CN113784724A - 使用可吞咽药品递送装置将药品递送到肠道内腔中的治疗剂制剂和方法 - Google Patents

使用可吞咽药品递送装置将药品递送到肠道内腔中的治疗剂制剂和方法 Download PDF

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Publication number
CN113784724A
CN113784724A CN202080028733.XA CN202080028733A CN113784724A CN 113784724 A CN113784724 A CN 113784724A CN 202080028733 A CN202080028733 A CN 202080028733A CN 113784724 A CN113784724 A CN 113784724A
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Prior art keywords
insulin
capsule
formulation
drug
balloon
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Pending
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CN202080028733.XA
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English (en)
Chinese (zh)
Inventor
米尔·哈什姆
瑞德黑卡·科鲁波鲁
贝博·赛义德
凯尔·霍伦
西姆雷特·贝拉基
帕德玛·卡拉姆切杜
阿文德·达拉
鲁道夫·鲁菲
艾普尔·林恩·托莱多
乔尔·哈利斯
米尔·伊姆兰
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Rani Therapeutics LLC
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Rani Therapeutics LLC
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Publication of CN113784724A publication Critical patent/CN113784724A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CN202080028733.XA 2019-03-13 2020-03-12 使用可吞咽药品递送装置将药品递送到肠道内腔中的治疗剂制剂和方法 Pending CN113784724A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962818053P 2019-03-13 2019-03-13
US62/818,053 2019-03-13
US201962820174P 2019-03-18 2019-03-18
US62/820,174 2019-03-18
PCT/US2020/022496 WO2020186121A1 (en) 2019-03-13 2020-03-12 Therapeutic agent preparations and methods for drug delivery into a lumen of the intestinal tract using a swallowable drug delivery device

Publications (1)

Publication Number Publication Date
CN113784724A true CN113784724A (zh) 2021-12-10

Family

ID=72424820

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080028733.XA Pending CN113784724A (zh) 2019-03-13 2020-03-12 使用可吞咽药品递送装置将药品递送到肠道内腔中的治疗剂制剂和方法

Country Status (10)

Country Link
US (1) US20200289620A1 (enExample)
EP (1) EP3937971A4 (enExample)
JP (1) JP2022524446A (enExample)
KR (1) KR20210138646A (enExample)
CN (1) CN113784724A (enExample)
AU (1) AU2020237517A1 (enExample)
BR (1) BR112021017993A2 (enExample)
CA (1) CA3133086A1 (enExample)
MX (1) MX2021011047A (enExample)
WO (1) WO2020186121A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8721620B2 (en) 2009-12-24 2014-05-13 Rani Therapeutics, Llc Swallowable drug delivery device and methods of drug delivery
US9415004B2 (en) 2010-12-23 2016-08-16 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8809269B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8734429B2 (en) 2010-12-23 2014-05-27 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US9402806B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9259386B2 (en) 2010-12-23 2016-02-16 Rani Therapeutics, Llc Therapeutic preparation comprising somatostatin or somatostatin analogoue for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10689460B2 (en) 2014-05-15 2020-06-23 Incube Labs, Llc PCSK9 antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
AU2018366110B2 (en) * 2017-11-07 2024-08-08 Rani Therapeutics, Llc Clotting factor preparations for delivery into tissue of the intestinal tract using a swallowable drug delivery device
CN112451500B (zh) * 2020-12-18 2022-05-17 南京鼓楼医院 一种磁响应载药微针机器人及其制备方法和应用
WO2025081168A1 (en) * 2023-10-12 2025-04-17 The Brigham And Women's Hospital, Inc. An intra-abdominal injection system

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110160699A1 (en) * 2009-12-24 2011-06-30 Incube Labs, Llc Swallowable Drug Delivery Device and Methods of Drug Delivery
US20150329630A1 (en) * 2014-05-15 2015-11-19 Incube Labs, Llc Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins
US20170051051A1 (en) * 2014-05-15 2017-02-23 Rani Therapeutics, Llc Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins
CN108055826A (zh) * 2015-07-02 2018-05-18 拉尼医疗有限公司 用于使用可吞服药物递送装置递送到肠道内腔中的治疗药剂制剂

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8809269B2 (en) * 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9402806B2 (en) * 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9402807B2 (en) * 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8980822B2 (en) * 2010-12-23 2015-03-17 Rani Therapeutics, Llc Therapeutic agent preparations comprising pramlintide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8734429B2 (en) * 2010-12-23 2014-05-27 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US9284367B2 (en) * 2010-12-23 2016-03-15 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8969293B2 (en) * 2010-12-23 2015-03-03 Rani Therapeutics, Llc Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9415004B2 (en) * 2010-12-23 2016-08-16 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9149617B2 (en) * 2010-12-23 2015-10-06 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US9283179B2 (en) * 2010-12-23 2016-03-15 Rani Therapeutics, Llc GnRH preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10639272B2 (en) * 2010-12-23 2020-05-05 Rani Therapeutics, Llc Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US9629799B2 (en) * 2010-12-23 2017-04-25 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9861683B2 (en) * 2010-12-23 2018-01-09 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9259386B2 (en) * 2010-12-23 2016-02-16 Rani Therapeutics, Llc Therapeutic preparation comprising somatostatin or somatostatin analogoue for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US20230374155A1 (en) * 2014-05-15 2023-11-23 Rani Therapeutics, Llc Pcsk9 antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10689460B2 (en) * 2014-05-15 2020-06-23 Incube Labs, Llc PCSK9 antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US11548940B2 (en) * 2014-05-15 2023-01-10 Rani Therapeutics, Llc Anti-interleukin antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
AU2018366110B2 (en) * 2017-11-07 2024-08-08 Rani Therapeutics, Llc Clotting factor preparations for delivery into tissue of the intestinal tract using a swallowable drug delivery device
US11473339B2 (en) * 2018-01-31 2022-10-18 Spectrum Brands, Inc. Field-handable gate latch
CN113543756B (zh) * 2018-12-31 2023-09-05 拉尼医疗有限公司 使用可吞服药物递送装置递送到肠道内腔的治疗剂制剂
CA3137539A1 (en) * 2019-05-03 2020-10-20 Rani Therapeutics, Llc Clotting factor preparations for delivery into tissue of the intestinal tract using a swallowable drug delivery device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110160699A1 (en) * 2009-12-24 2011-06-30 Incube Labs, Llc Swallowable Drug Delivery Device and Methods of Drug Delivery
US20150329630A1 (en) * 2014-05-15 2015-11-19 Incube Labs, Llc Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins
US20170051051A1 (en) * 2014-05-15 2017-02-23 Rani Therapeutics, Llc Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins
CN108055826A (zh) * 2015-07-02 2018-05-18 拉尼医疗有限公司 用于使用可吞服药物递送装置递送到肠道内腔中的治疗药剂制剂

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
臧彦楠等: "肠促胰岛素相关药物的药代动力学/药效学模型研究进展", 中国临床药理学杂志, vol. 31, no. 02, 31 January 2015 (2015-01-31), pages 146 - 149 *

Also Published As

Publication number Publication date
AU2020237517A1 (en) 2021-10-14
US20200289620A1 (en) 2020-09-17
AU2020237517A2 (en) 2021-11-04
EP3937971A1 (en) 2022-01-19
KR20210138646A (ko) 2021-11-19
EP3937971A4 (en) 2022-12-14
MX2021011047A (es) 2021-12-15
BR112021017993A2 (pt) 2022-01-18
CA3133086A1 (en) 2020-09-17
JP2022524446A (ja) 2022-05-02
WO2020186121A1 (en) 2020-09-17

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