CN113749976A - Portable nano antibacterial hand washing gel bead and preparation method, use method and application thereof - Google Patents
Portable nano antibacterial hand washing gel bead and preparation method, use method and application thereof Download PDFInfo
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- CN113749976A CN113749976A CN202110998637.4A CN202110998637A CN113749976A CN 113749976 A CN113749976 A CN 113749976A CN 202110998637 A CN202110998637 A CN 202110998637A CN 113749976 A CN113749976 A CN 113749976A
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- hand washing
- washing gel
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- gel bead
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y40/00—Manufacture or treatment of nanostructures
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a portable nano antibacterial hand washing gel bead as well as a preparation method, a use method and application thereof. The invention takes cellulose derivatives as water-soluble film materials, and coats a super-hydrophobic coating as the inner side to construct the portable nano antibacterial hand washing gel bead outer package; the antibacterial hand washing gel is internally provided with antibacterial hand washing gel, water is used as a solvent, natural antibacterial polysaccharide is used as a main raw material, food-grade clay is intercalated, and skin care ingredients such as glycerin and the like are added to finally prepare the portable antibacterial hand washing gel bead which is easy to carry, anhydrous and also can be used. The hand washing gel bead prepared by the invention takes biomass as a raw material, and is safe and degradable; the size is small, and the carrying is convenient; the disposable sterilization device is disposable, so that the contact with contaminated bacteria is effectively avoided; can be used under the waterless condition and is suitable for various occasions such as outwork, travel, military combat training and the like; the hand sanitizer contains natural antibacterial agents, effectively sterilizes and disinfects, reduces the risk of people to cause diseases by infecting hands with bacteria, provides an effective way for cutting off the propagation of the bacteria, and meets the requirements of skin cleaning products at the present stage.
Description
Technical Field
The invention belongs to the field of public health and health, and particularly relates to a portable nano antibacterial hand washing gel bead as well as a preparation method, a use method and application thereof.
Background
In the late epidemic era, people gradually recognize the importance of cleaning hands, and various products for cleaning hands, such as hand sanitizer, soap, wet tissue and the like, appear on the market. However, these products are generally large in size and inconvenient to carry and must be used in the presence of water. The problems of contact cross infection and the like exist in the using process, and some products have no sterilization effect and cannot meet the requirements of portability, sterilization and cleanness in daily outing, traveling and military combat training. In addition, most of the sterilization hand sanitizer and the sterilization wet tissues contain 75% of alcohol, which has great stimulation to skin, causes the problems of skin dryness, chapping and the like after long-term use, and is easy to cause fire hazard and other dangers during the storage and transportation of alcohol products. Therefore, the development of a hand washing product which is suitable for daily outing, traveling and military combat training, can be carried about, is safe, is free from washing and has excellent sterilization effect is an effective way for reducing the risk of people infecting pathogenic bacteria.
Inspired by the washing pearl, the hand washing pearl is similar to a bead, has small size and is convenient to carry. The prior antibacterial hand washing gel bead generally adopts silver ions as an antibacterial agent, is easy to cause accumulated toxicity, cannot be washed and is inconvenient to use (Huangrenhuan, Huanghuanting and Huangyinhao, a hand washing gel bead and a preparation method thereof [ P ]. Hunan province: CN111671671A,2020-09-18.), thereby having important significance for developing the antibacterial hand washing gel bead which is portable, can be washed and is safe and nontoxic to human bodies.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a hand washing bead for daily cleaning, in particular to a portable nano antibacterial hand washing bead which is easy to carry, does not need to be washed and has high antibacterial activity.
The invention also aims to provide a preparation method of the portable nano antibacterial hand washing bead. The hydroxypropyl methyl cellulose is natural in source, safe and non-toxic, has excellent water solubility and film forming property, and is a potential film material of the hand washing gel bead; however, the gel is contained in the gel and is directly coated with an outer film to be dissolved. Therefore, it is necessary to coat the super-hydrophobic layer inside the outer film to prevent the outer film from contacting the internal moisture. The carboxymethyl chitosan quaternary ammonium salt is an amphoteric polymer, has excellent antibacterial property, moisture absorption and retention property and oxidation resistance, and can be used as an effective antibacterial agent of beading. The cleaning of hands should have the cleaning effects of grease, heavy metals and the like in addition to sterilization. The food-grade clay is a layered clay mineral and has the advantages of no toxicity, biocompatibility and excellent grease and heavy metal adsorption performance. The food-grade clay intercalated carboxymethyl chitosan quaternary ammonium salt can be used for obtaining a clean nano composite material with more excellent antibacterial performance and adsorption performance.
Therefore, the hydroxypropyl methyl cellulose is used as an outer membrane material, and the super-hydrophobic coating is coated inside the membrane to prevent built-in condensation from dissolving the outer membrane; preparing the food-grade clay intercalated carboxymethyl chitosan quaternary ammonium salt into the built-in condensation with antibacterial and adsorptive properties, wrapping the built-in condensation by using an outer membrane through an automatic filling machine, and forming to obtain the portable nano antibacterial hand washing condensation bead, and finally obtaining the portable nano antibacterial hand washing condensation bead. When the outdoor combat training of daily going out, traveling and army, the adventitia is broken to the hand kneading, and built-in antibiotic condensation flows out, and both hands are rubbed, need not to wash, can play the clean effect of disinfecting, greatly reduced people infects the pathogenic risk of fungus. The used materials are all natural biomass, are safe and nontoxic, and have no pollution to the environment.
The purpose of the invention is realized by the following technical scheme.
A method for preparing the portable nanometer antibacterial hand washing gel bead, hydroxypropyl methylcellulose solution mixes with glycerin, the tape casting method is filmed, coat the super hydrophobic coating as the inside, then intercalate carboxymethyl chitosan quaternary ammonium salt into food-grade clay, prepare the built-in condensation after its aqueous solution mixes with glycerin, pack the built-in condensation with the adventitia finally, prepare the portable nanometer antibacterial hand washing gel bead with easy portability, no-wash property, antibacterial property; the method specifically comprises the following steps:
(1) adding glycerol into hydroxypropyl methyl cellulose solution under stirring, uniformly mixing, pouring onto a substrate, drying to form a film, and uncovering the film to obtain a cellulose film;
(2) uniformly coating a super-hydrophobic coating on the surface of the cellulose membrane in the step (1) to serve as the inner side, and constructing a portable nano antibacterial hand washing coagulated bead outer membrane;
(3) under the condition of stirring, adding a clay solution into a carboxymethyl chitosan quaternary ammonium salt solution, uniformly mixing, and adding glycerol to obtain a built-in nano antibacterial hand washing gel;
(4) and (3) wrapping the hand washing gel prepared in the step (3) in the outer membrane prepared in the step (2) for forming to obtain the portable nano antibacterial hand washing gel bead.
Preferably, in the step (1), the concentration of the hydroxypropyl methyl cellulose solution is 0.05-5 mol/L;
preferably, in the step (1), the glycerol accounts for 20-30% of the mass of the hydroxypropyl methyl cellulose;
preferably, in the step (1), the temperature for drying and film forming is 30-60 ℃;
preferably, in the step (1), the substrate is a teflon plate.
Preferably, in the step (2), the coating amount of the super-hydrophobic coating is 5-20% of the mass of the cellulose membrane.
Preferably, in the step (3), the concentration of the carboxymethyl chitosan quaternary ammonium salt solution is 1-10 mg/mL;
preferably, in the step (3), the concentration of the clay solution is 0.01-1 mg/mL;
preferably, in the step (3), the volume ratio of the clay solution to the carboxymethyl chitosan quaternary ammonium salt solution is 1:10-1: 50.
Preferably, in step (3), the clay is food grade clay.
Preferably, in the step (3), the glycerol accounts for 30-50% of the mass of the carboxymethyl chitosan quaternary ammonium salt.
Preferably, in the step (4), the volume of the hand washing gel built in the portable nano antibacterial hand washing gel bead is 1-5 mL.
The portable nano antibacterial hand washing gel bead prepared by the preparation method; the size is small, and the carrying is convenient; the washing is avoided, and the use is convenient; antibacterial components are added to effectively sterilize and disinfect; the used biomass materials are safe and nontoxic, and meet the requirements of daily cleaning products at the present stage.
According to the application method of the portable nano antibacterial hand washing gel bead, the outer membrane of the portable nano antibacterial hand washing gel bead is broken by hands, the built-in antibacterial gel flows out, and the two hands rub the gel bead.
The portable nano antibacterial hand washing gel bead is applied to the antibiosis of outgoing, work and travel and military combat training.
The hydroxypropyl methyl cellulose is used as an outer membrane material of the hand washing gel bead, is natural in source, safe and non-toxic, has excellent water solubility and film forming property, and can effectively relieve the pollution of a cleaning product to the environment; the inner side of the hydroxypropyl methyl cellulose membrane is coated with a super-hydrophobic coating, so that the dissolution of the outer membrane caused by excessive water in the built-in condensation is reduced; the carboxymethyl chitosan quaternary ammonium salt with excellent antibacterial property and moisture absorption and retention is used as an antibacterial component, so that the problem that the existing cleaning product has no antibacterial property is solved; the intercalation of the food-grade clay ensures that the built-in condensation has the cleaning effects of grease, heavy metal and the like besides the sterilization performance; the design of the small-size package endows the hand washing condensation bead with portability; thereby obtaining the hand washing bead with excellent antibacterial property, multi-directional cleaning, portability, no washing and safety.
Compared with the prior art, the invention has the following advantages and beneficial effects:
(1) the hydroxypropyl methyl cellulose adopted by the invention is natural in source, safe and nontoxic, has excellent water solubility and film forming property, and is a potential outer membrane material of hand washing gel beads;
(2) the natural antibacterial polysaccharide carboxymethyl chitosan quaternary ammonium salt is used as the antibacterial agent, so that the antibacterial agent has excellent antibacterial performance and high safety, and is not easy to harm human bodies and the environment; the intercalation of the food-grade clay is utilized, so that the hand washing gel bead also has the adsorption effect on grease, heavy metal and the like, and the multidirectional cleaning effect is achieved; the small-size design makes the hand washing gel bead more convenient to carry; certain water content, convenient use when facing anhydrous environment, greatly reduced people's risk of contracting a bacterium and causing disease.
(3) The preparation method has the advantages of wide raw material source, low energy consumption and the like;
(4) the portable nanometer antibacterial hand washing gel bead is easy to carry out, is free from water washing, has a good antibacterial effect, and can be applied to various occasions such as travel for work and travel and military combat training.
Detailed Description
The technical solution of the present invention is further described in detail with reference to the following specific examples, but the scope of the present invention is not limited thereto.
Example 1
The preparation method of the portable nano antibacterial hand washing gel bead comprises the following specific steps:
(1) adding 20% (based on the mass of hydroxypropyl methyl cellulose) of glycerol into 50mL of 0.05mol/L hydroxypropyl methyl cellulose solution under stirring, uniformly mixing, pouring on a substrate (polytetrafluoroethylene plate), and drying at 30 ℃ to form a film;
(2) uniformly coating 5% of a super-hydrophobic coating (equivalent to the mass of hydroxypropyl methyl cellulose film) on the surface of the membrane uncovering membrane prepared in the step (1) to serve as the inner side, and constructing the portable nano antibacterial hand washing gel bead outer package;
(3) under the condition of stirring, adding 5mL of 0.01mg/mL clay solution into 50mL of 1mg/mL carboxymethyl chitosan quaternary ammonium salt solution, uniformly mixing, and adding 30% glycerol (equivalent to the mass fraction of carboxymethyl chitosan quaternary ammonium salt) to obtain a built-in nano antibacterial hand washing gel;
(4) wrapping 1mL (3) of hand washing gel with the cellulose outer membrane obtained in the step (2), and forming to obtain the portable nano antibacterial hand washing gel bead.
The portable nano antibacterial hand washing gel bead prepared in the embodiment 1 is internally provided with 1mL of hand washing gel, is small in size, is suitable for being carried outside, is disposable, is free from water washing, and effectively avoids bacteria contamination and pathogenicity; because the film forming material is a natural high molecular material, natural antibacterial components, food-grade clay and certain moisture, when the antibacterial deodorant is used, the outer film is pinched by hands to break the outer film, the built-in antibacterial condensation flows out, and the hands knead the antibacterial deodorant without washing, so that the antibacterial deodorant can effectively sterilize, adsorb and clean, and cannot cause harm to human bodies and the environment.
Example 2
The preparation method of the portable nano antibacterial hand washing gel bead comprises the following specific steps:
(1) adding 23% (based on the mass of hydroxypropyl methyl cellulose) of glycerol into 50mL of 1mol/L hydroxypropyl methyl cellulose solution under stirring, uniformly mixing, pouring on a substrate (polytetrafluoroethylene plate), and drying at 40 ℃ to form a film;
(2) uniformly coating 10% of a super-hydrophobic coating (equivalent to the mass of hydroxypropyl methyl cellulose film) on the surface of the membrane uncovering membrane prepared in the step (1) to serve as the inner side, and constructing the portable nano antibacterial hand washing condensed bead outer package;
(3) under the condition of stirring, adding 5mL of 0.1mg/mL clay solution into 50mL of 3mg/mL carboxymethyl chitosan quaternary ammonium salt solution, uniformly mixing, and adding 35% glycerol (equivalent to the mass fraction of carboxymethyl chitosan quaternary ammonium salt) to obtain built-in nano antibacterial hand washing gel;
(4) wrapping 2mL of the hand washing gel prepared in the step (3) with the cellulose outer membrane obtained in the step (2), and forming to obtain the portable nano antibacterial hand washing gel bead.
The portable nano antibacterial hand washing gel bead prepared in the embodiment 2 is internally provided with 2mL of hand washing gel, is small in size, is suitable for being carried outside, is disposable, is free from water washing, and effectively avoids bacteria contamination and pathogenicity; because the film forming material is a natural high molecular material, natural antibacterial components, food-grade clay and certain moisture, when the antibacterial deodorant is used, the outer film is pinched by hands to break the outer film, the built-in antibacterial condensation flows out, and the hands knead the antibacterial deodorant without washing, so that the antibacterial deodorant can effectively sterilize, adsorb and clean, and cannot cause harm to human bodies and the environment.
Example 3
The preparation method of the portable nano antibacterial hand washing gel bead comprises the following specific steps:
(1) adding 27% (based on the mass of hydroxypropyl methyl cellulose) of glycerol into 50mL of 3mol/L hydroxypropyl methyl cellulose solution under stirring, uniformly mixing, pouring on a substrate (polytetrafluoroethylene plate), and drying at 50 ℃ to form a film;
(2) uniformly coating 15% of a super-hydrophobic coating (equivalent to the mass of hydroxypropyl methyl cellulose film) on the surface of the membrane uncovering membrane prepared in the step (1) to serve as the inner side, and constructing the portable nano antibacterial hand washing gel bead outer package;
(3) under the condition of stirring, adding 5mL of 0.5mg/mL clay solution into 50mL of 7mg/mL carboxymethyl chitosan quaternary ammonium salt solution, uniformly mixing, and adding 40% glycerol (equivalent to the mass fraction of carboxymethyl chitosan quaternary ammonium salt) to obtain built-in nano antibacterial hand washing gel;
(4) wrapping 3mL of the hand washing gel prepared in the step (3) with the cellulose outer membrane obtained in the step (2), and forming to obtain the portable nano antibacterial hand washing gel bead.
The portable nano antibacterial hand washing gel bead prepared in the embodiment 3 is internally provided with 3mL of hand washing gel, is small in size, is suitable for being carried outside, is disposable, is free from water washing, and effectively avoids bacteria contamination and pathogenicity; because the film forming material is a natural high molecular material, natural antibacterial components, food-grade clay and certain moisture, when the antibacterial deodorant is used, the outer film is pinched by hands to break the outer film, the built-in antibacterial condensation flows out, and the hands knead the antibacterial deodorant without washing, so that the antibacterial deodorant can effectively sterilize, adsorb and clean, and cannot cause harm to human bodies and the environment.
Example 4
The preparation method of the portable nano antibacterial hand washing gel bead comprises the following specific steps:
(1) adding 30 percent (based on the mass of hydroxypropyl methyl cellulose) of glycerol into 50mL of 5mol/L hydroxypropyl methyl cellulose solution under the stirring condition, uniformly mixing, pouring on a substrate (polytetrafluoroethylene plate) and drying at 60 ℃ to form a film;
(2) uniformly coating 20% of a super-hydrophobic coating (equivalent to the mass of hydroxypropyl methyl cellulose film) on the surface of the membrane uncovering membrane prepared in the step (1) to serve as the inner side, and constructing the portable nano antibacterial hand washing condensed bead outer package;
(3) under the stirring condition, adding 5mL of 1mg/mL clay solution into 50mL of 10mg/mL carboxymethyl chitosan quaternary ammonium salt solution, uniformly mixing, and adding 50% glycerol (equivalent to the mass fraction of carboxymethyl chitosan quaternary ammonium salt) to obtain a built-in nano antibacterial hand washing gel;
(4) and (3) wrapping 5mL of the hand washing gel prepared in the step (3) with the cellulose outer membrane obtained in the step (2), and forming to obtain the portable nano antibacterial hand washing gel bead.
The portable nano antibacterial hand washing gel bead prepared in the embodiment 4 is internally provided with 5mL of hand washing gel, is small in size, is suitable for being carried outside, is disposable, is free from water washing, and effectively avoids bacteria contamination and pathogenicity; because the film forming material is a natural high molecular material, natural antibacterial components, food-grade clay and certain moisture, when the antibacterial deodorant is used, the outer film is pinched by hands to break the outer film, the built-in antibacterial condensation flows out, and the hands knead the antibacterial deodorant without washing, so that the antibacterial deodorant can effectively sterilize, adsorb and clean, and cannot cause harm to human bodies and the environment.
The above examples are only preferred embodiments of the present invention, which are intended to be illustrative and not limiting, and those skilled in the art should understand that they can make various changes, substitutions and alterations without departing from the spirit and scope of the invention.
Claims (10)
1. A preparation method of a portable nanometer antibacterial hand washing gel bead is characterized by comprising the following steps:
(1) adding glycerol into hydroxypropyl methyl cellulose solution under stirring, uniformly mixing, pouring onto a substrate, drying to form a film, and uncovering the film to obtain a cellulose film;
(2) uniformly coating a super-hydrophobic coating on the surface of the cellulose membrane in the step (1) to serve as the inner side, and constructing a portable nano antibacterial hand washing coagulated bead outer membrane;
(3) under the condition of stirring, adding a clay solution into a carboxymethyl chitosan quaternary ammonium salt solution, uniformly mixing, and adding glycerol to obtain a built-in nano antibacterial hand washing gel;
(4) and (3) wrapping the hand washing gel prepared in the step (3) in the outer membrane prepared in the step (2) for forming to obtain the portable nano antibacterial hand washing gel bead.
2. The method according to claim 1, wherein in the step (1), the concentration of the hydroxypropylmethylcellulose solution is 0.05 to 5 mol/L; the glycerol accounts for 20-30% of the mass of the hydroxypropyl methyl cellulose; the temperature for drying and film forming is 30-60 ℃; the substrate is a polytetrafluoroethylene plate.
3. The production method according to claim 1, wherein in the step (2), the super-hydrophobic coating layer is coated in an amount of 5 to 20% by mass of the cellulose film.
4. The method according to claim 1, wherein in the step (3), the concentration of the carboxymethyl chitosan quaternary ammonium salt solution is 1 to 10 mg/mL; the concentration of the clay solution is 0.01-1 mg/mL; the volume ratio of the clay solution to the carboxymethyl chitosan quaternary ammonium salt solution is 1:10-1: 50.
5. The method according to claim 1, wherein in the step (3), the clay is a food grade clay.
6. The preparation method according to claim 1, wherein in the step (3), the glycerol is 30-50% of the mass of the carboxymethyl chitosan quaternary ammonium salt.
7. The preparation method of claim 1, wherein in step (4), the volume of the hand washing gel embedded in the portable nano antibacterial hand washing gel bead is 1-5 mL.
8. The portable nano antibacterial hand washing gel bead prepared by the preparation method of any one of claims 1 to 7.
9. The method of using the portable nano-antibacterial hand washing gel bead as claimed in claim 8, wherein the outer membrane of the portable nano-antibacterial hand washing gel bead is broken by hand, the built-in antibacterial gel is flowed out, and the gel bead is kneaded by two hands.
10. The use of the portable nano-sized antimicrobial hand washing gel bead of claim 8 for antimicrobial activities such as going out, work traveling, and military combat training.
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| US6669929B1 (en) * | 2002-12-30 | 2003-12-30 | Colgate Palmolive Company | Dentifrice containing functional film flakes |
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| KR20130085072A (en) * | 2012-01-18 | 2013-07-29 | 전남대학교산학협력단 | Multi-layer microbead, a method for preparing the same and bacterium-based microrobot comprising the same |
| CN105997528A (en) * | 2016-05-16 | 2016-10-12 | 阜阳欣奕华材料科技有限公司 | Portable hand-washing gel bead and preparation method and using method thereof |
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2021
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| US6669929B1 (en) * | 2002-12-30 | 2003-12-30 | Colgate Palmolive Company | Dentifrice containing functional film flakes |
| CN101735486A (en) * | 2009-12-17 | 2010-06-16 | 华南理工大学 | carboxymethyl chitosan quaternary ammonium salt/rectorite nano composite material and preparation method thereof |
| KR20130085072A (en) * | 2012-01-18 | 2013-07-29 | 전남대학교산학협력단 | Multi-layer microbead, a method for preparing the same and bacterium-based microrobot comprising the same |
| CN105997528A (en) * | 2016-05-16 | 2016-10-12 | 阜阳欣奕华材料科技有限公司 | Portable hand-washing gel bead and preparation method and using method thereof |
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