CN113795485A - 一类嘧啶化合物的盐、多晶型物及其药物组合物、制备方法和应用 - Google Patents
一类嘧啶化合物的盐、多晶型物及其药物组合物、制备方法和应用 Download PDFInfo
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- Veterinary Medicine (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明涉及化合物1的盐，及其多晶型物、以及包含它们的药物组合物，其中，所述盐优选为盐酸盐、磷酸盐、对甲苯磺酸盐、苯磺酸盐、琥珀酸盐、硫酸盐、单氢溴酸盐、二氢溴酸盐等。本发明还涉及制备上述物质的方法，它们的用途、以及包含这些盐和晶型的药物制剂。
Description
PCT国内申请，说明书已公开。
Claims (10)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019104060131 | 2019-05-16 | ||
| CN201910406013.1A CN110016017A (zh) | 2019-05-16 | 2019-05-16 | 一类嘧啶化合物的盐、多晶型物及其药物组合物、制备方法和应用 |
| PCT/CN2020/090429 WO2020228807A1 (zh) | 2019-05-16 | 2020-05-15 | 一类嘧啶化合物的盐、多晶型物及其药物组合物、制备方法和应用 |
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| CN113795485A true CN113795485A (zh) | 2021-12-14 |
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| CN201910406013.1A Pending CN110016017A (zh) | 2019-05-16 | 2019-05-16 | 一类嘧啶化合物的盐、多晶型物及其药物组合物、制备方法和应用 |
| CN202080028079.2A Pending CN113795485A (zh) | 2019-05-16 | 2020-05-15 | 一类嘧啶化合物的盐、多晶型物及其药物组合物、制备方法和应用 |
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Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20220213066A1 (zh) |
| CN (2) | CN110016017A (zh) |
| WO (1) | WO2020228807A1 (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110016017A (zh) * | 2019-05-16 | 2019-07-16 | 益方生物科技（上海）有限公司 | 一类嘧啶化合物的盐、多晶型物及其药物组合物、制备方法和应用 |
| WO2022105882A1 (zh) * | 2020-11-19 | 2022-05-27 | 上海翰森生物医药科技有限公司 | 一种含吲哚类衍生物的盐、晶型及其制备方法和应用 |
| WO2023011415A1 (zh) * | 2021-08-02 | 2023-02-09 | 贝达药业股份有限公司 | Egfr抑制剂的药物组合及其应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105085489A (zh) * | 2014-11-05 | 2015-11-25 | 上海页岩科技有限公司 | 嘧啶或吡啶类化合物、其制备方法和医药用途 |
| CN107973782A (zh) * | 2016-10-21 | 2018-05-01 | 正大天晴药业集团股份有限公司 | 一种三氟乙基取代吲哚的苯胺嘧啶化合物及其盐的结晶 |
| CN108057036A (zh) * | 2016-11-07 | 2018-05-22 | 正大天晴药业集团股份有限公司 | 一种egfr抑制剂的固体药物组合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110483485A (zh) * | 2015-09-02 | 2019-11-22 | 益方生物科技（上海）有限公司 | 嘧啶类化合物、其制备方法和医药用途 |
| WO2019218987A1 (en) * | 2018-05-15 | 2019-11-21 | Inventisbio Shanghai Ltd. | Egfr inhibitors |
| CN110016017A (zh) * | 2019-05-16 | 2019-07-16 | 益方生物科技（上海）有限公司 | 一类嘧啶化合物的盐、多晶型物及其药物组合物、制备方法和应用 |
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2019
- 2019-05-16 CN CN201910406013.1A patent/CN110016017A/zh active Pending
-
2020
- 2020-05-15 WO PCT/CN2020/090429 patent/WO2020228807A1/zh active Application Filing
- 2020-05-15 US US17/611,458 patent/US20220213066A1/en active Pending
- 2020-05-15 CN CN202080028079.2A patent/CN113795485A/zh active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105085489A (zh) * | 2014-11-05 | 2015-11-25 | 上海页岩科技有限公司 | 嘧啶或吡啶类化合物、其制备方法和医药用途 |
| CN107973782A (zh) * | 2016-10-21 | 2018-05-01 | 正大天晴药业集团股份有限公司 | 一种三氟乙基取代吲哚的苯胺嘧啶化合物及其盐的结晶 |
| CN108057036A (zh) * | 2016-11-07 | 2018-05-22 | 正大天晴药业集团股份有限公司 | 一种egfr抑制剂的固体药物组合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020228807A1 (zh) | 2020-11-19 |
| CN110016017A (zh) | 2019-07-16 |
| US20220213066A1 (en) | 2022-07-07 |
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Application publication date: 20211214 |