CN102879335B - Portable noninvasive real-time photoacoustic viscoelastic detector - Google Patents
Portable noninvasive real-time photoacoustic viscoelastic detector Download PDFInfo
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Abstract
The invention relates to a portable noninvasive real-time photoacoustic viscoelastic detector which comprises a semiconductor laser, an electrooptical modulator, a function generator, a measuring box, a focusing lens, a rectangular prism group, an ultrasonic transducer, a preposed signal amplifier, a lock-in amplifier and a data acquisition device; along the laser propagation direction, the semiconductor laser, the electrooptical modulator, and the measuring box are orderly arranged; in the measuring box, a laser inlet, the focusing lens, the rectangular prism group, and a laser outlet are arranged in a line; in the measuring box, along the acoustic wave propagation direction, the laser outlet, the rectangular prism group, and the ultrasonic transducer are orderly arranged; the ultrasonic transducer, the preposed signal amplifier, the lock-in amplifier and the data acquisition device are orderly connected electrically; the function generator is respectively connected with the electrooptical modulator and the lock-in amplifier. The invention has the advantages of simple structure, higher measurement precision and sensitivity, and convenient operation, and belongs to the technical field of biomedical detection.
Description
Technical field
The present invention relates to biomedical detection technique, specifically, relate to a kind of portable non-invasive, real-time optoacoustic viscoelastic detector.
Background technology
All the time, palpation is doctor's indispensable a kind of means in clinical diagnosis.By the palpation to soft tissue, can quality and viscoelastic change thereof in perceptual organization, thus judge the whether normal of tissue.Seeking and visiting especially for tumor tissues, usually through its quality of palpation perception, mobility and with surround relationship etc., to infer the good pernicious of tumour.It is generally acknowledged change and its pathologic process close relation of soft tissue quality.From mechanics angle, the change of soft tissue quality means the change of its mechanical characteristic, and that is, when organizing generation pathology, the viscoelasticity characteristic of tissue can change thereupon.Therefore, scholar is had to propose to detect the mechanical characteristic organized and viscoelasticity characteristic, expect the quality that accurately can reflect tissue, and viscoelasticity is the important parameter characterizing a kind of biological tissue mechanical characteristic, realize organ (such as liver by the Noninvasive testing of the viscoelastic property to biological tissue, skin or blood vessel) detection of relevant diseases and assessment are very important.
Existing viscoelasticity detection method is mainly ultrasonic viscoelasticity and detects, the method adopts static state/quasi-static tissue excitation method, utilize probe or a probe-stripper plate device, along longitudinal direction (axis) compress tissue of probe, to the strain organizing applying one small.Different according to the viscoelastic coefficient (stress/strain) of various different tissues (comprising normal and pathological tissue), after tissue is subject to external force or oscillation exchange, its strain (being mainly morphologic change) is also different, collect each signal segment in the measured body time period, the echoed signal of compound cross-correlation (CAM) method to reflection before and after compressing is utilized to analyze, the displacement of the inner diverse location of computation organization, then deformation extent is calculated, thus the difference of indirectly or direct mechanical attributes such as its elastic modulus of reflection.The method is applied acting force must first to tissue and be made it deformation, this also with regard to result in for receive ultrasound data with regard to, its reference point is motion, and when detecting, sonotrode is applied to the pressure size on medium and pops one's head in whether all will affect the result measured perpendicular to medium.In practical operation, testing result is easy to the impact being subject to operator's subjective factor, thus causes the result difference in measuring process larger.In addition, this mode of action puts on whole tissue, but not only for specific region to be measured, like this, the motion of specific region surrounding tissue and deformation also can affect the accuracy of result.
At present, utilize photoacoustic method to detect tissue elasticity to have been reported in China, as invention disclosed patent on September 7th, 2011: photoacoustic elastic imaging method and device, applicant: South China Normal University, the applying date: on January 14th, 2011, application number: 201110008213, the continuous light source that have employed intensity modulated excites generation ultrasonic signal, by measuring phase differential between this signal and modulation signal and point by point scanning can reconstruct the elasticity distribution image detecting sample.But in the above-mentioned methods, the reception of photo-acoustic excitation and acoustical signal fails to realize coaxial confocal structure, and the efficiency of therefore photo-acoustic excitation and detection is not high, reduces the accuracy of measurement result.And said method is subtend detecting pattern, lack the convenience of practical operation, be unfavorable for carrying out viscoelasticity measurement in soma, actual applying have received very large restriction.
Summary of the invention
For the technical matters existed in prior art, the object of the invention is: provide a kind of and irradiate tissue to be measured by laser, the speed according to tissue generation sound wave to be measured accurately judges a kind of portable non-invasive, the real-time optoacoustic viscoelastic detector of tissue viscoelasticity.
In order to achieve the above object, the present invention adopts following technical scheme:
A kind of portable non-invasive, real-time optoacoustic viscoelastic detector, comprise semiconductor laser, electrooptic modulator, function generator, measuring box, condenser lens, right-angle prism group, ultrasonic transducer, signal preamplifier, lock-in amplifier and data collector; Along the direction of propagation of laser, semiconductor laser, electrooptic modulator and measuring box set gradually; In measuring box, the outlet of the entrance of laser, condenser lens, right-angle prism group and laser sets gradually point-blank, and laser, by after right-angle prism group, is propagated along former direction; In measuring box, along sound direction of wave travel, the outlet of laser, right-angle prism group and ultrasonic transducer set gradually, and sound wave is by right-angle prism group rear steering; Ultrasonic transducer, signal preamplifier, lock-in amplifier and data collector are electrically connected successively; Function generator connects with electrooptic modulator and lock-in amplifier respectively.After adopting this structure, semiconductor laser sends the continuous laser with specific wavelength, be incident in electrooptic modulator, electrooptic modulator carries out intensity modulated according to the sine wave-shaped signal inputted by function generator to continuous laser, its modulating frequency is equal to the frequency by function generator input signal, obtain sinusoidal wave laser thus, the lens focus of sinusoidal wave laser in measuring box is to tissue to be measured, produce sound wave, for the tissue that viscoelastic coefficient is different, the speed of its acoustic emission produced is different, after acoustic signals is turned to by the reflection of right-angle prism group, receive through ultrasonic transducer and transfer electric signal to, electric signal is after signal preamplifier amplifies, the phase differential of electric signal and sinewave modulation signal is extracted by lock-in amplifier, namely the time that acoustical impedance is launched indirectly is obtained, data collector carries out analyzing and processing to data, draw the viscoelasticity of tissue to be measured.Usual viscoelasticity is higher, and the time postponing to produce sound wave is longer, and namely phase differential is larger.After adopting this structure, structure is simple, and Detection results is accurate, and can detect in real time, timely the viscoelasticity of tissue to be measured, be a kind of Non-invasive detection process.Why say that Detection results is accurate, mainly the sensitivity of laser is better, and in measuring process, and non-athletic of organizing to be measured, the facula position namely irradiating tissue to be measured is fixed.
Measuring box is closed container, wholely posts acoustic absorption material layer; The entrance of laser is positioned at one end of measuring box, and the outlet of laser is positioned at the other end of measuring box; Right-angle prism group, near the outlet of laser, comprises the right-angle prism that two pieces of reflecting slant are bonded to each other, and binding face and sound direction of wave travel be 45 degree, be 135 degree with the axis of ultrasonic transducer, and binding face is wiped with the acoustic reflecting layer of light-permeable.After adopting this structure, acoustic absorption material layer can effectively completely cut off outside useless sound wave, ensures that ultrasonic transducer only receives the sound wave of tissue emissions to be measured, makes final detection result accurately and reliably; The structure of right-angle prism group is simple, does not affect Cheng Jiguang and propagates along former road, and what can realize backhaul sound wave turns to propagation simultaneously.
The material of measuring box is organic glass, and acoustic absorption material layer is positioned at the inwall of measuring box; The exit of laser is provided with light transmission protecting film, is close to right-angle prism group inside light transmission protecting film, and tissue to be measured is close in outside; Ultrasonic transducer is close to by right-angle prism group by coupling liquid.After adopting this structure, light transmission protecting film is close to tissue to be measured can complete measurement, while proterctive equipment, and convenient operation.
The material of organic glass is polymethylmethacrylate; The material of light transmission protecting film is polystyrene; The material of acoustic reflecting layer is silicone oil.After adopting this structure, polystyrene can transmission laser and sound wave effectively, and can be out of shape along with extruding, can and to be measured organizing seamlessly stick together and there is no constriction; Acoustic reflecting layer needs printing opacity, needs the difference having acoustic impedance with the material glass of right-angle prism simultaneously, can select silicone oil or water etc., when selecting silicone oil, because it is few with the refringence of glass, less on the impact of laser, good printing opacity and acoustic reflection effect can be reached.
The wavelength coverage of the laser of semiconductor laser is near infrared spectrum district 780nm ~ 1100nm; The modulating frequency of electrooptic modulator is 10kHZ ~ 10MHZ.After adopting this structure, namely select the parameter of preferable range, may correspond to the absorbing wavelength of the light in most of biological tissue, make this photo-acoustic detection instrument be applicable to most biological tissue, good Detection results can be obtained.In general, the wavelength of laser preferably selects the value making the absorbing amount of tissue to be measured maximum, to obtain testing result more accurately.For the selection of frequency, the inspection of each ingredient performance frequently in Main Basis instrument, generally selects high-frequency to affect to the accuracy detected.
Fiber connection is passed through between semiconductor laser and electrooptic modulator, between electrooptic modulator and measuring box; The laser place of entering of electrooptic modulator is provided with collimation lens.After adopting this structure, collimation lens collimates the laser dispersed that optical fiber exports, and makes the light beam dispersed become parallel light beam, for electrooptical modulation is prepared.
Data collector comprises: the computing machine that data collecting card and data processing software are housed, and data collecting card connects with lock-in amplifier; Computing machine is connected with a display screen changed by graphic software platform viscoelasticity.After adopting this structure, data collecting card receives data, and computing machine carries out analyzing and processing by data processing software to data, draws the viscoelasticity of tissue to be measured, and display screen then real-time quantitative graphic software platform viscoelasticity change, testing process can intuitively show.
Portable non-invasive, real-time optoacoustic viscoelastic detector also comprise the translating device be arranged in measuring box, and condenser lens is moved between the entrance and right-angle prism group of laser by translating device.After adopting this structure, condenser lens translation, the i.e. focal position of adjustable laser, focus and to be measuredly organize more close, the utilization factor of laser is higher, and the signal intensity simultaneously obtained is larger, and testing result is more accurate.
The photo-acoustic detection method of tissue viscoelasticity, after comprising the steps: that the laser of a. standing wave length sends, carries out intensity modulated with sine wave signal to laser and obtains sinusoidal wave laser; B., after sinusoidal wave laser line focus lens, focus on tissue to be measured through right-angle prism group, wherein right-angle prism group does not change the direction of propagation of sinusoidal wave laser; C. sinusoidal wave laser excitation tissue to be measured sends sinusoidal wave sound wave, and sinusoidal wave sound wave, after the reflection of right-angle prism group, arrives ultrasonic transducer; D. ultrasonic transducer transfers sinusoidal wave acoustic signals to sinusoidal wave electric signal, and sinusoidal wave electric signal, after amplifying, arrives lock-in amplifier, extracted the phase differential of sinusoidal wave laser signal and sinusoidal wave electric signal by lock-in amplifier; E. according to phase place extent, the viscoelasticity of tissue to be measured is drawn by data collector.Adopt in this way, operating process is simple and convenient, and measurement effect is accurate, and can detect in real time, timely the viscoelasticity of tissue to be measured, be a kind of Non-invasive detection process.
Regulate the position of condenser lens thus regulate the focal position of sinusoidal wave laser, when lock-in amplifier shows the amplitude maximum of sinusoidal wave electric signal, being in the optimum efficiency state to tissue detection to be measured.Adopt in this way, the focal position of adjustable laser, focus and to be measuredly organize more close, the utilization factor of laser is higher, and the signal intensity simultaneously obtained is larger, and testing result is more accurate.
Generally speaking, tool of the present invention has the following advantages:
1, utilize the laser of high order focusing to detect, relative to traditional Ultrasonic Detection, photo-acoustic detection has higher measuring accuracy and sensitivity.
2, the present invention utilizes right-angle prism group that sound wave excitaton source and ultrasonic transducer are formed confocal arrangement, optical focus and area for sound,focal can be located at same point, greatly improve exciting and receiving efficiency of acoustic signals.
3, the present invention has automatic identification function for the acoustic signals received, and intercepts the noise signal introduced by environmental factor, thus ensures that the present invention has very strong dynamic environment adaptability.Specifically, used lock-in amplifier to detect, and lock-in amplifier utilizes heterodyne system oscillation technology, and detected signal and modulation signal are done multiplying, except the interference of de-noised signal, can finally obtain the phase differential of acoustic signals and modulation signal.
4, the present invention adopts cheap semiconductor laser to realize the detection of optoacoustic viscoelasticity, and the cost of overall instrument is relatively low, is easy to application.
Accompanying drawing explanation
Fig. 1 is the composition schematic diagram of a kind of portable non-invasive, real-time optoacoustic viscoelastic detector.
Fig. 2 is the structural representation of measuring box.
Fig. 3 is the viscoelasticity comparison diagram adopting a kind of portable non-invasive, real-time optoacoustic viscoelastic detector to detect different material in embodiment one.
Fig. 4 is the viscoelasticity comparison diagram adopting a kind of portable non-invasive, real-time optoacoustic viscoelastic detector to detect agar in embodiment two.
Wherein, 1 is semiconductor laser, and 2 is optical fiber, and 3 is electrooptic modulator; 4 is function generator, and 5 is measuring box, and 6 is condenser lens; 7 is right-angle prism group, and 8 is ultrasonic transducer, and 9 is signal preamplifier; 10 is lock-in amplifier, and 11 is computing machine, and 12 is collimation lens; 13 is optical fiber head, and 14 is light transmission protecting film, and 15 is acoustic absorption material layer; 16 is tissue to be measured, and 17 is sinusoidal wave laser, and 18 is sinusoidal wave sound wave.
Embodiment
Below in conjunction with the drawings and specific embodiments, the present invention will be further described in detail.
Embodiment one
Shown in Fig. 1 and Fig. 2, a kind of portable non-invasive of the present invention, real-time optoacoustic viscoelastic detector comprise semiconductor laser, electrooptic modulator, function generator, measuring box, condenser lens, right-angle prism group, ultrasonic transducer, signal preamplifier, lock-in amplifier, data collector, collimation lens and two optical fiber; Along the direction of propagation of laser, semiconductor laser, optical fiber, collimation lens, electrooptic modulator, optical fiber and measuring box set gradually; In measuring box, the outlet of the entrance of laser, condenser lens, right-angle prism group and laser sets gradually point-blank, and laser, by after right-angle prism group, is propagated along former direction; In measuring box, along sound direction of wave travel, the outlet of laser, right-angle prism group and ultrasonic transducer set gradually, and sound wave is by right-angle prism group rear steering; Ultrasonic transducer, signal preamplifier, lock-in amplifier and data collector are electrically connected successively; Function generator connects with electrooptic modulator and lock-in amplifier respectively.
Semiconductor laser can send the continuous laser of fixed wave length, regulates its parameter, can control the wavelength of laser, and the optical maser wavelength in the present embodiment is the continuous laser of 808nm.
The product of conoptics company of the U.S. selected by electrooptic modulator, and model is M-360, for regulating the intensity of laser.
Function generator is the product of Imtech, after connecting, makes electrooptic modulator according to the intensity of the Signal Regulation laser of sine wave with electrooptic modulator, and in the present embodiment, its output signal is set as that frequency is the sine wave-shaped signal of 50Khz.
Measuring box is closed container, and material is polymethylmethacrylate, and whole inwall all posts acoustic absorption material layer.Shown in Fig. 2, the entrance of laser is positioned at the upper end of measuring box, and the outlet of laser is positioned at the lower end of measuring box; Right-angle prism group, near the outlet of laser, comprises the right-angle prism that two pieces of reflecting slant are bonded to each other, and binding face and sound direction of wave travel be 45 degree, be 135 degree with the axis of ultrasonic transducer, and binding face is wiped with the acoustic reflecting layer of light-permeable, and material is silicone oil.The porch of laser is provided with optical fiber head, is sent by the laser of Optical Fiber Transmission with the form of pointolite.The exit of laser is provided with light transmission protecting film, and material is polystyrene, is close to right-angle prism group inside light transmission protecting film, and tissue to be measured is close in outside; Ultrasonic transducer is close to by right-angle prism group by coupling liquid.The Laser Focusing that condenser lens is used for pointolite to launch is in focus, and condenser lens, by being arranged on the translating device in measuring box, moves, to adjust the position of Laser Focusing between the entrance and right-angle prism group of laser.Translating device can adopt pinion and rack, transmitting gear, can be with carry-over bar translation, and then drives and the relatively-stationary condenser lens translation of tooth bar.
Ultrasonic transducer is unit or polynary ultrasonic transducer, is fixed in measuring box, for receiving the acoustic signals that right-angle prism group reflects, and acoustic signals is converted to electric signal.Right-angle prism group and ultrasonic transducer integrative packaging are in measuring box.
Signal preamplifier is used for electric signal to amplify, and prepares for follow-up data compare.
Lock-in amplifier receives the electric signal (i.e. sinusoidal wave acoustic signals) that signal preamplifier is sent, and the sine wave signal that receiver function generator is sent (i.e. sinusoidal wave laser signal), the phase differential of more sinusoidal wave laser signal and sinusoidal wave acoustic signals, can record to be measured be organized in be subject to laser irradiate after, acoustical impedance launch time.
Data collector comprises: the computing machine that data collecting card and data processing software are housed, and data collecting card connects with lock-in amplifier; Computing machine is connected with a display screen changed by graphic software platform viscoelasticity.Data processing software is LABVIEW data acquisition control program and data processing MATLAB program, and the data collected by data collecting card are by the change of display screen quantitative graphic software platform tissue viscoelasticity.Computing machine can select P4 microcomputer, inside there is more than 128M.
Tissue to be measured fat, muscle, liver etc. is had different viscoelastic biological tissue be placed in same plane.
The photo-acoustic detection method of tissue viscoelasticity, comprise the steps: that a. semiconductor laser sends the long laser of standing wave, laser is become parallel beam by collimation lens, function generator sends sine wave signal to electrooptic modulator, and electrooptic modulator sine wave signal carries out intensity modulated to laser and obtains sinusoidal wave laser; B. sinusoidal wave laser sends from optical fiber head with the form of pointolite, after line focus lens, focuses on tissue to be measured through right-angle prism group, and the hot spot after focusing is 1 square millimeter, and wherein right-angle prism group does not change the direction of propagation of sinusoidal wave laser; C. after sinusoidal wave laser excitation tissue to be measured, organizational delay to be measured sends sinusoidal wave sound wave, and sinusoidal wave sound wave, after right-angle prism group reflection 90 degree, arrives ultrasonic transducer; D. ultrasonic transducer transfers sinusoidal wave acoustic signals to sinusoidal wave electric signal, sinusoidal wave electric signal is after signal preamplifier amplifies, arrive lock-in amplifier, the phase differential of sinusoidal wave laser signal (being inputted by function generator) and sinusoidal wave electric signal is extracted by lock-in amplifier, namely indirectly obtain the phase differential of sinusoidal wave laser signal and sinusoidal wave acoustic signals, thus obtain the delay launch time of sound wave; E. data collecting card gathers this phase data, and computing machine, by data processing software analytical calculation, draws the viscoelasticity of tissue to be measured, shows in display screen, and simultaneous computer stores corresponding data.
Regulate the position of condenser lens by translating device thus regulate the focal position of sinusoidal wave laser, when lock-in amplifier shows the amplitude maximum of sinusoidal wave electric signal, being in the optimum efficiency state to tissue detection to be measured.Before each test, all first can adjust instrument, guarantee that it is in best test mode.
According to the successively detection of above-mentioned detection method to the fat of testing sample, muscle, several different material of liver, the phase data collected is detected to above-mentioned several material and compares, its viscoelastic difference (as shown in Figure 3) can be determined.From the viscoelastic difference that experimental result can find out a kind of portable non-invasive of the present invention, real-time optoacoustic viscoelastic detector can measure different material.
Embodiment two
The viscoelasticity that a kind of portable non-invasive of employing embodiment one, real-time optoacoustic viscoelastic detector realize object under test detects, and comprises the following steps:
(1) mix with 95g water with 5g agar, after boiling, form tissue to be measured, be fixed on below light transmission protecting film.
(2) laser of semiconductor laser is modulated into intensity becomes sinusoidal variations sinusoidal wave laser with the frequency of 50Khz after electrooptic modulator, is irradiated to tissue surface to be measured.
(3) the sinusoidal wave acoustic signals of ultrasonic transducer real-time reception tissue emissions to be measured, and sinusoidal wave acoustic signals is converted to sinusoidal wave electric signal, sinusoidal wave electric signal amplifies through signal preamplifier, finally examined frequently by lock-in amplifier and calculate phase differential, stored the phase difference value of tissue to be measured by computing machine in real time, utilize LABVIEW software to show the viscoelasticity change of tissue to be measured in real time.
The present invention can to show in agar cooling procedure viscoelasticity change in time in real time as seen from Figure 4.
The not mentioned part of the present embodiment is with embodiment one.
When detecting with the tissue of this instrument to patient; only need be close to tissue surface with the light transmission protecting film position of this instrument; the distance of condenser lens is regulated again by translating device; when the amplitude maximum of the sinusoidal wave electric signal shown; be in the optimum efficiency state to tissue detection to be measured, can start to detect.After viscoelastic data information being detected, detection and the assessment of organ lesion can be carried out according to this data message.
Above-described embodiment is the present invention's preferably embodiment; but embodiments of the present invention are not restricted to the described embodiments; change, the modification done under other any does not deviate from Spirit Essence of the present invention and principle, substitute, combine, simplify; all should be the substitute mode of equivalence, be included within protection scope of the present invention.
Claims (6)
1. portable non-invasive, a real-time optoacoustic viscoelastic detector, is characterized in that: comprise semiconductor laser, electrooptic modulator, function generator, measuring box, condenser lens, right-angle prism group, ultrasonic transducer, signal preamplifier, lock-in amplifier and data collector; Along the direction of propagation of laser, semiconductor laser, electrooptic modulator and measuring box set gradually; In measuring box, the outlet of the entrance of laser, condenser lens, right-angle prism group and laser sets gradually point-blank, and laser, by after right-angle prism group, is propagated along former direction; In measuring box, along sound direction of wave travel, the outlet of laser, right-angle prism group and ultrasonic transducer set gradually, and sound wave is by right-angle prism group rear steering; Ultrasonic transducer, signal preamplifier, lock-in amplifier and data collector are electrically connected successively; Function generator connects with electrooptic modulator and lock-in amplifier respectively;
Described measuring box is closed container, wholely posts acoustic absorption material layer; The entrance of laser is positioned at one end of measuring box, and the outlet of laser is positioned at the other end of measuring box; Right-angle prism group, near the outlet of laser, comprises the right-angle prism that two pieces of reflecting slant are bonded to each other, and binding face and sound direction of wave travel be 45 degree, be 135 degree with the axis of ultrasonic transducer, and binding face is wiped with the acoustic reflecting layer of light-permeable;
The material of described measuring box is organic glass, and acoustic absorption material layer is positioned at the inwall of measuring box; The exit of laser is provided with light transmission protecting film, is close to right-angle prism group inside light transmission protecting film, and tissue to be measured is close in outside; Ultrasonic transducer is close to by right-angle prism group by coupling liquid.
2. according to a kind of portable non-invasive according to claim 1, real-time optoacoustic viscoelastic detector, it is characterized in that: the material of described organic glass is polymethylmethacrylate; The material of light transmission protecting film is polystyrene; The material of acoustic reflecting layer is silicone oil.
3. according to a kind of portable non-invasive according to claim 1, real-time optoacoustic viscoelastic detector, it is characterized in that: the wavelength coverage of the laser of described semiconductor laser is near infrared spectrum district 780nm ~ 1100nm; The modulating frequency of electrooptic modulator is 10kHZ ~ 10MHZ.
4. according to a kind of portable non-invasive according to claim 1, real-time optoacoustic viscoelastic detector, it is characterized in that: between described semiconductor laser and electrooptic modulator, between electrooptic modulator and measuring box, pass through Fiber connection; The laser place of entering of electrooptic modulator is provided with collimation lens.
5. according to a kind of portable non-invasive according to claim 1, real-time optoacoustic viscoelastic detector, it is characterized in that: described data collector comprises: the computing machine that data collecting card and data processing software are housed, data collecting card connects with lock-in amplifier; Computing machine is connected with a display screen changed by graphic software platform viscoelasticity.
6. according to a kind of portable non-invasive according to claim 1, real-time optoacoustic viscoelastic detector, it is characterized in that: it also comprises the translating device be arranged in measuring box, condenser lens is moved between the entrance and right-angle prism group of laser by translating device.
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| CN105572048B (en) * | 2015-12-16 | 2018-10-23 | 华南师范大学 | The quantitative elasticity of optoacoustic, the two-parameter imaging method of viscosity and device |
| CN105572049B (en) * | 2015-12-16 | 2018-09-11 | 华南师范大学 | Optoacoustic quantifies elastograph imaging method and device |
| CN106769877A (en) * | 2016-11-29 | 2017-05-31 | 哈尔滨工业大学 | A kind of biological tissue's frequency domain photoacoustic imaging detection method and system |
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| US4267732A (en) * | 1978-11-29 | 1981-05-19 | Stanford University Board Of Trustees | Acoustic microscope and method |
| CN101918811A (en) * | 2007-10-25 | 2010-12-15 | 圣路易斯华盛顿大学 | Confocal photoacoustic microscopy with optical lateral resolution |
| CN102175776A (en) * | 2011-01-14 | 2011-09-07 | 华南师范大学 | Photoacoustic elastic imaging method and device |
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| US4267732A (en) * | 1978-11-29 | 1981-05-19 | Stanford University Board Of Trustees | Acoustic microscope and method |
| CN101918811A (en) * | 2007-10-25 | 2010-12-15 | 圣路易斯华盛顿大学 | Confocal photoacoustic microscopy with optical lateral resolution |
| CN102175776A (en) * | 2011-01-14 | 2011-09-07 | 华南师范大学 | Photoacoustic elastic imaging method and device |
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