CN113730947B - Concentration and crystallization device for pharmaceutical intermediate preparation and concentration method thereof - Google Patents
Concentration and crystallization device for pharmaceutical intermediate preparation and concentration method thereof Download PDFInfo
- Publication number
- CN113730947B CN113730947B CN202111107337.9A CN202111107337A CN113730947B CN 113730947 B CN113730947 B CN 113730947B CN 202111107337 A CN202111107337 A CN 202111107337A CN 113730947 B CN113730947 B CN 113730947B
- Authority
- CN
- China
- Prior art keywords
- fixed connection
- thick bamboo
- pipe
- outer protection
- air
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0004—Crystallisation cooling by heat exchange
- B01D9/0013—Crystallisation cooling by heat exchange by indirect heat exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0018—Evaporation of components of the mixture to be separated
- B01D9/0031—Evaporation of components of the mixture to be separated by heating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0059—General arrangements of crystallisation plant, e.g. flow sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0063—Control or regulation
Landscapes
- Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a concentration and crystallization device for a drug intermediate and a concentration method thereof, relates to the technical field of drug production, and aims to solve the problems that the concentration and crystallization device for the traditional drug intermediate in the prior art adopts stirring and evaporation modes to perform concentration and crystallization, and a crystallized drug intermediate is easy to attach to the inner wall of the device and is not easy to discharge. A fixed seat is arranged in the outer protection cylinder, the fixed seat is fixedly connected with the outer protection cylinder through a bolt, a concentrated crystallization cylinder is arranged in the outer protection cylinder, the concentrated crystallization cylinder is rotatably connected with the fixed seat through a bearing, an inner lining plate is arranged in the concentrated crystallization cylinder, and the lining plate is fixedly connected with the concentrated crystallization cylinder through a sealing screw, steel balls are arranged in the concentrated crystallization cylinder, a sealing cover is installed at one end of the concentrated crystallization cylinder and is rotatably connected with the concentrated crystallization cylinder, and a discharge hopper is installed on one side of the sealing cover.
Description
Technical Field
The invention relates to the technical field of drug production, in particular to a concentration and crystallization device for preparing a drug intermediate and a concentration method thereof.
Background
The pharmaceutical production refers to a process of processing raw materials into a pharmaceutical product for medical use, and the process of pharmaceutical production can be generally divided into a production stage of raw material drugs and a production stage of preparations in which the raw material drugs are prepared into a certain dosage form.
The pharmaceutical intermediate is actually some chemical raw materials or chemical products used in the process of synthesizing the medicine, and the chemical products can be produced in a common chemical plant without production licenses of the medicine, and can be used for synthesizing the medicine as long as the pharmaceutical intermediate reaches some levels; therefore, the market urgently needs to develop a concentration and crystallization device for preparing a drug intermediate and a concentration method thereof to help people solve the existing problems.
Disclosure of Invention
The invention aims to provide a concentration and crystallization device for pharmaceutical intermediate preparation and a concentration method thereof, and aims to solve the problems that the traditional concentration and crystallization device for pharmaceutical intermediate preparation proposed in the background art adopts stirring and evaporation modes to perform concentration and crystallization, and the crystallized pharmaceutical intermediate is easy to adhere to the inner wall of the device and is not easy to discharge.
In order to achieve the purpose, the invention provides the following technical scheme: the utility model provides a concentrated crystallization device is used to medicine intermediate body, includes base and an outer protection section of thick bamboo, the internally mounted of an outer protection section of thick bamboo has the fixing base, and fixing base and an outer protection section of thick bamboo pass through bolt fixed connection, the inside of an outer protection section of thick bamboo is provided with a concentrated crystallization section of thick bamboo, a concentrated crystallization section of thick bamboo passes through the bearing rotation with the fixing base and is connected, the internally mounted of a concentrated crystallization section of thick bamboo has the neck plate, and the neck plate passes through sealing screw fixed connection with a concentrated crystallization section of thick bamboo, the inside of a concentrated crystallization section of thick bamboo is provided with the steel ball, the sealed cowling is installed to the one end of a concentrated crystallization section of thick bamboo, and the sealed cowling rotates with a concentrated crystallization section of thick bamboo and is connected, a hopper is installed to one side of sealed cowling, and goes out hopper and pass through sealing screw fixed connection with the sealed cowling, the one end that goes out the hopper is installed and is inhaled the workbin and goes out the hopper through flange fixed connection.
Preferably, the second support frame is installed to the top of base, and the second support frame passes through bolt fixed connection with the base, the third motor is installed to the top of second support frame, and the third motor passes through bolt fixed connection with the second support frame, the inside of inhaling the workbin is provided with the turbofan, the turbofan is through linking a fixed connection with the third motor.
Preferably, inhale the top of workbin and install the discharging pipe, and the discharging pipe with inhale the workbin and pass through flange fixed connection, the top of discharging pipe is provided with first ejection of compact branch pipe and second ejection of compact branch pipe respectively, and just first ejection of compact branch pipe and second ejection of compact branch pipe all set up structure as an organic whole with the discharging pipe, the second valve is installed in the outside of second ejection of compact branch pipe, and second valve and second ejection of compact branch pipe fixed connection.
Preferably, first valve is installed in the outside of play hopper, and first valve and play hopper fixed connection, the air pump is installed to the top of outer protection section of thick bamboo, and the air pump passes through bolt fixed connection with outer protection section of thick bamboo, install first blast pipe on the preceding terminal surface of air pump, and first blast pipe passes through flange fixed connection with the air pump, the play wind hopper is installed to the top of outer protection section of thick bamboo, and goes out the wind hopper and pass through fastening screw fixed connection with outer protection section of thick bamboo, the internally mounted of outer protection section of thick bamboo has annular cooling tube, and annular cooling tube and outer protection section of thick bamboo pass through fastening screw fixed connection.
Preferably, the air-supply line is installed to one side of outer protection section of thick bamboo, and the air-supply line passes through the bearing rotation with outer protection section of thick bamboo and is connected, air-supply line and concentrated crystallization section of thick bamboo fixed connection, the inside of air-supply line is provided with the liquid feed pipe, the middle case is installed to the one end of air-supply line, and middle case and air-supply line pass through the bearing rotation and be connected, air-supply line and liquid feed pipe all communicate with concentrated crystallization section of thick bamboo.
Preferably, second motor and reduction gear are installed respectively to the top of base, and second motor and reduction gear all pass through bolt and base fixed connection, the drive wheel is installed to one side of reduction gear, and drive wheel and reduction gear pass through even axle fixed connection, the driving wheel is installed from the driving wheel in the outside of air-supply line, and from driving wheel and air-supply line fixed connection.
Preferably, first support frame is installed to the top of base, and first support frame passes through bolt fixed connection with the base, the fluid pump is installed to the top of first support frame, and the fluid pump passes through bolt fixed connection with first support frame, the feed liquor pipe is installed to the top of fluid pump, and the feed liquor pipe passes through flange fixed connection with the fluid pump.
Preferably, the second blast pipe is installed to the top of middle box, and the second blast pipe passes through flange fixed connection with the middle box, the heating cabinet is installed to the top of second blast pipe, and the heating cabinet passes through flange fixed connection with the second blast pipe, first motor is installed to the top of heating cabinet, and first motor passes through fastening screw fixed connection with the heating cabinet, the inside of heating cabinet is provided with the fan, the fan passes through even axle fixed connection with first motor, the internally mounted of heating cabinet has the heating resistor silk, and heating resistor silk and heating cabinet fixed connection.
A concentration method of a concentration crystallization device for preparing a pharmaceutical intermediate comprises the following steps:
s1: the drug solvent is conveyed to the interior of the liquid conveying pipe through the liquid pump and is conveyed to the interior of the concentrated crystallization cylinder through the liquid conveying pipe;
s2: starting a second motor, driving the concentration crystallization cylinder to rotate through the second motor, and enabling the steel balls to continuously roll in the concentration crystallization cylinder to impact the drug solvent;
s3: hot air is conveyed to the interior of an air inlet pipe through a heating box and conveyed to the interior of a concentration crystallization cylinder through the air inlet pipe, and a medicinal solvent is heated, so that the solvent is evaporated;
s4: the drug solvent is evaporated while flowing in the concentrated crystallization cylinder, solute crystals are left after the solvent is evaporated, and the crystals are impacted from the inner wall of the concentrated crystallization cylinder under the rolling of the steel balls;
s5: and finally, the material suction box sucks out crystals in the concentration crystallization cylinder to realize material discharge.
Compared with the prior art, the invention has the beneficial effects that:
1. according to the invention, through the arrangement of the concentration crystallization cylinder, firstly, the concentration crystallization cylinder is transversely arranged, different from the vertical arrangement of a traditional stirring kettle, a medicine solvent can be uniformly distributed, meanwhile, steel balls are arranged in the concentration crystallization cylinder, the steel balls can continuously rotate under the rotation of the concentration crystallization cylinder, on one hand, the medicine solvent can continuously flow in the concentration crystallization cylinder through the rotation of the concentration crystallization cylinder, and the uniform heating effect is achieved, so that the concentration crystallization cylinder and the stirring kettle have different and same work, and the impact of the steel balls can avoid the crystallized intermediate from being attached to the inner wall of the concentration crystallization cylinder, so that the intermediate crystal can continuously roll in the form of a fragment in the concentration crystallization cylinder, when the intermediate crystal needs to be taken out, the intermediate crystal cannot remain on the inner wall of the concentration crystallization cylinder, the inner wall of the concentration crystallization cylinder does not need to be washed by clear water, the production quality of the medicine intermediate crystal is improved, and the concentration crystallization device is more reliable and more efficient to use.
2. According to the invention, through the arrangement of the turbofan and the third motor, the turbofan can rotate under the driving of the third motor, the third motor is a servo motor, the rotating speed can be adjusted according to the production process, when steam needs to be discharged, the rotating speed can be adjusted to be low, the steam is slowly discharged out of the concentration crystallization cylinder, the interior of the concentration crystallization cylinder is in a high-pressure environment, so that the temperature of the interior of the concentration crystallization cylinder is higher, and the drug solvent can be quickly evaporated conveniently, and when the concentrated intermediate crystal needs to be taken out, the turbofan is driven to rotate at a high speed through the third motor, and compared with the traditional suction fan, the turbofan has stronger exhaust capacity, so that high-strength negative pressure is instantly formed in the suction box, the intermediate crystal in the concentration crystallization cylinder can be quickly sucked out, the discharge is convenient, and the concentration crystallization device is more convenient and quicker to use.
Drawings
FIG. 1 is a front view of a concentrated crystallization device for pharmaceutical intermediate preparation in accordance with the present invention;
FIG. 2 is a schematic view of the internal structure of the outer protective sleeve of the present invention;
FIG. 3 is a schematic view showing the internal structure of the intermediate tank of the present invention;
FIG. 4 is a schematic view showing the internal structure of a concentration crystallization cylinder according to the present invention;
FIG. 5 is a schematic view of the internal structure of the suction box of the present invention;
fig. 6 is a schematic view showing an internal structure of the heating cabinet of the present invention.
In the figure: 1. a base; 2. an outer protective cylinder; 3. an air pump; 4. a first blast pipe; 5. an air outlet hopper; 6. a support table; 7. an intermediate box; 8. a second blast pipe; 9. a heating box; 10. a first motor; 11. an air inlet pipe; 12. a second motor; 13. a speed reducer; 14. a drive wheel; 15. a driven wheel; 16. a first support frame; 17. a liquid pump; 18. a liquid inlet pipe; 19. a second support frame; 20. a material suction box; 21. a third motor; 22. a discharge hopper; 23. a first valve; 24. a discharge pipe; 25. a first discharge branch pipe; 26. a second discharge branch pipe; 27. a second valve; 28. a liquid delivery pipe; 29. a concentration crystallization cylinder; 30. an annular cooling tube; 31. a sealing cover; 32. a fixed seat; 33. a sealing seat; 34. an inner lining plate; 35. steel balls; 36. a turbofan; 37. a fan; 38. heating the resistance wire.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
Referring to fig. 1-6, an embodiment of the present invention is shown: a concentrated crystallization device for preparing a drug intermediate comprises a base 1 and an outer protection barrel 2, wherein a fixed seat 32 is arranged inside the outer protection barrel 2, the fixed seat 32 is fixedly connected with the outer protection barrel 2 through a bolt, a concentrated crystallization barrel 29 is arranged inside the outer protection barrel 2, the concentrated crystallization barrel 29 is rotatably connected with the fixed seat 32 through a bearing, a lining plate 34 is arranged inside the concentrated crystallization barrel 29, the lining plate 34 is fixedly connected with the concentrated crystallization barrel 29 through a sealing screw, a steel ball 35 is arranged inside the concentrated crystallization barrel 29, a sealing cover 31 is arranged at one end of the concentrated crystallization barrel 29, the sealing cover 31 is rotatably connected with the concentrated crystallization barrel 29, a discharge hopper 22 is arranged at one side of the sealing cover 31, the discharge hopper 22 is fixedly connected with the sealing cover 31 through a sealing screw, a material suction box 20 is arranged at one end of the discharge hopper 22, the suction box 20 is fixedly connected with the discharge hopper 22 through a flange, a discharge pipe 24 is arranged above the suction box 20, the discharge pipe 24 is fixedly connected with the suction box 20 through a flange, a first discharge branch pipe 25 and a second discharge branch pipe 26 are respectively arranged above the discharge pipe 24, the first discharge branch pipe 25 and the second discharge branch pipe 26 are both integrated with the discharge pipe 24, a second valve 27 is arranged on the outer side of the second discharge branch pipe 26, the second valve 27 is fixedly connected with the second discharge branch pipe 26, the second discharge branch pipe 26 is used for discharging, the first discharge branch pipe 25 is used for discharging steam, a first valve 23 is arranged on the outer side of the discharge hopper 22, the first valve 23 is fixedly connected with the discharge hopper 22, an air pump 3 is arranged above the outer protection barrel 2, the air pump 3 is fixedly connected with the outer protection barrel 2 through bolts, a first air supply pipe 4 is arranged on the front end face of the air pump 3, the first air supply pipe 4 is fixedly connected with the air pump 3 through a flange, an air discharge hopper 5 is arranged above the outer protection barrel 2, the air outlet hopper 5 is fixedly connected with the outer protection barrel 2 through a fastening screw, an annular cooling pipe 30 is arranged inside the outer protection barrel 2, the annular cooling pipe 30 is fixedly connected with the outer protection barrel 2 through the fastening screw, a first valve 23 is an electric valve and is used for controlling the blockage and opening of a channel between the air outlet hopper 22 and the material suction box 20, a second support frame 19 is arranged above the base 1, the second support frame 19 is fixedly connected with the base 1 through a bolt, a third motor 21 is arranged above the second support frame 19, the third motor 21 is fixedly connected with the second support frame 19 through a bolt, a turbofan 36 is arranged inside the material suction box 20, the turbofan 36 is fixedly connected with the third motor 21 through a connecting shaft, the third motor 21 is a servo motor, the rotating speed of the third motor 21 is adjustable, a second motor 12 and a speed reducer 13 are respectively arranged above the base 1, the second motor 12 and the reducer 13 are fixedly connected with the base 1 through bolts, one side of the reducer 13 is provided with a driving wheel 14, the driving wheel 14 is fixedly connected with the reducer 13 through a connecting shaft, the outer side of the air inlet pipe 11 is provided with a driven wheel 15, the driven wheel 15 is fixedly connected with the air inlet pipe 11, the driven wheel 15 is rotatably connected with the driving wheel 14 through a belt, one side of the outer protection barrel 2 is provided with the air inlet pipe 11, the air inlet pipe 11 is rotatably connected with the outer protection barrel 2 through a bearing, the air inlet pipe 11 is fixedly connected with a concentration crystallization barrel 29, a liquid feeding pipe 28 is arranged inside the air inlet pipe 11, one end of the air inlet pipe 11 is provided with a middle box 7, the middle box 7 is rotatably connected with the air inlet pipe 11 through a bearing, the air inlet pipe 11 and the liquid feeding pipe 28 are both communicated with the concentration crystallization barrel 29, the liquid feeding pipe 28 rotates, the support table 6 is arranged above the base 1, the support table 6 is fixedly connected with the base 1, and is used for supporting the middle box 7, a second support frame 19 is arranged above the base 1, the second support frame 19 is fixedly connected with the base 1 through bolts, a third motor 21 is arranged above the second support frame 19, the third motor 21 is fixedly connected with the second support frame 19 through bolts, a turbofan 36 is arranged inside the material suction box 20, the turbofan 36 is fixedly connected with the third motor 21 through a connecting shaft, the third motor 21 is a servo motor, the rotating speed of the third motor 21 is adjustable, a first support frame 16 is arranged above the base 1, the first support frame 16 is fixedly connected with the base 1 through bolts, a liquid pump 17 is arranged above the first support frame 16, the liquid pump 17 is fixedly connected with the first support frame 16 through bolts, a liquid inlet pipe 18 is arranged above the liquid pump 17, the liquid inlet pipe 18 is fixedly connected with the liquid pump 17 through a flange, and the liquid pump 17 is fixedly connected with the liquid delivery pipe 28 through a flange, the inside of middle box 7 is equipped with seal receptacle 33, seal receptacle 33 and middle box 7 fixed connection, seal receptacle 33 is used for the junction of sealed liquid delivery pipe 28 and middle box 7, second blast pipe 8 is installed to the top of middle box 7, second blast pipe 8 passes through flange fixed connection with middle box 7, heating cabinet 9 is installed to the top of second blast pipe 8, heating cabinet 9 passes through flange fixed connection with second blast pipe 8, first motor 10 is installed to the top of heating cabinet 9, first motor 10 passes through fastening screw fixed connection with heating cabinet 9, the inside of heating cabinet 9 is provided with fan 37, fan 37 passes through axle connecting fixed connection with first motor 10, the inside of heating cabinet 9 is equipped with heating resistor 38, heating resistor 38 and heating cabinet 9 fixed connection, the top of heating cabinet 9 is provided with the air inlet, the air inlet sets up structure as an organic whole with heating cabinet 9.
A concentration method of a concentration crystallization device for preparing a pharmaceutical intermediate comprises the following steps:
s1: the drug solvent is fed into the liquid feeding tube 28 by the liquid pump 17 and fed into the concentrated crystallization cylinder 29 through the liquid feeding tube 28;
s2: starting the second motor 12, driving the concentration crystallization cylinder 29 to rotate through the second motor 12, so that the steel balls 35 continuously roll in the concentration crystallization cylinder 29 to impact the drug solvent;
s3: hot air is conveyed to the interior of an air inlet pipe 11 through a heating box 9 and conveyed to the interior of a concentration crystallization cylinder 29 through the air inlet pipe 11, so that the drug solvent is heated, and the solvent is evaporated;
s4: the drug solvent is evaporated while flowing in the concentrating and crystallizing cylinder 29, the solute crystal is left after the solvent is evaporated, and the crystal is impacted from the inner wall of the concentrating and crystallizing cylinder 29 under the rolling of the steel balls 35;
s5: finally, the material suction box 20 sucks out the crystals in the concentration crystallization cylinder 29, so that the material discharge is realized.
The working principle is as follows: when in use, the liquid inlet pipe 18 is connected with a conveying pipeline of the drug solvent, the drug solvent is conveyed to the inside of the liquid conveying pipe 28 through the liquid pump 17 and is conveyed to the inside of the concentration crystallization cylinder 29 through the liquid conveying pipe 28, simultaneously, the first motor 10 is started, the first motor 10 drives the fan 37 to rotate, the air is heated through the heating resistance wire 38, the hot air is conveyed to the inside of the middle box 7, the middle box 7 is communicated with the air inlet pipe 11, thereby delivering hot air to the interior of the concentration crystallization cylinder 29, so as to heat and evaporate the drug solvent in the interior of the concentration crystallization cylinder 29, at this time, the second motor 12 is started, the second motor 12 is decelerated by the decelerator 13 to drive the driving wheel 14 to rotate, the driving wheel 14 drives the air inlet pipe 11 to rotate by the driven wheel 15, the air inlet pipe 11 drives the concentration crystallization cylinder 29 to rotate, so as to turn over the drug solvent in the concentrated crystallization cylinder 29, and make the drug solvent be distributed in the concentrated crystallization cylinder 29 evenly under the rolling of the steel ball 35, the crystal attached to the inner wall of the concentrated crystallization cylinder 29 will be impacted, the first valve 23 at this moment is opened, the third motor 21 will drive the turbofan 36 to rotate, extract the steam in the concentrated crystallization cylinder 29, and discharge through the first discharging branch pipe 25, after the evaporation concentration work is completed, the first discharging branch pipe 25 can be blocked by the sealing plug, then the second valve 27 is opened, and the intermediate crystal in the concentration crystallization cylinder 29 is sucked out by the turbofan 36 rotating at high speed and discharged through the second discharging branch pipe 26, the cooling speed of the concentration crystallization cylinder 29 can be improved by the arrangement of the annular cooling pipe 30, and the air pump 3 can also blow the concentrated crystallization cylinder 29 to accelerate cooling, and the heat during heat dissipation can be discharged in a hot air mode through the air outlet hopper 5 and carried away by cooling water filled in the annular cooling pipe 30.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Claims (6)
1. The utility model provides a concentrated crystallization device is used to medicine intermediate preparation, includes base (1) and outer protection section of thick bamboo (2), its characterized in that: the inner mounting of outer protection section of thick bamboo (2) has fixing base (32), and fixing base (32) and outer protection section of thick bamboo (2) pass through bolt fixed connection, the inside of outer protection section of thick bamboo (2) is provided with concentrated crystallization section of thick bamboo (29), concentrated crystallization section of thick bamboo (29) is connected through bearing rotation with fixing base (32), the inner mounting of concentrated crystallization section of thick bamboo (29) has interior bushing plate (34), and interior bushing plate (34) and concentrated crystallization section of thick bamboo (29) pass through sealing screw fixed connection, the inside of concentrated crystallization section of thick bamboo (29) is provided with steel ball (35), sealed cowling (31) is installed to the one end of concentrated crystallization section of thick bamboo (29), and sealed cowling (31) and concentrated crystallization section of thick bamboo (29) rotate and be connected, hopper (22) is installed to one side of sealed cowling (31), and goes out hopper (22) and sealing cowling (31) and pass through sealed fixed screw connection, the one end of play hopper (22) is installed and is inhaled workbin (20), and inhales hopper (22) and goes out hopper (22) and passes through flange fixed connection, the top of base (1) is installed second support frame (19), and support frame (19) and third support frame (21) and motor (21) are connected through bolt fixed connection, inhale the inside of workbin (20) and be provided with turbofan (36), turbofan (36) and third motor (21) are through linking a fixed connection, air-supply line (11) are installed to one side of outer protection section of thick bamboo (2), and air-supply line (11) and outer protection section of thick bamboo (2) rotate through the bearing and be connected, air-supply line (11) and concentrated crystallizer (29) fixed connection, the inside of air-supply line (11) is provided with liquid delivery pipe (28), middle case (7) are installed to the one end of air-supply line (11), and middle case (7) rotate through the bearing with air-supply line (11) and be connected, air-supply line (11) and liquid delivery pipe (28) all communicate with concentrated crystallizer (29), second motor (12) and reduction gear (13) are installed respectively to the top of base (1), and second motor (12) and reduction gear (13) all through bolt and base (1) fixed connection, drive wheel (14) are installed to one side of reduction gear (13), and drive wheel (14) and reduction gear (13) are through linking a fixed connection, from driving wheel (15) and driven wheel (11) and driven wheel (15).
2. The apparatus of claim 1, wherein the apparatus comprises: inhale the top of workbin (20) and install discharging pipe (24), and discharging pipe (24) with inhale workbin (20) and pass through flange fixed connection, the top of discharging pipe (24) is provided with first ejection of compact branch pipe (25) and second ejection of compact branch pipe (26) respectively, and first ejection of compact branch pipe (25) and second ejection of compact branch pipe (26) all set up structure as an organic whole with discharging pipe (24), second valve (27) are installed in the outside of second ejection of compact branch pipe (26), and second valve (27) and second ejection of compact branch pipe (26) fixed connection.
3. A concentrated crystallization device for pharmaceutical intermediate preparation according to claim 2, wherein: first valve (23) are installed in the outside of play hopper (22), and first valve (23) and play hopper (22) fixed connection, air pump (3) are installed to the top of outer protection section of thick bamboo (2), and pass through bolt fixed connection with outer protection section of thick bamboo (2) air pump (3), install first blast pipe (4) on the preceding terminal surface of air pump (3), and first blast pipe (4) pass through flange fixed connection with air pump (3), air outlet hopper (5) are installed to the top of outer protection section of thick bamboo (2), and air outlet hopper (5) and outer protection section of thick bamboo (2) through fastening screw fixed connection, the internally mounted of outer protection section of thick bamboo (2) has annular cooling tube (30), and annular cooling tube (30) and outer protection section of thick bamboo (2) through fastening screw fixed connection.
4. A concentrated crystallization device for pharmaceutical intermediate preparation according to claim 3, wherein: first support frame (16) are installed to the top of base (1), and first support frame (16) pass through bolt fixed connection with base (1), liquid pump (17) are installed to the top of first support frame (16), and liquid pump (17) pass through bolt fixed connection with first support frame (16), feed liquor pipe (18) are installed to the top of liquid pump (17), and feed liquor pipe (18) pass through flange fixed connection with liquid pump (17).
5. The apparatus according to claim 4, wherein the apparatus comprises: second blast pipe (8) are installed to the top of intermediate box (7), and second blast pipe (8) pass through flange fixed connection with intermediate box (7), heating cabinet (9) are installed to the top of second blast pipe (8), and heating cabinet (9) pass through flange fixed connection with second blast pipe (8), first motor (10) are installed to the top of heating cabinet (9), and just first motor (10) pass through fastening screw fixed connection with heating cabinet (9), the inside of heating cabinet (9) is provided with fan (37), fan (37) are through linking axle fixed connection with first motor (10), the internally mounted of heating cabinet (9) has heating resistor silk (38), and heating resistor silk (38) and heating cabinet (9) fixed connection.
6. A concentration method of a concentration crystallization device for pharmaceutical intermediate preparation, which is realized based on the concentration crystallization device for pharmaceutical intermediate preparation of claim 5, and is characterized by comprising the following steps:
s1: the drug solvent is conveyed to the inside of a liquid conveying pipe (28) through a liquid pump (17) and is conveyed to the inside of a concentrated crystallization cylinder (29) through the liquid conveying pipe (28);
s2: starting a second motor (12), driving a concentration crystallization cylinder (29) to rotate through the second motor (12), and enabling the steel balls (35) to continuously roll in the concentration crystallization cylinder (29) to impact the medicinal solvent;
s3: hot air is conveyed to the interior of an air inlet pipe (11) through a heating box (9), and is conveyed to the interior of a concentrated crystallization cylinder (29) through the air inlet pipe (11) to heat a medicine solvent, so that the solvent is evaporated;
s4: the drug solvent is evaporated while flowing in the concentrating and crystallizing cylinder (29), solute crystals are left after the solvent is evaporated, and the crystals are impacted from the inner wall of the concentrating and crystallizing cylinder (29) under the rolling of the steel balls (35);
s5: finally, the material suction box (20) sucks out the crystals in the concentration crystallization cylinder (29) to realize material discharge.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111107337.9A CN113730947B (en) | 2021-09-22 | 2021-09-22 | Concentration and crystallization device for pharmaceutical intermediate preparation and concentration method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111107337.9A CN113730947B (en) | 2021-09-22 | 2021-09-22 | Concentration and crystallization device for pharmaceutical intermediate preparation and concentration method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113730947A CN113730947A (en) | 2021-12-03 |
| CN113730947B true CN113730947B (en) | 2022-12-20 |
Family
ID=78740227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111107337.9A Active CN113730947B (en) | 2021-09-22 | 2021-09-22 | Concentration and crystallization device for pharmaceutical intermediate preparation and concentration method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113730947B (en) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109224501A (en) * | 2018-09-30 | 2019-01-18 | 新昌县三维精工机械有限公司 | Crystallization apparatus for chemical industry solutions crystallization |
| CN209221514U (en) * | 2018-12-03 | 2019-08-09 | 浙江三晟化工有限公司 | A kind of MVR evaporator convenient for discharging crystal salt |
| CN210786267U (en) * | 2019-10-16 | 2020-06-19 | 河北农业大学 | Medicine midbody vacuum concentration device |
| CN213580759U (en) * | 2020-11-24 | 2021-06-29 | 毛煦 | Intelligent detection control equipment of water works |
-
2021
- 2021-09-22 CN CN202111107337.9A patent/CN113730947B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN113730947A (en) | 2021-12-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2015003660A1 (en) | Air-cooling drop pill production line | |
| CN113462558B (en) | High-density fermentation culture equipment and preparation process for veterinary traditional Chinese medicine microecological preparation | |
| CN107787947A (en) | A kind of freely adjustable corn planting pesticide spray truck | |
| CN113730947B (en) | Concentration and crystallization device for pharmaceutical intermediate preparation and concentration method thereof | |
| CN113786916A (en) | Grinding granulation equipment for biological medicine | |
| CN112812955A (en) | Constant-temperature fermentation equipment for traditional Chinese medicine decoction pieces and working method thereof | |
| CN113758193B (en) | Device is air-dried in crystal washing for intermediate preparation of medicine | |
| CN211926352U (en) | Spray drying device for honey processing | |
| CN113244644B (en) | Chinese-medicinal material concentrator | |
| CN206274735U (en) | Seed mixes medicine equipment | |
| CN212041894U (en) | Beer fermentation tank belt cleaning device | |
| CN212016786U (en) | Special crystallization device for bulk drugs | |
| CN219022384U (en) | Injection production liquid sterilization equipment | |
| CN207221042U (en) | A kind of novel container disinfection cabinet | |
| CN219466654U (en) | Bubble film production automatic feeding | |
| CN110115855A (en) | A kind of gibberellin plant growth regulator special-purpose crystallization pot | |
| CN221630360U (en) | Smelting rotary furnace for quartz product processing | |
| CN220878786U (en) | Hydrogenation device for tetrahydrocurcumin | |
| CN220852891U (en) | Medicinal material drying device is used in animal remedy production | |
| CN210495300U (en) | Crystallization kettle for valine synthesis | |
| CN221490288U (en) | Medicine spraying device for tooth Zhou Nianmo ulcer | |
| CN221579732U (en) | Medicinal auxiliary material spray drier | |
| CN114616949B (en) | Crop seed coating machine | |
| CN216392039U (en) | Vertical centrifugal seed coating machine | |
| CN213961652U (en) | Humidification sterilizing equipment is used in nut production |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |