CN113784691A - 眼戴式治疗剂释放装置 - Google Patents

眼戴式治疗剂释放装置 Download PDF

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Publication number
CN113784691A
CN113784691A CN202080019749.4A CN202080019749A CN113784691A CN 113784691 A CN113784691 A CN 113784691A CN 202080019749 A CN202080019749 A CN 202080019749A CN 113784691 A CN113784691 A CN 113784691A
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CN
China
Prior art keywords
therapeutic agent
region
delivery device
delivery
polymeric substrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080019749.4A
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English (en)
Chinese (zh)
Inventor
C·古铁雷斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Twenty Twenty Therapeutics LLC
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Twenty Twenty Therapeutics LLC
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Publication of CN113784691A publication Critical patent/CN113784691A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097—Medicinal compositions released by microdevices, e.g. microelectromechanical systems [MEMS], microdevices comprising chips or microdevices on silicon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/0436—Material of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448—Drug reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36046—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the eye
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0001—Means for transferring electromagnetic energy to implants
    • A61F2250/0002—Means for transferring electromagnetic energy to implants for data transfer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Electrotherapy Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN202080019749.4A 2019-01-09 2020-01-07 眼戴式治疗剂释放装置 Pending CN113784691A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962790313P 2019-01-09 2019-01-09
US62/790,313 2019-01-09
PCT/US2020/012552 WO2020146362A1 (en) 2019-01-09 2020-01-07 Eye mounted device for therapeutic agent release

Publications (1)

Publication Number Publication Date
CN113784691A true CN113784691A (zh) 2021-12-10

Family

ID=69400668

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080019749.4A Pending CN113784691A (zh) 2019-01-09 2020-01-07 眼戴式治疗剂释放装置

Country Status (9)

Country Link
US (2) US11399976B2 (https=)
EP (1) EP3908238B1 (https=)
JP (1) JP7465271B2 (https=)
KR (1) KR102650504B1 (https=)
CN (1) CN113784691A (https=)
BR (1) BR112021013455A2 (https=)
CA (1) CA3126135A1 (https=)
IL (1) IL284731B2 (https=)
WO (1) WO2020146362A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114870245A (zh) * 2022-04-15 2022-08-09 杭州宝尔科技有限公司 一种微电脑脉冲近视防治仪
CN114917072A (zh) * 2022-04-27 2022-08-19 南方科技大学 眼部递送装置及其制备方法

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102650504B1 (ko) 2019-01-09 2024-03-22 트웬티 트웬티 테라퓨틱스 엘엘씨 치료제 방출을 위한 눈 장착형 장치
WO2022026720A1 (en) * 2020-07-31 2022-02-03 Board Of Regents Of The University Of Nebraska Hydrogel ionic circuit based devices for electrical stimulation and drug therapy
US20230331935A1 (en) * 2020-09-18 2023-10-19 The Regents Of The University Of California Micro-engineered poly(hema) hydrogel for wearable contact lens biosensing and other applications
WO2023076105A1 (en) * 2021-10-25 2023-05-04 Twenty Twenty Therapeutics Llc Fluid osmolarity sensing and associated systems, devices, and methods
WO2023076141A1 (en) * 2021-10-28 2023-05-04 Twenty Twenty Therapeutics Llc Controlled release of a therapeutic from an ophthalmic device with a locally enhanced concentration of chloride ions
US12544262B2 (en) * 2021-11-05 2026-02-10 W. L. Gore & Associates, Inc. Fluid drainage devices, systems, and methods
US12527691B2 (en) * 2021-11-05 2026-01-20 W. L. Gore & Associates, Inc. Fluid drainage devices, systems, and methods
US20230398019A1 (en) * 2022-06-14 2023-12-14 Twenty Twenty Therapeutics Llc Systems and methods for preventing or slowing the progression of myopia with a smart ophthalmic device
WO2024148197A1 (en) 2023-01-04 2024-07-11 Twenty Twenty Therapeutics Llc Dry eye treatment device
WO2024232885A1 (en) * 2023-05-10 2024-11-14 Twenty Twenty Therapeutics Creating a drug dispensing ophthalmic device with integrated modular elements
US12508156B2 (en) * 2023-05-12 2025-12-30 Verily Life Sciences Llc Achieving uniform patterned drug release via at least one embedded microchannel in an ophthalmic device
US20250082499A1 (en) * 2023-08-22 2025-03-13 Verily Life Sciences Llc Active drug dispensing ophthalmic device having a controller-responder architecture
KR102883994B1 (ko) * 2023-09-25 2025-11-10 서강대학교산학협력단 항암 치료를 위한 이온토포레시스 경피 약물 전달 장치 및 시스템

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US20060135911A1 (en) * 2004-12-17 2006-06-22 Aravindkumar Mittur Temperature modulation of transdermal drug delivery
WO2007050645A2 (en) * 2005-10-24 2007-05-03 Aciont, Inc. Intraocular iontophoretic device and associated methods
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US20150190279A1 (en) * 2012-08-06 2015-07-09 Baylor College Of Medicine Therapeutics dispensing device and methods of making same
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4014335A (en) * 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
US20020099358A1 (en) * 2001-01-22 2002-07-25 Lloyd Lindsay B. Ocular iontophoretic device and method for inhibiting vascular endothelial growth factor (VEGF) using the same
WO2003039622A2 (en) * 2001-11-02 2003-05-15 Ceramatec Inc. Novel iontophoretic drug delivery systems
US20050267440A1 (en) * 2004-06-01 2005-12-01 Herman Stephen J Devices and methods for measuring and enhancing drug or analyte transport to/from medical implant
US20060024358A1 (en) * 2004-07-30 2006-02-02 Santini John T Jr Multi-reservoir device for transdermal drug delivery and sensing
US20060135911A1 (en) * 2004-12-17 2006-06-22 Aravindkumar Mittur Temperature modulation of transdermal drug delivery
WO2007050645A2 (en) * 2005-10-24 2007-05-03 Aciont, Inc. Intraocular iontophoretic device and associated methods
US20080214985A1 (en) * 2007-02-02 2008-09-04 Activatek, Inc. Active transdermal medicament patch
US20150190279A1 (en) * 2012-08-06 2015-07-09 Baylor College Of Medicine Therapeutics dispensing device and methods of making same
CN203389001U (zh) * 2013-05-30 2014-01-15 中山大学中山眼科中心 一种眼后段透巩膜控释给药装置
US20160213514A1 (en) * 2015-01-22 2016-07-28 Eyegate Pharmaceuticals, Inc. Iontophoretic contact lens

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114870245A (zh) * 2022-04-15 2022-08-09 杭州宝尔科技有限公司 一种微电脑脉冲近视防治仪
CN114917072A (zh) * 2022-04-27 2022-08-19 南方科技大学 眼部递送装置及其制备方法
CN114917072B (zh) * 2022-04-27 2026-02-10 南方科技大学 眼部递送装置及其制备方法

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Publication number Publication date
BR112021013455A2 (pt) 2021-09-14
KR102650504B1 (ko) 2024-03-22
KR20210111827A (ko) 2021-09-13
JP2022516945A (ja) 2022-03-03
EP3908238A1 (en) 2021-11-17
EP3908238B1 (en) 2026-03-25
US11399976B2 (en) 2022-08-02
IL284731B2 (en) 2023-10-01
IL284731B1 (en) 2023-06-01
US20220339029A1 (en) 2022-10-27
WO2020146362A1 (en) 2020-07-16
IL284731A (en) 2021-08-31
CA3126135A1 (en) 2020-07-16
US12167978B2 (en) 2024-12-17
JP7465271B2 (ja) 2024-04-10
US20200214887A1 (en) 2020-07-09

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Application publication date: 20211210