CN102138809A - Opto-acoustic scan imaging method and device for detecting prostate - Google Patents
Opto-acoustic scan imaging method and device for detecting prostate Download PDFInfo
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Abstract
The invention discloses an opto-acoustic scan imaging method and an opto-acoustic scan imaging device for detecting prostate, and relates to an opto-acoustic method for detecting the human prostate. The method comprises the following steps that; an ultrasonic transducer receives an ultrasonic wave signal and transmits the ultrasonic wave signal to a data acquisition card for digitalizing the signal, and the data acquisition card transmits the digitalized data to a computer for imaging. The method is characterized in that: an optical fiber of which the front end part is a soft diffuse optical fiber enters the prostate part through human urethra, and the laser of a laser generator is transmitted via the optical fiber, and is emitted in the radial direction of the circumference and on the end surface of the prostate through the soft diffuse optical fiber to perform light irradiation on the inner wall of the prostate. The invention has the advantages that: the multi-mode end part diffuse optical fiber is adopted to transmit the multi-wave length laser, and the optical fiber end part emits the diffuse laser in the radial direction of the circumference and the end surface. After the optical fiber enters the prostate part via the urethra, the optical fiber can realize uniform laser irradiation on each part of the prostate in all dimensions simultaneously. The immersion type long lens area ultrasonic transducer is placed inside rectum for detecting the opto-acoustic signal formed in the prostate, and the resolution is high.
Description
Technical field:
The present invention relates to human body prostate photo-acoustic detection method, particularly prostate optical acoustic scanning imaging detection method and device.
Background technology:
The prostate detection method mainly is now: digital rectal examination is checked in conjunction with blood-serum P SA, is carried out the ultrasound diagnosis of rectum prostate in case of necessity.Digital rectal examination refers to the doctor and touches patient's prostate with the finger per anum, feels to judge by finger tip whether prostate has hard tubercle, can only check out 25% carcinoma of prostate.It is prostatic cancer specific tumor index that blood-serum P SA is known as, general with the PSA value greater than the marginal value of 4ng/ml as the prostate examination, it not is to mean certain trouble carcinoma of prostate that but the PSA value raises, because hyperplasia of prostate, acute and chronic prostatitis, digital rectal examination, even (be equivalent to massage of prostate) by bike and rectum prostate ultrasound diagnosis etc. can cause that all blood-serum P SA increases.Because the prostata tissue structure, per-rectum ultrasonic seeking and visiting can only be observed prostate overall dimensions and position, can not determine to ensconce the size and the position of malignant tumor wherein.Therefore, if find suspicious unusually, then need to carry out the aspiration biopsy of prostatic gland art.Biopsy can provide definite carninomatosis reason diagnostic message, generally can not produce false positive, is that all cancers comprise the goldstandard that carcinoma of prostate is checked at present.Though false positive has been got rid of in the biopsy of Transrectal Ultrasound guiding, also can produce significant false negative.The recall rate of general single puncture has only 60～70%, and the prostata tissue that puncture obtains can not be represented whole prostata tissue.Therefore, under suspicious situation about can not get rid of, need carry out repeated puncture, till cancer detects (positive) or under the negative findings situation, continue tight monitoring and follow up a case by regular visits to digital rectal examination, blood-serum P SA inspection and the ultrasound diagnosis of rectum prostate.Though the biopsy technology of endorectal ultrasonography guiding has greatly improved, and still has bigger risk.Because centering on prostatic is the nerve and the vascular bundle of bunchiness,, might cause male erectile dysfunction if in the aspiration biopsy diagnosis, damage its nerve.In addition, aspiration biopsy also might cause complication such as infection and haemophilia, even can cause the transfer of cancer.Therefore, novel harmless and effective prostate detection method still is urgent and very important.The place of this meaning of the present invention just.
As everyone knows, the optical property of tissue and its pathological state are closely related, as: the malignant tumor that increases needs a large amount of blood supplies fast, and tumor of prostate also is so, and it is abundant that the result always contains blood.Contain hemoglobin in the blood, the blood absorption near infrared light is stronger than other tissue, and the contrast of optical detection method is than high many of common supersonic detection method, and the spectral information of tissue can provide valuable diagnosis basis.In addition, method of optics and have the advantage that the low and patient of equipment cost avoids ionizing radiation (as the X-ray) harm concurrently.Therefore, the optical diagnostic means of biological tissue is subjected to the deepest concern of Chinese scholars institute for many years.But simple optical imagery is because tissue to the strong scattering of light, causes the investigation depth deficiency, and resolution is not high.So the optoacoustic effect of just being found and being applied by Bell in 1880 is used to carry out function of organization's imaging, and has become a kind of emerging harmless medical imaging technology.In simple terms, photoacoustic imaging is a kind of imaging of tissue technology in conjunction with optics and ultrasonic technique.This technology is based on photic ultransonic physical effect, by detecting the difference that photoacoustic signal reflects the light energy absorption of organizer; Therefore the photoacoustic imaging technology well combines optics and ultrasonic these two kinds of imaging techniques advantage separately.At first, be ultrasonic signal owing to what survey, so this technology has overcome the deficiency that pure optical image technology can not get both on imaging depth and resolution.Secondly, the image difference of photoacoustic technique derives from the difference of organizer optical absorption; This can overcome effectively pure ultrasonic imaging technique soft tissue contrast and functional aspect defective.Therefore, photoacoustic technique can realize the high-resolution of the big degree of depth of organizer, the functional imaging of high-contrast.
In recent years, there are 10 research groups to be engaged in the diagnosis research of the carcinoma of prostate that optics combines with ultrasonic technique in the world approximately, have only the paper of nearly about 20 pieces prostate photoacoustic imaging in meeting, to report or deliver so far at magazine.These are at prostatic photoacoustic imaging scheme, though be confined to the checking of phantom more, but all affirmed the imaging advantage of optics and combination of ultrasound fully, that is: taken into account sufficiently high contrast sensitivity, dark investigation depth with and submillimeter resolution.But, these schemes all use a computer unlimitedly the chromatographic technique route and with rectum as pulsed light excitation and ultrasound detection place, use the supersonic sounding array to gather more weak photoacoustic signal because of the rectum space is narrow and small, thereby the arduousness of the image reconstruction that causes ultrasound detection in these schemes and produce because of prostate anatomical position complexity, and have influence on Application feasibility clinically thus.
The disclosed animal prostate detection method of open source literature is: zootomy is taken a sample, then prostate is carried out direct irradiation of laser or fiber end face irradiation, fiber end face irradiation is meant that the end face of optic fibre end launches light and carry out folk prescription to irradiation, the luminous energy of prostata tissue bulk absorption then produces thermal-elastic expansion, thereby generation ultrasound wave, reuse arrayed ultrasonic transducer received ultrasonic signal, then transducer is transferred to data collecting card (A/D converter) with signal and carries out analog signal digital conversion, and A/D converter is transferred to the Computer Processing imaging with digitalized data.Arrayed ultrasonic transducer has the branch of transducer in the medical external and medical body.Current these methods also are confined to the checking of phantom, but have also all affirmed the imaging advantage of optics and combination of ultrasound fully.
When the photoacoustic signal of unofficial biography adopted the arrayed ultrasonic transducer detection and carries out inversion imaging, imaging process mainly depended on imaging algorithm.The algorithm quality is bigger to the degree of depth, the precision influence of imaging.Algorithm is had relatively high expectations to the completeness of data collection in this case.Yet, when adopting arrayed ultrasonic transducer to carry out signals collecting in vivo, can only carry out the scanning of limited angle, be difficult to obtain complete imaging data, therefore, be subject to the influence of algorithm, to the bigger influence of precision generation of imaging.
Summary of the invention:
Purpose of the present invention provides a kind of prostate optical acoustic scanning imaging detection method and device proposing new laser irradiation mode and ultrasonic receive mode.
The detection method of the solution of the present invention is: comprise that the ultrasonic transducer received ultrasonic signal is transferred to the data collecting card digitized, data collecting card is transferred to the Computer Processing imaging with digitalized data, it is characterized in that: ultrasonic signal encourages prostata tissue by the pulse laser through fiber optic conduction and produces, wherein the optical fiber leading section is soft dispersion fiber head and enters the prostate centre by the human body urethra, carries out photoirradiation during facing to the prostate inwall.
The present invention program's checkout gear comprises laser generator, ultrasonic transducer, data collecting card, computer, ultrasonic transducer is connected with the data collecting card circuit, data collecting card is connected with computer circuitry, it is characterized in that: the optical fiber leading section of laser generator is soft dispersion fiber, during detection, soft dispersion fiber per urethra places in the human body prostatic inwall.
The invention has the advantages that:
1, adopted multimode end dispersion fiber transmission multiwavelength laser, and sent disperse laser by optical fiber end, per urethra can be realized preceding irradiation uniformly to each position of prostate.
2, adopt the long burnt district of immersion type ultrasonic transducer, place internal rectum that the photoacoustic signal that prostate forms is detected and resolve pulse optoacoustic time resolution signal, its resolution can reach 0.3mm, and depth measurement Du Keda is from about 2～7cm; On horizontal detection, owing to adopt the ultrasonic probe two-dimensional scan and in conjunction with the deconvolution processing technology, realized that lateral resolution is 0.5mm, investigative range reaches 5 * 5cm
2, can cover whole prostata tissue.
Description of drawings:
Fig. 1 is the focusing ultrasonic transducer structural representation in the long burnt district of immersion type.
Fig. 2 is the A-A cutaway view of Fig. 1.
Fig. 3 is the B-B cutaway view of Fig. 1.
The specific embodiment:
Ultrasonic transducer is medical external arrayed ultrasonic transducer, is used for external received ultrasonic signal.
Ultrasonic transducer is an arrayed ultrasonic transducer in the medical body, is used to stretch into rectum short distance reception ultrasonic signal in the body.
Ultrasonic transducer is the focusing ultrasonic transducer in the long burnt district of immersion type.
Ultrasonic transducer is medical external arrayed ultrasonic transducer.
Ultrasonic transducer is an arrayed ultrasonic transducer in the medical body.
Ultrasonic transducer is the focusing ultrasonic transducer in the long burnt district of immersion type, is made up of cover for seat 8, parallel moving mechanism, reduction cover 9, rotating mechanism, ultrasonic transducer 11; Cover for seat 8 offers symmetric elongated slot for the tubular body inwall, is sheathed with sealing ring in the annular groove that front inner wall is offered, and the disk cover 1 in rear end is sealed on the tubular body rear port, offers a through hole on the disk cover 1; The micromachine 2 of parallel moving mechanism is fixed on disk cover 1 inner surface, micromachine 2 lead-out wires pass disk cover 1 through hole and are connected with power circuit, fit is fixed a screw mandrel 3 on micromachine 2 main shafts, nut seat 4 is circle ring disk of cylindrical body upper edge disjunctor extension, the screwed hole of cylindrical body rear end is linked on the screw mandrel 3, the circle ring disk cylindrical of cylindrical body is enclosed within the cover for seat 8 interior circles movingly, a pair of radially boss of circle ring disk outer disjunctor extension, and radially boss is enclosed within the elongated slot of cover for seat 8 correspondences movingly; Rotating mechanism is the circle ring disk upper surface that another micromachine 5 is fixed on cylindrical body, and circle ring disk through hole, disk cover 1 through hole that micromachine 5 lead-out wires pass cylindrical body are connected with power circuit; Described micromachine 5 main shafts are implemented to fixedly connected by axle sleeve 6 with the rear axle 7 of an engineering plastics material, rear axle 7 front end flange dishes are connected with ultrasonic transducer 11 bolt rear surface bolts, ultrasonic transducer 11 front surfaces are fixedlyed connected with front axle 12 flange plate bolts, ultrasonic transducer 11 power lines pass rear axle 7 medium pores and are connected with two slick and sly brush ring circuits on the rear axle 7 middle part cylindricals, front axle 12 offers central blind hole, this blind hole bottom is communicated with ring flange top radial hole, and a screw passes that sealing gasket is stubborn to be combined in the screw thread of front axle 12 medium pore front ports; Reduction cover 9 is a tubular body, cylindrical is enclosed within the interior circle of cover for seat 8 front ends movingly, reduction is overlapped 9 lower port cavitys and is covered on outside micromachine 5 cylindricals, fixedly connected with the circle ring disk of cylindrical body in its lower end, reduction is overlapped 9 cavitys tops tube wall brushgear 15 by the spring marble of overcoat insulation tube radially is installed in two through holes on the boss, and brushgear 15 lead-out wires are by radially back stomidium, the circle ring disk through hole of cylindrical body, disk cover 1 through hole of boss are connected with power circuit; Reduction is overlapped 9 top ultrasonic transducers, 11 spatial tube walls of living in and is provided with arc notch, and the sealing cover type is pasted with arc transparent plastic diaphragm 13 on the arc notch step opening; Reduction overlaps that 9 arc notch inwall both sides are sealed respectively to be equipped with the bearing cap 10 that bearing and inside and outside circle are equipped with sealing ring, and two bearings is covered 10 endoporus and is enclosed within movingly respectively on front axle 12, rear axle 7 cylindricals; The cap 14 that 9 upper surface cylindrical seams fixedly are sheathed with the band sealing ring is overlapped in reduction.
For prostate, because of its position hidden, if be difficult to arrive at prostate with the end face bright dipping from irradiated in vitro laser with optical fiber; Enter to tubular wall radiation with the fiber end face bright dipping from urethra and be difficult to form all irradiation of ring, irradiation when also can't realize each leaf of prostate.Using cylindric soft dispersion fiber is to send sagittal rays week and carry out closely comprehensive inwall radiation at whole section and ring, can overcome foregoing laser irradiation problem.Simultaneously, this system adopts by being built in intrarectal long burnt district focus supersonic scanning probe collection, synthetic Jiao Qu is time resolution photoacoustic signal and in conjunction with around the axial fan-shaped rotation and the photoacoustic signal of translation scan vertically radially, can obtain covering the 3D function photoacoustic imaging figure of whole prostate and perienchyma thereof, thereby characteristicness and the cancerous protuberance of exploring the carcinoma of prostate photoacoustic imaging are invaded outward and metastatic rule, for clinical accurate judgement, carcinoma of prostate excision and Comprehensive Treatment provide objective basis.The main feature of this imaging mode is the Jiao head of district of focused transducer, and the space of scanning is big, need not complicated algorithm and gets final product fast imaging.
The focusing ultrasonic transducer 11 in the long burnt district of immersion type passes through front axle 12 medium pores after water filling between two bearing caps 10, the screw shutoff, and ultrasonic transducer 11 is immersed in to act in the water and is cooling.Screw mandrel 3 rotates and makes nut seat 4 translations that constrain in the elongated slot, and drives reduction and overlap 9 translations, and micromachine 5 drives ultrasonic transducers 11 by front axle 12 and rotates, and makes it to finish translation, rotates two dimensional motion scanning.Reduction cover 9 is filled in by anus, and cover for seat 8 is stayed external, and it is short with the prostate spacing that ultrasonic transducer 11 is in the rectum, and the signal reception is good, and image is more clear.
Claims (8)
1. prostate optical acoustic scanning imaging detection method, comprise that the ultrasonic transducer received ultrasonic signal is transferred to the data collecting card digitized, the color truck of data is transferred to the Computer Processing imaging with digitalized data, it is characterized in that: it is to be the optical fiber of soft dispersion fiber with leading section that ultrasonic signal produces, enter prostatic by the human body urethra, the laser of laser generator sends laser by soft dispersion fiber radially reaching end face prostate internal ring week by the optical fiber transmission, row photoirradiation during facing to the prostate inwall.
2. a kind of prostate optical acoustic scanning imaging detection method according to claim 1, it is characterized in that: ultrasonic transducer is medical external arrayed ultrasonic transducer, is used for external received ultrasonic signal.
3. a kind of prostate optical acoustic scanning imaging detection method according to claim 1 is characterized in that: ultrasonic transducer is an arrayed ultrasonic transducer in the medical body, is used to stretch into rectum short distance reception ultrasonic signal in the body.
4. a kind of prostate optical acoustic scanning imaging detection method according to claim 1 is characterized in that: ultrasonic transducer is the focusing ultrasonic transducer in the long burnt district of immersion type.
5. prostate optical acoustic scanning imaging detection device, comprise laser generator, ultrasonic transducer (11), data collecting card, computer, ultrasonic transducer (11) is connected with the data collecting card circuit, data collecting card is connected with computer circuitry, it is characterized in that: the optical fiber leading section of laser generator is soft dispersion fiber, during detection, soft dispersion fiber per urethra places in the human body prostatic inwall.
6. a kind of prostate optical acoustic scanning imaging detection device according to claim 5 is characterized in that: ultrasonic transducer is medical external arrayed ultrasonic transducer.
7. a kind of prostate optical acoustic scanning imaging detection device according to claim 5 is characterized in that: ultrasonic transducer is an arrayed ultrasonic transducer in the medical body.
8. a kind of prostate optical acoustic scanning imaging detection device according to claim 5, it is characterized in that: ultrasonic transducer is the focusing ultrasonic transducer in the long burnt district of immersion type, is made up of cover for seat (8), parallel moving mechanism, reduction cover (9), rotating mechanism, ultrasonic transducer (11); Cover for seat (8) offers symmetric elongated slot for the tubular body inwall, is sheathed with sealing ring in the annular groove that front inner wall is offered, and the disk cover in rear end (1) is sealed on the tubular body rear port, offers a through hole on the disk cover (1); The micromachine of parallel moving mechanism (2) is fixed on disk cover (1) inner surface, micromachine (2) lead-out wire passes disk cover (1) through hole and is connected with power circuit, fit is fixed a screw mandrel (3) on micromachine (2) main shaft, nut seat (4) is circle ring disk of cylindrical body upper edge disjunctor extension, the screwed hole of cylindrical body rear end is linked on the screw mandrel (3), the circle ring disk cylindrical of cylindrical body is enclosed within the interior circle of cover for seat (8) movingly, the a pair of radially boss of circle ring disk outer disjunctor extension, radially boss is enclosed within the corresponding elongated slot of cover for seat (8) movingly; Rotating mechanism is the circle ring disk upper surface that another micromachine (5) is fixed on cylindrical body, and circle ring disk through hole, disk cover (1) through hole that micromachine (5) lead-out wire passes cylindrical body are connected with power circuit; Described micromachine (5) main shaft is implemented to fixedly connected by axle sleeve (6) with the rear axle (7) of an engineering plastics material, rear axle (7) front end flange dish is connected with ultrasonic transducer (11) bolt rear surface bolt, ultrasonic transducer (11) front surface is fixedlyed connected with front axle (12) flange plate bolt, two slick and sly brush ring circuits that ultrasonic transducer (11) power line passes on the cylindrical of rear axle (7) medium pore and rear axle (7) middle part are connected, front axle (12) offers central blind hole, this blind hole bottom is communicated with ring flange top radial hole, and a screw passes that sealing gasket is stubborn to be combined in the screw thread of front axle (12) medium pore front port; Reduction cover (9) is a tubular body, cylindrical is enclosed within the interior circle of cover for seat (8) front end movingly, reduction cover (9) lower port cavity covers on outside micromachine (5) cylindrical, fixedly connected with the circle ring disk of cylindrical body in its lower end, reduction cover (9) cavity top tube wall radially is equipped with the brushgear (15) by the spring marble of overcoat insulation tube on the boss in two through holes, brushgear (15) lead-out wire is by radially back stomidium, the circle ring disk through hole of cylindrical body, disk cover (1) through hole of boss are connected with power circuit; Reduction cover (9) top ultrasonic transducer (11) spatial tube wall of living in is provided with arc notch, and the sealing cover type is pasted with arc transparent plastic diaphragm (13) on the arc notch step opening; Reduction cover (9) arc notch inwall both sides are sealed respectively to be equipped with the bearing cap (10) that bearing and inside and outside circle are equipped with sealing ring, and two bearings lid (10) endoporus is enclosed within respectively on front axle (12), rear axle (7) cylindrical movingly; Reduction cover (9) upper surface cylindrical seam fixedly is sheathed with the cap (14) of band sealing ring.
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| CN 201110038731 CN102138809A (en) | 2011-02-15 | 2011-02-15 | Opto-acoustic scan imaging method and device for detecting prostate |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105167804A (en) * | 2015-10-30 | 2015-12-23 | 天津迈达医学科技股份有限公司 | Monocrystal miniature ultrasonic scan probe |
| CN105167808A (en) * | 2015-09-02 | 2015-12-23 | 上海爱声生物医疗科技有限公司 | Transurethral ultrasound prostate detection method, diagnostic apparatus and transducer |
| CN106413567A (en) * | 2014-05-20 | 2017-02-15 | 日本电波工业株式会社 | Ultrasound probe |
| CN107468283A (en) * | 2017-07-25 | 2017-12-15 | 北华航天工业学院 | A kind of hand-held optical biopsy instrument |
| CN107822595A (en) * | 2017-09-28 | 2018-03-23 | 华南师范大学 | The per urethra optoacoustic prostate developing method and device received based on ring battle array |
| CN113854963A (en) * | 2021-09-15 | 2021-12-31 | 同济大学 | Prostate cancer photoacoustic spectrum database and construction method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107468283A (en) * | 2017-07-25 | 2017-12-15 | 北华航天工业学院 | A kind of hand-held optical biopsy instrument |
| CN107822595A (en) * | 2017-09-28 | 2018-03-23 | 华南师范大学 | The per urethra optoacoustic prostate developing method and device received based on ring battle array |
| CN113854963A (en) * | 2021-09-15 | 2021-12-31 | 同济大学 | Prostate cancer photoacoustic spectrum database and construction method thereof |
| CN113854963B (en) * | 2021-09-15 | 2022-12-16 | 同济大学 | Prostate cancer photoacoustic spectrum database and construction method thereof |
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Application publication date: 20110803 |