CN114532985A - Photo-acoustic imaging-based quantitative photo-thermal irradiation device and method - Google Patents
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Abstract
The invention discloses a quantification photo-thermal irradiation device and method based on photo-acoustic imaging, wherein the device comprises a scanning module, a data acquisition module, a photo-acoustic imaging module and a photo-thermal irradiation module; the scanning module is used for generating a trigger signal through the controller to control the pulse laser to emit pulse laser and scan the surface of the tissue to be imaged; the data acquisition module is used for receiving photoacoustic signals obtained by scanning tissues to be imaged and determining acquired data; the photoacoustic imaging module is used for reconstructing collected data and determining a photoacoustic image; the photo-thermal irradiation module is used for carrying out image parameter extraction processing on the photo-acoustic image and carrying out photo-thermal irradiation on the target part. The embodiment of the invention performs photoacoustic imaging on the target part, reduces ionizing radiation, improves the imaging accuracy and can be widely applied to the technical field of photoacoustic imaging.
Description
Technical Field
The invention relates to the technical field of photoacoustic imaging, in particular to a quantitative photothermal irradiation device and method based on photoacoustic imaging.
Background
Malignant tumors seriously threaten human health, and the incidence and mortality of the malignant tumors are on the rise in recent ten years. The onset position and early stage characteristics of different tumors are different, and compared with superficial tumors, digestive tract cancers represented by colorectal cancer, gastric cancer, esophageal cancer and the like have the characteristics of position hiding, invasive growth in early stage, unobvious clinical manifestations and the like. Therefore, how to realize accurate imaging of malignant tumors has important significance for improving the survival rate of patients.
The traditional imaging method is limited by imaging depth and resolution, is difficult to accurately identify tumor boundaries, cannot accurately identify tumors, and has the problems of ionizing radiation, allergy to exogenous contrast agents and the like. In the actual photothermal irradiation process, because the irregular area of the tumor boundary, the conventional photothermal irradiation adopts the circular large light spot irradiation, the irradiation to the normal area can be realized, and the damage to the normal tissue is caused, so how to accurately position the tumor tissue and simultaneously identify the tumor boundary has important significance for realizing the accurate photothermal irradiation. Therefore, there is a need for a new imaging method without ionizing radiation, exogenous contrast agent and high resolution in cancer diagnosis.
Disclosure of Invention
The present invention is directed to solving at least one of the problems of the prior art. Therefore, the invention provides a quantitative photothermal irradiation device and method based on photoacoustic imaging, which can reduce ionizing radiation and improve imaging accuracy.
In one aspect, the invention provides a quantified photothermal irradiation device based on photoacoustic imaging, which comprises a scanning module, a data acquisition module, a photoacoustic imaging module and a photothermal irradiation module;
the scanning module is used for generating a trigger signal through the controller to control the pulse laser to emit pulse laser, the pulse laser is coupled into the single-mode fiber through the fiber coupler, reaches the surface of the tissue to be imaged through the imaging probe and scans the surface of the tissue to be imaged;
the data acquisition module is used for receiving photoacoustic signals obtained by scanning tissues to be imaged, converting the photoacoustic signals into electric signals, enabling the electric signals to enter the signal amplifier through a coaxial cable, acquiring and processing the amplified electric signals by an acquisition card and determining acquired data;
the photoacoustic imaging module is used for reconstructing collected data and determining a photoacoustic image;
and the photo-thermal irradiation module is used for extracting image parameters of the photo-acoustic image, adjusting the pulse laser according to the extracted image parameters and carrying out photo-thermal irradiation on the target part.
Optionally, the scanning module includes an imaging probe for scanning the surface of the tissue to be imaged, and the imaging probe includes a mirror, a mems mirror, a collimator, a fiber bundle, a focusing lens, a light-transmissive mirror, and a transducer.
Optionally, the photoacoustic imaging module comprises:
the device comprises a first unit, a second unit and a third unit, wherein the first unit is used for carrying out denoising average processing on collected data and determining denoising average data;
and the second unit is used for imaging the denoised average data by a maximum projection method and determining the photoacoustic image.
Optionally, the photothermal irradiation module comprises:
the third unit is used for extracting image parameters of the photoacoustic image according to a threshold segmentation method and determining image parameters, wherein the image parameters comprise a target boundary and a target depth;
and the fourth unit is used for controlling the pulse laser to carry out positioning irradiation on the target part according to the target boundary and adjusting the irradiation dose of the pulse laser according to the target depth.
Optionally, the scanning module comprises a controller for generating square wave signals of different frequencies to be used as the pulse laser trigger signal, and the photoacoustic image imaging time is changed by changing the frequency of the trigger signal.
Optionally, the imaging probe is an endoscopic structure and performs endoscopic imaging on a narrow cavity.
Optionally, the imaging probe performs scanning imaging in a forward scanning manner.
On the other hand, the embodiment of the invention also provides a quantified photothermal irradiation device based on photoacoustic imaging, which comprises a pulse laser, an optical fiber coupler, an imaging probe, a controller, a computer, an acquisition card and a signal amplifier, wherein the pulse laser is electrically connected with the optical fiber coupler, the optical fiber coupler is electrically connected with the imaging probe, the imaging probe is electrically connected with the signal amplifier, the signal amplifier is electrically connected with the acquisition card, the acquisition card is electrically connected with the computer, the computer is electrically connected with the controller, and the controller is electrically connected with the pulse laser.
On the other hand, the embodiment of the invention also provides a quantitative photothermal irradiation method based on photoacoustic imaging, which comprises the following steps:
the controller generates a trigger signal to control the pulse laser to emit pulse laser, the pulse laser is coupled into the single-mode fiber by the fiber coupler, reaches the surface of the tissue to be imaged through the imaging probe and scans the surface of the tissue to be imaged;
receiving a photoacoustic signal obtained by scanning a tissue to be imaged, converting the photoacoustic signal into an electric signal, enabling the electric signal to enter a signal amplifier through a coaxial cable, collecting and processing the amplified electric signal by a collecting card, and determining collected data;
reconstructing the acquired data to determine a photoacoustic image;
and carrying out image parameter extraction processing on the photoacoustic image, adjusting the pulse laser according to the extracted image parameters, and carrying out photothermal irradiation on the target part.
On the other hand, the embodiment of the invention also discloses an electronic device, which comprises a processor and a memory;
the memory is used for storing programs;
the processor executes the program to implement the method as described above.
On the other hand, the embodiment of the invention also discloses a computer readable storage medium, wherein the storage medium stores a program, and the program is executed by a processor to realize the method.
In another aspect, an embodiment of the present invention further discloses a computer program product or a computer program, where the computer program product or the computer program includes computer instructions, and the computer instructions are stored in a computer-readable storage medium. The computer instructions may be read by a processor of a computer device from a computer-readable storage medium, and the computer instructions executed by the processor cause the computer device to perform the foregoing method.
Compared with the prior art, the invention adopting the technical scheme has the following technical effects: the embodiment of the invention controls a pulse laser to emit pulse laser by generating a trigger signal through a controller, the pulse laser is coupled into a single-mode fiber through a fiber coupler, reaches the surface of a tissue to be imaged through an imaging probe and scans the surface of the tissue to be imaged; receiving a photoacoustic signal obtained by scanning a tissue to be imaged, converting the photoacoustic signal into an electric signal, enabling the electric signal to enter a signal amplifier through a coaxial cable, collecting and processing the amplified electric signal by a collecting card, and determining collected data; reconstructing the acquired data to determine a photoacoustic image; the photoacoustic image with high accuracy can be acquired based on the photoacoustic effect, and ionizing radiation is reduced.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
FIG. 1 is a schematic diagram of a system configuration according to an embodiment of the present invention;
FIG. 2 is a schematic diagram of an apparatus according to an embodiment of the present invention;
fig. 3 is a flow chart of a method according to an embodiment of the invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present application more apparent, the present application is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the present application and are not intended to limit the present application.
Referring to fig. 1, the present invention provides a photoacoustic imaging-based quantitative photothermal irradiation apparatus, including a scanning module, a data acquisition module, a photoacoustic imaging module, and a photothermal irradiation module;
the scanning module is used for generating a trigger signal through the controller to control the pulse laser to emit pulse laser, the pulse laser is coupled into the single-mode fiber through the fiber coupler, reaches the surface of the tissue to be imaged through the imaging probe and scans the surface of the tissue to be imaged;
the data acquisition module is used for receiving photoacoustic signals obtained by scanning tissues to be imaged, converting the photoacoustic signals into electric signals, enabling the electric signals to enter the signal amplifier through a coaxial cable, acquiring and processing the amplified electric signals by an acquisition card and determining acquired data;
the photoacoustic imaging module is used for reconstructing collected data and determining a photoacoustic image;
and the photo-thermal irradiation module is used for extracting image parameters of the photo-acoustic image, adjusting the pulse laser according to the extracted image parameters and carrying out photo-thermal irradiation on the target part.
Specifically, the embodiment of the invention can perform photoacoustic imaging and accurate photo-thermal irradiation on the target part, the photoacoustic imaging module delineates the boundary of the target part through the photoacoustic imaging, the photo-thermal irradiation module realizes the accurate targeted photo-thermal irradiation on the target part through the pulse laser excitation light thermal effect, and meanwhile, the scanning module can perform real-time nondestructive monitoring on the target part. The embodiment of the invention controls the pulse laser to emit pulse laser to scan the surface of the tissue to be imaged by the trigger signal generated by the controller, the tissue to be imaged is stimulated to generate ultrasonic signals, the ultrasonic signals are received and converted into electric signals by the transducer, and the analog electric signals from the transducer are converted into digital signals by the data acquisition card in the data acquisition module and are sent into the photoacoustic imaging module. And performing Hilbert transform on the acquired data through the photoacoustic imaging module to obtain processed data. Because the data acquisition position is highly related to the imaging position, the three-dimensional data is reconstructed by adopting a direct projection method, a reconstruction slice sequence is obtained, each row of pixel points in the slice sequence corresponds to a time sequence signal acquired by the transducer at a corresponding space position, and then the signal is projected to a two-dimensional plane by adopting a maximum projection method to obtain a photoacoustic image. And finally, performing image parameter extraction processing on the photoacoustic image through a photothermal irradiation module, adjusting pulse laser according to the extracted image parameters, and performing photothermal irradiation on the target part.
Further preferably, the scanning module includes an imaging probe, and the imaging probe is used for scanning the surface of the tissue to be imaged and includes a reflector, a mems mirror, a collimator, a fiber bundle, a focusing lens, a light-transmitting anti-acoustic mirror and a transducer.
Specifically, a pulse laser emits pulse laser to enter an imaging probe, and the pulse laser scans the surface of a tissue to be imaged through an entrance reflector, a micro-electro-mechanical system mirror, a collimator, a fiber bundle, a focusing lens and a light-transmitting anti-sound mirror. The pulse laser enters the single-mode fiber through the coupling of the fiber coupler, the single-mode fiber is connected with a collimator in the imaging probe, emergent light enters the MEMS mirror through the collimation of the collimator, the MEMS mirror can change the scanning range of spatial light, the scanning light is reflected by reflected light and then enters the near end of the fiber guide, and the scanning light passes through the light-transmitting echoing mirror after being emitted from the far end of the fiber guide and then enters the surface of the tissue to be imaged. The transducer is used for acquiring ultrasonic signals generated by the excited tissue.
Further as a preferred embodiment, the photoacoustic imaging module includes:
the device comprises a first unit, a second unit and a third unit, wherein the first unit is used for carrying out denoising average processing on collected data and determining denoising average data;
and the second unit is used for imaging the denoised average data by a maximum projection method and determining the photoacoustic image.
Specifically, the first unit receives a digital signal from the acquisition card and performs denoising average processing on the original data. The second unit adopts a maximum projection algorithm to reconstruct the denoising average data to obtain a photoacoustic image of a scanning area, and the photoacoustic image is used for presenting the space position and boundary characteristics of a target tissue and delineating a biological target area for a photothermal irradiation process.
Further preferably, the photothermal irradiation module includes:
the third unit is used for extracting image parameters of the photoacoustic image according to a threshold segmentation method and determining image parameters, wherein the image parameters comprise a target boundary and a target depth;
and the fourth unit is used for controlling the pulse laser to carry out positioning irradiation on the target part according to the target boundary and adjusting the irradiation dose of the pulse laser according to the target depth.
Specifically, the photoacoustic imaging module realizes a three-dimensional visual image of an imaging area to obtain a three-dimensional space distribution image of a target area; the third unit obtains image parameters of the target area by adopting a threshold value method, the image parameters comprise three-dimensional space coordinates (x, y, z), wherein (x, y) represents a target boundary, z represents a target depth, the image parameters are fed back to the fourth unit, the fourth unit performs laser irradiation along the target boundary by controlling pulse laser, and meanwhile, the laser irradiation dose is adjusted by combining the target depth, so that accurate boundary and quantitative irradiation of the target area are realized. The power can be changed for different tumor positions in the photothermal irradiation process, so that tumor cells are ablated to the maximum extent, and thermal damage to surrounding normal cells is reduced.
Further as a preferred embodiment, the scanning module comprises a controller for generating square wave signals of different frequencies to be used as the pulse laser trigger signal, and the photoacoustic image imaging time is changed by changing the frequency of the trigger signal.
Specifically, the controller of the embodiment of the invention can select an STM32 series single chip microcomputer, the controller can generate square wave signals with different frequencies to be used as the trigger signals of the pulse laser, and the imaging time of the photoacoustic image can be changed by changing the frequency of the trigger signals. It is contemplated that the controller may also quantify the exposure of different target sites by varying the intensity of the trigger signal, and thus the laser output power. The controller controls the pulse laser to selectively irradiate the target boundary tissue according to the target boundary characteristics in the photoacoustic image, so that only the inside and the edge of the target tissue are excited, and quantitative photothermal irradiation is realized.
In a further preferred embodiment, the imaging probe has an endoscopic structure and performs endoscopic imaging on a narrow cavity.
Specifically, the embodiment of the present invention may select an imaging probe with an endoscopic structure, for example, for a tumor focus inside a cavity, the endoscopic imaging probe may be adopted to penetrate into a narrow tissue for endoscopic imaging, so as to obtain deep tissue information. It is conceivable that the embodiment of the present invention may also use a microscopic imaging probe to perform body surface microscopic imaging.
Further as a preferred embodiment, the imaging probe performs scanning imaging in a forward scanning manner.
Specifically, the imaging probe of the embodiment of the invention adopts a forward scanning mode. The working distance can be effectively prolonged by adopting an optical fiber bundle in a forward scanning mode, the photoacoustic echo signal can be reflected by adding a light-transmitting and sound-reflecting mirror at the front end of the probe and received by a side-wall high-frequency ultrasonic transducer, the main frequency of the high-frequency ultrasonic transducer is 40M, the bandwidth is 80 percent, and the amplification gain of a signal amplifier is 50 dB.
Referring to fig. 2, an embodiment of the present invention further provides a photoacoustic imaging-based quantitative photothermal irradiation apparatus, including a pulse laser, an optical fiber coupler, an imaging probe, a controller, a computer, an acquisition card, and a signal amplifier, where the pulse laser is electrically connected to the optical fiber coupler, the optical fiber coupler is electrically connected to the imaging probe, the imaging probe is electrically connected to the signal amplifier, the signal amplifier is electrically connected to the acquisition card, the acquisition card is electrically connected to the computer, the computer is electrically connected to the controller, and the controller is electrically connected to the pulse laser.
Specifically, in the embodiment of the invention, a pulse laser is emitted by a pulse laser to enter an optical fiber coupler for coupling, an incident imaging probe scans the surface of a tissue to be imaged, the tissue to be imaged is excited to generate a photoinduced ultrasonic signal, an energy converter in the imaging probe receives the ultrasonic signal and converts the ultrasonic signal into an electric signal at the same time, the electric signal is amplified by a signal amplifier and is transmitted to a computer by a capture card, the photoacoustic image is generated by reconstruction of the computer, the parameter extraction is carried out on the photoacoustic image, the controller is electrically controlled according to the image parameters, and the controller generates a trigger signal to control the pulse laser.
Referring to fig. 3, an embodiment of the present invention further provides a method for quantitative photothermal irradiation based on photoacoustic imaging, including:
the controller generates a trigger signal to control the pulse laser to emit pulse laser, the pulse laser is coupled into the single-mode fiber by the fiber coupler, reaches the surface of the tissue to be imaged through the imaging probe and scans the surface of the tissue to be imaged;
receiving a photoacoustic signal obtained by scanning a tissue to be imaged, converting the photoacoustic signal into an electric signal, enabling the electric signal to enter a signal amplifier through a coaxial cable, collecting and processing the amplified electric signal by a collecting card, and determining collected data;
reconstructing the acquired data to determine a photoacoustic image;
and carrying out image parameter extraction processing on the photoacoustic image, adjusting the pulse laser according to the extracted image parameters, and carrying out photothermal irradiation on the target part.
The process of the invention specifically comprises the following steps: the controller generates a trigger signal to control the pulse laser to emit pulse laser, the pulse laser is coupled into the single-mode fiber by the fiber coupler, reaches the surface of the tissue to be imaged through the imaging probe and scans the surface of the tissue to be imaged; and receiving a photoacoustic signal obtained by scanning the tissue to be imaged, converting the photoacoustic signal into an electric signal, feeding the electric signal into a signal amplifier through a coaxial cable, and acquiring and processing the amplified electric signal by an acquisition card to obtain acquired data. And reconstructing the acquired data to obtain the photoacoustic image. The embodiment of the invention can be applied to imaging tumor tissues, the vascular network distribution can be obtained by reconstructed images, compared with normal tissues, the vascular network of the tumor tissues is dense and curved, the corresponding vascular network image is a strong signal area, the tumor tissues and the normal tissues can be distinguished by judging the signal intensity of an irradiation area, and the output power of a pulse laser can be quantitatively irradiated according to the signal intensities of different positions of the tumor in the photothermal process. The embodiment of the invention can not only perform photoacoustic imaging on the target area, but also display the vascular network by utilizing the specific absorption of the hemoglobin on 532nm pulse laser, compared with normal tissues, the vascular network near the tumor tissue is dense, the vascular curvature is large, the oxygen content of blood flow is low, the corresponding vascular network image is a strong signal area, the space position and the solid boundary of the tumor tissue can be clearly distinguished according to the structural characteristics of the vascular network, and meanwhile, the tumor boundary tissue can be selectively irradiated according to the characteristics of the tumor boundary in the photoacoustic image, so that the purpose of exciting only the inside and the edge of the tumor tissue is realized, and the quantitative photothermal irradiation is realized.
Corresponding to the method of fig. 3, an embodiment of the present invention further provides an electronic device, including a processor and a memory; the memory is used for storing programs; the processor executes the program to implement the method as described above.
Corresponding to the method of fig. 3, the embodiment of the present invention further provides a computer-readable storage medium, which stores a program, and the program is executed by a processor to implement the method as described above.
The embodiment of the invention also discloses a computer program product or a computer program, which comprises computer instructions, and the computer instructions are stored in a computer readable storage medium. The computer instructions may be read by a processor of a computer device from a computer-readable storage medium, and the computer instructions executed by the processor cause the computer device to perform the method illustrated in fig. 3.
In summary, the embodiments of the present invention have the following advantages:
(1) the embodiment of the invention realizes the integration of photoacoustic imaging and photothermal irradiation.
(2) Compared with the traditional imaging technology, the photoacoustic imaging technology has the characteristics of high optical imaging resolution and deep acoustic imaging depth, the imaging principle is based on the photoacoustic effect, no exogenous contrast medium is needed, no ionizing radiation is generated, the tumor microvascular network can be imaged, and the spatial position and the boundary contour of the tumor tissue are obtained.
(3) According to the embodiment of the invention, the space position and the distribution of the tumor are obtained through the photoacoustic image, a photothermal irradiation scheme is formulated according to different tumor characteristics, the tumor contour can be displayed in real time in the photothermal irradiation process, the central region of the tumor is irradiated by the pulse laser, so that the tumor target tissue is heated, solidified and necrotic, the power of the pulse laser is adjustable, the power can be reduced in the tumor boundary region, the noise thermal damage to surrounding normal tissues is avoided, and the accurate photothermal irradiation is realized.
In alternative embodiments, the functions/acts noted in the block diagrams may occur out of the order noted in the operational illustrations. For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or the blocks may sometimes be executed in the reverse order, depending upon the functionality/acts involved. Furthermore, the embodiments presented and described in the flow charts of the present invention are provided by way of example in order to provide a more thorough understanding of the technology. The disclosed methods are not limited to the operations and logic flows presented herein. Alternative embodiments are contemplated in which the order of various operations is changed and in which sub-operations described as part of larger operations are performed independently.
Furthermore, although the present invention is described in the context of functional modules, it should be understood that, unless otherwise stated to the contrary, one or more of the described functions and/or features may be integrated in a single physical device and/or software module, or one or more functions and/or features may be implemented in a separate physical device or software module. It will also be appreciated that a detailed discussion of the actual implementation of each module is not necessary for an understanding of the present invention. Rather, the actual implementation of the various functional modules in the apparatus disclosed herein will be understood within the ordinary skill of an engineer, given the nature, function, and internal relationship of the modules. Accordingly, those skilled in the art can, using ordinary skill, practice the invention as set forth in the claims without undue experimentation. It is also to be understood that the specific concepts disclosed are merely illustrative of and not intended to limit the scope of the invention, which is defined by the appended claims and their full scope of equivalents.
The functions, if implemented in the form of software functional units and sold or used as a stand-alone product, may be stored in a computer readable storage medium. Based on such understanding, the technical solution of the present invention may be embodied in the form of a software product, which is stored in a storage medium and includes instructions for causing a computer device (which may be a personal computer, a server, or a network device) to execute all or part of the steps of the method according to the embodiments of the present invention. And the aforementioned storage medium includes: a U disk, a removable hard disk, a Read-only Memory (ROM), a Random Access Memory (RAM), a magnetic disk or an optical disk, and other various media capable of storing program codes.
The logic and/or steps represented in the flowcharts or otherwise described herein, e.g., an ordered listing of executable instructions that can be considered to implement logical functions, can be embodied in any computer-readable medium for use by or in connection with an instruction execution system, apparatus, or device, such as a computer-based system, processor-containing system, or other system that can fetch the instructions from the instruction execution system, apparatus, or device and execute the instructions. For the purposes of this description, a "computer-readable medium" can be any means that can contain, store, communicate, propagate, or transport the program for use by or in connection with the instruction execution system, apparatus, or device.
More specific examples (a non-exhaustive list) of the computer-readable medium would include the following: an electrical connection (electronic device) having one or more wires, a portable computer diskette (magnetic device), a Random Access Memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber device, and a portable compact disc read-only memory (CDROM). Additionally, the computer-readable medium could even be paper or another suitable medium upon which the program is printed, as the program can be electronically captured, via for instance optical scanning of the paper or other medium, then compiled, interpreted or otherwise processed in a suitable manner if necessary, and then stored in a computer memory.
It should be understood that portions of the present invention may be implemented in hardware, software, firmware, or a combination thereof. In the above embodiments, the various steps or methods may be implemented in software or firmware stored in memory and executed by a suitable instruction execution system. For example, if implemented in hardware, as in another embodiment, any one or combination of the following techniques, which are known in the art, may be used: a discrete logic circuit having a logic gate circuit for implementing a logic function on a data signal, an application specific integrated circuit having an appropriate combinational logic gate circuit, a Programmable Gate Array (PGA), a Field Programmable Gate Array (FPGA), or the like.
In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
While embodiments of the invention have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.
While the preferred embodiments of the present invention have been illustrated and described, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (10)
1. A quantification photo-thermal irradiation device based on photoacoustic imaging is characterized by comprising a scanning module, a data acquisition module, a photoacoustic imaging module and a photo-thermal irradiation module;
the scanning module is used for generating a trigger signal through the controller to control the pulse laser to emit pulse laser, the pulse laser is coupled into the single-mode fiber through the fiber coupler, reaches the surface of the tissue to be imaged through the imaging probe and scans the surface of the tissue to be imaged;
the data acquisition module is used for receiving photoacoustic signals obtained by scanning tissues to be imaged, converting the photoacoustic signals into electric signals, enabling the electric signals to enter the signal amplifier through a coaxial cable, acquiring and processing the amplified electric signals by an acquisition card and determining acquired data;
the photoacoustic imaging module is used for reconstructing collected data and determining a photoacoustic image;
and the photo-thermal irradiation module is used for extracting image parameters of the photo-acoustic image, adjusting the pulse laser according to the extracted image parameters and carrying out photo-thermal irradiation on the target part.
2. The photo-acoustic imaging based quantitative photo-thermal irradiation device according to claim 1, wherein the scanning module comprises an imaging probe for scanning the tissue surface to be imaged, comprising a reflector, a micro-electro-mechanical system mirror, a collimator, a fiber bundle, a focusing lens, a light transmissive reflector and a transducer.
3. The photo-acoustic imaging based quantitative photo-thermal irradiation device according to claim 1, wherein the photo-acoustic imaging module comprises:
the device comprises a first unit, a second unit and a third unit, wherein the first unit is used for carrying out denoising average processing on collected data and determining denoising average data;
and the second unit is used for imaging the denoised average data by a maximum projection method and determining the photoacoustic image.
4. The photo-thermal irradiation apparatus for quantification based on photoacoustic imaging according to claim 1, wherein the photo-thermal irradiation module comprises:
the third unit is used for extracting image parameters of the photoacoustic image according to a threshold segmentation method and determining image parameters, wherein the image parameters comprise a target boundary and a target depth;
and the fourth unit is used for controlling the pulse laser to carry out positioning irradiation on the target part according to the target boundary and adjusting the irradiation dose of the pulse laser according to the target depth.
5. The photo-acoustic imaging based quantitative photo-thermal irradiation device according to claim 1, wherein the scanning module comprises a controller for generating square wave signals with different frequencies as the pulse laser trigger signal, and the photo-acoustic image imaging time is changed by changing the frequency of the trigger signal.
6. The photo-acoustic imaging-based quantitative photo-thermal irradiation device according to claim 2, wherein the imaging probe is of an endoscopic structure and performs endoscopic imaging on a narrow cavity.
7. The photo-acoustic imaging based quantitative photo-thermal irradiation device according to claim 2, wherein the imaging probe performs scanning imaging in a forward scanning manner.
8. The utility model provides a quantization light and heat irradiation device based on optoacoustic formation of image, its characterized in that includes pulse laser, fiber coupler, formation of image probe, controller, computer, acquisition card and signal amplifier, pulse laser is connected with fiber coupler electricity, fiber coupler is connected with the formation of image probe electricity, the formation of image probe is connected with the signal amplifier electricity, signal amplifier is connected with the acquisition card electricity, the acquisition card is connected with the computer electricity, the computer is connected with the controller electricity, the controller is connected with the pulse laser electricity.
9. A method for quantitative photothermal irradiation based on photoacoustic imaging, comprising:
the controller generates a trigger signal to control the pulse laser to emit pulse laser, the pulse laser is coupled into the single-mode fiber by the fiber coupler, reaches the surface of the tissue to be imaged through the imaging probe and scans the surface of the tissue to be imaged;
receiving a photoacoustic signal obtained by scanning a tissue to be imaged, converting the photoacoustic signal into an electric signal, enabling the electric signal to enter a signal amplifier through a coaxial cable, collecting and processing the amplified electric signal by a collecting card, and determining collected data;
reconstructing the acquired data to determine a photoacoustic image;
and carrying out image parameter extraction processing on the photoacoustic image, adjusting the pulse laser according to the extracted image parameters, and carrying out photothermal irradiation on the target part.
10. An electronic device comprising a processor and a memory;
the memory is used for storing programs;
the processor executing the program realizes the method as claimed in claim 9.
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