CN105919883A - Cosmetic composition and preparation method thereof - Google Patents

Cosmetic composition and preparation method thereof Download PDF

Info

Publication number
CN105919883A
CN105919883A CN201610414484.3A CN201610414484A CN105919883A CN 105919883 A CN105919883 A CN 105919883A CN 201610414484 A CN201610414484 A CN 201610414484A CN 105919883 A CN105919883 A CN 105919883A
Authority
CN
China
Prior art keywords
cosmetic composition
extract
effective ingredient
deionized water
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610414484.3A
Other languages
Chinese (zh)
Inventor
季浩
闫成亮
于燕燕
阚建伟
窦长清
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Tiansheng Pharmaceutical Co Ltd
Original Assignee
Jiangsu Tiansheng Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Tiansheng Pharmaceutical Co Ltd filed Critical Jiangsu Tiansheng Pharmaceutical Co Ltd
Priority to CN201610414484.3A priority Critical patent/CN105919883A/en
Publication of CN105919883A publication Critical patent/CN105919883A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses a cosmetic composition whose active ingredients at least include bearberry leaf extract containing arbutin and fucus extract containing a polysaccharide-amino acid complex. The invention further discloses a preparation method of the cosmetic composition. Natural compound extract solutions are used as the active ingredients, so that the cosmetic composition is safer and free of heavy metal and organic solvent residue, the bearberry leaf extract contains arbutin which is a newly-emerging natural whitening active substance free of irritation and allergy and high in compatibility, the polysaccharide-amino acid complex in the fucus extract has natural moisturizing effect similar to that of a biological sponge, gel is used for reinforcement, and oat kernel and chrysanthemum extract has effect of relieving and calming skin; the cosmetic composition is longer in shelf life, and color and flavor of the cosmetic composition can be maintained longer than 12 months.

Description

A kind of cosmetic composition and preparation method thereof
Technical field
The present invention relates to a kind of cosmetic composition and preparation method thereof, belong to cosmetics of everyday use technical field.
Background technology
Along with the deterioration of atmospheric environment, the skin of modern is faced with increasing problem, people's need to cosmetics The amount of asking is increasing year by year, and the kind of cosmetics gets more and more, and daily life has be unable to do without cosmetics.Whitening series is Through being one of most important category on current Cosmetic Market.But the existing whitening product in market is the most all to be closed by chemistry One-tenth is made, although have whitening function, but wherein human body can be damaged by fractions, and therefore consumer is buying Time can be irresolute, there is the biggest demand in market to the cosmetics that naturalization is harmless.
Summary of the invention
In order to solve the problems referred to above, it is an object of the invention to provide a kind of safety, natural harmless, whitening skin and preserving moisture is effective Cosmetic composition and preparation method thereof.
The technical scheme is that
A kind of cosmetic composition, at least with the uva ursi extract containing arbutin with containing polysaccharide-amino acid complex Fucus Vesiculosus extract is as effective ingredient.
Arbutin is a kind of emerging non-stimulated, without allergy, natural whiting active substance that compatibility is strong;Fucus Vesiculosus is extracted Polysaccharide-amino acid complex in thing has natural moistening effect.
Present invention also offers a kind of cosmetic composition, except with the uva ursi extract containing arbutin with containing many The Fucus Vesiculosus extract of sugar-amino acid complex is as effective ingredient, also using oat kernel extract, Flos Chrysanthemi extract as effectively Composition.Skin is played and releives and sedation by oat kernel and Flos Chrysanthemi extract.
Present invention also offers a kind of cosmetic composition, compound extract solution and adjuvant solution including effective ingredient,
Described effective ingredient compounds the raw material of extract solution and includes following components, and the parts by weight of each component are respectively as follows: Uva ursi 25-35 part, Fucus Vesiculosus 6-8 part, oat kernel 2-3 part, Flos Chrysanthemi 2-3 part and deionized water 50-60 part;
The raw material of described adjuvant solution includes following components, and the parts by weight of each component are respectively as follows: sodium benzoate 0.4-0.6 Part, butanediol 2-3 part, potassium sorbate 0.5-0.6 part, tetradecane fat acid 0.3-0.8 part, Palmic acid 0.5-0.8 part, tocopherol 0.6-0.9 part, Butyrospermum parkii 0.5-0.8 part and deionized water 12-20 part.
In above-mentioned cosmetic composition, described effective ingredient compounds the preparation method of extract solution and is: first-selection will Deionized water 50-60 part joins in reaction pot, and is heated to 60-65 DEG C, adds Bears the most while stirring in deionized water Really leaf 25-35 part, Fucus Vesiculosus 6-8 part, oat kernel 2-3 part and Flos Chrysanthemi 2-3 part, mixing and stirring, after decocting 0.5h, filters Compounding decoction liquor to effective ingredient, after continuing to stir, at 20-30 DEG C, placement processes 30 minutes, filters i.e. to obtain and effectively becomes Divide compounding extract solution.
The preparation method of described adjuvant solution is then: by sodium benzoate 0.4-0.6 part, butanediol 2-3 part, sorbic acid Potassium 0.5-0.6 part, tetradecane fat acid 0.3-0.8 part, Palmic acid 0.5-0.8 part, tocopherol 0.6-0.9 part, Butyrospermum parkii 0.5-0.8 and deionized water 12-20 part mixing and stirring obtain compounding extract solution.
Above-mentioned cosmetic composition is the cosmetic composition for moisturizing whitening.
Present invention also offers the preparation method of a kind of above-mentioned cosmetic composition, comprise the following steps:
S1: prepare effective ingredient and compound extract solution: deionized water 50-60 part is joined in reaction pot by first-selection, and heats To 60-65 DEG C, the most while stirring in deionized water add uva ursi 25-35 part, Fucus Vesiculosus 6-8 part, oat kernel 2-3 part and Flos Chrysanthemi 2-3 part, mixing and stirring, after decocting 0.5h, it is filtrated to get effective ingredient and compounds decoction liquor, after continuing to stir, At 20-30 DEG C, placement processes 30 minutes, filters and i.e. obtains effective ingredient and compound extract solution;
S2: prepare adjuvant solution: by sodium benzoate 0.4-0.6 part, butanediol 2-3 part, potassium sorbate 0.5-0.6 part, the tetradecane Fat acid 0.3-0.8 part, Palmic acid 0.5-0.8 part, tocopherol 0.6-0.9 part, Butyrospermum parkii 0.5-0.8 and deionized water 12- 20 parts of mixing and stirring obtain compounding extract solution;
S3: prepare cosmetic composition: the adjuvant solution prepared in S2 step is joined and prepares in S1 step Effective ingredient compounds in extract solution, stirs, and placement processes 30 minutes at 20-30 DEG C, filters, is cooled to room temperature Obtain.
The invention have the benefit that in cosmetic composition of the present invention, with natural built-up extract solution be Effective ingredient so that cosmetic composition is safer, heavy metal free and organic solvent residual, and wherein uva ursi extract includes Have arbutin, arbutin be a kind of emerging non-stimulated, without allergy, natural whiting active substance that compatibility is strong, Fucus Vesiculosus carries Polysaccharide-the amino acid complex taken in thing has natural moistening effect, and effect is similar to one " bio-sponge ", and uses gel Agent is strengthened, and skin is then played and releives and sedation by oat kernel and Flos Chrysanthemi extract;And it is longer to make cosmetics have Shelf life, color and abnormal smells from the patient keep can exceed that 12 months.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention will be described in detail.
Embodiment 1:
Deionized water 50kg is joined in reaction pot by first-selection, and is heated to 60-65 DEG C, the most while stirring in deionized water Add uva ursi 25kg, Fucus Vesiculosus 6 kg, oat kernel 3 kg and Flos Chrysanthemi 3 kg, mixing and stirring, after decocting 0.5h, filter Compounding decoction liquor to effective ingredient, after continuing to stir, at 20-30 DEG C, placement processes 30 minutes, filters i.e. to obtain and effectively becomes Divide compounding extract solution;Secondly by sodium benzoate 0.6 kg, butanediol 2 kg, potassium sorbate 0.5kg, tetradecane fat acid 0.3 Kg, Palmic acid 0.6 kg, tocopherol 0.8 kg, Butyrospermum parkii 0.5kg and deionized water 20 kg mixing and stirring are answered Join extract solution;Finally adjuvant solution is joined effective ingredient and compound in extract solution, stir, and at 20-30 At DEG C, placement processes 30 minutes, filters, is cooled to room temperature and get final product.
Embodiment 2:
Deionized water 55kg is joined in reaction pot by first-selection, and is heated to 60-65 DEG C, the most while stirring in deionized water Add uva ursi 30kg, Fucus Vesiculosus 8kg, oat kernel 2 kg and Flos Chrysanthemi 2 kg, mixing and stirring, after decocting 0.5h, filter Compounding decoction liquor to effective ingredient, after continuing to stir, at 20-30 DEG C, placement processes 30 minutes, filters i.e. to obtain and effectively becomes Divide compounding extract solution;Secondly by sodium benzoate 0.4kg, butanediol 3 kg, potassium sorbate 0.5kg, tetradecane fat acid 0.5kg, Palmic acid 0.8kg, tocopherol 0.9 kg, Butyrospermum parkii 0.8kg and deionized water 15 kg mixing and stirring obtain Compounding extract solution;Finally adjuvant solution is joined effective ingredient and compound in extract solution, stir, and at 20- At 30 DEG C, placement processes 30 minutes, filters, is cooled to room temperature and get final product.
Embodiment 3:
Deionized water 60kg is joined in reaction pot by first-selection, and is heated to 60-65 DEG C, the most while stirring in deionized water Add uva ursi 35kg, Fucus Vesiculosus 6 kg, oat kernel 3 kg and Flos Chrysanthemi 3 kg, mixing and stirring, after decocting 0.5h, filter Compounding decoction liquor to effective ingredient, after continuing to stir, at 20-30 DEG C, placement processes 30 minutes, filters i.e. to obtain and effectively becomes Divide compounding extract solution;Secondly by sodium benzoate 0.5 kg, butanediol 2 kg, potassium sorbate 0.6kg, tetradecane fat acid 0.8 Kg, Palmic acid 0.5 kg, tocopherol 0.6 kg, Butyrospermum parkii 0.7kg and deionized water 12kg mixing and stirring are answered Join extract solution;Finally adjuvant solution is joined effective ingredient and compound in extract solution, stir, and at 20-30 At DEG C, placement processes 30 minutes, filters, is cooled to room temperature and get final product.
The moisturizing whitening test of the cosmetic composition described in embodiment of the present invention 1-3 is as follows:
Irritation test: subjects be 19-25 year women, 90 people, biological whitening skin and preserving moisture liquid prepared by the present invention be coated with In the back of the hand 30 people, ancon 30 people, 30 people after ear, area is 25mm × 25mm, after 4 days, and only 1 people's elbow Portion have difference sensation, other per capita without itching, pimple, redness.Practical effect test: subjects be 19-25 year Women, 30 people, skin is more black, and canthus, buccal have mottle, and having pinched skin with thumb and forefinger has fine wrinkles, canthus wrinkle Substantially, skin is substantially dried.The biological whitening skin and preserving moisture liquid present invention prepared is applied to face skin morning, evening, after 30 days, and face Portion is moist, flexible, has pinched skin fine wrinkles with thumb and forefinger and has disappeared, and mottle is substantially desalinated, and skin is delicate.
Experimental subject selects standard: age 18-52 year normal female, without serious, systemic disease, without immunodeficiency or Autoimmune disease person, without anaphylactic disease person, previously to skin-care cosmetics without allergies, not whole body in nearly January Using hormone medicine and immunosuppressant person, do not participate in other clinical trial persons, volunteer participates in and can be complete by test requirements document Become specified content person, do not include gestation or mend breast phase women, outside work be main, cannot avoid during Exposure to Sunlight person, test because of respectively Planting reason causes Exposure to Sunlight enhancer, trial employment period whole body application hormones, immune formulation class medicine person, trial employment period face to be answered With anti-inflammatory drug person, do not use according to regulations tested material or the infull person of data.
Experimenter's number: 96 people (meet cosmetics moistening effect evaluation guide and whitening class cosmetic industry assessment side Experimenter's quantity (more than 30 people) of method guideline defined), it is randomly divided into three groups, often organizes 32 people, according to group respectively The cosmetic composition of embodiment 1-3 on probation.
One, irritant experiment: method: after cosmetic composition is applied to the back of the hand, ancon, ear respectively, area be 25mm × 25mm, after 7 days, all without difference, nothing is itched, pimple, red and swollen situation occur.
Two, whitening, moisturizing experiment:
Method: using face forehead, chin, left cheek, right cheek as pilot region.Within 2-3 days, can not use any before Ce Shi Cosmetics, experimenter's unified cleaning skin of face, by dry medicated napkin wiped clean, then coat embodiment 1-3 in test block Cosmetic composition, twice daily, carry out in 8 and at 10 in evening the most in the morning, follow-on test 12 weeks.Utilize sense organ Evaluate whitening performance, utilize numeral skin tester, use and be averaging (moisture of skin-the experiment after increasing value=experiment of increasing value method Front moisture of skin) test performance of keeping humidity (with morning), result is respectively as shown in table 1-table 4:
Table 1: whitening experiment Analyses Methods for Sensory Evaluation Results statistical table:
Table 2: the performance of keeping humidity test result statistical table of embodiment 1:
Table 3: the performance of keeping humidity test result statistical table of embodiment 2:
Table 4: the performance of keeping humidity test result statistical table of embodiment 3:
From above experimental result: the cosmetic composition that preparation method of the present invention prepares has good Whitening and moistening effect, and safe and non-stimulating, allergic phenomena will not be produced.
Above detailed description of the invention limits the present invention the most in any form, every in the way of equivalent or equivalent transformation The technical scheme obtained, all falls within protection scope of the present invention.

Claims (7)

1. a cosmetic composition, it is characterised in that at least with the uva ursi extract containing arbutin with containing polysaccharide-ammonia The Fucus Vesiculosus extract of base acid complex is as effective ingredient.
A kind of cosmetic composition the most according to claim 1, it is characterised in that also carry with oat kernel extract, Flos Chrysanthemi Take thing as effective ingredient.
A kind of cosmetic composition the most according to claim 1, it is characterised in that include that effective ingredient compounds extract molten Liquid and adjuvant solution,
Described effective ingredient compounds the raw material of extract solution and includes following components, and the parts by weight of each component are respectively as follows: Uva ursi 25-35 part, Fucus Vesiculosus 6-8 part, oat kernel 2-3 part, Flos Chrysanthemi 2-3 part and deionized water 50-60 part;
The raw material of described adjuvant solution includes following components, and the parts by weight of each component are respectively as follows: sodium benzoate 0.4-0.6 Part, butanediol 2-3 part, potassium sorbate 0.5-0.6 part, tetradecane fat acid 0.3-0.8 part, Palmic acid 0.5-0.8 part, tocopherol 0.6-0.9 part, Butyrospermum parkii 0.5-0.8 part and deionized water 12-20 part.
A kind of cosmetic composition the most according to claim 3, it is characterised in that described effective ingredient compounds extract The preparation method of solution is: deionized water 50-60 part is joined in reaction pot by first-selection, and is heated to 60-65 DEG C, and then limit is stirred Mix limit in deionized water, add uva ursi 25-35 part, Fucus Vesiculosus 6-8 part, oat kernel 2-3 part and Flos Chrysanthemi 2-3 part, mix and blend Uniformly, being filtrated to get effective ingredient and compound decoction liquor after decocting 0.5h, after continuing to stir, at 20-30 DEG C, placement processes 30 minutes, filter and i.e. obtain effective ingredient and compound extract solution.
A kind of cosmetic composition the most according to claim 3, it is characterised in that the preparation method of described adjuvant solution For: by sodium benzoate 0.4-0.6 part, butanediol 2-3 part, potassium sorbate 0.5-0.6 part, tetradecane fat acid 0.3-0.8 part, Petiolus Trachycarpi Acid 0.5-0.8 part, tocopherol 0.6-0.9 part, Butyrospermum parkii 0.5-0.8 and deionized water 12-20 part mixing and stirring obtain To compounding extract solution.
6. according to the cosmetic composition described in claim 1-5 any one claim, it is characterised in that described cosmetics Compositions is the cosmetic composition for moisturizing whitening.
7. the preparation method of the cosmetic composition described in a claim 3, it is characterised in that comprise the following steps:
S1: prepare effective ingredient and compound extract solution: deionized water 50-60 part is joined in reaction pot by first-selection, and heats To 60-65 DEG C, the most while stirring in deionized water add uva ursi 25-35 part, Fucus Vesiculosus 6-8 part, oat kernel 2-3 part and Flos Chrysanthemi 2-3 part, mixing and stirring, it is filtrated to get effective ingredient after decocting 0.5h and compounds decoction liquor, after continuing to stir, At 20-30 DEG C, placement processes 30 minutes, filters and i.e. obtains effective ingredient and compound extract solution;
S2: prepare adjuvant solution: by sodium benzoate 0.4-0.6 part, butanediol 2-3 part, potassium sorbate 0.5-0.6 part, the tetradecane Fat acid 0.3-0.8 part, Palmic acid 0.5-0.8 part, tocopherol 0.6-0.9 part, Butyrospermum parkii 0.5-0.8 and deionized water 12- 20 parts of mixing and stirring obtain compounding extract solution;
S3: prepare cosmetic composition: the adjuvant solution prepared in S2 step is joined and prepares in S1 step Effective ingredient compounds in extract solution, stirs, and placement processes 30 minutes at 20-30 DEG C, filters, is cooled to room temperature Obtain.
CN201610414484.3A 2016-06-14 2016-06-14 Cosmetic composition and preparation method thereof Pending CN105919883A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610414484.3A CN105919883A (en) 2016-06-14 2016-06-14 Cosmetic composition and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610414484.3A CN105919883A (en) 2016-06-14 2016-06-14 Cosmetic composition and preparation method thereof

Publications (1)

Publication Number Publication Date
CN105919883A true CN105919883A (en) 2016-09-07

Family

ID=56834035

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610414484.3A Pending CN105919883A (en) 2016-06-14 2016-06-14 Cosmetic composition and preparation method thereof

Country Status (1)

Country Link
CN (1) CN105919883A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107088172A (en) * 2017-06-08 2017-08-25 广州市花安堂生物科技有限公司 A kind of cosmetic material containing bladder-wrack extract
CN109820811A (en) * 2019-04-02 2019-05-31 陈晓艳 A kind of anti-aging technology based on tcm therapy

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6431707A (en) * 1987-07-28 1989-02-02 Nikko Chemicals Dermal agent for external use
CN103520065A (en) * 2013-11-01 2014-01-22 青岛明月爱熙化妆品有限公司 Moisture-retention liquid and method for preparing same
CN104173231A (en) * 2014-08-04 2014-12-03 法国微拉芙生命科学研究院亚洲研发中心有限公司 Method for extracting fucus extract and application of fucus extract in anti-aging cosmetics
CN105078852A (en) * 2015-09-27 2015-11-25 龚灿锋 Whitening cosmetic emulsion containing plant extractives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6431707A (en) * 1987-07-28 1989-02-02 Nikko Chemicals Dermal agent for external use
CN103520065A (en) * 2013-11-01 2014-01-22 青岛明月爱熙化妆品有限公司 Moisture-retention liquid and method for preparing same
CN104173231A (en) * 2014-08-04 2014-12-03 法国微拉芙生命科学研究院亚洲研发中心有限公司 Method for extracting fucus extract and application of fucus extract in anti-aging cosmetics
CN105078852A (en) * 2015-09-27 2015-11-25 龚灿锋 Whitening cosmetic emulsion containing plant extractives

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107088172A (en) * 2017-06-08 2017-08-25 广州市花安堂生物科技有限公司 A kind of cosmetic material containing bladder-wrack extract
CN107088172B (en) * 2017-06-08 2019-05-21 花安堂生物科技集团有限公司 A kind of cosmetic material containing bladder-wrack extract
CN109820811A (en) * 2019-04-02 2019-05-31 陈晓艳 A kind of anti-aging technology based on tcm therapy

Similar Documents

Publication Publication Date Title
CN106038330B (en) A kind of mildy wash and preparation method thereof
JP6554540B2 (en) Composition for treating skin conditions
EP3159043B1 (en) Peel-off type eyebrow coloring composition and manufacturing method thereof
CN110652481B (en) Hyaluronic acid mild moisturizing facial cleanser and preparation method thereof
CN113648275B (en) Whitening and anti-wrinkle composition and composite fermentation whitening and anti-wrinkle essence and preparation process thereof
CN104771335B (en) Anti-dandruff nourishing essence dew of plant and preparation method thereof
CN110575410A (en) Cosmetic containing blue light-shielding component
CN110693779B (en) Clean and limpid olive cleansing oil and preparation method thereof
KR20130030006A (en) Composition for preventing hair loss and promoting hair growth
CN111631965A (en) Plant-derived facial mask with cleaning and makeup removing functions
CN105919883A (en) Cosmetic composition and preparation method thereof
CN108309866A (en) A kind of adult's shower cream containing licorice
CN107737039A (en) Containing ginger without silicone oil without sulfate health-care shampoo and its preparation technology
CN107260623A (en) A kind of whitening essence and preparation method thereof
CN106727132A (en) A kind of gentle moisturizing mildy wash and preparation method thereof
CN107184516A (en) A kind of skin care compositions with moisture-keeping efficacy and preparation method and application
CN108888568B (en) Composition and cosmetic containing the same
CN107875079B (en) Fat-particle-removing essence and preparation method thereof
JP5828355B1 (en) Powdered skin external preparation for hair growth / hair growth and skin condition improvement
CN106580748A (en) Skincare makeup remover and preparation method thereof
JPH04187623A (en) Hair cosmetics
CN104771336B (en) Anti-dandruff nursing elite dew of plant and preparation method thereof
CN106434049A (en) Method for preparing dendrobe enzyme handmade soap
CN105853814A (en) Chinese herb extract and preparing method and application thereof
CN104706552A (en) Foam cleansing lotion and preparation method thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20160907

RJ01 Rejection of invention patent application after publication