CN207055480U - A kind of lateral scanning opto-acoustic imaging devices for prostate - Google Patents
A kind of lateral scanning opto-acoustic imaging devices for prostate Download PDFInfo
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- CN207055480U CN207055480U CN201720119767.5U CN201720119767U CN207055480U CN 207055480 U CN207055480 U CN 207055480U CN 201720119767 U CN201720119767 U CN 201720119767U CN 207055480 U CN207055480 U CN 207055480U
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Abstract
The utility model proposes a kind of lateral scanning opto-acoustic imaging devices for prostate, device includes lateral signal excitation source and lateral signal receiving device, and lateral signal excitation source includes optical fiber, speculum, conduit and pulsed laser light source；Catheter tip is the light transmitting terminal of lateral printing opacity, and speculum is provided with light transmitting terminal tip；Set optical fiber in conduit cavity, fiber-optic output is adjacent with speculum and directional mirror；When operating, rotary guide pipe makes speculum make that the photic ultrasonic signal of tissue generation need to be scanned, lateral signal receiving device is according to signal generation scan image through optical fiber, speculum emission pulse laser towards that need to scan tissue, light source；The utility model irradiates through per urethram carrying out a wide range of light of lossless introversive side lighting-out tpye to prostata tissue with preferable luminous intensity, and the scanning probe by being placed in intrarectal lateral focal length area ultrasonic transducer deploys noninvasive ultrasonic reception operation, the three-dimensional photoacoustic imaging of a wide range of, big depth can be achieved.
Description
Technical field
Medical diagnostic apparatus is the utility model is related to, especially a kind of lateral scanning photoacoustic imaging for prostate fills
Put.
Background technology
For example same front and rear slightly flat inversion chestnut of prostate profile, it is deep to ensconce bone between bladder and urethra reproduction diaphragm
In basin, before paste pubic symphysis, behind according to rectum, centre be installed with urethra, determine that prostate position is hidden, be not easy the spy examined
Point.Photoacoustic imaging technology will unavoidably solve two problems in the application of tumor of prostate early detection：It is deep penetration, comprehensive
Non-invasive light sound excite and undamaged supersonic sounding.
Focusing optical acoustic scanning imaging presses certain repetition rate irradiated tissue using short-pulse laser, because light absorbs are adiabatic
Expansion and caused ultrasonic signal after the propagation in tissue, can be in tissue surface focused transducer receive.
And focused ultrasonic transducer is due to the characteristic responded with the photoacoustic signal in Zhi Duiqijiao areas, the ultrasonic signal gathered
It is mainly derived from its Jiao Qu, therefore by burnt area's point by point scanning organizer of ultrasonic transducer, combines longitudinal optoacoustic of multiple positions
Signal can be obtained by the two-dimentional light absorbs figure of organizer.The focal spot that the spatial resolution of this method depends on transducer is big
It is small.When focused transducer is the probe in focal length area, the one-dimensional time resolution optoacoustic on transducers focus axial direction can also be utilized
Signal, the anti-organizer that releases combine plane orthogonal to the axial direction in the upward energy absorption distribution of ultrasonic transducer focal axis
Transversal scanning obtained by multiple longitudinal signals, you can form a 3-D view, have imaging algorithm it is simple the characteristics of.This
The lateral resolution of the image of sample still depends on the focal spot size of transducer；Longitudinal frame is then by the frequency range of photoacoustic signal
Determined with the response time of ultrasonic transducer.
For prostate, the image quality of optical acoustic scanning imaging depends greatly on radiation modality, such as in gland
In vitro（Belly or rectum）Light irradiation is carried out, then is easily caused light penetration depth insufficient by the serious optical attenuation of peripheral organization,
Especially urethra side body of gland and external irradiation light source distance is larger, and its light absorbs energy seriously diminishes, it is difficult to carries out effective light
Sound excites；It is internal and the interior lights irradiation that per urethra is carried out can allow have more fully energy absorption inside prostata tissue
Light absorbs distribution is larger, in fact, per urethra optical transport mode and the prostate photodynamic therapy realized have obtained generally
Use, this shows that the inside photo-acoustic excitation that per urethra is carried out has great Clinical feasibility.
The technical principle method for the tumor of prostate optoacoustic Non-Destructive Testing that the irradiation of per urethra interior lights is carried out is lateral letter
Number excitaton source per urethra inserts and irradiates prostate, is absorbing weaker normal gland tissue and is absorbing stronger tumor region production
The ultrasonic signal of raw strength difference, because the spread speed of light in the tissue is much larger than the velocity of sound in organizer, so in sample
What photoacoustic signal caused by absorber can be regarded as while was excited substantially.And the distance of the absorber of diverse location and probe
Difference, its caused photoacoustic signal can be received after different time delays by probe, and therefore, the position of target absorption body can
Determined by the photoacoustic signal propagation time；In addition, the amplitude of photoacoustic signal and the direct phase of energy absorption degree of target absorption body
Close, therefore the energy absorption situation of target absorption body can also be understood from the range value of photoacoustic signal.For tumor of prostate
Caused photoacoustic signal can then make full use of the adjacent rectal void of rear side, be put by lateral focal length area focused ultrasonic transducer
Non-Destructive Testing is peeped in being carried out in rectum.Transducer is axially carrying out detecting around axle sectoring on some position first, hereafter,
Rotary positioning apparatus rotary guide pipe changes the irradiation orientation of pulse laser, to produce the ultrasonic signal in new orientation；Signal receives dress
Put continuation and progress sectoring detection is driven by rotating stepper motor.The electricity containing radially time-resolved ultrasound information exported
Signal inputs oscillograph after amplifier amplifies, filtered and handled by computer, and computer generates according to multi-faceted ultrasonic signal
Scan image is simultaneously spliced, and realizes the comprehensive two-dimensional imaging that need to scan tissue.Connect by electronic control translation stage drive signal
Receiving apparatus produces axial translation, and the covering of the fan rotation that signal receiving device continues to make under multidirectional irradiation on new axial location is swept
Retouch, can so complete to cover scanning around axle sector scan and axial translation for prostate and perienchyma, realize whole sample
The collection of three-dimensional light energy deposition distribution data, so as to obtain the function comprising physiology and pathological information of prostata tissue into
As figure.Because the focused transducer based on focal length area detects photoacoustic signal, the feelings of transducer lengthwise position can need not adjusted
Longer effective imaging region is obtained under condition, so as to conveniently realize the photoacoustic imaging of higher depth tissue；So medical worker is just
The hurtless measure external detection to the prostate cancer of hidden focus can be realized.
But the detection of higher depth tissue needs scanning imaging technology to have enough imaging depths, also implies that receiving is swept
Enough intensities of illumination are must assure that in the target retouched.The photo-acoustic excitation used currently for the photoacoustic imaging system of prostate is more
For through at belly or rectum irradiate, using mode of excitation inside dispersion fiber because light path is discrete so that on target detection face
Light energy it is weaker, one side light penetration depth deficiency, easily influences unilateral imaging depth when causing same energy input；And
Some such lateral old systems need to spend time multiple rotary light source to ensure to see because light irradiation area is smaller in experiment
Whole absorbers are observed, have severely impacted scan efficiency；During additionally, due to prostate photo-acoustic detection, rectal void is preferred
The place of ultrasound signal receipt device, and arrayed ultrasonic transducer is limited to rectal void can only carry out the signal of limited angle
Collection, it is difficult to obtain enough data, easily influence imaging depth and precision, extreme difficulties are brought to image reconstruction.If examining
Need to carry out receiver the signal for receiving new orientation apart from lateral displacement to adjust directional bearing to be used for greatly during survey, it will cause
The serious discomfort of subject；How to solve these be related to deep penetration, comprehensive non-invasive light sound excite and not damaged ultrasound visit
The problem of survey, it is a significant research direction.
The content of the invention
, can be through per urethram with preferable the utility model proposes a kind of lateral scanning opto-acoustic imaging devices for prostate
Luminous intensity carries out lossless introversive side lighting-out tpye to human prostate tissues, and scan-type light irradiates in a big way, and by being placed in
The ultrasonic waves no-wound scanning probe of lateral focal length area ultrasonic transducer in human rectum, the three of a wide range of, big depth can be achieved
Tie up photoacoustic imaging.
The utility model uses following technical scheme.
A kind of lateral scanning opto-acoustic imaging devices for prostate, the lateral scanning opto-acoustic imaging devices include lateral
Signal excitation source and lateral signal receiving device, the lateral signal excitation source include optical fiber, speculum, conduit and pulse laser
Light source；The conduit is the detection conduit that can be inserted into position to be detected；Catheter tip for can lateral printing opacity light transmitting terminal, light sends out
Penetrate at the tip of end and be provided with the speculum set with conduit bevel；Conduit top is connected with rotary positioning apparatus；The catheter tube
Intracavitary sets optical fiber, and the optic fibre input end is connected with pulsed laser light source；Fiber-optic output be located at light transmitting terminal and with reflection
Mirror is adjacent, and fiber-optic output tip is polished to, the light direction directional mirror of fiber-optic output vertical with optical fiber body；It is described
Lateral signal receiving device is lateral submerged long-focus area focused ultrasonic probe, ultrasonic receiver；When laterally scanning photoacoustic imaging fills
When putting work, rotary positioning apparatus rotary guide pipe makes speculum, and towards that need to scan tissue, pulsed laser light source is through optical fiber, speculum
To that need to scan tissue emissions pulse laser, tissue need to be scanned by, which making, produces photic ultrasonic signal；The reflection set with conduit bevel
Mirror converts it towards orientation as needed；Signal receiving device receives the lower caused letter of each orientation irradiation in a manner of sectoring
Number and deliver to external computer, computer is according to the folk prescription position of signal generation X/Y plane or the comprehensive two dimensional image being spliced into；
The signal receiving end of lateral signal receiving device is on translation stage, when signal receiving end is moved to change its reception on Z axis
During position, external computer is handled the signal of new and old received bit to realize the three-dimensional photoacoustic imaging on the XYZ axles of scanning target.
The optical fiber is end-fire multimode fibre, be provided with the smooth transmitting terminal tip with conduit set into 45 degree of angles it is anti-
Penetrate mirror.
The catheter outer diameter scope is identical with common Medical urethral catheter external diametrical extent.
The lateral signal receiving device is lateral submerged long-focus area focused transducer.
The translation stage is electronic control translation stage, and electronic control translation stage is loaded with rotating stepper motor, and the lateral signal receives dress
The signal receiving end put is connected with rotating stepper motor, and rotating stepper motor changes the reception direction of signal receiving end, automatically controlled flat
Moving stage carrying signal receiving terminal moves on Z axis.
The lateral scanning opto-acoustic imaging devices human prostate is carried out the method for work of lateral scanning photoacoustic imaging according to
It is secondary to comprise the following steps；
A1, conduit inserted through catheter or direct per urethra insertion human prostate position, make the light transmitting terminal of conduit
Positioned at the side that need to scan tissue, nothing outside progress body of gland in the signal receiving end insertion human rectum of lateral signal receiving device
Create ultrasonic reception operation；
A2, rotary positioning apparatus rotary guide pipe make speculum light direction need scanning group towards conduit light transmitting terminal side
Knit；
A3, pulsed laser light source, to that need to scan tissue emissions pulse laser, make that tissue generation need to be scanned through optical fiber, speculum
Photic ultrasonic signal；
A4, the signal receiving end receive ultrasonic signal, while lateral signal receiving device changes letter under static state
Towards to realize the signal receiving plane of fan-shaped track, signal receiving device reaches the ultrasonic signal data received for number receiving terminal
External computer, computer generate the scan image of folk prescription position according to ultrasonic signal；
A5, rotary positioning apparatus rotary guide pipe change the irradiation orientation of pulse laser, and lateral signal receiving device signal connects
Data are reached external computer by receiving end after original position continuation covering of the fan receives ultrasonic signal caused by new irradiation orientation,
Computer generates the scan image in new orientation according to ultrasonic signal and spliced until obtaining comprehensive two dimensional image；
After A6, lateral signal receiving device are moved to new position by electronic control translation stage drive on Z axis, to this XY axial plane
On multidirectional irradiation under caused ultrasonic scanning signal re-start fan-shaped reception, computer is believed according to lateral signal receiving device
After number receiving terminal generates and spliced new comprehensive two-dimensional scan image in all ultrasonic signals that new position receives, then
With the two-dimensional image data merging treatment that is obtained in step A5 to generate the three-dimensional imaging for the XYZ axles that need to scan tissue.
The ultrasonic signal that the transducer receives is sent after carrying out amplitude limit, shaping, filtering and amplification by ultrasonic pulse receiver
Enter digital oscilloscope, the digital oscilloscope ultrasonic signal take multiple averaging handle after through GPIB cards obtained by processing
Data deliver to computer.
The spacing of the fiber-optic output and speculum is 5mm, and the fiber-optic output, speculum are consolidated with adhesive
It is fixed.
The pulsed laser light source for can output wavelength be 680-1000nm wave band continuously adjustabe pulse lasers or independence
Export that 532nm or 1064nm wavelength pulsed lasers, pulsewidth 6-8ns, individual pulse energy are about 4mJ, repetition rate 10Hz swashs
The OPO pulse lasers of light beam, the optically coupled device of pulse laser input laser to optical fiber.
In the utility model, lateral signal excitation source include end-fire end-fire multimode fibre (numerical aperture 0.25,
Diameter 1.5mm) and one piece of 45 degree of inclination angle speculum and conduit；Optical fiber connector throws flat and, end and speculum vertical with optical axis
Have one section of about 5mm distance, because optical fiber output light has certain angle of divergence (29 degree), then reach speculum hot spot compared with
Greatly, after the reflex of oblique angle speculum is further amplified, light beam arrives tissue to be approximately perpendicular to the irradiation of the direction of optical fiber
Sample, help to realize compared with large spot（Diameter 5mm) lateral irradiation；Due to the lateral Radiation Characteristics of lateral light source, and instead
The characteristics of reflective light intensity of penetrating mirror is preferable, optical energy loss is small, improves the photoacoustce signal intensity for needing emphasis scanning area so that this
Utility model is more suitable for tumour orientation and substantially understood, but needs the diagnosis occasion further confirmed that.
In the utility model, key area scanning easily can be only carried out, conduit need to be only rotated to predetermined angular
, without the receiving terminal of overall transverse shifting ultrasonic probe, ultrasonic receiver, so as to improve sweep speed；When doctor is only concerned urine
When road one side absorber is distributed and is not intended to understand urethra surrounding whole absorber information, unilateral imaging of the present utility model
Feature then can more meet such the needs of carrying out diagnostic scan to key area, and due to sweep speed quickening and scanning information measures
With simplification, the speed of doctor's examination garbage is improved, so as to improve diagnosis and treatment efficiency.
In the utility model, fiber-optic output tip is polished to, the light direction of fiber-optic output vertical with optical fiber body
Directional mirror；The design make it that the emergent light of fiber-optic output is more neat, goes out light dispersion caused by reducing concave plane,
So as to help to lift output intensity.
In the utility model, the lateral signal receiving device is lateral submerged long-focus area focused transducer；
The photoacoustic signal in its burnt area is responded because focused ultrasonic transducer has, it is several to the photoacoustic signal response outside its Jiao Qu
The characteristic for being zero, the ultrasonic signal gathered are mainly derived from the region where its focus, therefore by Jiao of ultrasonic transducer
Point by point scanning organizer of area, combine the two-dimentional light absorbs figure that multiple position longitudinal directions photoacoustic signal can be obtained by organizer；Therefore
The utility model is rotated to predetermined angular with conduit first when carrying out lateral photoacoustic imaging to prostata tissue body, lateral
Focal length area ultrasonic transducer is axially carrying out detecting around axle sectoring on some position, and what is exported is time-resolved containing radial direction
The electric signal of ultrasound information inputs oscillograph after amplifier amplifies, filtered and handled by computer；Hereafter, rotary positioning apparatus revolves
Turn the irradiation orientation of change conduit, computer continues the sectoring for driving lateral signal receiving device to carry out new orientation photoacoustic signal
Detection.Computer generates scan image and spliced according to caused ultrasonic signal under multidirectional irradiation respectively, and realization need to be swept
Retouch the comprehensive two-dimensional imaging of tissue；Lateral signal receiving device can do axially flat via the two-dimension translational of electronic control translation stage
Move, continue on new axial location under multidirectional irradiation around axle scanning probe, can so complete to cover whole forefront
The collection of the three-dimensional light energy deposition distribution data of adenoid product, so as to obtain prostata tissue comprising physiology and pathological information
Functional imaging figure, the lateral imaging method carried out with the utility model can realize the multi-orientation detection to scanning target, therefore
Imaging is more reliable；Additionally due to prostate is one of minimum organ of human body, due to output intensity of the present utility model and model
When enclosing and ensured, therefore being detected by the utility model device, intrarectal focal length area ultrasonic probe, ultrasonic receiver only needs to protect
Hold and carry out that slightly the whole tissue of range of receiving covering can be made around axial displacement in rectum, solve using conventional medical array
Formula ultrasonic transducer can only gather limited angle photoacoustic signal and cause image reconstruction to have the problem of arduous and complexity, nothing
Its horizontal receiving position must be changed, the inspection that can greatly reduce the personnel of being checked is uncomfortable.
Compared with traditional fiber light source, the utility model is simple easily standby, and cost is low, makes simply, is advantageous to irradiation direction
In a big way with the imaging of absorber Embedded in depth, it is weaker to solve the current lateral light emission rate of column dispersion fiber, is easily caused list
Sidelight penetration depth deficiency and the problem of influence unilateral imaging depth；With the lateral light source phase of the existing total reflection principle based on light
Than it can be avoided to need to spend time multiple rotary light source all to absorb to ensure to observe in experiment because irradiation luminous point is small
The shortcomings that body.
When the lateral light source of the utility model design is used for internal photo-acoustic excitation, there is preferable stationkeeping ability to absorber
And imaging capability, unilateral areas imaging is bigger, has absolutely proved advantage of the lateral light source in one side imaging, and specific
Imaging operation in, operating personnel can pass through lateral light source rotation change other orientation imaging of absorber Embedded；In view of morning
That is at the rear of prostate, the lateral light source is expected to turn into early stage the peripheral zone that phase prostate cancer mostly occurs in prostate
A kind of new light-source structure in prostate cancer photoacoustic imaging technology, has important value.
Brief description of the drawings
With reference to the accompanying drawings and detailed description to the further details of explanation of the utility model：
Accompanying drawing 1 is imaging device principle schematic of the present utility model；
Accompanying drawing 2 is the light extraction schematic diagram of conduit light transmitting terminal of the present utility model；
Accompanying drawing 3 is the light extraction schematic diagram on the other direction of conduit light transmitting terminal of the present utility model；
Accompanying drawing 4 is optical fiber of the present utility model, the cut-away illustration at speculum；
Accompanying drawing 5 is imaging results schematic diagram of the present utility model；
Accompanying drawing 6 is another schematic diagram of imaging results of the present utility model；
In figure：1- pulsed laser light sources；2- conduits；The light transmitting terminal of 3- conduits；The lateral signal receiving devices of 4-（It is focusing
Focal length area ultrasonic probe, ultrasonic receiver）；5- rectum；6- urethras or catheter；7- need to scan tissue（Tumor of prostate）；8- is automatically controlled flat
Moving stage；9- rotating stepper motors；10- computers；11- speculums；12- optical fiber；13- digital oscilloscopes；14- rotating stepper motors
Rotating shaft；15- rotary positioning apparatus.
Embodiment
As shown in figures 1 to 6；A kind of lateral scanning opto-acoustic imaging devices for prostate, the lateral scanning photoacoustic imaging
Device includes lateral signal excitation source and lateral signal receiving device, and the lateral signal excitation source includes optical fiber 12, speculum
11st, conduit 2 and pulsed laser light source 1；The conduit 2 is the detection conduit that can be inserted into position to be detected；The end of conduit 2 is can side
To the light transmitting terminal 3 of printing opacity, the speculum 11 set with conduit bevel is provided with the tip of light transmitting terminal 3；The top of conduit 2 and rotation
Rotation positioning device is connected；Optical fiber 12 is set in the conduit cavity, the input of optical fiber 12 is connected with pulsed laser light source 1；Light
Fine output end be located at it is at light transmitting terminal and adjacent with speculum 11, fiber-optic output tip be polished to it is vertical with the body of optical fiber 12,
The light direction directional mirror 11 of fiber-optic output；The lateral signal receiving device focuses on for lateral submerged long-focus area
Formula ultrasonic probe, ultrasonic receiver 4；When laterally scanning opto-acoustic imaging devices work, rotary positioning apparatus rotary guide pipe 2 makes speculum
11 towards that need to scan tissue, and pulsed laser light source, to that need to scan the emission pulse laser of tissue 7, makes to need through optical fiber 12, speculum 11
Scanning tissue 7 produces photic ultrasonic signal；The speculum set with conduit bevel converts it towards orientation as needed；Signal
Reception device is received the lower caused signal of each orientation irradiation in a manner of sectoring and delivers to external computer, and computer is according to signal
Generate the comprehensive two dimensional image that is folk prescription position or being spliced into of X/Y plane；The signal receiving end of lateral signal receiving device is set
In on translation stage, when signal receiving end is being moved to change its received bit on Z axis, signal of the external computer to new and old received bit
Handled to realize the three-dimensional photoacoustic imaging on the XYZ axles of scanning target.
The optical fiber 12 is end-fire multimode fibre, is provided with the smooth tip of transmitting terminal 3 and is set with conduit 2 into 45 degree of angles
Speculum 11.
The external diametrical extent of conduit 2 is identical with the common external diametrical extent of Medical urethral catheter 6.
The lateral signal receiving device is lateral submerged long-focus area focused transducer.
The translation stage is electronic control translation stage, and electronic control translation stage is loaded with rotating stepper motor 9, and the lateral signal receives dress
The signal receiving end put is connected with rotating stepper motor（It is connected with rotating shaft 14）, rotating stepper motor changes signal receiving end and connects
Debit is to electronic control translation stage carrying signal receiving terminal moves on Z axis.
In this example, electronic control translation stage is fixed in sleeve pipe, is connected by screw mandrel with miniature rotating stepper motor, ultrasonic transduction
Device is fixed on the motor shaft of miniature electric rotating machine, and casing wall is the sound transmitting window for having thickness to be 0.5mm below ultrasonic transducer, thoroughly
Sound window axial length is 40mm, and sound transmitting window is 60 degree to motor shaft subtended angle.Overall package is in sleeve pipe.
The lateral scanning opto-acoustic imaging devices human prostate is carried out the method for work of lateral scanning photoacoustic imaging according to
It is secondary to comprise the following steps；
A1, conduit 2 inserted through catheter 6 or direct per urethra insertion human prostate position, launch the light of conduit
End is positioned at the side that need to scan tissue, outside progress body of gland in the signal receiving end insertion human rectum of lateral signal receiving device
Noninvasive ultrasonic reception operation；
A2, rotary positioning apparatus rotary guide pipe 2 sweep the need of the light direction of speculum 11 towards the side of conduit light transmitting terminal 3
Retouch tissue 7；
A3, pulsed laser light source 1, to that need to scan the emission pulse laser of tissue 7, make to need scanning group through optical fiber 12, speculum 11
Knit 7 generation ultrasonic signals；
A4, the signal receiving end receive ultrasonic signal, while lateral signal receiving device changes letter under static state
Number receiving terminal is towards to realize the signal receiving plane of fan-shaped track（Sector is fan-shaped around axle）, signal receiving device is receiving
Ultrasonic signal data reach external computer, and computer generates the scan image of folk prescription position according to ultrasonic signal；
A5, rotary positioning apparatus rotary guide pipe change the irradiation orientation of pulse laser, and lateral signal receiving device signal connects
Data are reached external computer by receiving end after original position continuation covering of the fan receives ultrasonic signal caused by new irradiation orientation,
Computer generates the scan image in new orientation according to ultrasonic signal and spliced until obtaining comprehensive two dimensional image；
After A6, lateral signal receiving device are moved to new position by electronic control translation stage drive on Z axis, to this XY axial plane
On multidirectional irradiation under caused ultrasonic scanning signal re-start fan-shaped reception, computer is believed according to lateral signal receiving device
After number receiving terminal generates and spliced new comprehensive two-dimensional scan image in all ultrasonic signals that new position receives, then
With the two-dimensional image data merging treatment that is obtained in step A5 to generate the three-dimensional imaging for the XYZ axles that need to scan tissue.
The ultrasonic signal that the transducer receives is sent after carrying out amplitude limit, shaping, filtering and amplification by ultrasonic pulse receiver
Enter digital oscilloscope 13, the digital oscilloscope 13 ultrasonic signal take multiple averaging handle after through GPIB cards handling
The data obtained delivers to computer.
The output end of optical fiber 12 and the spacing of speculum 11 are 5mm, and the output end of optical fiber 12, speculum 11 are with viscous
Mixture is fixed.
The pulsed laser light source for can output wavelength be 680-1000nm wave band continuously adjustabe pulse lasers or independence
Export that 532nm or 1064nm wavelength pulsed lasers, pulsewidth 6-8ns, individual pulse energy are about 4mJ, repetition rate 10Hz swashs
The OPO pulse lasers of light beam, the optically coupled device of pulse laser input laser to optical fiber.
The optical fiber is numerical aperture 0.25, diameter 1.5mm end-fire multimode fibre.
In this example, when carrying out human prostate's scanning photoacoustic imaging, mobile performance of the signal receiving end on Z axis
For motion of retreating of the signal receiving end at human rectum position.
Pulse laser is taken to realize adopting for photoacoustic signal for synchronous triggering signal trigger data acquisition computer operation in this example
Collection record.
In this example, because prostate volume is small（Upper end transverse diameter about 4cm, vertical diameter about 3cm, anteroposterior diameter about 2cm）, and it is lateral
Signal excitation source is larger to irradiation range（2-3cm）, it is only necessary to the lateral irradiation of four direction can cover global tissue.And
The signal receiving device being connected with rotating stepper motor rotating shaft need to only be driven by rotating stepper motor and done in four times in rectal void
Low-angle can completely receive the ultrasonic scanning signal for being related to whole body of gland around axle sectoring.
Conventional adult's catheter has tetra- kinds of models of 12F, 14F, 16F, 18F, and its external diameter is 4-6mm.The catheter outer diameter
In the catheter external diametrical extent generally used.
When testing the present apparatus, human prostate can be simulated using simulated tissue, its preparation method is analog sample base
Bottom is by agar powder（2g）, distilled water (100ml), Fat Emulsion 20ml（Concentration 20%）Heating is poured into column glassware and condensed into, greatly
It is small to be（4.5*4.5*5cm）, centre is reserved with 6mm through holes simulation urethra, and simulates tumour with carbon-point.
Claims (8)
- A kind of 1. lateral scanning opto-acoustic imaging devices for prostate, it is characterised in that：The lateral scanning photoacoustic imaging dress Put includes optical fiber, speculum, conduit including lateral signal excitation source and lateral signal receiving device, the lateral signal excitation source And pulsed laser light source；The conduit is the detection conduit that can be inserted into position to be detected；Catheter tip for can lateral printing opacity light Transmitting terminal, the speculum set with conduit bevel is provided with light transmitting terminal tip；Conduit top is connected with rotary positioning apparatus； Optical fiber is set in the conduit cavity, the optic fibre input end is connected with pulsed laser light source；Fiber-optic output is located at light transmitting terminal Place is simultaneously adjacent with speculum, and fiber-optic output tip is polished to, the light direction sensing of fiber-optic output vertical with optical fiber body Speculum；The lateral signal receiving device is lateral submerged long-focus area focused ultrasonic probe, ultrasonic receiver；Swept when laterally When retouching opto-acoustic imaging devices work, rotary positioning apparatus rotary guide pipe makes speculum direction to scan tissue, pulsed laser light source Through optical fiber, speculum to that need to scan tissue emissions pulse laser, tissue need to be scanned by, which making, produces photic ultrasonic signal；With conduit into oblique The speculum that angle is set converts it towards orientation as needed；Signal receiving device is received each orientation in a manner of sectoring and shone Penetrate lower caused signal and deliver to external computer, computer is according to the folk prescription position of signal generation X/Y plane or is spliced into comprehensive Two dimensional image；The signal receiving end of lateral signal receiving device on translation stage, when signal receiving end moved on Z axis with When changing its received bit, external computer is handled the signal of new and old received bit to realize three on the XYZ axles of scanning target Tie up photoacoustic imaging.
- A kind of 2. lateral scanning opto-acoustic imaging devices for prostate according to claim 1, it is characterised in that：It is described Optical fiber is end-fire multimode fibre, and the speculum set with conduit into 45 degree of angles is provided with the smooth transmitting terminal tip.
- A kind of 3. lateral scanning opto-acoustic imaging devices for prostate according to claim 2, it is characterised in that：It is described Catheter outer diameter scope is identical with common Medical urethral catheter external diametrical extent.
- A kind of 4. lateral scanning opto-acoustic imaging devices for prostate according to claim 3, it is characterised in that：It is described Lateral signal receiving device is lateral submerged long-focus area focused transducer.
- A kind of 5. lateral scanning opto-acoustic imaging devices for prostate according to claim 4, it is characterised in that：It is described Translation stage is electronic control translation stage, and electronic control translation stage is loaded with rotating stepper motor, and the signal of the lateral signal receiving device receives End is connected with rotating stepper motor, and rotating stepper motor changes the reception direction of signal receiving end, electronic control translation stage carrying signal Receiving terminal moves on Z axis.
- A kind of 6. lateral scanning opto-acoustic imaging devices for prostate according to claim 5, it is characterised in that：It is described The ultrasonic signal that transducer receives is sent into digital oscilloscope after carrying out amplitude limit, shaping, filtering and amplification by ultrasonic pulse receiver, The digital oscilloscope to the ultrasonic signal take multiple averaging through GPIB cards processing the data obtained to be delivered to calculating after handling Machine.
- A kind of 7. lateral scanning opto-acoustic imaging devices for prostate according to claim 1, it is characterised in that：It is described The spacing of fiber-optic output and speculum is 5mm, and the fiber-optic output, speculum are fixed with adhesive.
- A kind of 8. lateral scanning opto-acoustic imaging devices for prostate according to claim 1, it is characterised in that：It is described Pulsed laser light source for can output wavelength be 680-1000nm wave band continuously adjustabe pulse lasers or independent output 532nm or 1064nm wavelength pulsed lasers, pulsewidth 6-8ns, individual pulse energy are about 4mJ, the OPO arteries and veins of repetition rate 10Hz laser beam Laser is rushed, the optically coupled device of pulse laser inputs laser to optical fiber.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106691391A (en) * | 2017-02-09 | 2017-05-24 | 集美大学 | Lateral scanning photoacoustic imaging method and device for prostate glands |
| WO2020093239A1 (en) * | 2018-11-06 | 2020-05-14 | Shenzhen Xpectvision Technology Co., Ltd. | Apparatus for imaging the prostate |
-
2017
- 2017-02-09 CN CN201720119767.5U patent/CN207055480U/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106691391A (en) * | 2017-02-09 | 2017-05-24 | 集美大学 | Lateral scanning photoacoustic imaging method and device for prostate glands |
| CN106691391B (en) * | 2017-02-09 | 2023-06-23 | 集美大学 | Lateral scanning photoacoustic imaging method and device for prostate |
| WO2020093239A1 (en) * | 2018-11-06 | 2020-05-14 | Shenzhen Xpectvision Technology Co., Ltd. | Apparatus for imaging the prostate |
| CN112930485A (en) * | 2018-11-06 | 2021-06-08 | 深圳帧观德芯科技有限公司 | Prostate imaging device |
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