CN113795280B - 核酸、药物组合物与缀合物及制备方法和用途 - Google Patents

核酸、药物组合物与缀合物及制备方法和用途 Download PDF

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CN113795280B
CN113795280B CN202080033909.0A CN202080033909A CN113795280B CN 113795280 B CN113795280 B CN 113795280B CN 202080033909 A CN202080033909 A CN 202080033909A CN 113795280 B CN113795280 B CN 113795280B
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nucleotide sequence
nucleotide
sirna
seq
iii
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CN113795280A (zh
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张鸿雁
高山
康代武
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Suzhou Ruibo Biotechnology Co ltd
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    • C12N2320/30—Special therapeutic applications
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CN202080033909.0A 2019-05-24 2020-05-21 核酸、药物组合物与缀合物及制备方法和用途 Active CN113795280B (zh)

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EP3719126B1 (en) 2017-12-01 2025-01-01 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, composition and conjugate containing nucleic acid, preparation method therefor and use thereof
DK3719128T3 (da) 2017-12-01 2025-03-03 Suzhou Ribo Life Science Co Ltd Dobbelt-strenget oligonukleotid, sammensætning og konjugat bestaende dobbelt-strenget oligonukleotid, fremgangsmåde herfor og anvendelse heraf
EP3719127A4 (en) 2017-12-01 2021-10-20 Suzhou Ribo Life Science Co., Ltd. NUCLEIC ACID, COMPOSITION AND CONJUGATE WITH IT, MANUFACTURING METHOD AND USE
CN110944675B9 (zh) 2017-12-01 2024-08-09 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
WO2020038377A1 (zh) 2018-08-21 2020-02-27 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的药物组合物和缀合物及其用途
US11896674B2 (en) 2018-09-30 2024-02-13 Suzhou Ribo Life Science Co., Ltd. SiRNA conjugate, preparation method therefor and use thereof
WO2020135673A1 (zh) 2018-12-28 2020-07-02 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
AU2020280439B2 (en) 2019-05-22 2025-08-14 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use
KR20220011689A (ko) * 2019-05-22 2022-01-28 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 핵산, 약제학적 조성물, 접합체, 제조 방법, 및 용도
US12590304B2 (en) 2019-05-22 2026-03-31 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use
CN113795582B (zh) 2019-05-24 2024-05-24 苏州瑞博生物技术股份有限公司 核酸、药物组合物与缀合物及制备方法和用途
CN115028670B (zh) * 2022-06-24 2023-07-28 四川大学华西医院 一种n-乙酰基-d-半乳糖胺三聚体前体的制备方法
WO2024255747A1 (zh) * 2023-06-16 2024-12-19 施能康医药科技(苏州)有限公司 靶向补体成分5的核酸及其用途
WO2025026124A1 (zh) * 2023-08-03 2025-02-06 苏州炫景生物科技有限公司 C4b基因抑制剂组合物及其应用
CN119585432B (zh) * 2023-08-22 2025-08-12 成都先衍生物技术有限公司 一种靶向AGT基因表达的siRNA及其缀合物和用途

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CN118217305A (zh) 2024-06-21
JP2022535708A (ja) 2022-08-10
WO2020238763A1 (zh) 2020-12-03
JP2025041739A (ja) 2025-03-26
CN113795280A (zh) 2021-12-14
EP3978029A1 (en) 2022-04-06
CA3140233A1 (en) 2020-12-03
AU2020282453A1 (en) 2021-12-16
KR20220012284A (ko) 2022-02-03
EP3978029A4 (en) 2023-07-19
US20220186221A1 (en) 2022-06-16
JP7613751B2 (ja) 2025-01-15

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