CN113813318A - Anti-radiation composition, preparation method and application thereof - Google Patents
Anti-radiation composition, preparation method and application thereof Download PDFInfo
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- CN113813318A CN113813318A CN202111157709.9A CN202111157709A CN113813318A CN 113813318 A CN113813318 A CN 113813318A CN 202111157709 A CN202111157709 A CN 202111157709A CN 113813318 A CN113813318 A CN 113813318A
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Abstract
The invention provides a composition with an anti-radiation damage effect and a preparation method and application thereof, and relates to the field of anti-radiation preparations. The composition with the efficacy of resisting radiation damage comprises the following raw materials in parts by weight: 1-40 parts of vine tea, 1-10 parts of golden flower and 1-20 parts of green tea. The invention relates to application of a composition with the effect of resisting radiation damage in preparing radiation-resistant food, beverage and medicine. Pharmacological tests show that the composition has good radiation resistance. The composition, the preparation method and the application thereof have simple process, are easy to realize industrial production, and have obvious radiation protection effect.
Description
Technical Field
The invention belongs to the technical field of health-care food and medicine, relates to a composition with functionality, in particular to a plant extract composition, and an application of the composition in preparing health-care products and medicines for radiation injury and tumor radiation adjuvant therapy; the invention also relates to a method for producing the composition into beverages, tablets and solid instant tea.
Background
With the increasing of radioactive substances in the environment, the popularization of high-tech electronic products and the development of nuclear technology, including clinical diagnosis and treatment and the application development of military industry, bring certain radiation hazards. The well-known tumor radiotherapy in daily life brings about vitality to tumor patients and also brings about strong side effects.
Radiotherapy is a short term for radiotherapy, and is one of the main methods for treating tumors, and mainly uses radiation to kill cancer cells, so that the tumors shrink or disappear. From the data available, 70% of tumor patients need to receive radiation therapy, and thus it can be seen that radiation therapy has an irreplaceable role in the course of tumor therapy. Except postoperative adjuvant radiotherapy, some special tumors can be cured by radiotherapy alone, such as nasopharyngeal carcinoma.
Radiotherapy can produce strong side effects, such as fatigue and weakness; disorders of the digestive tract, such as anorexia, nausea, vomiting, etc.; skin reactions such as pruritus, papular urticaria; low immunity; leukopenia.
Researchers invest a great deal of energy in research and development of radiation protection medicines and health care products, but so far, neither medicines nor health care products can fundamentally solve and meet the protection requirements of consumers on organisms in the radiotherapy process. Therefore, there is a need to develop a product with significant radioprotective effect to meet the clinical needs and special events.
Camellia nitidissima belongs to Theaceae and Camellia, and is formally named as Camellia nitidissima C.W.Chi by a relative scripture of Chinese botanical scientists in 1948. The flos Daturae Metelis contains flavone, tea polysaccharide, saponin, and polyphenols, and has anticancer, antioxidant, and blood lipid reducing effects.
The vine tea contains abundant flavone, polysaccharide and polyphenol compounds, and the main flavone components in the vine tea comprise dihydromyricetin, quercetin, myricetin, hesperetin, apigenin, ampelopsin and the like, and the highest content of dihydromyricetin is used as the main active component in the vine tea. The vine tea is considered by folk as a cleaning agent for cleaning harmful substances in human bodies, and has good health care and curative effects.
Green tea is unfermented tea, and due to its characteristics, it retains more of the natural substances in the fresh leaves. Wherein, the tea polyphenol and the caffeine keep more than 85 percent of fresh leaves, the chlorophyll keeps about 50 percent, and the vitamin loss is less, thereby forming the characteristics of green tea, namely green leaves with clear soup and strong taste astringency. Has special effects on aging prevention, cancer resistance, sterilization, inflammation elimination and the like, and is not good enough for fermented tea and the like. The health-care tea not only has the pharmacological effects of refreshing and clearing away heart-fire, clearing away summer-heat, helping digestion and reducing phlegm, removing greasiness and losing weight, clearing away heart-fire and relieving restlessness, detoxifying and sobering up, promoting the production of body fluid to quench thirst, reducing pathogenic fire and improving eyesight, and stopping dysentery and dehumidifying, but also has certain pharmacological effects on modern diseases, such as radiation disease, cardiovascular and cerebrovascular diseases, cancer and the like. The sun-dried green tea has the best quality of Yunnan large-leaf seeds, and is called as Dianqing; the other herbs such as Chuan Qing, Qian Qing, Gui Qing and Huo Qing are of different quality in thousands of autumn, but not as good as Dian Qing. The green tea of this patent includes, but is not limited to, large leaf green tea.
At present, the composition research of the ampelopsis grossedentata, the golden flower and the green tea is not carried out at home and abroad, and the research of applying the ampelopsis grossedentata, the golden flower and the green tea to the radiation protection field is not carried out.
Disclosure of Invention
The embodiment of the application aims to provide the composition with the body protection effect in the radiotherapy and the production method of the beverage and the instant tea thereof, the process is simple, the industrial production is easy to realize, and the product has the obvious body protection effect.
In a first aspect, the embodiment of the present application provides a radiotherapeutic organism protection composition, which comprises the following raw materials by weight:
1-40 parts of vine tea
1-10 parts of golden flower
1-20 parts of green tea;
in the technical scheme, the ampelopsis grossedentata, the golden flower and the green tea are used as basic compositions to form the radiation protection composition.
In one achievable form, the starting materials include, by weight:
1-10 parts of vine tea
1-3 parts of golden flower
1-5 parts of green tea;
in the technical scheme, the radiation protection composition formed according to the raw material proportion realizes the purposes of improving survival rate and protecting hematopoietic and immune systems, and has obvious body protection effect in radiotherapy.
The anti-radiation composition is characterized in that the anti-radiation composition can be further mixed with proper pharmaceutical or health-care product auxiliary materials, such as cane sugar, cyclodextrin, stevioside, citric acid, fructose, glucose, aspartame, menthol, ascorbic acid, microcrystalline cellulose, lactose, compressible starch and the like, and prepared into beverages, solid instant tea, tablet candy, capsules and the like with anti-radiation function.
In a second aspect, the present application provides a method for preparing the radioprotective composition of the first aspect suitable for mass production, comprising pulverizing the raw materials, and extracting with water.
In the scheme, the raw materials are directly crushed and extracted by adding water, the method is simple, the industrial production is easy to realize, the effective components in the raw materials can be efficiently extracted, the synergistic effect of the effective components is promoted, the remarkable radiation protection is realized, and the immune function of the organism is increased.
In one possible embodiment, the three raw materials are extracted separately, with 20 times the amount of water, twice, boiled, 0.5-1 hour each time, and the extracts are combined. The scheme can fully extract the effective components in the three raw materials and enhance the using effect.
In the above extraction process, the extraction temperature is preferably 100 deg.C, and the extraction period can be shortened.
The extracted medicinal liquid is required to be kept still at 4-8 ℃ to remove insoluble substances.
The above medicinal liquids can be mixed and concentrated into extract for use.
In a third aspect, the embodiments herein provide the use of the radioprotective composition provided in the first aspect in the preparation of a beverage, a granule, a capsule, a tabletted confection.
The method for preparing the health functional beverage by adopting the composition is characterized by comprising the following steps:
step 1: respectively crushing the raw materials according to parts by weight to prepare crude medicinal powder, adding 20 times of water, decocting and extracting, heating and stirring the mixture, extracting for two times at the same temperature for the same time, and collecting supernatant of the two times;
step 2: cooling the three solutions, centrifuging, collecting supernatant, and mixing;
and step 3: mixing the above solutions and diluting to a certain volume;
and 4, step 4: adding appropriate amount of nutritional supplement such as vitamin C, vitamin B6, vitamin B12, zinc citrate or zinc gluconate into the above solution;
and 5: adding appropriate amount of flavoring agent such as cyclodextrin, stevioside, citric acid, fructose, glucose, aspartame, menthol, etc.;
step 6: adding an appropriate amount of antioxidant such as sodium D-erythorbate to the above solution;
and 7: adding antiseptic such as potassium sorbate and sodium benzoate into the above solution;
and 8: filtering the above solution, packaging in a packaging bottle, and sterilizing.
Further, the preparation method for preparing the corresponding solid instant tea is characterized by comprising the following steps:
step 1: respectively crushing the raw materials according to parts by weight to prepare crude medicinal powder, adding 20 times of water, decocting, heating and stirring, extracting for two times at the same temperature for the same time, and collecting the supernatants of the two times;
step 2: cooling the three solutions, centrifuging, collecting supernatant, and mixing;
and step 3: concentrating the solution to a density of about 1.1 to 1.2;
and 4, step 4: adding appropriate amount of nutritional supplement such as vitamin C, vitamin B6, vitamin B12, zinc citrate or zinc gluconate into the concentrated solution;
and 5: adding appropriate amount of flavoring agent such as cyclodextrin, stevioside, citric acid, fructose, glucose, aspartame, menthol, etc.;
step 6: adding appropriate amount of diluent such as lactose, sucrose, dextrin, and glucose, sieving, and granulating;
and 7: drying the obtained granules to obtain granules with the moisture content of less than 5 percent by mass, namely the solid instant tea.
Further, a process for the preparation of capsules/tablets, characterized in that:
step 1: respectively crushing the raw materials according to parts by weight to prepare crude medicinal powder, adding 20 times of water, decocting and extracting, heating and stirring the mixture, extracting for two times at the same temperature for the same time, and collecting supernatant of the two times;
step 2: cooling the three solutions, centrifuging, collecting supernatant, and mixing;
and step 3: concentrating the solution to a density of about 1.2 to 1.3;
and 4, step 4: drying the concentrated solution under reduced pressure, and pulverizing to obtain raw material;
and 5: adding appropriate amount of nutritional supplement, such as vitamin C, vitamin B6, vitamin B12, zinc citrate or zinc gluconate;
step 6: adding diluent and forming agent such as microcrystalline cellulose, lactose, and compressible starch, adding binder such as polyvinylpyrrolidone and hydroxypropyl methylcellulose, and granulating;
and 7: and (3) filling the granules and a lubricant such as silicon dioxide into capsules or tabletting to obtain the tablet.
The method for preparing the radiation damage resistant composition and the application product is characterized in that the extraction in the step 1 is carried out for 30-60 minutes at 90-100 ℃.
When the cold storage temperature in the step 2 is 4-10 ℃ when the composition is used for preparing the anti-radiation damage composition and application products.
When the preparation method is used for preparing the radiation damage resistant beverage, the beverage is filled in a 200-mL 400-mL container in the step 8, and the sterilization condition can adopt UHT sterilization or autoclave sterilization process.
When the preparation method is used for preparing the radiation damage resistant solid preparation, the decompression temperature in the step 3 is 55-65 ℃, the concentration is carried out while decompressing in the concentration process, the vacuum degree is 300-750mmHg until the specific gravity of the concentration is 1.1-1.2.
When the preparation method is used for preparing the anti-radiation damage instant tea, in step 6, small blocks of 2-3 cm are pressed under the pressure of 0.001-0.005MPa, and are granulated through a 16-20 mesh sieve in a swing granulator.
And (3) when the instant tea is used for preparing the anti-radiation damage instant tea, packaging the instant tea obtained in the step (7) in a packaging machine, wherein the specification is 1 g/bag, and packaging.
The invention also provides a composition, which comprises the medicine composition disclosed by the invention and proper auxiliary materials for health care products.
The composition can be applied to the application of foods and medicines for resisting radiation damage. Wherein the radiation damage is radiation damage, including radiation damage in tumor radiation therapy and radiation damage that is long-term engaged in radiation-related tasks.
The composition of the present invention can be used for health food, including solid food and liquid food; the composition of the invention can be used for medicines, including solid oral preparations and liquid oral preparations.
In the scheme, the prepared body radiation protection product is easy to accept in taste, remarkable in effect and wide in application, and can be used for preparing food, beverage and the like. The preparation method is simple and easy to implement, and is suitable for industrial mass production.
The invention is used for the development and research of radiation protection by matching the ampelopsis grossedentata, golden flower and green tea beverage composition for the first time, and is one of the innovation points of the invention. The experimental result of the invention shows that the experiment passes the 7.2Gy dosage137When a C57 mouse is irradiated by Cs gamma rays (the dose rate is 0.99Gy/min), the beverage composition has remarkable effects on the survival rate of the irradiated mouse and the protection of a hematopoietic system, and the details are shown in the pharmacological data part.
Drawings
FIG. 1 is a statistical chart of the survival rate of mice irradiated with 7.2Gy systemically;
FIG. 2 is a statistical chart of mouse whole-body 4Gy irradiated peripheral blood leukocytes;
FIG. 3 is a statistical chart of mouse whole-body 4Gy irradiated peripheral red blood cells;
FIG. 4 is a statistical chart of 4Gy irradiated peripheral platelets in whole body of a mouse;
FIG. 5 is a statistical chart of 4Gy irradiated peripheral blood hemoglobin of mice;
FIG. 6 is a statistical chart of the index of 4Gy irradiated thymus and spleen organs of a mouse;
FIG. 7 is a statistical chart of bone marrow femoral nucleated cells irradiated with 4Gy of the whole body of a mouse.
Detailed Description
In order to make the implementation objects, technical solutions and advantages of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or apparatus used are not indicated by the manufacturer, and are all conventional products available commercially.
The radiation shielding compositions and methods of preparation of the embodiments of the present application are described in detail below.
EXAMPLE 1 radiation resistant composition
1 part of golden flower
1 part of green tea
Respectively crushing the raw materials according to the parts by weight to prepare crude medicinal powder, adding 15 times of water for extraction, heating and stirring the mixture, extracting the mixture for two times at the same temperature for the same time, and collecting the supernatants of the two times; cooling the three solutions, centrifuging, collecting supernatant, and mixing; the concentrated extract of the above samples was used.
EXAMPLE 2 radiation resistant compositions
10 portions of golden flower
1 part of green tea
Respectively crushing the raw materials according to the parts by weight to prepare crude medicinal powder, adding 25 times of water for extraction, heating and stirring the mixture, extracting the mixture for two times at the same temperature for the same time, and collecting the supernatants of the two times; cooling the three solutions, centrifuging, collecting supernatant, and mixing; the concentrated extract of the above samples was used.
EXAMPLE 3 radiation resistant compositions
1 part of golden flower
10 portions of green tea
Respectively crushing the raw materials according to the parts by weight to prepare crude medicinal powder, adding 25 times of water for extraction, heating and stirring the mixture, extracting the mixture for two times at the same temperature for the same time, and collecting the supernatants of the two times; cooling the three solutions, centrifuging, collecting supernatant, and mixing; the concentrated extract of the above samples was used.
EXAMPLE 4 radiation resistant compositions
3 parts of golden flower
5 parts of green tea
Respectively crushing the raw materials according to the parts by weight to prepare crude medicinal powder, adding 20 times of water for extraction, heating and stirring the mixture, extracting the mixture for two times at the same temperature for the same time, and collecting the supernatants of the two times; cooling the three solutions, centrifuging, collecting supernatant, and mixing; the concentrated extract of the above samples was used.
EXAMPLE 5 radiation resistant compositions
Vine tea 1 part
1 part of golden flower
1 part of green tea
Respectively crushing the raw materials according to the parts by weight to prepare crude medicinal powder, adding 15 times of water for extraction, heating and stirring the mixture, extracting the mixture for two times at the same temperature for the same time, and collecting the supernatants of the two times; cooling the three solutions, centrifuging, collecting supernatant, and mixing; the concentrated extract of the above samples was used.
EXAMPLE 6 radiation resistant compositions
2 parts of golden flower
1 part of green tea
Respectively crushing the raw materials according to the parts by weight to prepare crude medicinal powder, adding 10 times of water for extraction, heating and stirring the mixture, extracting the mixture for two times at the same temperature for the same time, and collecting the supernatants of the two times; cooling the three solutions, centrifuging, collecting supernatant, and mixing; the concentrated extract of the above samples was used.
Example 7 radiation resistant composition
1 part of golden flower
2 parts of green tea
Respectively crushing the raw materials according to the parts by weight to prepare crude medicinal powder, adding 20 times of water for extraction, heating and stirring the mixture, extracting the mixture for two times at the same temperature for the same time, and collecting the supernatants of the two times; cooling the three solutions, centrifuging, collecting supernatant, and mixing; the concentrated extract of the sample is used for evaluating the biological activity.
EXAMPLE 8 radiation resistant oral liquid
Step 1: extraction of medicinal materials
Extracting vine tea:
extracting 20kg of vine tea with 20 times of water at 100 ℃ for 30 minutes, beating compressed air during the extraction process, stirring, and discharging liquid for later use; continuously adding 20 times of water, extracting at 100 deg.C for 30 min, and stirring with compressed air during extraction. Mixing the above two extractive solutions, cooling at 4-8 deg.C, and standing for 24 hr. Centrifuging the extractive solution, collecting supernatant, and adding water to 800L.
2. Extracting golden flowers: extracting 5kg of golden flower with 20 times of water at 100 ℃ for 30 minutes, stirring with compressed air during the extraction process, after extraction, discharging liquid for later use, continuously adding 20 times of water at 100 ℃, extracting for 30 minutes, and stirring with compressed air during the extraction process. Mixing the above two extractive solutions, cooling at 4-8 deg.C, standing for 24 hr, centrifuging the extractive solution for 15 min at 5000 rpm, collecting supernatant, and adding water to 200L.
3. Green tea extraction: adding 10kg of green tea into 20 times of water, extracting at 70 deg.C for 30 min, stirring with compressed air during extraction, extracting, draining, adding 20 times of water, extracting at 100 deg.C for 30 min, and stirring with compressed air during extraction.
4. Mixing the above two extractive solutions, cooling at 4-8 deg.C, and standing for 24 hr.
5. Centrifuging the extracting solution for 15 minutes under the condition of 5000 revolutions,
step 2, beverage preparation: mixing the above extractive solutions, adding water (water temperature of 70-80 deg.C) 80-90% of total medicinal liquid, sequentially adding zinc citrate, vitamin B6, vitamin C, and stevioside, stirring to dissolve, coarse filtering, fine filtering, adding water to full volume, charging nitrogen, bottling, and sterilizing at 105 deg.C for 30 min.
Example 9 radiation resistant capsules/tablets
Step 1: extraction of medicinal materials
Extracting vine tea:
extracting 20kg of vine tea with 20 times of water at 100 ℃ for 30 minutes, beating compressed air during the extraction process, stirring, and discharging liquid for later use; continuously adding 20 times of water, extracting at 100 deg.C for 30 min, and stirring with compressed air during extraction. Mixing the above two extractive solutions, cooling at 4-8 deg.C, and standing for 24 hr. Centrifuging the extractive solution, collecting supernatant, and adding water to 800L.
2. Extracting golden flowers: extracting 5kg of golden flower with 20 times of water at 100 ℃ for 30 minutes, stirring with compressed air during the extraction process, after extraction, discharging liquid for later use, continuously adding 20 times of water at 100 ℃, extracting for 30 minutes, and stirring with compressed air during the extraction process. Mixing the above two extractive solutions, cooling at 4-8 deg.C, standing for 24 hr, centrifuging the extractive solution for 15 min at 5000 rpm, collecting supernatant, and adding water to 200L.
3. Green tea extraction: adding 10kg of green tea into 20 times of water, extracting at 70 deg.C for 30 min, stirring with compressed air during extraction, extracting, draining, adding 20 times of water, extracting at 100 deg.C for 30 min, and stirring with compressed air during extraction.
4. Mixing the above two extractive solutions, cooling at 4-8 deg.C, and standing for 24 hr.
5. Centrifuging the extractive solution for 15 min at 5000 rpm, collecting supernatant, concentrating at 55-65 deg.C until the density is 1.2-1.3, oven drying, and pulverizing to obtain raw material.
Step 2, preparation of tablets and capsules: adding microcrystalline cellulose and lactose according to prescription dose into the extracted powder of the vine tea, the golden flower and the green tea, adopting 10% polyvinylpyrrolidone K30 aqueous solution for granulation, passing through a 24-mesh sieve, adding silicon dioxide into the obtained granules, and filling into capsules or tabletting.
Example 10 radiation resistant particles
| 1 bag | 10000 bags | |
| Vine tea | 0.4g | 4kg |
| Jinhua | 0.1g | 1kg |
| Green tea | 0.2g | 2kg |
| Sucrose | 0.1g | 1kg |
Step 1: extraction of medicinal materials
(1) Extracting vine tea: extracting 20kg of vine tea with 20 times of water at 100 ℃ for 30 minutes, beating compressed air during the extraction process, stirring, and discharging liquid for later use; continuously adding 20 times of water, extracting at 100 deg.C for 30 min, and stirring with compressed air during extraction. Mixing the above two extractive solutions, cooling at 4-8 deg.C, and standing for 24 hr. Centrifuging the extractive solution, collecting supernatant, and adding water to 800L.
(2) Extracting golden flowers: extracting 5kg of golden flower with 20 times of water at 100 ℃ for 30 minutes, stirring with compressed air during the extraction process, after extraction, discharging liquid for later use, continuously adding 20 times of water at 100 ℃, extracting for 30 minutes, and stirring with compressed air during the extraction process. Mixing the above two extractive solutions, cooling at 4-8 deg.C, standing for 24 hr, centrifuging the extractive solution for 15 min at 5000 rpm, collecting supernatant, and adding water to 200L.
(3) Green tea extraction: adding 10kg of green tea into 20 times of water, extracting at 70 deg.C for 30 min, stirring with compressed air during extraction, extracting, draining, adding 20 times of water, extracting at 100 deg.C for 30 min, and stirring with compressed air during extraction.
(4) Mixing the above two extractive solutions, cooling at 4-8 deg.C, and standing for 24 hr.
(5) Centrifuging the extractive solution for 15 min at 5000 rpm, collecting supernatant, and concentrating at 55-65 deg.C until the density is 1.1-1.2.
Step 2, preparation of instant tea: pressing into 2-3 cm pieces under 0.001-0.005MPa, granulating with 16-20 mesh sieve in swing granulator, packaging with a packaging machine to obtain 1 g/bag, and packaging.
EXAMPLE 11 biological Activity test of radiation-resistant compositions
1. Study of radioprotective Effect
(1) Grouping of experimental animals
C57BL/6 male mice, 8 weeks old, raised on SPF grade barrier system, weigh 20 + -2 g. Animals were randomly grouped into groups of 10 animals each. The experiment sets three dose groups of low, medium and high of the irradiation control group and the anti-radiation composition.
(2) Dosage and mode of administration
Irradiating the control group with stomach-filling distilled water, and setting the dosage of the anti-radiation composition (vine tea: golden flower: green tea) in example 7 at three levels of low, medium and high.
(3) Irradiation conditions
137The Cs gamma ray is irradiated on the whole body at one time, the irradiation dose rate is 0.99Gy/min, and the irradiation dose of the mouse is 7.2 Cy.
(4) Experimental procedure
Before irradiation, each dosage group of the radiation-resistant composition is continuously infused with the gastric beverage composition for 2 days, after irradiation, the radiation-resistant composition is continuously administered for 5 days, and the irradiation control group is always administered with distilled water with the same volume as that of the radiation-resistant group. The survival time of the mice was observed after irradiation.
(5) And experimental results
As can be seen from table 1 and fig. 1, the low dose group of the radiation-resistant composition increased the survival rate of the radiation-damaged mice by 70% for 30 days, and the medium and high dose groups increased the survival rate of the radiation-damaged mice by 80% for 30 days, as compared to the single irradiation group. The average survival time of the mice with radiation injury is prolonged by 8-9 days, which indicates that the beverage composition has better overall radiation protection effect on the C57 mice.
TABLE 1 survival of C57 mice after 7.2Gy gamma irradiation at each dose of the radiation resistant composition for 30 days
Note: p < 0.01 compared to the single shot group irradiation.
2. Protection experiment for hematopoietic and immune systems of mice
(1) Animal grouping and administration
50C 57 male mice were selected, randomly divided into 5 groups of 10 mice each, and a blank control group, a single irradiation group, a low dose group of a radiation resistant composition, a medium dose group of a radiation resistant composition, and a high dose group of a radiation resistant composition were set. Intragastric administration, continuously administering for 2 days before irradiation, administering for 1 hr before irradiation day, and administering137The Cs gamma ray 4Gy is irradiated on the whole body once, and the administration is continuously carried out for 5 days after the irradiation.
(2) Detecting the index
1) Hemogram analysis
On day 8 after irradiation, mouse eyeballs were bled, placed in EP tubes containing EDTA-2K anticoagulant, and the number of White Blood Cells (WBC), Red Blood Cells (RBC), Platelets (PLT), and Hemoglobin (HGB) were measured with a full-automatic hematology analyzer for statistical analysis.
The results of the WBC count in peripheral blood of the mice are shown in FIG. 2; results of peripheral red blood cell RBC number in mice are shown in fig. 3; the results of the number of peripheral platelets PLT in the mice are shown in FIG. 4; the results of peripheral blood hemoglobin HGB content in mice are shown in FIG. 5. Compared with the single irradiation group, the radiation-resistant composition group can increase the WBC number, and the improvement effect is more obvious as the dosage of the beverage is increased. In addition, RBC and HGB are improved to some extent. Suggesting that the beverage composition has a certain protective effect on the hematopoietic system of the irradiated mice.
2) Index of visceral organs
And (3) carrying out dislocation and sacrifice on cervical vertebrae of the mice on the 8 th day after irradiation, dissecting and taking spleen, thymus and gonad of the mice, washing clean blood stains by using normal saline, weighing by using an electronic balance, recording results, and calculating the index of the viscera according to the following formula.
Organ index is organ mass (mg)/body weight (g).
The results of spleen and thymus index of the mice are shown in figure 6, and compared with the single irradiation group, the thymus and spleen index of the irradiated mice is improved by each dose group of the anti-radiation composition, which indicates that the anti-radiation composition has a certain protection effect on the organs of the irradiated mice.
3) Bone marrow nucleated cell number (BMNC)
And (3) dislocation of cervical vertebrae of the mouse is killed on 8 days after irradiation, the left femur of the mouse is dissected, all muscular tissues are removed, normal saline is used for washing, the femoral head at one end is cut off, the tail end of the femur is punctured by a No. 7 needle at the other end, and the femoral cavity is repeatedly washed by 1ml of normal saline until the femur is white. The number of femoral nucleated cells is detected by a full-automatic hematology analyzer. The result of the content of the femur nucleated cells of the mice is shown in figure 7, which shows that the radiation-resistant composition can improve the BMNC content of the irradiated mice and has a certain protection effect on the visceral organs of the irradiated mice.
The oral administration of the anti-radiation composition can improve the survival rate of the mice damaged by radiation; the thymus index, the spleen index and the gonad index of the irradiated mice are improved to different degrees, and the hematopoietic system of the mice damaged by radiation is protected to a certain extent.
Claims (17)
1. The radiation-resistant composition is characterized by comprising the following raw materials in parts by weight:
1-40 parts of vine tea
1-10 parts of golden flower
1-20 parts of green tea.
2. The radiation-resistant composition according to claim 1, wherein the raw materials comprise, in parts by weight:
1-10 parts of vine tea
1-3 parts of golden flower
1-5 parts of green tea.
3. The radiation-resistant composition according to claim 1, wherein the raw materials comprise, in parts by weight:
4 parts of vine tea
1-2 parts of golden flower
1-2 parts of green tea.
4. A method for preparing a beverage using the composition of claims 1-3, characterized in that:
respectively crushing the raw materials according to parts by weight to prepare crude medicinal powder, adding 20 times of water, decocting and extracting, heating and stirring the mixture, extracting for two times at the same temperature for the same time, and collecting supernatant of the two times;
cooling the three solutions, centrifuging, collecting supernatant, and mixing;
mixing the above solutions and diluting to a certain volume;
adding appropriate amount of nutritional supplement such as vitamin C, vitamin B6, vitamin B12, zinc citrate or zinc gluconate into the above solution;
adding appropriate amount of flavoring agent such as cyclodextrin, stevioside, citric acid, fructose, glucose, aspartame, menthol, etc.;
adding an appropriate amount of antioxidant such as sodium D-erythorbate to the above solution;
adding antiseptic such as potassium sorbate and sodium benzoate into the above solution;
filtering the above solution, packaging in a packaging bottle, and sterilizing.
5. A process for preparing solid instant tea from the composition of claims 1-3, characterized in that:
respectively crushing the raw materials according to parts by weight to prepare crude medicinal powder, adding 20 times of water, decocting and extracting, heating and stirring the mixture, extracting for two times at the same temperature for the same time, and collecting supernatant of the two times;
cooling the three solutions, centrifuging, collecting supernatant, and mixing;
concentrating the solution to a density of about 1.1 to 1.2;
adding appropriate amount of nutritional supplement such as vitamin C, vitamin B6, vitamin B12, zinc citrate or zinc gluconate into the concentrated solution;
adding appropriate amount of flavoring agent such as cyclodextrin, stevioside, citric acid, fructose, glucose, aspartame, menthol, etc.;
adding appropriate amount of diluent such as lactose, sucrose, dextrin, and glucose, sieving, and granulating;
drying the obtained granules to obtain granules with the moisture content of less than 5 percent by mass, namely the solid instant tea.
6. A process for the preparation of capsules/tablets from the composition according to claims 1-3, characterized in that:
respectively crushing the raw materials according to parts by weight to prepare crude medicinal powder, adding 20 times of water, decocting and extracting, heating and stirring the mixture, extracting for two times at the same temperature for the same time, and collecting supernatant of the two times;
cooling the three solutions, centrifuging, collecting supernatant, and mixing;
concentrating the solution to a density of about 1.2 to 1.3;
drying the concentrated solution under reduced pressure, and pulverizing to obtain raw material;
adding appropriate amount of nutritional supplement, such as vitamin C, vitamin B6, vitamin B12, zinc citrate or zinc gluconate;
adding diluent and forming agent such as microcrystalline cellulose, lactose, and compressible starch, adding binder such as polyvinylpyrrolidone and hydroxypropyl methylcellulose, and granulating;
and (3) filling the granules and a lubricant such as silicon dioxide into capsules or tabletting to obtain the tablet.
7. The method of claim 4, for preparing a radiation damage resistant composition and use products, wherein the extraction in step 1 is performed at 90-100 ℃ for 30-60 minutes.
8. The method of claim 4, for preparing a radiation damage resistant composition and products for use, wherein the cooling temperature in step 2 is 4-10 ℃.
9. The method as claimed in claim 4, for preparing the radiation damage resistant beverage, wherein the step 8 is performed in a 200-400mL container, and the sterilization condition can be UHT sterilization or autoclaving.
10. The method as claimed in claim 5, for preparing the radiation damage resistant instant tea, the decompression temperature in step 3 is 55-65 ℃, the concentration is carried out while decompressing, the vacuum degree is 300-750mmHg, until the concentration ratio is 1.1-1.2.
11. The method of claim 5, for preparing instant tea with radiation damage resistance, wherein in step 6, 2-3 cm small blocks are pressed under the pressure of 0.001-0.005MPa, and granulated through 16-20 mesh sieve in a swing granulator.
12. The process of claim 5 for preparing radiation damage resistant instant tea, wherein the instant tea is packaged in a packaging machine at a 1 g/bag format.
13. A composition comprising the pharmaceutical combination of claims 1-3.
14. The composition of claims 1-3 can be used in food and pharmaceutical applications for protection against radiation damage.
15. Radiation damage resistant according to claim 14, including radiation damage in tumor radiation therapy and radiation damage that is long-term engaged in radiation-related tasks.
16. The composition of claim 13, which is used for the preparation of health foods, including solid foods and liquid foods.
17. The composition of claim 13, which is used for preparing a pharmaceutical product, including a solid oral preparation and a liquid oral preparation.
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| 刘畅 等: "藤茶生物活性成分及其制备工艺研究进展", 《食品工业》 * |
| 曹芬 等: "金花茶研究进展", 《中国药业》 * |
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Application publication date: 20211221 |