CN1137730C - Matrix for Chinese medicine plaster and its preparation technology - Google Patents
Matrix for Chinese medicine plaster and its preparation technology Download PDFInfo
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- CN1137730C CN1137730C CNB001006282A CN00100628A CN1137730C CN 1137730 C CN1137730 C CN 1137730C CN B001006282 A CNB001006282 A CN B001006282A CN 00100628 A CN00100628 A CN 00100628A CN 1137730 C CN1137730 C CN 1137730C
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- chinese medicine
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- cataplasma
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Abstract
The present invention relates to a Chinese medicine cataplasm substrate to which Chinese medicine extract can be added, and a preparation technology thereof. The Chinese medicine cataplasm substrate is made by mixing sodium polyacrylate, sodium carboxymethyl cellulose, polyvinyl alcohol, kaolin, glycerol, phosphorous acid, aluminium potassium sulfate, gelatin and water. The Chinese medicine cataplasm substrate is large in carried dosage and is suitable to manufacture Chinese medicine cataplasm. The Chinese medicine cataplasm substrate has the advantages of no stimulation on skin, comfortable attachment, capability of recycle, stable properties and low cost, and does not react with the basic remedy.
Description
The present invention relates to a kind of substrate and preparation technology thereof of substrate employed material, particularly a kind of Chinese medicine patcher of external plaster agent.
Cataplasma is to be the external plaster agent of main matrix with the water-soluble high-molecular material.At present common on the market various be the rubber plaster of substrate with rubber, Colophonium, because of determined curative effect, easy to use and be used widely.But because resinae substrate is big to skin irritation, side effect such as the in use voluminous rawhide skin of patient stimulates, allergy and limited the application of this dosage form.And rubber plaster is easily aging, can not paste usefulness repeatedly.Therefore, select a kind ofly to be difficult for agingly, water conservation, to breathe freely, pasting comfortable substrate very necessary.
Pharmacopeia of Japan the 7th to the 13 edition has all recorded cataplasma.System's glycerol, kaolin etc. and Oleum menthae, compositions such as methyl salicylate are made poultice.Be loaded in the airtight bottle, the time spent is applied to the affected part.Its shortcoming is the viscosity deficiency, and cohesiveness is poor, thereby uses inconvenience, pollution clothes.In Pharmacopeia of Japan the tenth, 11,12,13 editions commentaries, proposed in substrate, to add high molecular polymers such as sodium polyacrylate, the not enough problem of cohesiveness of original poultice is improved.Through consulting, the spy opens flat 5-271077 patent gazette and discloses the indometacin cataplasma, and its substrate prescription is made up of nearly 20 kinds of adjuvants.Substrate is various in style, the formula components complexity, and so big at home its raw material sources of prescription are very difficult.Institute looks in the Japan Patent, all is chemistry or chemical synthetic drug, even if natural drug is arranged, also makes cataplasma after purifying.Because the little effect of amount of chemicals used is big, the ratio in mastic is less, thereby also little to the physical behavior influence of mastic.And the Chinese medical concrete amount is big, the large percentage in whole mastic and mostly be compound recipe, complicated component.The affiliation that adds of Chinese medical concrete has influence on the physical behavior of substrate, as: phenomenons such as viscosity descends or pigment is divided a word with a hyphen at the end of a line.Thereby influenced the application of Chinese medicine patcher.
The objective of the invention is to, provide a kind of non-stimulated, do not had external Traditional Chinese Medicine Babb Reagent Substrate And Its Preparation Method hypersensitive, this substrate has persistent viscosity, do not carry on the back and dye, preserve moisture, breathe freely, the prescription composition is simple, makes without high temperature, drug loading is big, be applicable to various Chinese medicine compound extractum, its stable in properties does not react with principal agent.Existing all to mention zest about the cataplasma data little, and fail to reach nonirritant.
Worker's medicine catablasm base material of the present invention is to be made of by weight mixing following natural and synthetic high molecular polymer:
1～6 part of 2～10 parts of sodium carboxymethyl cellulose of sodium polyacrylate
2～10 parts in 1～6 part of gelatin of polyvinyl alcohol
0.1～1 part in 6～18 parts of phosphorous acid of Kaolin
30～60 parts in 0.1～0.8 part of water of aluminium potassium sulfate
2～10 parts of glycerol
Wherein, polypropylene sodium, sodium carboxymethyl cellulose, polyvinyl alcohol are adhesive matrix, and glycerol is wetting agent, and gelatin is an excipient, and Kaolin is filler, and aluminium potassium sulfate etc. are cross-linking agent.
The preparation technology of Chinese medicine patcher is as follows:
A component: gelatin is added 8～16 parts in water,, add phosphorous acid, aluminium potassium sulfate, Kaolin then and stir 40～60 ℃ of down dissolvings.
B component: sodium polyacrylate is scattered in the glycerol, adds water then and be dissolved into transparent colloid for 11～22 parts.
The C component: polyvinyl alcohol adds 11～22 parts in water, adds sodium carboxymethyl cellulose after being heated to 60～75 ℃ of dissolvings, stirs.
Preparation catablasm base material: mix A component and C component, under 40～60 ℃, stir, add the B component again, under 40～60 ℃, stir and promptly get the catablasm base material mastic.
The ordinary rubber plaster is applied on the material of mounting after adding prescription medicament, and its coating is very thin.The contained medicament of the substrate of this kind plaster is a Western medicine, and content of dispersion needn't be very high, so must very big drug loading not arranged substrate, this kind substrate can not add Chinese medical concrete, makes Chinese medicine patcher.
This catablasm base material has the big characteristics of drug loading, and medicine can reach 1 with the ratio of substrate: 4-10, thereby the suitable Chinese medical concrete that adds is made Chinese medicine patcher.Its preparation method is simple, only needs Chinese medicine thick paste and this catablasm base material are stirred, and coating then, blooming, cutting is promptly.Through pharmacodynamic experiment---carry out analgesic experiment with mice tepidarium tail-flick method and two kinds of methods of acetic acid twisting method, the result shows: obviously improve 1 hour animal threshold of pain after the administration, and pain suppression ratio and matched group relatively have significant difference.Illustrate that percutaneous drug delivery promptly shows analgesic activity after 1 hour, and lasted till 12 hours.Carry out this product antiinflammatory experiment with the dimethylbenzene ear expanding test, showing has tangible antiinflammatory action.Also carried out simultaneously the experiment of skin irritation and anaphylaxis.By the pastille cataplasma and not pastille substrate rabbit intact skin and damaged skin local action were observed 24,48,72 hours, show speckle and edema occur.Illustrate this pastille cataplasma and not pastille substrate to intact skin and the equal nonirritant of damaged skin.Anaphylaxis experiment is by pastille cataplasma, the not catablasm base material and the positive drug 2 of pastille, and the 4-dinitrochlorobenzene is to guinea pig skin sensitization (0,7,14d) and excite (28d), observation 6,24,48,72h at last repeatedly.The positive drug group 6,24, in various degree erythema and edema appear in 48h all animals skin, the sensitization rate is 100%, and the pastille cataplasma and not the catablasm base material treated animal skin of pastille abnormal response does not appear.The result shows that this Chinese medicine patcher and substrate thereof do not have sensitization to skin.
The present invention has following advantage:
1, non-stimulated to skin, there is not irritated phenomenon, preserve moisture, breathe freely, pasting comfortable, convenient.
2, pollution clothes not in the time of need taking off during sticking, can also stick again.
3, drug loading is big, be applicable to make the Chinese patent medicine external plaster, and good with the medicine intermiscibility.
4, host material stable in properties does not react with principal agent.
5, the prescription of substrate and preparation technology are simple, do not need high temperature, do not destroy effective ingredient.
6, used base starting material is all homemade, and is with low cost.
Embodiment 1
Chinese medicine patcher is made of by weight mixing following raw material:
2.5 parts in 5 parts of carboxymethyl cellulose ropes of sodium polyacrylate sodium
10.0 parts of 1.5 parts of Kaolin of polyvinyl alcohol
0.15 part of 0.3 part of aluminium potassium sulfate of phosphorous acid
20.0 parts of 4.0 parts of glycerol of gelatin
55.0 parts in water
Embodiment 2
A: gelatin adds 15 parts in water, and heating makes 60 ℃ of dissolvings, adds phosphorous acid, aluminium potassium sulfate again, makes dissolving, adds Kaolin, zinc oxide, stirs;
B: sodium polyacrylate disperses with glycerol, adds 20 parts of dissolvings of water;
C: polyvinyl alcohol adds 20 parts in water, be heated to 70 ℃ of dissolvings after, add sodium carboxymethyl cellulose, stir;
D:A adds C and stirred 5 minutes at 50 ℃, adds B again and stirs 15～20 minutes, promptly gets the catablasm base material mastic.
Embodiment 3
By weight with respectively 1 part of Radix Aconiti, Radix Aconiti Kusnezoffii, Olibanum, Myrrha, Semen Strychni; Respectively 2 parts of Cortex Cinnamomi, Schizonepeta tenuifolia Briq, Radix Saposhnikoviae, Herba Erodii, Cortex Periplocae, Rhizoma Drynariae; Respectively 3 parts of the Radix Angelicae Dahuricae, Rhizoma Kaempferiae, Rhizoma Zingiberiss are ground into coarse powder, use 90% ethanol percolation, reclaim ethanol, be concentrated into the thick paste of relative density 1.2～1.3, add emplastrum common drugs such as methyl salicylate, azone, Mentholum, Borneolum Syntheticum, Camphora, Semen daturae, mix homogeneously again by the 0.4-0.6 of crude drug thick paste weight, become extractum, extractum is added in the catablasm base material, and the two ratio is 1: 4～10, after the stirring refining is closed evenly, coat on the material of mounting, contain Chinese medicine patcher through cutting promptly to make.Through pharmacodynamic experiment, analgesic activity is preferably arranged with mice tepidarium tail-flick method and two kinds of method proofs of acetic acid twisting method.With the dimethylbenzene ear expanding test tangible antiinflammatory action is also arranged.Through three months 40 ℃ of following accelerated tests, the equal no change of every physical behavior.Illustrate that said preparation is stable., observed 24,48,72 hours rabbit intact skin and local skin effect by this pastille cataplasma, show speckle and edema do not illustrate that this Chinese medicine patcher is to intact skin and the equal nonirritant of damaged skin.
Claims (4)
1, make the Chinese medicine patcher substrate of cataplasma, it is characterized in that: this substrate is made of by weight mixing following natural and synthetic high molecular polymer:
1～6 part of 2～10 parts of sodium carboxymethyl cellulose of sodium polyacrylate
2～10 parts in 1～6 part of gelatin of polyvinyl alcohol
0.1～1 part in 6～18 parts of phosphorous acid of Kaolin
30～60 parts in 0.1～0.8 part of water of aluminium potassium sulfate
10～20 parts of glycerol.
2, the Chinese medicine patcher substrate of cataplasma according to claim 1, the raw material weight that it is characterized in that this substrate is such as following:
2.5 parts of 5 parts of sodium carboxymethyl cellulose of sodium polyacrylate
10 parts of 1.5 parts of Kaolin of polyvinyl alcohol
0.15 part of 0.3 part of aluminium potassium sulfate of phosphorous acid
20 parts of 4.0 parts of glycerol of gelatin
55 parts in water.
3, be used for the preparation technology of the Chinese medicine patcher substrate of the described cataplasma of claim 1, it is characterized in that:
A component: gelatin is added 8～6 parts in water,, add phosphorous acid, aluminium potassium sulfate, Kaolin then 40～60 ℃ of dissolvings down;
B component: sodium polyacrylate is scattered in the glycerol, adds water then and be dissolved into transparent colloid for 11～22 parts;
The C component: polyvinyl alcohol adds 11～22 parts in water, adds sodium carboxymethyl cellulose after being heated to 60～75 ℃ of dissolvings, stirs;
Preparation catablasm base material: mix A component and C component, under 40～60 ℃, stir, add the B component again, under 40～60 ℃, stir and promptly get the catablasm base material mastic.
4, with the Chinese medicine patcher substrate manufacturing of the described cataplasma of claim 1, has antiinflammatory, the Chinese medicine patcher finished product of analgesic activity, it is characterized in that by weight Radix Aconiti Kusnezoffii, Radix Aconiti, Olibanum, Myrrha, each portion of Semen Strychni, Cortex Cinnamomi, Schizonepeta tenuifolia Briq, Radix Saposhnikoviae, Herba Erodii, Cortex Periplocae, each 2 parts of Rhizoma Drynariae, the Radix Angelicae Dahuricae, Rhizoma Kaempferiae, each 3 parts of Rhizoma Zingiberiss, be ground into coarse powder, use 90% ethanol percolation, reclaim ethanol, be concentrated into the thick paste of relative density 1.2～1.3, the 0.4-0.6 that presses crude drug thick paste weight adds methyl salicylate, Mentholum, Borneolum Syntheticum, Camphora, Semen daturae, emplastrum common drugs such as azone, mix homogeneously becomes extractum, above-mentioned extractum is added in the Chinese medicine patcher substrate of cataplasma, Chinese medical concrete and substrate ratio are 1: 4～10, coat on the material of mounting after refining is closed through stirring, through cutting contain Chinese medicine patcher.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001006282A CN1137730C (en) | 2000-01-24 | 2000-01-24 | Matrix for Chinese medicine plaster and its preparation technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001006282A CN1137730C (en) | 2000-01-24 | 2000-01-24 | Matrix for Chinese medicine plaster and its preparation technology |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1306862A CN1306862A (en) | 2001-08-08 |
| CN1137730C true CN1137730C (en) | 2004-02-11 |
Family
ID=4575577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB001006282A Expired - Lifetime CN1137730C (en) | 2000-01-24 | 2000-01-24 | Matrix for Chinese medicine plaster and its preparation technology |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1137730C (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9278155B2 (en) | 2003-06-05 | 2016-03-08 | 3M Innovative Properties Company | Adhesive compositions, articles incorporating same and methods of manufacture |
| CN1686139B (en) * | 2005-04-30 | 2012-07-11 | 福建师范大学 | Application of ketosolin in new type analgesic for treatig inflammatory pain |
| CN105935354A (en) * | 2016-06-14 | 2016-09-14 | 孟红琳 | Preparation method of cataplasm for orthopedic clinical use |
| CN110302183B (en) * | 2019-07-12 | 2023-02-28 | 杭州师范大学 | Compound gel plaster for diminishing inflammation and pain and preparation method thereof |
| CN115969942A (en) * | 2022-02-07 | 2023-04-18 | 河南合智医药科技有限公司 | Cataplasm acupoint plaster for treating infantile wind-cold cough and preparation method thereof |
| CN116672327A (en) * | 2023-05-31 | 2023-09-01 | 海南钧华医疗科技有限公司 | Apricot and perilla cough-relieving cataplasm acupoint patch and preparation method thereof |
-
2000
- 2000-01-24 CN CNB001006282A patent/CN1137730C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1306862A (en) | 2001-08-08 |
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| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Jiangsu 707 Natural Pharmaceutical Co., Ltd. Assignor: Traditional Chinese Medicine Inst., China Academy of Traditional Chinese Medicin Contract fulfillment period: 2006.1.30 to 2016.1.30 Contract record no.: 2008320000167 Denomination of invention: Matrix for Chinese medicine plaster and its preparation technology Granted publication date: 20040211 License type: Exclusive license Record date: 20080922 |
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| LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENCE; TIME LIMIT OF IMPLEMENTING CONTACT: 2006.1.30 TO 2016.1.30 Name of requester: JIANGSU NO.707 NATURAL PHARMACEUTICAL CO. Effective date: 20080922 |
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| CX01 | Expiry of patent term |
Granted publication date: 20040211 |
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| CX01 | Expiry of patent term |