CN113811613A - 核酸、药物组合物与缀合物及制备方法和用途 - Google Patents

核酸、药物组合物与缀合物及制备方法和用途 Download PDF

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CN113811613A
CN113811613A CN202080035486.6A CN202080035486A CN113811613A CN 113811613 A CN113811613 A CN 113811613A CN 202080035486 A CN202080035486 A CN 202080035486A CN 113811613 A CN113811613 A CN 113811613A
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nucleotide sequence
nucleotide
sirna
seq
nucleotides
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CN113811613B (zh
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张鸿雁
高山
康代武
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Suzhou Ruibo Biotechnology Co Ltd
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Abstract

一种抑制激肽原(KNG)基因表达的siRNA，含有该siRNA的药物组合物和siRNA缀合物。所述siRNA中的每个核苷酸各自独立地为修饰或未修饰的核苷酸，该siRNA含有正义链和反义链，所述正义链含有核苷酸序列I，所述核苷酸序列I与SEQ ID NO:1所示的核苷酸序列长度相等，且不多于3个核苷酸差异，所述反义链含有核苷酸序列II，所述核苷酸序列II与SEQ ID NO:2所示的核苷酸序列长度相等，且不多于3个核苷酸差异。所述siRNA及其药物组合物和siRNA缀合物，可以有效治疗和/或预防败血症。

Description

PCT国内申请，说明书已公开。

Claims (71)

  1. PCT国内申请，权利要求书已公开。
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WO2015006740A2 (en) * 2013-07-11 2015-01-15 Alnylam Pharmaceuticals, Inc. Oligonucleotide-ligand conjugates and process for their preparation
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WO2015006740A2 (en) * 2013-07-11 2015-01-15 Alnylam Pharmaceuticals, Inc. Oligonucleotide-ligand conjugates and process for their preparation
CN108271386A (zh) * 2015-05-06 2018-07-10 阿尔尼拉姆医药品有限公司 因子XII(哈格曼因子)(F12)、激肽释放酶B、血浆(夫列契因子)1(KLKB1)和激肽原1(KNG1)iRNA组合物及其使用方法

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US20240200060A1 (en) 2024-06-20
EP3974529A1 (en) 2022-03-30
WO2020233680A1 (zh) 2020-11-26
JP2022533421A (ja) 2022-07-22
EP3974529A4 (en) 2024-02-07
CN118252843A (zh) 2024-06-28
CN113811613B (zh) 2024-04-05

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