大学 | Prostate cancer photoacoustic spectrum database and construction method thereof |
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| CN106691391B (en) | 2023-06-23 |
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