CN105935354A - Preparation method of cataplasm for orthopedic clinical use - Google Patents
Preparation method of cataplasm for orthopedic clinical use Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 230000000399 orthopedic effect Effects 0.000 title claims abstract description 7
- 238000003756 stirring Methods 0.000 claims abstract description 23
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 6
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 6
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 6
- 238000010438 heat treatment Methods 0.000 claims abstract description 5
- 239000000203 mixture Substances 0.000 claims abstract description 4
- 239000000243 solution Substances 0.000 claims description 36
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 24
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- 239000007864 aqueous solution Substances 0.000 claims description 11
- 241000628997 Flos Species 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 239000004744 fabric Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 4
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 4
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 4
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 4
- 229920002125 Sokalan® Polymers 0.000 claims description 4
- 150000001336 alkenes Chemical class 0.000 claims description 4
- 229920002674 hyaluronan Polymers 0.000 claims description 4
- 229960003160 hyaluronic acid Drugs 0.000 claims description 4
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical class CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims description 4
- 229920000609 methyl cellulose Polymers 0.000 claims description 4
- 239000001923 methylcellulose Substances 0.000 claims description 4
- 235000010981 methylcellulose Nutrition 0.000 claims description 4
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 4
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims description 4
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 4
- 235000019830 sodium polyphosphate Nutrition 0.000 claims description 4
- 238000009835 boiling Methods 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 7
- 238000012986 modification Methods 0.000 abstract description 4
- 230000004048 modification Effects 0.000 abstract description 4
- 239000000126 substance Substances 0.000 abstract 1
- 229910000831 Steel Inorganic materials 0.000 description 7
- 239000010959 steel Substances 0.000 description 7
- 239000013521 mastic Substances 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 239000010408 film Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000000465 moulding Methods 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000005096 rolling process Methods 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000010409 thin film Substances 0.000 description 2
- 210000000707 wrist Anatomy 0.000 description 2
- BZSXEZOLBIJVQK-UHFFFAOYSA-N 2-methylsulfonylbenzoic acid Chemical group CS(=O)(=O)C1=CC=CC=C1C(O)=O BZSXEZOLBIJVQK-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920004933 Terylene® Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000006266 etherification reaction Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- -1 filter out residue Substances 0.000 description 1
- PQTCMBYFWMFIGM-UHFFFAOYSA-N gold silver Chemical compound [Ag].[Au] PQTCMBYFWMFIGM-UHFFFAOYSA-N 0.000 description 1
- 210000004247 hand Anatomy 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 235000012149 noodles Nutrition 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 238000013441 quality evaluation Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- FDRCDNZGSXJAFP-UHFFFAOYSA-M sodium chloroacetate Chemical compound [Na+].[O-]C(=O)CCl FDRCDNZGSXJAFP-UHFFFAOYSA-M 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
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- Medicinal Chemistry (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
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Abstract
The invention relates to a preparation method of cataplasm for orthopedic clinical use. The method includes: step 1, preparing a first solution; step 2, preparing a second solution; step 3, preparing a third solution; step 4, mixing the second solution and the third solution, conducting heating, stirring the mixture evenly, then adding the first solution, and stirring the substances evenly to obtain the cataplasm. The cataplasm provided by the invention has good stickiness, and can be removed and sticked repeatedly. Through modification treatment on sodium carboxymethylcellulose, the uniformity and rolling-ball adhesion of the cataplasm are improved, so that the cataplasm can better adapt to the skin, and has better skin comfort and stickiness.
Description
Technical field
The present invention relates to the preparation method of the cataplasma that a kind of Orthopedic Clinical uses, belong to orthopaedic medical treatment ointment technology neck
Territory.
Background technology
For the clinical treatment of orthopaedics, clamping plate are common apparatuses, during for the treatment of the patients such as fracture, need to pass through
Clamping plate make its extremity fix.But when the process used, easily occur that during life-time service, patient skin breathability is bad, feels
The problems such as sultry, pruritus, redness, and owing to clamping plate are typically to be fixed by bandage, can cause can not be along with patient body feature
It is adjusted, there is the uncomfortable problem of wearing；It addition, part orthopaedics patient is simultaneously need to for red and swollen, the skin of inflammation again
Skin applies external-applied ointment, and existing cataplasma viscosity is bad, it is impossible to enough patches of repeatedly taking off, and the uniformity of cataplasma and spin are glued
Attached property is the most not ideal enough.
Summary of the invention
It is an object of the invention to: the skin comfort providing a kind of Orthopedic Clinical to use and the system of viscosity more preferably cataplasma
Preparation Method.
Technical scheme is:
The preparation method of the cataplasma that a kind of Orthopedic Clinical uses, comprises the following steps:
1st step, prepares the first solution: by weight, 5 parts of Resina persicaes, 1 part of sodium polyphosphate, 7 parts of sodium carboxymethyl cellulose, 7 parts
Sodium polyacrylate adds glycerol 16 parts, stirs, obtain the first solution；
2nd step, prepares the second solution: by weight, by 5 parts of carbomers, 6 parts of arabic gums, 0.6 part of L-TARTARIC ACID, poly-second
The aqueous solution of propylene glycol 2 that azone aqueous solution 0.3 part that alkene pyrrolidone 4 parts, volumetric concentration are 1.5%, volumetric concentration are 1.5%
Part, 4 parts of methylcellulose be scattered in glycerol 30 parts, add 15 parts water-swellable, be heated to 35 DEG C, stirring the most i.e. obtain the second solution；
3rd step, prepares the 3rd solution: by weight, by 4 parts of isopropyl palmitates, 2 parts of sodium bicarbonate, 0.3 part of hyaluronic acid
With 6 parts of thick pastes with 15 parts of water dissolutioies, stir, obtain the 3rd solution；
4th step, mixes the second molten and the 3rd solution, heating, stirs, add the first solution, and stir, obtain bar
Cloth agent；Wherein, the preparation method of described thick paste is: by weight, takes Flos Chrysanthemi 20 parts, Herba Taraxaci 5 parts, Folium Artemisiae Argyi 5 parts, gold silver
Spending 15 parts of mix homogeneously, boiling, after obtaining extracting solution, filter out residue, filtrate reduced in volume becomes thick paste.
Beneficial effect
The cataplasma viscosity that the present invention provides is good, can repeatedly take off patch.By to sodium carboxymethyl cellulose modification so that bar
Uniformity and the spin adhesiveness of cloth agent are improved；Can preferably adapt to skin, have more preferable skin comfort and
Viscosity.
Detailed description of the invention
Cataplasma its preparation method example is as follows:
First, by weight, Flos Chrysanthemi 20 parts, Herba Taraxaci 5 parts, Folium Artemisiae Argyi 5 parts, 15 parts of mix homogeneously of Flos Lonicerae are taken, boiling,
After obtaining extracting solution, filtering out residue, filtrate reduced in volume becomes thick paste；
It follows that carry out the preparation of cataplasma
The first sample:
1st step, prepares the first solution: by weight, 5 parts of Resina persicaes, 1 part of sodium polyphosphate, 7 parts of sodium carboxymethyl cellulose, 7 parts
Sodium polyacrylate adds glycerol 16 parts, stirs, obtain the first solution；
2nd step, prepares the second solution: by weight, by 5 parts of carbomers, 6 parts of arabic gums, 0.6 part of L-TARTARIC ACID, poly-second
The aqueous solution of propylene glycol 2 that azone aqueous solution 0.3 part that alkene pyrrolidone 4 parts, volumetric concentration are 1.5%, volumetric concentration are 1.5%
Part, 4 parts of methylcellulose be scattered in glycerol 30 parts, add 15 parts water-swellable, be heated to 35 DEG C, stirring the most i.e. obtain the second solution；
3rd step, prepares the 3rd solution: by weight, by 4 parts of isopropyl palmitates, 2 parts of sodium bicarbonate, 0.3 part of hyaluronic acid
With 6 parts of thick pastes with 15 parts of water dissolutioies, stir, obtain the 3rd solution；
4th step, mixes the second molten and the 3rd solution, heating, stirs, add the first solution, and stir, obtain bar
Cloth agent.
The second sample: above-mentioned sodium carboxymethyl cellulose can also pass through modification, and method of modifying is:
1st step, in kneader, add 100 parts of cotton fiber, ethanol 30 parts, mass concentration be 3% sodium hydrate aqueous solution 40
Part, after stirring, adding mass concentration is the aqueous hydrogen peroxide solution 15 parts of 20%, continues reaction；
2nd step, then adding ethanol 5 parts, mass concentration in the reactant that the 1st step obtains is the monoxone aqueous solution 25 of 5%
Part, it is warming up to 70 DEG C of etherification reaction 2h, cooling discharge；
3rd step, above-mentioned material washing with alcohol, solids is leached, solids is sequentially added into hydrochloric acid solution 20 parts, secondary
Sodium chlorate aqueous solution 20 parts is neutralized, add mass concentration be 20% aqueous hydrogen peroxide solution 15 parts carry out process 1h, then
Solids is leached and washes；
4th step, mixes the above-mentioned solids that obtains with 60 parts of water, Polyethylene Glycol 20 parts, temperature reaction, and reaction temperature is 85 DEG C,
Response time 4h, obtains white serosity, after being spray-dried, obtains modified carboxy methyl cellulose sodium.
The preparation of the second sample cataplasma
1st step, prepares the first solution: by weight, at 5 parts of Resina persicaes, 1 part of sodium polyphosphate, 7 parts of modified carboxy methyl celluloses
Sodium, 7 parts of sodium polyacrylate add glycerol 16 parts, stirs, obtain the first solution；
2nd step, prepares the second solution: by weight, by 5 parts of carbomers, 6 parts of arabic gums, 0.6 part of L-TARTARIC ACID, poly-second
The aqueous solution of propylene glycol 2 that azone aqueous solution 0.3 part that alkene pyrrolidone 4 parts, volumetric concentration are 1.5%, volumetric concentration are 1.5%
Part, 4 parts of methylcellulose be scattered in glycerol 30 parts, add 15 parts water-swellable, be heated to 35 DEG C, stirring the most i.e. obtain the second solution；
3rd step, prepares the 3rd solution: by weight, by 4 parts of isopropyl palmitates, 2 parts of sodium bicarbonate, 0.3 part of hyaluronic acid
With 6 parts of thick pastes with 15 parts of water dissolutioies, stir, obtain the 3rd solution；
4th step, mixes the second molten and the 3rd solution, heating, stirs, add the first solution, and stir, obtain bar
Cloth agent.
The catablasm base material of gained is carried out performance test, and result is:
Table 1
As can be seen from the table, the cataplasma viscosity that the present invention provides is good, can repeatedly take off patch.To carboxymethyl in the second sample
Sodium cellulosate modification so that uniformity and the spin adhesiveness of cataplasma are improved.
Other quality evaluations of cataplasma are tested
It is that the cataplasma of molding is affixed on 10 trial volunteer wrist backs, to being coated with exhibition and flexibility, film residual, skin
Tracing ability, mastic uniformity, skin are uncomfortable and pain is evaluated.Every evaluation criterion is as follows:
It is coated with exhibition and flexibility: during mastic coating, casting anchor property is good, the uniform unbroken noodles of mastic, touches with hands, soft feel, the most satiny
For best.
Film residual: take molding cataplasma, with 180 ° of strippings, the amount on thin film that remains in is the fewest more good.
Skin tracing ability: this index Japanese evaluates the method for cataplasma, and molding patch is affixed on wrist back, uses
Power is got rid of 10 times and is not fallen off.
Mastic uniformity: prepared mastic is uniform, denseness is suitable, be coated on by lining without graininess micelle, exquisiteness,
The consistent person of thin and thick is best.
Skin is uncomfortable and pain: be attached on skin there is no pruritus, allergy, fester and take off pull time best without pain.
Above five each be 20 points, respectively take above-mentioned each cataplasma sample, 10 volunteers give a mark according to all standard, will
Each item rating is added the most afterwards and tries to achieve total score.The results are shown in Table 2.Result shows, the comprehensive score of product of the present invention all more than 90 points,
All preferable to painting exhibition and flexibility, film residual, skin tracing ability, mastic uniformity, without skin, uncomfortable and pain, can take off repeatedly
Pull and apply ointment or plaster.It is good to the biocompatibility of skin, affinity, breathability, absorption of perspiration that result discloses product of the present invention, and does not allows
Easily allergy.
Table 2 Chinese medicine catablasm base material results of property
| Film residual | It is coated with exhibition and flexibility | Skin is uncomfortable and keenly feels | Skin tracing ability | Uniformity | Total score | |
| 20 | 20 | 20 | 20 | 20 | 100 | |
| Embodiment 1 | 14.6 | 14.6 | 13.7 | 15.2 | 13.1 | 71.2 |
| Reference examples 1 | 16.7 | 16.9 | 17.1 | 17.6 | 18.2 | 86.5 |
The test method of rolling ball method is:
Take test sample 3, at room temperature, remove lid lining, be placed in long 30cm, (press respectively this kind item with the horizontal 15 ° or 30 °
Lower regulation) inclined-plane grounder device central authorities, cream is towards upper, and terylene thick for top, inclined-plane 10cm and bottom 15cm 0.025mm is thin
Film covers, and centre reserves 5cm cream face, by the steel ball (see table) of regulation under respectively this kind item, freely rolls down from beveled top end.3
Sheet test sample should there be 2 or more than 2 can cling steel ball on test section, can not cling if any 1, then with less No. 1
Ball test, should be able to cling.As only 1 can cling steel ball, and another 2 steel balls that can only cling less No. 1, should separately take 3
Sheet retrial.3 all should be able to cling steel ball is qualified.The specification of steel ball is:
Steel ball specification in rolling ball method
As can be seen from the above table, two kinds of above-mentioned sample cataplasmas can preferably adapt to skin, particularly the second sample
There is more preferable skin comfort and viscosity.
Claims (1)
1. the preparation method of the cataplasma of an Orthopedic Clinical use, it is characterised in that comprise the following steps:
1st step, prepares the first solution: by weight, 5 parts of Resina persicaes, 1 part of sodium polyphosphate, 7 parts of sodium carboxymethyl cellulose, 7 parts
Sodium polyacrylate adds glycerol 16 parts, stirs, obtain the first solution；
2nd step, prepares the second solution: by weight, by 5 parts of carbomers, 6 parts of arabic gums, 0.6 part of L-TARTARIC ACID, poly-second
The aqueous solution of propylene glycol 2 that azone aqueous solution 0.3 part that alkene pyrrolidone 4 parts, volumetric concentration are 1.5%, volumetric concentration are 1.5%
Part, 4 parts of methylcellulose be scattered in glycerol 30 parts, add 15 parts water-swellable, be heated to 35 DEG C, stirring the most i.e. obtain the second solution；
3rd step, prepares the 3rd solution: by weight, by 4 parts of isopropyl palmitates, 2 parts of sodium bicarbonate, 0.3 part of hyaluronic acid
With 6 parts of thick pastes with 15 parts of water dissolutioies, stir, obtain the 3rd solution；Wherein, the preparation method of described thick paste is: by weight
Amount part meter, takes Flos Chrysanthemi 20 parts, Herba Taraxaci 5 parts, Folium Artemisiae Argyi 5 parts, 15 parts of mix homogeneously of Flos Lonicerae, boiling, after obtaining extracting solution,
Filtering out residue, filtrate reduced in volume becomes thick paste；
4th step, mixes the second molten and the 3rd solution, heating, stirs, add the first solution, and stir, obtain bar
Cloth agent.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107115254A (en) * | 2017-06-04 | 2017-09-01 | 张东 | A kind of sleep mask acted on moisturizing and pore cleanser and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1306862A (en) * | 2000-01-24 | 2001-08-08 | 中国中医研究院中药研究所 | Matrix for Chinese medicine plaster and its preparation technology |
| CN103169688A (en) * | 2013-02-07 | 2013-06-26 | 江苏七○七天然制药有限公司 | Traditional Chinese medicine cataplasm matrix and preparation method |
| CN103316082A (en) * | 2013-06-27 | 2013-09-25 | 华南理工大学 | Jiufen cataplasm and preparation method thereof |
| CN105168190A (en) * | 2015-09-23 | 2015-12-23 | 傅兴琴 | Preparation method of cataplasm matrix containing rose essential oil for skin black removing |
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2016
- 2016-06-14 CN CN201610414024.0A patent/CN105935354A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1306862A (en) * | 2000-01-24 | 2001-08-08 | 中国中医研究院中药研究所 | Matrix for Chinese medicine plaster and its preparation technology |
| CN103169688A (en) * | 2013-02-07 | 2013-06-26 | 江苏七○七天然制药有限公司 | Traditional Chinese medicine cataplasm matrix and preparation method |
| CN103316082A (en) * | 2013-06-27 | 2013-09-25 | 华南理工大学 | Jiufen cataplasm and preparation method thereof |
| CN105168190A (en) * | 2015-09-23 | 2015-12-23 | 傅兴琴 | Preparation method of cataplasm matrix containing rose essential oil for skin black removing |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107115254A (en) * | 2017-06-04 | 2017-09-01 | 张东 | A kind of sleep mask acted on moisturizing and pore cleanser and preparation method thereof |
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