CN113786409B - 包含磷酸肌醇3-激酶抑制剂和第二抗增殖剂的组合物 - Google Patents

包含磷酸肌醇3-激酶抑制剂和第二抗增殖剂的组合物 Download PDF

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Publication number
CN113786409B
CN113786409B CN202111104917.2A CN202111104917A CN113786409B CN 113786409 B CN113786409 B CN 113786409B CN 202111104917 A CN202111104917 A CN 202111104917A CN 113786409 B CN113786409 B CN 113786409B
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inhibitor
group
kinase inhibitor
alkyl
pharmaceutical composition
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CN113786409A (zh
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斯蒂芬·约瑟夫·沙特勒沃斯
安德鲁·大卫·惠尔
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Fukang Biotechnology Shanghai Co ltd
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Fukang Shanghai Health Technology Co ltd
Karus Therapeutics Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202111104917.2A 2015-08-19 2016-08-19 包含磷酸肌醇3-激酶抑制剂和第二抗增殖剂的组合物 Active CN113786409B (zh)

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GB1514760.6 2015-08-19
GBGB1514760.6A GB201514760D0 (en) 2015-08-19 2015-08-19 Compounds and method of use
PCT/GB2016/052575 WO2017029517A1 (en) 2015-08-19 2016-08-19 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent
CN201680057437.6A CN108348505B (zh) 2015-08-19 2016-08-19 包含磷酸肌醇3-激酶抑制剂和第二抗增殖剂的组合物
CN202111104917.2A CN113786409B (zh) 2015-08-19 2016-08-19 包含磷酸肌醇3-激酶抑制剂和第二抗增殖剂的组合物

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CN201680057437.6A Active CN108348505B (zh) 2015-08-19 2016-08-19 包含磷酸肌醇3-激酶抑制剂和第二抗增殖剂的组合物

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GB201514758D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Formulation
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US20220008409A1 (en) * 2018-09-18 2022-01-13 Kabushiki Kaisha Yakult Honsha Cancer combination therapy using quinoline carboxamide derivative
FI3930715T3 (fi) * 2019-02-27 2024-08-05 Astrazeneca Ab Sarakatinibi käytettäväksi idiopaattisen keuhkofibroosin hoidossa
CN111904958B (zh) * 2019-05-09 2022-09-13 浙江大学 Umi-77作为线粒体自噬诱导剂在制备治疗炎症及神经退行性疾病药物中的应用
GB201909468D0 (en) * 2019-07-01 2019-08-14 Karus Therapeutics Ltd Compounds for treating cancer
CN114533879B (zh) * 2020-11-19 2023-09-29 广州顺健生物医药科技有限公司 治疗癌症的联合疗法

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RS64095B1 (sr) 2023-04-28
CA2995898A1 (en) 2017-02-23
PT3337477T (pt) 2023-03-20
LT3337477T (lt) 2023-03-10
US12257254B2 (en) 2025-03-25
MX2018001926A (es) 2018-06-19
HRP20230376T1 (hr) 2023-06-23
HUE061615T2 (hu) 2023-07-28
SI3337477T1 (sl) 2023-04-28
SMT202300063T1 (it) 2023-03-17
JP2018523689A (ja) 2018-08-23
EP3337477A1 (en) 2018-06-27
US20230066999A1 (en) 2023-03-02
ES2939815T3 (es) 2023-04-27
HK1251467A1 (en) 2019-02-01
DK3337477T3 (en) 2023-02-20
IL257499A (en) 2018-07-31
US11291669B2 (en) 2022-04-05
EP3337477B1 (en) 2023-02-01
FI3337477T3 (fi) 2023-04-27
CN113786409A (zh) 2021-12-14
KR20180064387A (ko) 2018-06-14
CN108348505B (zh) 2021-10-12
AU2016307885B2 (en) 2019-07-25
PL3337477T3 (pl) 2023-07-03
GB201514760D0 (en) 2015-09-30
WO2017029517A1 (en) 2017-02-23
US20180243313A1 (en) 2018-08-30
CN108348505A (zh) 2018-07-31
AU2016307885A1 (en) 2018-03-08
US10668077B2 (en) 2020-06-02
US20210069200A1 (en) 2021-03-11

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