CN114532985A - Photo-acoustic imaging-based quantitative photo-thermal irradiation device and method - Google Patents

Abstract

The invention discloses a quantitative photothermal irradiation device and method based on photoacoustic imaging, wherein the device comprises a scanning module, a data acquisition module, a photoacoustic imaging module and a photothermal irradiation module; the scanning module is used for generating a trigger signal through a controller The pulsed laser is controlled to emit pulsed laser light to scan the surface of the tissue to be imaged; the data acquisition module is used to receive the photoacoustic signal obtained by scanning the tissue to be imaged to determine the acquisition data; the photoacoustic imaging module is used to reconstruct the acquired data and determine the photoacoustic signal Image; the photothermal irradiation module is used to extract the image parameters of the photoacoustic image, and perform photothermal irradiation on the target part. The embodiment of the present invention performs photoacoustic imaging on a target site, reduces ionizing radiation, improves imaging accuracy, and can be widely used in the technical field of photoacoustic imaging.

Description

A Quantitative Photothermal Irradiation Device and Method Based on Photoacoustic Imaging

technical field

The invention relates to the technical field of photoacoustic imaging, in particular to a quantitative photothermal irradiation device and method based on photoacoustic imaging.

Background technique

Malignant tumors are a serious threat to human health, and the morbidity and mortality of malignant tumors have been on the rise in recent decades. The location and early characteristics of different tumors are different. Compared with superficial tumors, gastrointestinal cancers represented by colorectal cancer, gastric cancer, esophageal cancer, etc. have hidden locations, and show invasive growth in the early stage, and the clinical manifestations are not obvious. and other characteristics. Therefore, how to achieve accurate imaging of malignant tumors is of great significance to improve the survival rate of patients.

The traditional imaging method is limited by the imaging depth and resolution, it is difficult to accurately identify the tumor boundary, and the accurate tumor identification cannot be achieved. In the actual photothermal irradiation process, due to the irregular area of the tumor boundary, the traditional photothermal irradiation uses a large circular spot to illuminate the normal area, causing damage to the normal tissue. Therefore, how to accurately locate the tumor tissue and identify the tumor boundary It is of great significance to achieve precise photothermal irradiation. Therefore, a novel imaging method with no ionizing radiation, no exogenous contrast agent and high resolution is urgently needed in the current cancer diagnosis.

SUMMARY OF THE INVENTION

The present invention aims to solve at least one of the technical problems existing in the prior art. Therefore, the present invention provides a quantitative photothermal irradiation device and method based on photoacoustic imaging, which can reduce ionizing radiation and improve imaging accuracy.

In one aspect, the present invention provides a quantitative photothermal irradiation device based on photoacoustic imaging, comprising a scanning module, a data acquisition module, a photoacoustic imaging module and a photothermal irradiation module;

Wherein, the scanning module is used for generating a trigger signal by the controller to control the pulse laser to emit pulsed laser, the pulsed laser is coupled into the single-mode optical fiber by the fiber coupler, reaches the surface of the tissue to be imaged through the imaging probe, and scans the surface of the tissue to be imaged;

The data acquisition module is used to receive the photoacoustic signal obtained by scanning the tissue to be imaged, convert it into an electrical signal, enter the signal amplifier through a coaxial cable, and collect and process the amplified electrical signal by the acquisition card to determine the acquisition data;

The photoacoustic imaging module is used for reconstructing the collected data to determine the photoacoustic image;

The photothermal irradiation module is used to perform image parameter extraction processing on the photoacoustic image, adjust the pulsed laser according to the extracted image parameters, and perform photothermal irradiation on the target portion.

Optionally, the scanning module includes an imaging probe, which is used to scan the surface of the tissue to be imaged, including a mirror, a MEMS mirror, a collimator, an optical fiber bundle, a focusing lens, and a light-transmitting acoustic mirror. and transducer.

Optionally, the photoacoustic imaging module includes:

The first unit is used to perform denoising and averaging processing on the collected data to determine the denoising average data;

The second unit is used for imaging the denoised average data by the maximum projection method to determine the photoacoustic image.

Optionally, the photothermal irradiation module includes:

The third unit is configured to perform image parameter extraction processing on the photoacoustic image according to the threshold segmentation method, and determine the image parameters, and the image parameters include the target boundary and the target depth;

The fourth unit is used to control the pulsed laser to position and irradiate the target part according to the target boundary, and at the same time adjust the pulsed laser irradiation dose according to the target depth.

Optionally, the scanning module includes a controller configured to generate square wave signals of different frequencies as a pulse laser trigger signal, and change the photoacoustic image imaging time by changing the frequency of the trigger signal.

Optionally, the imaging probe is an endoscopic structure, and performs endoscopic imaging on a narrow cavity.

Optionally, the imaging probe performs scanning imaging in a forward scanning manner.

On the other hand, an embodiment of the present invention also provides a quantitative photothermal irradiation device based on photoacoustic imaging, including a pulsed laser, a fiber coupler, an imaging probe, a controller, a computer, a capture card and a signal amplifier. The pulsed laser It is electrically connected with a fiber optic coupler, the fiber optic coupler is electrically connected with the imaging probe, the imaging probe is electrically connected with the signal amplifier, the signal amplifier is electrically connected with the acquisition card, the acquisition card is electrically connected with the computer, the computer It is electrically connected to the controller, and the controller is electrically connected to the pulsed laser.

On the other hand, an embodiment of the present invention also provides a quantitative photothermal irradiation method based on photoacoustic imaging, comprising:

The trigger signal is generated by the controller to control the pulsed laser to emit pulsed laser, the pulsed laser is coupled into the single-mode fiber by the fiber coupler, and reaches the surface of the tissue to be imaged through the imaging probe, and scans the surface of the tissue to be imaged;

Receive the photoacoustic signal scanned by the tissue to be imaged, convert it into an electrical signal, enter the signal amplifier through a coaxial cable, and collect and process the amplified electrical signal by the acquisition card to determine the acquisition data;

Reconstruct the collected data to determine the photoacoustic image;

Image parameter extraction processing is performed on the photoacoustic image, the pulsed laser is adjusted according to the extracted image parameters, and photothermal irradiation is performed on the target part.

On the other hand, an embodiment of the present invention also discloses an electronic device, including a processor and a memory;

the memory is used to store programs;

The processor executes the program to implement the method as described above.

On the other hand, an embodiment of the present invention further discloses a computer-readable storage medium, where the storage medium stores a program, and the program is executed by a processor to implement the aforementioned method.

On the other hand, an embodiment of the present invention also discloses a computer program product or computer program, where the computer program product or computer program includes computer instructions, and the computer instructions are stored in a computer-readable storage medium. The computer instructions can be read from the computer-readable storage medium by a processor of the computer device, and the processor executes the computer instructions to cause the computer device to perform the foregoing method.

Compared with the prior art, the present invention adopts the above technical solution, and has the following technical effects: in the embodiment of the present invention, a trigger signal is generated by the controller to control the pulse laser to emit pulsed laser light. Reach the surface of the tissue to be imaged, scan the surface of the tissue to be imaged; receive the photoacoustic signal scanned by the tissue to be imaged, convert it into an electrical signal, enter the signal amplifier through a coaxial cable, and collect and process the amplified electrical signal by the acquisition card , determine the acquisition data; reconstruct the acquired data to determine the photoacoustic image; based on the photoacoustic effect, the photoacoustic image with high accuracy can be obtained, and the ionizing radiation can be reduced.

Description of drawings

In order to illustrate the technical solutions in the embodiments of the present application more clearly, the following briefly introduces the drawings that are used in the description of the embodiments. Obviously, the drawings in the following description are only some embodiments of the present application. For those of ordinary skill in the art, other drawings can also be obtained from these drawings without creative effort.

1 is a schematic diagram of a system structure according to an embodiment of the present invention;

2 is a schematic structural diagram of a device according to an embodiment of the present invention;

FIG. 3 is a schematic flowchart of a method according to an embodiment of the present invention.

Detailed ways

In order to make the purpose, technical solutions and advantages of the present application more clearly understood, the present application will be described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application, but not to limit the present application.

1, the present invention provides a quantitative photothermal irradiation device based on photoacoustic imaging, including a scanning module, a data acquisition module, a photoacoustic imaging module and a photothermal irradiation module;

Wherein, the scanning module is used for generating a trigger signal by the controller to control the pulse laser to emit pulsed laser, the pulsed laser is coupled into the single-mode optical fiber by the fiber coupler, reaches the surface of the tissue to be imaged through the imaging probe, and scans the surface of the tissue to be imaged;

The data acquisition module is used to receive the photoacoustic signal obtained by scanning the tissue to be imaged, convert it into an electrical signal, enter the signal amplifier through a coaxial cable, and collect and process the amplified electrical signal by the acquisition card to determine the acquisition data;

The photoacoustic imaging module is used for reconstructing the collected data to determine the photoacoustic image;

The photothermal irradiation module is used to perform image parameter extraction processing on the photoacoustic image, adjust the pulsed laser according to the extracted image parameters, and perform photothermal irradiation on the target portion.

Specifically, the embodiment of the present invention can perform photoacoustic imaging and precise photothermal irradiation on the target part, the photoacoustic imaging module delineates the boundary of the target part through photoacoustic imaging, and the photothermal irradiation module excites the photothermal effect through the pulsed laser to realize the target part. The precise targeted photothermal irradiation can be used for real-time non-destructive monitoring of the target site through the scanning module. In the embodiment of the present invention, the controller generates a trigger signal to control the pulsed laser to emit pulsed laser to scan the surface of the tissue to be imaged, and the tissue to be imaged is stimulated to generate an ultrasonic signal, which is received by the transducer and converted into an electrical signal, which is collected through the data acquisition module in the data acquisition module. The card converts the analog electrical signal from the transducer into a digital signal and sends it into the photoacoustic imaging module. The Hilbert transform is performed on the collected data by the photoacoustic imaging module to obtain the processed data. Since the data collection position is highly correlated with the imaging position, the direct projection method is used to reconstruct the three-dimensional data. By obtaining the reconstructed slice sequence, each column of pixel points in the slice sequence corresponds to the time series signal collected by the transducer at the corresponding spatial position, and then the reconstructed slice sequence is obtained. The maximum projection method is used to project the signal onto a two-dimensional plane to obtain a photoacoustic image. Finally, the photoacoustic image is extracted and processed by the photothermal irradiation module, and the pulsed laser is adjusted according to the extracted image parameters to perform photothermal irradiation on the target part.

Further as a preferred embodiment, the scanning module includes an imaging probe, and the imaging probe is used to scan the surface of the tissue to be imaged, including a mirror, a MEMS mirror, a collimator, an optical fiber bundle, a focusing lens, a light transmission Acoustic mirrors and transducers.

Specifically, the pulsed laser emits pulsed laser light into the imaging probe, and the pulsed laser scans the surface of the tissue to be imaged through the entering mirror, MEMS mirror, collimator, fiber bundle, focusing lens, and light-transmitting acoustic mirror. The pulsed laser is coupled into the single-mode fiber through the fiber coupler, and the single-mode fiber is connected to the collimator in the imaging probe. The outgoing light is collimated into the MEMS mirror through the collimator. The MEMS mirror can change the spatial light scanning range. The reflected light enters the proximal end of the optical fiber guide fiber after being reflected, and then exits from the distal end of the optical fiber guide fiber and enters the surface of the tissue to be imaged through the light-transmitting acoustic mirror. Transducers are used to collect ultrasound signals generated by tissue stimulation.

Further as a preferred embodiment, the photoacoustic imaging module includes:

The first unit is used to perform denoising and averaging processing on the collected data to determine the denoising average data;

The second unit is used for imaging the denoised average data by the maximum projection method to determine the photoacoustic image.

Specifically, the first unit receives the digital signal from the acquisition card, and performs denoising and averaging processing on the original data. The second unit uses the maximum projection algorithm to reconstruct the denoised average data to obtain a photoacoustic image of the scanned area, which is used to present the spatial position and boundary features of the target tissue, and at the same time delineate the biological target area for the photothermal irradiation process.

Further as a preferred real-time manner, the photothermal irradiation module includes:

The third unit is configured to perform image parameter extraction processing on the photoacoustic image according to the threshold segmentation method, and determine the image parameters, and the image parameters include the target boundary and the target depth;

The fourth unit is used to control the pulsed laser to position and irradiate the target part according to the target boundary, and at the same time adjust the pulsed laser irradiation dose according to the target depth.

Specifically, the photoacoustic imaging module realizes the three-dimensional visualization image of the imaging area, and obtains the three-dimensional spatial distribution image of the target area; the third unit adopts the threshold method to obtain the image parameters of the target area, including the three-dimensional space coordinates (x, y, z), wherein (x, y) represents the target boundary, z represents the target depth, and the image parameters are fed back to the fourth unit. The fourth unit controls the pulsed laser to irradiate along the target boundary. At the same time, the laser irradiation dose is adjusted according to the target depth to achieve the target. Precise boundaries and quantitative exposure of areas. During the photothermal irradiation process, the power can be changed according to the position of the tumor to achieve maximum ablation of tumor cells while reducing thermal damage to surrounding normal cells.

As a further preferred embodiment, the scanning module includes a controller, and the controller is configured to generate square wave signals of different frequencies as the trigger signal of the pulsed laser, and the imaging time of the photoacoustic image can be changed by changing the frequency of the trigger signal.

Specifically, the controller of the embodiment of the present invention can select STM32 series single chip microcomputer, the controller can generate square wave signals of different frequencies as the pulse laser trigger signal, and the photoacoustic image imaging time can be changed by changing the trigger signal frequency. It is conceivable that the controller can also quantitatively irradiate different target parts by changing the intensity of the trigger signal to change the output power of the laser. The controller controls the pulsed laser to selectively irradiate the target boundary tissue according to the target boundary characteristics in the photoacoustic image, so that only the interior and edges of the target tissue are excited, thereby realizing quantitative photothermal irradiation.

As a further preferred embodiment, the imaging probe is an endoscopic structure, and performs endoscopic imaging on a narrow cavity.

Specifically, an imaging probe with an endoscopic structure can be selected in the embodiment of the present invention. For example, for tumor foci inside the cavity, an endoscopic imaging probe can be used to penetrate into the narrow tissue to perform endoscopic imaging to obtain deep tissue information. It is conceivable that in the embodiment of the present invention, a microscopic imaging probe may also be selected to perform microscopic imaging of the body surface.

As a further preferred embodiment, the imaging probe adopts a forward scanning manner to perform scanning imaging.

Specifically, the imaging probe of the embodiment of the present invention adopts a forward scanning manner. The use of optical fiber bundles in the forward scanning mode can effectively extend the working distance. The addition of a translucent and acoustic mirror at the front end of the probe can reflect the photoacoustic echo signal, which is received by the high-frequency ultrasonic transducer on the side wall. The frequency is 40M, the bandwidth is 80%, and the amplification gain of the signal amplifier is 50dB.

Referring to FIG. 2 , an embodiment of the present invention further provides a quantitative photothermal irradiation device based on photoacoustic imaging, including a pulsed laser, a fiber coupler, an imaging probe, a controller, a computer, a capture card and a signal amplifier. The pulsed laser It is electrically connected with a fiber optic coupler, the fiber optic coupler is electrically connected with the imaging probe, the imaging probe is electrically connected with the signal amplifier, the signal amplifier is electrically connected with the acquisition card, the acquisition card is electrically connected with the computer, the computer It is electrically connected to the controller, and the controller is electrically connected to the pulsed laser.

Specifically, in the embodiment of the present invention, a pulsed laser is used to transmit a pulsed laser into a fiber coupler for coupling, and the incident imaging probe scans the surface of the tissue to be imaged, and the tissue to be imaged is excited to generate a photo-induced ultrasonic signal, which is received by an internal transducer of the imaging probe. The ultrasonic signal is converted into an electrical signal at the same time, the electrical signal is amplified by the signal amplifier, transmitted to the computer through the acquisition card, and the photoacoustic image is reconstructed and generated by the computer, and the parameters of the photoacoustic image are extracted, and the controller is electrically controlled according to the image parameters. , the controller generates a trigger signal to control the pulsed laser.

Referring to FIG. 3 , an embodiment of the present invention further provides a method for quantitative photothermal irradiation based on photoacoustic imaging, including:

The trigger signal is generated by the controller to control the pulsed laser to emit pulsed laser, the pulsed laser is coupled into the single-mode fiber by the fiber coupler, and reaches the surface of the tissue to be imaged through the imaging probe, and scans the surface of the tissue to be imaged;

Receive the photoacoustic signal scanned by the tissue to be imaged, convert it into an electrical signal, enter the signal amplifier through a coaxial cable, and collect and process the amplified electrical signal by the acquisition card to determine the acquisition data;

Reconstruct the collected data to determine the photoacoustic image;

Image parameter extraction processing is performed on the photoacoustic image, the pulsed laser is adjusted according to the extracted image parameters, and photothermal irradiation is performed on the target part.

The process of the present invention specifically includes: generating a trigger signal by the controller to control the pulsed laser to emit pulsed laser, the pulsed laser is coupled into the single-mode optical fiber by the fiber coupler, reaches the surface of the tissue to be imaged through the imaging probe, and scans the surface of the tissue to be imaged; The photoacoustic signal obtained by the imaging tissue scan is converted into an electrical signal, which enters the signal amplifier through a coaxial cable, and the amplified electrical signal is collected and processed by the acquisition card to obtain the collected data. The acquired data is reconstructed to obtain a photoacoustic image. The embodiment of the present invention can be applied to imaging tumor tissue, and the distribution of blood vessel network can be obtained from the reconstructed image. Compared with normal tissue, the blood vessel network of tumor tissue is dense and curved, and the corresponding blood vessel network image is a strong signal area. By judging the signal intensity of the irradiation area It can distinguish tumor tissue from normal tissue, and the output power of the pulsed laser can be quantified and irradiated according to the signal intensity of different positions of the tumor during the photothermal process. The embodiment of the present invention can not only perform photoacoustic imaging on the target area, but also use hemoglobin to specifically absorb the 532 nm pulsed laser to present a blood vessel network. Compared with normal tissue, the blood vessel network near the tumor tissue is dense, the blood vessel curvature is large, and the blood flow oxygen content Low, the corresponding vascular network image is a strong signal area. According to the structural characteristics of the vascular network, the spatial position and solid boundary of the tumor tissue can be clearly distinguished. At the same time, the tumor boundary tissue can be selectively irradiated according to the characteristics of the tumor boundary in the photoacoustic image, so that only the tumor tissue can be irradiated. The interior and edges are excited to achieve quantified photothermal irradiation.

Corresponding to the method in FIG. 3 , an embodiment of the present invention further provides an electronic device, including a processor and a memory; the memory is used to store a program; the processor executes the program to implement the method described above.

Corresponding to the method in FIG. 3 , an embodiment of the present invention further provides a computer-readable storage medium, where the storage medium stores a program, and the program is executed by a processor to implement the aforementioned method.

The embodiment of the present invention also discloses a computer program product or computer program, where the computer program product or computer program includes computer instructions, and the computer instructions are stored in a computer-readable storage medium. The processor of the computer device can read the computer instructions from the computer-readable storage medium, and the processor executes the computer instructions to cause the computer device to perform the method shown in FIG. 3 .

To sum up, the embodiments of the present invention have the following advantages:

(1) The embodiment of the present invention realizes the integration of photoacoustic imaging and photothermal irradiation.

(2) Compared with the traditional imaging technology in the embodiment of the present invention, the photoacoustic imaging technology has the characteristics of high optical imaging resolution and deep acoustic imaging depth. The imaging principle is based on the photoacoustic effect, no external contrast agent, and no ionizing radiation. The tumor microvascular network can be imaged to obtain the spatial position and boundary contour of the tumor tissue.

(3) In the embodiment of the present invention, the spatial position and distribution of the tumor are obtained through the photoacoustic image, and the photothermal irradiation plan is formulated according to the characteristics of different tumors. Tissue heating, coagulation and necrosis, the pulsed laser power can be adjusted, and the power can be reduced in the tumor boundary area to avoid noise thermal damage to surrounding normal tissue, and achieve precise photothermal irradiation.

In some alternative implementations, the functions/operations noted in the block diagrams may occur out of the order noted in the operational diagrams. For example, two blocks shown in succession may, in fact, be executed substantially concurrently or the blocks may sometimes be executed in the reverse order, depending upon the functionality/operations involved. Furthermore, the embodiments presented and described in the flowcharts of the present invention are provided by way of example in order to provide a more comprehensive understanding of the technology. The disclosed methods are not limited to the operations and logic flows presented herein. Alternative embodiments are contemplated in which the order of the various operations are altered and in which sub-operations described as part of larger operations are performed independently.

Furthermore, while the invention is described in the context of functional modules, it is to be understood that, unless stated to the contrary, one or more of the described functions and/or features may be integrated in a single physical device and/or or software modules, or one or more functions and/or features may be implemented in separate physical devices or software modules. It will also be appreciated that a detailed discussion of the actual implementation of each module is not necessary to understand the present invention. Rather, given the attributes, functions, and internal relationships of the various functional modules in the apparatus disclosed herein, the actual implementation of the modules will be within the routine skill of the engineer. Accordingly, those skilled in the art, using ordinary skill, can implement the invention as set forth in the claims without undue experimentation. It is also to be understood that the specific concepts disclosed are illustrative only and are not intended to limit the scope of the invention, which is to be determined by the appended claims along with their full scope of equivalents.

The functions, if implemented in the form of software functional units and sold or used as independent products, may be stored in a computer-readable storage medium. Based on this understanding, the technical solution of the present invention can be embodied in the form of a software product in essence, or the part that contributes to the prior art or the part of the technical solution. The computer software product is stored in a storage medium, including Several instructions are used to cause a computer device (which may be a personal computer, a server, or a network device, etc.) to execute all or part of the steps of the methods described in the various embodiments of the present invention. The aforementioned storage medium includes: U disk, mobile hard disk, Read-Only Memory (ROM, Read-Only Memory), Random Access Memory (RAM, Random Access Memory), magnetic disk or optical disk and other various storage media that can store program codes. medium.

The logic and/or steps represented in flowcharts or otherwise described herein, for example, may be considered an ordered listing of executable instructions for implementing the logical functions, may be embodied in any computer-readable medium, For use with, or in conjunction with, an instruction execution system, apparatus, or device (such as a computer-based system, a system including a processor, or other system that can fetch instructions from and execute instructions from an instruction execution system, apparatus, or apparatus) or equipment. For the purposes of this specification, a "computer-readable medium" can be any device that can contain, store, communicate, propagate, or transport the program for use by or in connection with an instruction execution system, apparatus, or apparatus.

More specific examples (non-exhaustive list) of computer readable media include the following: electrical connections with one or more wiring (electronic devices), portable computer disk cartridges (magnetic devices), random access memory (RAM), Read Only Memory (ROM), Erasable Editable Read Only Memory (EPROM or Flash Memory), Fiber Optic Devices, and Portable Compact Disc Read Only Memory (CDROM). In addition, the computer readable medium may even be paper or other suitable medium on which the program may be printed, as the paper or other medium may be optically scanned, for example, followed by editing, interpretation, or other suitable medium as necessary process to obtain the program electronically and then store it in computer memory.

It should be understood that various parts of the present invention may be implemented in hardware, software, firmware or a combination thereof. In the above-described embodiments, various steps or methods may be implemented in software or firmware stored in memory and executed by a suitable instruction execution system. For example, if implemented in hardware, as in another embodiment, it can be implemented by any one or a combination of the following techniques known in the art: Discrete logic circuits, application specific integrated circuits with suitable combinational logic gates, Programmable Gate Arrays (PGA), Field Programmable Gate Arrays (FPGA), etc.

In the description of this specification, description with reference to the terms "one embodiment," "some embodiments," "example," "specific example," or "some examples", etc., mean specific features described in connection with the embodiment or example , structure, material or feature is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

Although embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, The scope of the invention is defined by the claims and their equivalents.

The above is a specific description of the preferred implementation of the present invention, but the present invention is not limited to the described embodiments, and those skilled in the art can also make various equivalent deformations or replacements on the premise of not violating the spirit of the present invention, These equivalent modifications or substitutions are all included within the scope defined by the claims of the present application.

Claims (10)

1. A quantification photo-thermal irradiation device based on photoacoustic imaging is characterized by comprising a scanning module, a data acquisition module, a photoacoustic imaging module and a photo-thermal irradiation module;

the scanning module is used for generating a trigger signal through the controller to control the pulse laser to emit pulse laser, the pulse laser is coupled into the single-mode fiber through the fiber coupler, reaches the surface of the tissue to be imaged through the imaging probe and scans the surface of the tissue to be imaged;

the data acquisition module is used for receiving photoacoustic signals obtained by scanning tissues to be imaged, converting the photoacoustic signals into electric signals, enabling the electric signals to enter the signal amplifier through a coaxial cable, acquiring and processing the amplified electric signals by an acquisition card and determining acquired data;

the photoacoustic imaging module is used for reconstructing collected data and determining a photoacoustic image;

and the photo-thermal irradiation module is used for extracting image parameters of the photo-acoustic image, adjusting the pulse laser according to the extracted image parameters and carrying out photo-thermal irradiation on the target part.

2. The photo-acoustic imaging based quantitative photo-thermal irradiation device according to claim 1, wherein the scanning module comprises an imaging probe for scanning the tissue surface to be imaged, comprising a reflector, a micro-electro-mechanical system mirror, a collimator, a fiber bundle, a focusing lens, a light transmissive reflector and a transducer.

3. The photo-acoustic imaging based quantitative photo-thermal irradiation device according to claim 1, wherein the photo-acoustic imaging module comprises:

the device comprises a first unit, a second unit and a third unit, wherein the first unit is used for carrying out denoising average processing on collected data and determining denoising average data;

and the second unit is used for imaging the denoised average data by a maximum projection method and determining the photoacoustic image.

4. The photo-thermal irradiation apparatus for quantification based on photoacoustic imaging according to claim 1, wherein the photo-thermal irradiation module comprises:

the third unit is used for extracting image parameters of the photoacoustic image according to a threshold segmentation method and determining image parameters, wherein the image parameters comprise a target boundary and a target depth;

and the fourth unit is used for controlling the pulse laser to carry out positioning irradiation on the target part according to the target boundary and adjusting the irradiation dose of the pulse laser according to the target depth.

5. The photo-acoustic imaging based quantitative photo-thermal irradiation device according to claim 1, wherein the scanning module comprises a controller for generating square wave signals with different frequencies as the pulse laser trigger signal, and the photo-acoustic image imaging time is changed by changing the frequency of the trigger signal.

6. The photo-acoustic imaging-based quantitative photo-thermal irradiation device according to claim 2, wherein the imaging probe is of an endoscopic structure and performs endoscopic imaging on a narrow cavity.

7. The photo-acoustic imaging based quantitative photo-thermal irradiation device according to claim 2, wherein the imaging probe performs scanning imaging in a forward scanning manner.

8. The utility model provides a quantization light and heat irradiation device based on optoacoustic formation of image, its characterized in that includes pulse laser, fiber coupler, formation of image probe, controller, computer, acquisition card and signal amplifier, pulse laser is connected with fiber coupler electricity, fiber coupler is connected with the formation of image probe electricity, the formation of image probe is connected with the signal amplifier electricity, signal amplifier is connected with the acquisition card electricity, the acquisition card is connected with the computer electricity, the computer is connected with the controller electricity, the controller is connected with the pulse laser electricity.

9. A method for quantitative photothermal irradiation based on photoacoustic imaging, comprising:

the controller generates a trigger signal to control the pulse laser to emit pulse laser, the pulse laser is coupled into the single-mode fiber by the fiber coupler, reaches the surface of the tissue to be imaged through the imaging probe and scans the surface of the tissue to be imaged;

receiving a photoacoustic signal obtained by scanning a tissue to be imaged, converting the photoacoustic signal into an electric signal, enabling the electric signal to enter a signal amplifier through a coaxial cable, collecting and processing the amplified electric signal by a collecting card, and determining collected data;

reconstructing the acquired data to determine a photoacoustic image;

and carrying out image parameter extraction processing on the photoacoustic image, adjusting the pulse laser according to the extracted image parameters, and carrying out photothermal irradiation on the target part.

10. An electronic device comprising a processor and a memory;

the memory is used for storing programs;

the processor executing the program realizes the method as claimed in claim 9.

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