CN211131008U

CN211131008U - Multi-mode breast tumor imaging device based on multi-spectral ultrasonic modulation

Info

Publication number: CN211131008U
Application number: CN201921217850.1U
Authority: CN
Inventors: 朱莉莉; 章小曼; 彭东青; 李晖; 宋海洋
Original assignee: Fujian Normal University
Current assignee: Fujian Normal University
Priority date: 2019-07-31
Filing date: 2019-07-31
Publication date: 2020-07-31
Anticipated expiration: 2029-07-31

Abstract

The utility model relates to a breast tumour multimode image device based on multispectral ultrasonic modulation. The device comprises a laser, an adjustable attenuator, a first variable diaphragm, a second variable diaphragm, a photomultiplier, a preamplifier, a multifunctional power supply, a phase-locked amplifier, an ultrasonic pulse transmitting and receiving device, an ultrasonic transducer and a three-dimensional scanning system. The utility model discloses a with different wavelength laser and focus supersound simultaneous action in the sample that awaits measuring, utilize focus ultrasonic modulation and location spectral signal, obtain the multispectral signal of ultrasonic modulation of mammary gland tumour to make focus ultrasonic transducer carry out three-dimensional scanning to the sample through three-dimensional scanning system, accomplish the collection of data, finally realize the formation of image of same formation of image region multi-parameter.

Description

Multi-mode breast tumor imaging device based on multi-spectral ultrasonic modulation

Technical Field

The utility model relates to a breast tumour multimode image device based on multispectral ultrasonic modulation.

Background

Breast cancer is one of the most common malignant tumors in women, and the incidence rate of malignant tumors in women is the first place. Early detection, early diagnosis is the key to improve the cure rate of breast cancer and reduce the fatality rate, is also a research hotspot of the current prevention and treatment of breast cancer, and has great significance. The optical imaging method has been increasingly paid attention to by researchers due to its safety, non-destructive characteristics, high detection sensitivity, and inherent advantages in chemical composition analysis and functional imaging of tissues. Especially, multi-modal imaging combined with optical imaging can improve the accuracy of tumor detection and grading, and has become the first choice method for early cancer diagnosis at present. For example, the ultrasonic light scattering tomography combines light scattering tomography (DOT) with ultrasound, obtains the morphological characteristics of the tumor through ultrasound, obtains the functional imaging of the tumor through DOT, and combines acoustics and optics into a whole. For example, fluorescence-optical combined tomography (FDOT-DOT) combines Fluorescence Diffusion Optical Tomography (FDOT) with high contrast and blood oxygen DOT capable of providing intrinsic functional information, so that the location, qualitative and quantitative information of the lesion can be provided more accurately, and the morbidity of the blood oxygen DOT reconstruction process is effectively improved.

Ultrasonic modulation optical imaging, also called acousto-optic imaging, is one of optical imaging methods, and belongs to two branches of acousto-optic interaction imaging technology together with photoacoustic imaging. The technology greatly improves the spatial resolution of optical imaging in tissues by utilizing the positioning and modulation functions of ultrasonic waves, has the advantages of high spatial resolution of ultrasonic imaging and high sensitivity of optical imaging, and is a promising nondestructive medical imaging technology.

Disclosure of Invention

The utility model aims at providing a breast tumour multi-mode imaging device based on multispectral ultrasonic modulation, which realizes multi-parameter imaging in the same imaging area; on one hand, the advantage of the ultrasonic modulation optical imaging locatable imaging is utilized to obtain the morphological image of the breast tumor with high spatial resolution and sensitivity, and meanwhile, the hemoglobin concentration and the blood oxygen saturation of the breast tumor are obtained by adopting the multi-wavelength near-infrared light source, so that the functional imaging of the breast tumor is realized.

In order to achieve the above purpose, the technical scheme of the utility model is that: a breast tumor multi-mode imaging device based on multi-spectral ultrasonic modulation comprises a laser, an adjustable attenuator, a first iris diaphragm, a second iris diaphragm, a photomultiplier, a preamplifier, a multifunctional power supply, a lock-in amplifier, an ultrasonic pulse transmitting receiver, an ultrasonic transducer and a three-dimensional scanning system; the laser emits laser, and the laser irradiates on a sample to be measured through the adjustable attenuator; the ultrasonic pulse transmitting and receiving device drives the ultrasonic transducer to generate focused ultrasound and simultaneously act on a sample to be measured; scattered light passing through a sample to be detected is received by a photomultiplier through a first iris diaphragm and a second iris diaphragm, amplified by a preamplifier and then input into a phase-locked amplifier for signal correlation processing, and an acousto-optic signal of the sample to be detected at the position of an ultrasonic focal region is obtained; the multifunctional power supply provides power for the photomultiplier and the preamplifier; the three-dimensional scanning system drives the objective table to enable the sample to be detected to move in three dimensions, so that acoustic and optical signals of all positions of the whole sample to be detected are acquired, and imaging is finally achieved.

The utility model discloses a laser instrument is the collimation laser diode that can send 2 at least near infrared wavelength in turn, also can use the laser instrument of many different wavelengths to replace. When performing structural imaging of breast tumors, only one wavelength needs to be used. When the breast tumor is subjected to functional imaging, two wavelengths with different absorption differences of oxygenated hemoglobin and deoxygenated hemoglobin are respectively used for imaging, for example, near infrared light of 780nm and 830nm is used, and the blood oxygen saturation of different positions of the breast tumor can be obtained through later data processing.

The ultrasonic transducer of the utility model is a water immersion type focusing ultrasonic transducer with a center frequency of 1MHz-10MHz, the front surface of the ultrasonic transducer is arranged in the water tank, and the size of the ultrasonic focal area is usually sub-millimeter magnitude. The size of the ultrasonic focal zone determines the lateral resolution of the structure imaging, and the smaller the ultrasonic focal zone, the higher the lateral resolution of the imaging.

The water tank of the utility model is connected with the ultrasonic transducer and can move together. The bottom of the water tank is sealed by a transparent film and can be in seamless contact with a sample to be measured.

The utility model discloses a two iris diaphragms, its one of which is placed before the sample that awaits measuring, and another is fixed in on photomultiplier's the detection window, can remove along with photomultiplier to steerable photomultiplier's actual detection area. The two diaphragms block most of scattered light (namely useless signals) which is not modulated by ultrasound outside the diaphragms, and a large ultrasound modulation signal can be obtained by selecting a proper diaphragm area and a proper diaphragm position, so that the signal-to-noise ratio of an imaging system is improved.

The utility model discloses a spectral response scope and the used light source spectrum phase-match of photomultiplier cover whole near-infrared spectral region.

The utility model discloses a lock-in amplifier selects the external reference mode, and the external reference source is ultrasonic pulse transceiver's TT L output signal, carries out relevant processing with the modulation signal input lock-in amplifier that detects and ultrasonic pulse transceiver's TT L signal, can draw out weak modulation signal from powerful unmodulated background signal, improves entire system's SNR effectively.

The utility model discloses a three-dimensional scanning system control objective table carries out three-dimensional removal to the sample that awaits measuring, accomplishes the three-dimensional scanning formation of image to the sample that awaits measuring. During imaging, other instruments, including the ultrasound transducer, are stationary.

Compared with the prior art, the utility model discloses following beneficial effect has: the utility model combines the spectrum technology and the acousto-optic imaging technology, provides a multispectral ultrasonic modulation optical imaging device suitable for early diagnosis of breast cancer, and realizes multi-parameter imaging in the same imaging area; on one hand, the advantage of the ultrasonic modulation optical imaging locatable imaging is utilized to obtain the morphological image of the breast tumor with high spatial resolution and sensitivity, and meanwhile, the hemoglobin concentration and the blood oxygen saturation of the breast tumor are obtained by adopting the multi-wavelength near-infrared light source, so that the functional imaging of the breast tumor is realized. The combination of morphological imaging and functional imaging can provide richer and more accurate information basis for the early diagnosis of the breast cancer.

Drawings

Fig. 1 is a block diagram of a multi-mode breast tumor imaging device based on multi-spectral ultrasound modulation according to an embodiment of the present invention;

fig. 2 is a schematic diagram of a position of a water tank for placing an ultrasonic transducer and a sample to be measured according to an embodiment of the present invention.

FIG. 3 shows the optical signal detected by the photomultiplier tube according to an embodiment of the present invention; wherein (a) is an optical signal with ultrasonic modulation, and (b) is an optical signal without ultrasonic modulation;

FIG. 4 is an ultrasonic modulated optical imaging of a simulated sample implicit diffuser and absorber using the apparatus of FIG. 1; wherein (a) is a sample structure schematic diagram, and (b) is a corresponding ultrasonic modulation optical imaging one-dimensional diagram.

Detailed Description

The technical solution of the present invention will be specifically described below with reference to the accompanying drawings.

As shown in fig. 1, the present invention provides a breast tumor multi-modality imaging device based on multi-spectral ultrasound modulation, which comprises: the device comprises a laser 1, an adjustable attenuator 2, two

variable diaphragms

4 and 5, a photomultiplier 6, a preamplifier 7, a multifunctional power supply 8, a lock-in amplifier 9, an ultrasonic pulse transmitting and receiving device 10, an ultrasonic transducer 11, a water tank 12, a three-dimensional scanning system 13 and a computer 14; the laser 1 emits laser, and the laser irradiates a sample after the incident light power is controlled by the adjustable attenuator 2; in the vertical direction of the optical axis, the ultrasonic pulse transmitter-receiver 10 is set to a transmitting mode, and the ultrasonic transducer 11 is driven to generate focused ultrasound and act on a sample simultaneously; the scattered light which passes through the sample and is modulated by the ultrasound is received by the photomultiplier 6 through the two

diaphragms

4 and 5, amplified by the preamplifier 7 and then input into the phase-locked amplifier 9 for signal correlation processing to obtain the acousto-optic signal of the sample at the position of the ultrasonic focal region; the computer 14 controls the three-dimensional scanning system 13 to drive the object stage 15 to move the sample in three dimensions, so that acousto-optic signals of the whole sample space in three-dimensional positions can be acquired, and the spatial distribution map of the absorption coefficient and the scattering coefficient of the sample can be obtained through data processing.

Specifically, the laser 1 is a collimated laser diode capable of alternately emitting at least 2 near infrared wavelengths, and a plurality of lasers having different wavelengths may be used instead. The spectral response range of the photomultiplier tube 6 should be matched to the light source to cover the entire near infrared spectrum. When the breast tumor is subjected to structural imaging, only one wavelength is used. When the breast tumor is imaged functionally, two wavelengths with different absorption differences of oxygenated hemoglobin and deoxygenated hemoglobin are used for imaging respectively, for example, near infrared light of 780nm and 830nm is used, and the blood oxygen saturation of different positions of the breast tumor can be obtained through later data processing.

As shown in fig. 2, the ultrasonic transducer 11 is a water immersion type focusing ultrasonic transducer with a center frequency of 1MHz to 10MHz, the front surface of the ultrasonic transducer is placed in the water tank 12, and the size of the ultrasonic focal zone is sub-millimeter. The water tank 12 is fixed to the ultrasonic transducer 11 and movable together. The bottom of the water tank 12 is sealed with a transparent film 15 and can be in seamless contact with the sample 3 to be measured.

The utility model discloses image device's application method as follows:

1) two kinds of continuous near infrared light (630 nm-1000 nm) with different wavelengths are irradiated on the sample to be measured successively.

2) In the direction perpendicular to the optical axis, focused ultrasonic waves having a center frequency of 1MHz to 10MHz are simultaneously applied to the sample. Focused ultrasound has the effect of locating and modulating optical signals. The ultrasonic focal zone is positioned on the optical axis, and the incident light passes through the ultrasonic focal zone to obtain a larger ultrasonic modulation light signal.

3) The scattered light passing through the sample and the ultrasonic focal region is received by the photomultiplier through the two diaphragms, amplified by the preamplifier and then input into the lock-in amplifier for signal correlation processing. Weak regular modulation signals are extracted from strong unmodulated background signals by utilizing the space filtering function of the diaphragm and the time filtering function of the phase-locked amplifier, so that the signal-to-noise ratio of the system is improved. By detecting the modulation component in the scattered light, the optical and ultrasonic properties of the tissue in the ultrasonic region can be inferred.

4) The computer controls the three-dimensional scanning system to drive the object stage to move the sample in three dimensions, complete the whole scanning of the sample by the ultrasonic field and obtain the spatial distribution diagram of the optical and ultrasonic responses of the sample through data analysis and reconstruction, namely obtain the morphological image of the sample with high spatial resolution and high sensitivity.

5) The ultrasonic modulation signals of the breast tumor are obtained by utilizing the near-infrared light sources with different wavelengths, the absorption coefficients of the breast tumor under different wavelengths are deduced, and the hemoglobin concentration and the blood oxygen saturation of different parts of the breast tumor can be obtained by combining the modified Lambert-beer theorem (applicable to high scattering media), so that the functional imaging of the breast tumor is realized.

In one embodiment of the present invention, a breast tumor simulation sample is subjected to structural imaging, the laser uses a helium-neon laser (CVI Melles Griot, 25-L HR-925 230) with an output wavelength of 632.8nm, an ultrasonic generator (Panametrics NDT 5800PR) drives a focused ultrasonic transducer (Panametrics-NDT A314S; center frequency is 1MHz, pulse width is 0.48 MHz, diameter is 0.75 inch, focal length is 1.006 inch) to generate pulsed ultrasound (repetition frequency is 2 kHz, pulse energy is 100 muJ) to act on the sample, the tumor simulation sample is coagulated by 0.1% fat emulsion solution and agar powder, and scattering coefficient is about 5cm^-11cm in thickness and 13cm in width. The inclusion of foreign bodies along the x-axis is respectively: 1. the strong absorber is prepared from Chinese ink and agar powder, and has absorption coefficient of about 8cm^-1And the width is 6 mm; 2. weak absorber (absorption coefficient about 1.6 cm)^-1) The width is 6 mm; 3. scatterer (scattering coefficient about 10 cm)^-1) The width is 11 mm; 4. small absorber (absorption coefficient about 8 cm)^-1) The width is 3 mm.

FIG. 3 is a diagram showing the optical signals detected by the photomultiplier tube in this embodiment; wherein (a) is an optical signal with ultrasonic modulation, and (b) is an optical signal without ultrasonic modulation.

FIG. 4 is an ultrasonic modulated optical imaging of a simulated sample implicit scatterer and absorber in this example; wherein (a) is a sample structure schematic diagram, and (b) is a corresponding ultrasonic modulation optical imaging one-dimensional diagram. It can be seen from the figure that a one-dimensional imaging diagram of an implicit absorber and a scatterer in a scattering medium reconstructed by using an optical signal modulated by ultrasound is basically consistent with a real object diagram.

The above only is the embodiment of the present invention, not limiting the scope of the present invention, all the equivalent structures or equivalent processes of the present invention are used in the specification and the attached drawings, or directly or indirectly applied to other related technical fields, and the same principle is included in the protection scope of the present invention.

Claims

1. A breast tumor multi-mode imaging device based on multi-spectral ultrasonic modulation is characterized by comprising a laser (1), an adjustable attenuator (2), a first variable diaphragm (4), a second variable diaphragm (5), a photomultiplier (6), a preamplifier (7), a multifunctional power supply (8), a phase-locked amplifier (9), an ultrasonic pulse transmitting receiver (10), an ultrasonic transducer (11) and a three-dimensional scanning system (13); the laser (1) emits laser, and the laser irradiates on a sample to be measured through the adjustable attenuator (2); the ultrasonic pulse transmitting and receiving device (10) drives the ultrasonic transducer (11) to generate focused ultrasound and simultaneously act on a sample to be measured; scattered light passing through a sample to be detected is received by a photomultiplier (6) through a first iris diaphragm (4) and a second iris diaphragm (5), amplified by a preamplifier (7) and then input into a phase-locked amplifier (9) for signal correlation processing, and acousto-optic signals of the sample to be detected at an ultrasonic focal region position are obtained; the multifunctional power supply (8) provides power for the photomultiplier (6) and the preamplifier (7); the three-dimensional scanning system (13) drives the objective table (15) to enable the sample to be detected to move in a three-dimensional mode, so that acousto-optic signals of all positions of the whole sample to be detected are collected, and imaging is finally achieved.

2. The breast tumor multi-modality imaging device based on multi-spectral ultrasound modulation according to claim 1, further comprising a water tank (12), wherein the ultrasound transducer (11) is an underwater focused ultrasound transducer with a center frequency of 1MHz-10MHz, a front surface of the ultrasound transducer is disposed in the water tank (12), and an ultrasound focal zone size is sub-millimeter order.

3. The multi-spectral ultrasound modulation-based breast tumor multi-modality imaging apparatus according to claim 2, wherein the water tank (12) is connected to the ultrasound transducer (11) and is movable together; the bottom of the water tank is sealed by a transparent film and can be in seamless contact with a sample to be measured.

4. The device for multi-spectral ultrasound modulation-based multi-modality imaging of breast tumors according to claim 1, characterized in that the laser (1) is a collimated laser diode capable of emitting at least 2 near infrared wavelengths alternately, or a plurality of lasers (1) of different wavelengths may be used instead.

5. The breast tumor multi-modality imaging device based on multi-spectral ultrasound modulation as claimed in claim 1, characterized in that the first iris diaphragm (4) is close to the sample to be measured, the second iris diaphragm (5) is fixed on the detection window of the photomultiplier tube (6), the second iris diaphragm (5) can move along with the photomultiplier tube (6), and the actual detection area of the photomultiplier tube (6) can be controlled.

6. The device according to claim 1, wherein the spectral response range of the photomultiplier tube (6) covers the entire near infrared spectrum.

7. The breast tumor multi-modality imaging device based on multi-spectral ultrasound modulation as claimed in claim 1, characterized in that the lock-in amplifier (9) selects an external reference mode, and the external reference source is the TT L output signal of the ultrasound pulse transmitting receiver (10).

8. The multi-spectral ultrasound modulation-based breast tumor multi-modality imaging device according to claim 1, wherein the three-dimensional scanning system (13) is composed of a two-dimensional electrically controlled translation stage and a displacement control box, and the three-dimensional scanning system (13) is connected with the object stage (15) and can control the object stage to move in three dimensions.