CN113813316A - 一种治疗阳痿的中西药复合方 - Google Patents

一种治疗阳痿的中西药复合方 Download PDF

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CN113813316A
CN113813316A CN202111190871.0A CN202111190871A CN113813316A CN 113813316 A CN113813316 A CN 113813316A CN 202111190871 A CN202111190871 A CN 202111190871A CN 113813316 A CN113813316 A CN 113813316A
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杨洪胜
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Abstract

本发明公开一种治疗阳痿的中西药复合方，其由中药方和PDE5i抑制剂制成，所述中药方由分心木、猪腰、半枝莲、虎杖、败酱草、马鞭草、马齿苋、怀牛膝、锁阳、玛咖、人参、白花蛇舌草、当归、枸杞、大枣、生牡蛎、杏仁、桃仁、王不留行、茯苓、熟地黄、冬虫夏草、露蜂房、白蒺藜、蛇床子、地龙、柴胡组成；所述PDE5i抑制剂为西地拉非或他地拉非。本发明将中西药结合，以西地拉非为主，中药方为辅，主辅联用，从局部到整体实现多重治疗，疗效高，效果显著，标本兼治。

Description

一种治疗阳痿的中西药复合方
技术领域
本发明涉及药物技术领域，具体涉及一种治疗阳痿的中西药复合方。
背景技术
众所周知，正常男性性功能包括性欲、性兴奋、阴茎勃起、性交、射精和性欲高潮过程。这一过程是正常的心理、神经、内分泌系统、血管系统及正常生殖系统参与完成的一个极为复杂的过程，其中主要受到大脑控制和支配。最常见的男子性功能障碍是勃起障碍和早泄，也称阳痿。勃起障碍指持续反复不能达到或维持足够阴茎勃起以完成满意性生活，早泄一般认为性交时阴茎能勃起但对射精失去控制能力，阴茎插入阴道前或刚插入即射精。临床西医治疗主要是采取药物对症局部处理及激素治疗，但是西医主要是从生理病理角度切入找到分子水平的发病机理，从细胞、分子水平层面快速进行治疗，但是目前的西药对阳痿的治疗不能从人整体进行治疗，治疗虽然见效快，但治疗会治标不治本，而阳痿在中医上将其归属于“阴痿”“筋痿”“阳痿”“不起”“阳事不用”等范畴，中医对其的治疗是从整体进行出发，对其治疗实现标本兼治。
发明内容
因此基于以上背景，本发明结合将中西医结合，优势互补，提供一种治疗阳痿的中西药复合方，治疗疗程短，且效果显著，可实现标本兼治。
本发明提供的技术方案为：
其由中药方和PDE5i抑制剂制成；
所述中药方由分心木、猪腰、半枝莲、虎杖、败酱草、马鞭草、马齿苋、怀牛膝、锁阳、玛咖、人参、白花蛇舌草、当归、枸杞、大枣、生牡蛎、杏仁、桃仁、王不留行、茯苓、熟地黄、冬虫夏草、露蜂房、白蒺藜、蛇床子、地龙、柴胡；
所述PDE5i抑制剂为西地拉非或他地拉非。
进一步地，所述中药方中的各原料用量为：
分心木30份、猪腰30份、半枝莲15份、虎杖15份、败酱草30份、马鞭草30份、马齿苋30份、怀牛膝15份、锁阳15份、玛咖30份、人参10份、白花蛇舌草15份、当归15份、枸杞15份、大枣30份、生牡蛎30份、杏仁15份、桃仁10份、王不留行15份、茯苓30份、熟地黄15份、冬虫夏草5份、露蜂房10份、白蒺藜15份、蛇床子15份、地龙10份、柴胡15份。
进一步地，所述中药方和PDE5i抑制剂的用量配比为10：1。
进一步地，其制备方法为将中药方原料磨粉后与PDE5i抑制剂混合后，加入常用辅料制成糖果片或蜜丸。
进一步地，所述PDE5I为西地拉非。
本发明的PDE5i抑制剂中的西地拉非或他地拉非均为一种高选择性，长效的PDE5i抑制剂，其药效的持续时间长达36小时，其用来治疗阳痿的原理为是其能够间接的扩张海绵体血管，通过避免能够促进海绵体扩张的细胞“CGMP”被身体代谢和水解，从而提高“CGMP”的有效浓度，在“CGMP”持续作用下，海绵体能够维持充足而有效的扩张和充血避免阳痿的发生。而中医认为阳痿是一种肝郁肾虚血瘀症，肝脉瘀阻、湿热浸淫、情志刺激为其病因病机，外在表现为正虚夹杂、宗筋失养，肾虚肝郁是主要的病例特点，肾虚是主要的病理趋势，血瘀是最终的病理趋势，所以从阳痿致病的整体出发，应该以疏肝解郁、滋补肾、活血通脉为治疗原则，本发明的中药方中的分心木：涩精缩尿，止血止带；猪腰(猪肾)：补肾益阴，利水；半枝莲：清热解毒，化瘀利尿；虎杖：活血定痛，清热利湿，解毒通便，化痰止咳；败酱草：清热解毒、祛瘀排脓；马鞭草：活血散瘀，解毒；马齿苋：清热解毒，祛湿止带；怀牛膝：活血通经，补肝肾，强筋骨；锁阳：滋肝健肾，可调节生理机能、均衡营养、促进血液循环；玛咖：增强免疫功能、抗疲劳、抗贫血、调节内分泌、改善性功能；人参：补气挽脱、补益脾肺、安神；白花蛇舌草：清热除湿、散结止痛、利尿解毒；当归：补血活血，调经止痛，润肠；枸杞：滋补肝肾，益精明目；大枣：补中益气，养血安神，调和药性；生牡蛎：重镇安神，潜阳补阴，软坚散结；杏仁：镇咳，平喘，增强人体免疫力，延缓衰老，调节血脂；桃仁：活血化瘀和润肠通便；王不留行：活血通经；茯苓：利水渗湿，健脾宁心；熟地黄：滋阴补血，益精填髓；冬虫夏草：补肾益肺、止血化痰；露蜂房：补肾壮阳，滋阴补肾，固精下元；白蒺藜：平抑肝阳，疏肝解郁，明目，祛风止痒；蛇床子：温肾壮阳，燥湿，祛风，杀虫；地龙：清热定惊，通络，平喘，利尿；柴胡：和解表里，疏肝，升阳。
本发明的中药方诸药合用，具有疏肝解郁，柔肝养血，活血通络，祛瘀、补肾振痿的功效，从整体对阳痿进行治疗。本发明中的西地拉非对阳痿的治疗从分子水平对病患处进行直接作用治疗，其到主要的治疗作用，而中药方重在调理，起到辅助的作用，但起效时间偏长，而本发明的复合方在对于阳痿的治疗时，在以西地拉非为主的药物治疗作用下，不但能够快速的改善阳痿的症状，满足阳痿患者的基本性生活的需求，提升心理自信心，同时这种心理的改变对致病的肝气郁结具有改善的作用，在此情况下，通过中药方的疏肝益阳、补肾、祛瘀等药物的调理下，又反过来对西地拉非的治疗起到积极的作用，最后达到局部与整体治疗的效果；并且本发明不仅对病理性阳痿起到良好的治疗效果，并且对心理性的阳痿也具有良好的治疗效果。
采取上述技术方案，具有的有益效果如下：
本发明将中西药结合，以西地拉非为主，中药方为辅，主辅联用，从局部到整体实现多重治疗，疗效高，效果显著，标本兼治。
具体实施方式
为使本发明实施例的目的、技术方案和优点更加清楚，下面将结合本发明实施例中，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例1：一种治疗阳痿的中西药复合方，其由中药方和PDES抑制剂制成；
所述中药方中的各原料用量为：
分心木30份、猪腰30份、半枝莲15份、虎杖15份、败酱草30份、马鞭草30份、马齿苋30份、怀牛膝15份、锁阳15份、玛咖30份、人参10份、白花蛇舌草15份、当归15份、枸杞15份、大枣30份、生牡蛎30份、杏仁15份、桃仁10份、王不留行15份、茯苓30份、熟地黄15份、冬虫夏草5份、露蜂房10份、白蒺藜15份、蛇床子15份、地龙10份、柴胡15份；
所述PDES抑制剂为西地拉非。
所述中药方和PDE5I抑制剂的用量配比为10：1。
本实施中的猪腰为新鲜猪腰。
本实施例将中药方原料磨粉后与PDE5I抑制剂混合后，加入常用辅料制成糖果片，一片0.5g，一次服用2-3片。
本发明的中药方中的杏仁、桃仁均通过本领域常用的方法进行炮制去毒性后进行使用。
实施例2：临床疗效
选取2016年至2019年确诊为肝郁型阳痿患者30例，按照抽签的方式，随机分为三组，分别是对照组1、对照组2、观察组3，其中对照组年龄22～51岁，平均年龄(35.24±6.89)岁；病程为5-60个月；对照组2：年龄20-51岁，平均年龄(34.68±6.63)岁；病程4-61个月；观察组年龄21～50岁，平均年龄(34.42±6.57)岁；病程4.5-59个月，三组患者年龄、病程比较，差异均无统计学意义，具有可比性。
西医诊断标准：
(1)成年男子在有效性刺激下，不能够持续达到或维持足够硬度的阴茎勃起以完成满意性交，且患病时间超过3个月，同时勃起功能国际问卷-5(IIEF-5)积分≤21分，诊断为ED。(2)从初次性交开始射精往往或总是在插入阴道1min左右发生，总是或几乎总是不能延迟射精，诊断为PE。同时满足(1)和(2)。
中医诊断标准：
符合肝郁肾虚中医辨证标准。主症：腰膝酸软、胸胁胀痛；次症：心情抑郁、头晕耳鸣、胸闷善太息、性欲淡漠、舌淡紫、脉弦细。
排除标准：
(1)严重的器质性ED或PE患者；(2)无正常性生活；(3)3个月内曾使用其他方法治疗PE或ED的患者；(4)在观察期间服用影响阴茎勃起功能的药物。
疗效标准：
治愈：IIEF-5≥22分且IELT≥2min；
显效：IIEF-5＜22分但较前上升5分及以上且IELT显著延长；
有效：IEF-S＜22分但较前上升2～4分且IELT有所延长；
无效：IIEF-5＜22分但较前上升≤1分或无上升或有下降且IELT无延长或有缩短。
总有效率为治愈、显效与有效之和。
分组给药：对照1组每晚睡前1～2h给予西地拉非口服片剂5mg，对照2组给予中药方制成的胶囊剂，每日4粒(0.25g/粒)，观察组给予实施例2所制成的蜜丸，连续给药2个月。
对比组1治愈2例，显效1例，有效4例，总有效率70％；对照2组治愈3例，显效2例，有效3例，总有效率80.07％；观察组治愈5例，显效3例，有效1例，有效率90.0％。
实施例3：典型案例
案例1：孙某，男，31岁，阳痿2年，阴茎无法勃起，中医诊断为肝郁肾虚并血瘀，服用实施例2所制的蜜丸，连续服用1周后，阴茎有泵感，能够勃起，继续服药2个月后，痊愈。
案例2：赵某，男，42岁，阳痿1年多，阴茎无法勃起，中医诊断为肾虚血瘀，服用实施例1所制得的糖果片后，连续服10天后，阴茎可完全勃起，继续服用2个月后，痊愈，痊愈停药后半年，阴茎勃起依旧正常。
以上对本发明及其实施方式进行了描述，这种描述没有限制性，所示的也只是本发明的实施方式之一，实际的结构并不局限于此。总而言之如果本领域的普通技术人员受其启示，在不脱离本发明创造宗旨的情况下，不经创造性的设计出与该技术方案相似的结构方式及实施例，均应属于本发明的保护范围。

Claims (4)

1.一种治疗阳痿的中西药复合方，其特征在于，
其由中药方和PDE5i抑制剂制成；
所述中药方由分心木、猪腰、半枝莲、虎杖、败酱草、马鞭草、马齿苋、怀牛膝、锁阳、玛咖、人参、白花蛇舌草、当归、枸杞、大枣、生牡蛎、杏仁、桃仁、王不留行、茯苓、熟地黄、冬虫夏草、露蜂房、白蒺藜、蛇床子、地龙、柴胡组成；
所述PDE5i抑制剂为西地拉非或他地拉非。
2.根据权利要求1所述的一种治疗阳痿的中西药复合方，其特征在于，所述中药方中的各原料用量为：
分心木30份、猪腰30份、半枝莲15份、虎杖15份、败酱草30份、马鞭草30份、马齿苋30份、怀牛膝15份、锁阳15份、玛咖30份、人参10份、白花蛇舌草15份、当归15份、枸杞15份、大枣30份、生牡蛎30份、杏仁15份、桃仁10份、王不留行15份、茯苓30份、熟地黄15份、冬虫夏草5份、露蜂房10份、白蒺藜15份、蛇床子15份、地龙10份、柴胡15份。
3.根据权利要求2所述的一种治疗阳痿的中西药复合方，其特征在于，所述中药方和PEDS抑制剂的用量配比为10：1。
4.根据权利要求1所述的一种治疗阳痿的中西药复合方，其特征在于，其制备方法为将中药方原料磨粉后与PDE5i抑制剂混合后，加入常用辅料制成糖果片或蜜丸。
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