CN113730518A - Composition for promoting diuresis and tonifying spleen and preparation method and application thereof - Google Patents
Composition for promoting diuresis and tonifying spleen and preparation method and application thereof Download PDFInfo
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Abstract
The invention provides a composition for promoting diuresis and invigorating spleen, which is prepared from the following components in parts by weight: 10-30 parts of Chinese yam, 5-15 parts of poria cocos, 5-15 parts of white hyacinth bean, 5-15 parts of black bean, 30-50 parts of gordon euryale seed, 10-30 parts of coix seed, 5-15 parts of dried orange peel and 5-15 parts of phaseolus calcaratus. The composition has the advantages of low cost, simple preparation, excellent effect, good taste and smell, easy acceptance by consumers and good popularization and application value.
Description
Technical Field
The invention belongs to the field of food and medicine, and particularly relates to a composition for promoting diuresis and tonifying spleen, and a preparation method and application thereof.
Background
The pattern of spleen deficiency with excessive dampness is usually seen in the diseases of exogenous pathogenic factors and endogenous dampness, with the damp pathogen staying in the middle energizer for a long time; or excessive administration of cold food and medicine can damage spleen yang, and lead to spleen yang deficiency, middle-jiao deficiency cold, and internal retention of cold-dampness. It is commonly seen in chronic gastritis, enteritis, pancreatitis, etc. Clinically, it is manifested as abdominal fullness and distention, pale mouth, poor appetite, heavy body, aversion to cold, cold limbs, diarrhea and defecation, duck's feces, pale tongue with white fur, white and greasy fur, and deep and slow pulse. If the treatment is proper, the disease can be cured slowly, and if the disease is delayed for a long time, the kidney yang can be injured. The clinical symptoms are mostly expressed as: inappetence, loose stool, stomachache, gastrectasia, poor immunity, dyspepsia, listlessness, debilitation, etc.
The treatment method for spleen deficiency and excessive dampness is mainly to promote diuresis and invigorate spleen, and although numerous foods or medicines for promoting diuresis and strengthening spleen are reported in the prior art, the traditional Chinese medicine composition is often large in component quantity, high in cost, or complex in preparation and difficult to popularize; and the problems of poor mouthfeel and smell and difficult acceptance by consumers exist.
Therefore, the composition for removing dampness and tonifying spleen, which is novel, low in cost, good in property, simple to prepare, excellent in effect and easy to accept by consumers, is provided, and has important significance in further research on application and popularization of the composition in the fields of food, health care products and medicines.
Disclosure of Invention
The invention aims to provide a composition for promoting diuresis and tonifying spleen.
The invention provides a composition for promoting diuresis and invigorating spleen, which is prepared from the following components in parts by weight:
10-30 parts of Chinese yam, 5-15 parts of poria cocos, 5-15 parts of white hyacinth bean, 5-15 parts of black bean, 30-50 parts of gordon euryale seed, 10-30 parts of coix seed, 5-15 parts of dried orange peel and 5-15 parts of phaseolus calcaratus.
Further, the composition is prepared from the following components in parts by weight:
15-25 parts of Chinese yam, 8-13 parts of poria cocos, 8-13 parts of white hyacinth bean, 8-13 parts of black bean, 35-45 parts of gordon euryale seed, 15-25 parts of coix seed, 7-12 parts of dried orange peel and 8-13 parts of phaseolus calcaratus.
Furthermore, the composition is prepared from the following components in parts by weight:
20 parts of Chinese yam, 10 parts of tuckahoe, 10 parts of white hyacinth bean, 10 parts of black bean, 40 parts of gordon euryale seed, 20 parts of coix seed, 7.5 parts of dried orange peel and 10 parts of phaseolus calcaratus.
Further, the health food or health care product is prepared by uniformly mixing the components, or extracting the components by adding water or an organic solvent and adding food auxiliary materials.
Furthermore, the medicine is a medicinal preparation prepared by uniformly mixing the components, or extracting the components by adding water or an organic solvent and adding pharmaceutically acceptable auxiliary materials.
The invention provides application of the composition in preparing food or health care products for promoting diuresis and tonifying spleen.
Preferably, the health-care product for promoting diuresis and tonifying spleen is a health-care product for improving immunity.
The invention also provides application of the composition in preparing a medicine for promoting diuresis and tonifying spleen.
Preferably, the medicine is used for improving spleen deficiency and excessive dampness and/or lung and spleen qi deficiency.
Preferably, the dampness-removing and spleen-invigorating medicine is a medicine for improving inappetence, loose stool, stomachache and gastrectasia, poor immunity, dyspepsia and poor sleep quality.
The composition has the main effects of tonifying spleen and removing dampness, and has obvious improvement effect on spleen deficiency and excessive dampness (symptoms of loose stool, dizziness, heavy head, emaciation, poor appetite, pale tongue, white and greasy fur and deficient and slow pulse) or lung and spleen qi deficiency (symptoms of short breath, hypodynamia, emaciation, easy cold, pale tongue, white fur and deficient pulse).
The assay is as follows: the syndrome of the recipe is caused by the weakness of the spleen and stomach and the retention of damp-turbidity in the interior. Spleen deficiency failing to transport and dampness failing to control the interior, resulting in loose stool and poor appetite; when spleen qi is weak and qi and blood are not sufficient, the body becomes thin; a pale tongue with white and greasy coating and a weak and slow pulse are the symptoms of spleen deficiency and dampness stagnation. For treatment, it is good at tonifying qi, invigorating spleen, removing dampness and checking diarrhea.
Chinese yam and gordon euryale seed are added in the formula of the invention for replenishing qi and invigorating spleen, and for astringency and relieving diarrhea, the Chinese yam and the gordon euryale seed are used as monarch drugs; the tuckahoe and the coix seeds enhance the effects of invigorating spleen and eliminating dampness and are used as ministerial drugs; white hyacinth bean, red bean and black bean have the functions of promoting diuresis, eliminating dampness, and invigorating spleen, and the dried orange peel has the functions of regulating qi, invigorating spleen and eliminating dampness, which are used as adjuvant drugs. The medicines are compatible to tonify spleen qi, assist transportation and transformation, dispel damp turbidity, move qi stagnation, recover transportation and ascending of spleen and stomach, and cure all the symptoms. The spleen governs healthy and normal functions and generates qi and blood, so this recipe can also be used for treating shortness of breath, lassitude and susceptibility to cold due to qi deficiency of lung and spleen.
The composition for promoting diuresis and tonifying spleen has the advantages of low cost, simple preparation and excellent effect, can obviously improve inappetence, loose stool, stomachache and gastrectasia, poor immunity, dyspepsia and poor sleep quality caused by spleen deficiency and dampness excess, has homology of medicine and food of raw materials and high safety, can be prepared into food, health-care products or medicines, has good taste and smell, is easy to be accepted by consumers, and has good popularization and application values.
Obviously, many modifications, substitutions, and variations are possible in light of the above teachings of the invention, without departing from the basic technical spirit of the invention, as defined by the following claims.
The present invention will be described in further detail with reference to the following examples. This should not be understood as limiting the scope of the above-described subject matter of the present invention to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.
Detailed Description
The raw materials and equipment used in the invention are known products and are obtained by purchasing commercial products.
Example 1 preparation of a composition according to the invention
The formula is as follows: 2g of Chinese yam, 1g of tuckahoe, 1g of white hyacinth bean, 1g of black bean, 4g of gordon euryale seed, 2g of coix seed, 0.75g of dried orange peel and 1g of phaseolus calcaratus.
The preparation method comprises the following steps:
(1) the raw materials except the yam and the tuckahoe are respectively fried. Weighing all the raw materials according to the weight ratio, crushing into fine powder, and uniformly mixing to obtain powder.
Or (2) parching the above materials except rhizoma Dioscoreae and Poria respectively. Weighing all the raw materials according to the weight ratio, crushing into fine powder, uniformly mixing, adding water or milk, stirring into paste, and preparing into instant biscuits with various appearances according to a common biscuit preparation method in the field of food.
Or (3) parching the above materials except rhizoma Dioscoreae and Poria respectively. Weighing all the raw materials according to the weight ratio, crushing into fine powder, uniformly mixing, adding yeast, adding water or milk, and stirring into paste. According to the common making method of steamed sponge cakes in the food field, the instant steamed sponge cakes with various appearances are made.
Or (4) parching the above materials except rhizoma Dioscoreae and Poria respectively. Weighing all the raw materials according to the weight ratio, crushing into fine powder, uniformly mixing, adding water or milk, and stirring into paste. Making into noodles with various appearances according to the common noodle making method in food field.
Example 2 preparation of the composition of the invention
The formula is as follows: 2.5g of Chinese yam, 1g of tuckahoe, 1g of white hyacinth bean, 1g of black bean, 4.5g of gordon euryale seed, 1g of coix seed, 0.5g of tangerine peel and 1.3g of phaseolus calcaratus. The preparation method is the same as example 1.
Example 3 preparation of the composition of the invention
The formula is as follows: 1g of Chinese yam, 0.5g of tuckahoe, 0.5g of white hyacinth bean, 0.5g of black bean, 3g of gordon euryale seed, 1g of coix seed, 0.5g of tangerine peel and 0.5g of phaseolus calcaratus. The preparation method is the same as example 1.
Example 4 preparation of the composition of the invention
The formula is as follows: 3g of Chinese yam, 1.5g of tuckahoe, 1.5g of white hyacinth bean, 1.5g of black bean, 5g of gordon euryale seed, 3g of coix seed, 1.5g of tangerine peel and 1.5g of phaseolus calcaratus. The preparation method is the same as example 1.
Example 5 preparation of a composition according to the invention
The formula is as follows: 1.5g of Chinese yam, 0.8g of tuckahoe, 0.8g of white hyacinth bean, 0.8g of black bean, 3.5g of gordon euryale seed, 1.5g of coix seed, 0.7g of dried orange peel and 0.8g of phaseolus calcaratus. The preparation method is the same as example 1.
Example 6 preparation of a composition of the invention
The formula is as follows: 2.5g of Chinese yam, 1.3g of tuckahoe, 1.3g of white hyacinth bean, 1.3g of black bean, 4.5g of gordon euryale seed, 2.5g of coix seed, 1.2g of dried orange peel and 1.3g of phaseolus calcaratus. The preparation method is the same as example 1.
The beneficial effects of the compositions of the present invention are demonstrated by the following experimental examples.
Experimental example 1 formulation screening of the composition of the present invention
(1) And (3) trial evaluation: 4 groups of powder with different prescriptions are prepared according to the raw material proportion listed in the table 1, 50 trial eaters are randomly selected for each group of formula, the powder with different prescriptions is decocted by adding water and then trial eaten, and the taste, the properties and the like are evaluated.
TABLE 1
The evaluation results are shown in table 2:
TABLE 2
Note: + shows good taste (fine and smooth particles, easy swallowing)/good smell (fragrant and sweet smell, easy acceptance)/proper appearance/no gastrointestinal discomfort after taking, easy acceptance by consumers; means poor mouthfeel/bad smell/poor appearance/gastrointestinal discomfort after administration, not readily acceptable to the consumer.
(2) And (3) evaluating the efficacy: 4 sets of powders of different formulations were prepared according to the raw material ratios listed in Table 1.
80 subjects who are diagnosed as spleen deficiency and dampness-prevailing syndrome by differentiation of symptoms of traditional Chinese medicine and have symptoms of poor appetite, loose stool, stomach pain and stomach distention, dyspepsia, lethargy, insomnia and bile reflux are selected and divided into 4 groups, wherein each group comprises 20 subjects, and the dose of each subject is 10 subjects which are 1 time and 2 times of the dose of the whole formula. Each group of powder with different prescriptions is decocted with water and taken after being mixed, the taking time is 30 days and 1 time per day, and the efficacy of the powder is evaluated. The results are shown in Table 3.
The evaluation criteria are as follows:
appetite: the appetite is slightly improved compared with the appetite before taking the prescription, and the food intake of each meal is improved by 1 to 5 percent, and then the evaluation is plus; the appetite is improved, and the food intake of each meal is improved by 5 to 10 percent, and then the evaluation is ++; the appetite is obviously improved, and the food intake of each meal is improved by 10 to 15 percent, and then the evaluation is +++.
Stool: the stool state changed from loose and watery to slightly thin and thick, and no molding before taking the prescription, and was evaluated as +; the loose stool changed from watery to formed but sticky and soft, and was rated as ++; the loose stool changed from watery to normal banana-type stool and was rated +++.
Stomach ache and flatulence: before taking the prescription, the continuous severe stomach ache and the flatulence become slight stomach ache and the evaluation is plus; become occasionally mild gastralgia or bloating, then rated as + +; the symptom disappeared, then it was evaluated as +++.
Dyspepsia: when the abdominal distension after long-term retention of food is changed to slight abdominal distension before taking the prescription, the food retention abdominal distension symptom disappears, and the food retention abdominal distension symptom is evaluated as ++.
Sleepiness: before taking the prescription, if the sleeping time exceeds 10 hours, the patient still suffers from drowsiness and listlessness, and the state of mind is good after long-term sleep, the state is evaluated as + and the state is slightly listened after normal 8-hour sleep, and the state is evaluated as + +; the mental state after the transition to normal 8 hours sleep was good, and evaluated as +++.
Insomnia and difficulty in falling asleep: the time to fall asleep is shortened by 1 to 10 percent compared with the time before taking the prescription, and the evaluation is plus; the time to fall asleep is shortened by 10-30%, and then the evaluation is ++; if the time to fall asleep is shortened by 30% or more, it is evaluated as +++.
Bile reflux: the total bile acid of gastric mucosa tissue is reduced by 1-5% compared with the measurement result before taking the prescription, and the total bile acid is evaluated as plus, the total bile acid is reduced by 5-10%, and the total bile acid is evaluated as plus, and the total bile acid is reduced by more than 10%.
TABLE 3
Note: the greater the number of "+" the better the effect. The results in the table are the most numerous of the assessments given to each group of subjects.
After 80 subjects take the composition powder, 68 subjects with obviously improved symptoms (in the symptoms of appetite, stool, stomachache and gastrectasia, dyspepsia, somnolence, insomnia, bile reflux and the like, the subjects with + + or more evaluations exist according to the evaluation standards, and the symptoms are defined to be obviously improved) exist, and the effective rate is as high as 85%.
The test result shows that the pharmaceutical composition has excellent taste, excellent smell and high acceptability, can obviously improve a plurality of symptoms such as poor appetite, loose stool and the like caused by spleen deficiency and dampness excess, and has good application prospect.
Experimental example 2 typical cases
1. People who are born in a certain place, professor of retirement, women who are 83 years old, heart failure, coronary heart disease, Parkinson's disease, weakness, shortness of breath and extremely easy cold, and after taking the medicine for 6 months, the speaking voice is loud and the cold frequency is reduced greatly. The physical strength is obviously increased from the original one-time walking of only 100 and 200 meters to the current one-time walking of about 2000 meters.
2. Certain Luo, retired cadre, male, 86 years old, suffered from diabetes for 27 years, loose stool and foreign odor for a long time, and after taking the medicine of the invention for 2 months, the stool is normal and the foreign odor is eliminated.
3. Relaxing a certain woman or a woman, and retiring a cadre, which is 58 years old, suffering from hypertension and diabetes for more than 10 years, and having no shape, dyspepsia, poor spirit and easy sleepiness in defecation for a long time, after taking the medicine disclosed by the invention for 4 months, the defecation is normal, the mental state is greatly changed, particularly under the condition of no sleeping afternoon, dizziness and sleepiness are avoided in the afternoon, and the skin becomes fine and smooth and has a red face.
4. When a certain person is aged, farmers and women are 80 years old, suffer from old and chronic diseases for many years, have cholecystectomy, and are also accompanied with diseases such as chronic gastroenteritis, frequent gastralgia and bile reflux for more than ten years (the stomach feels burning pain when 2-3 am every day), extreme weakness, emaciation, frequent cold, long-term eating shortage, no need to eat dinner for decades, after 2 months of taking the medicine, appetite is obviously increased, fluid real objects can be eaten at night, the cold frequency is reduced, after 6 months, three meals a day is the same as normal people, bile reflux basically disappears, basically no cold is caused, weight is obviously increased, sleep is greatly improved, and energy is vigorous.
5. Dungji, free occupations and women, age 54, because of the heavy moisture, dizziness and drowsiness for a long time, the people need to sleep for more than 12 hours a day, and the stool is strange and smelly for a long time, after taking the medicine of the invention for 1 month, the strange and smelly stool basically disappears, the sleeping time is reduced for 2-3 hours, after taking the soil culture powder for 2 months, the sleeping time is basically about 8 hours, the strange and smelly stool disappears, the vigor is vigorous, and the people can not worry about when working.
6. Zheng a certain, freely occupational, male and 57 years old, because of heavy dampness, dizziness and heaviness, sleeping for more than 12 hours a day, poor immunity, frequent cold, intolerance of cold, temperature of more than 20 ℃, leather clothing or down jackets are also worn, but continuous sweating is still needed, cotton clothing can not be taken off, after 2 months of taking the medicine, the sleeping time is basically about 8 hours, the people can wear the medicine normally, the face color is ruddy and glossy, and the number of cold times is obviously reduced.
7. After the medicine is taken for 3 months, the blood pressure is more stable than before, the number of heartache is obviously less than before, and the sleep is also improved.
8. Some of the fan, retired cadres, men and 79 years old have chronic gastritis, and stomach ache and gastrectasia can occur when people eat the medicine carelessly for a little time.
9. When a certain swallow is in the age of 59, doctors and men, the loose stool is not shaped for a long time, the defecation is not smooth, the swallow cannot be easily washed after being stuck in a urinal, and after the swallow pill is taken for half a month, the defecation is shaped, the swallow cannot be stuck in the urinal, and the defecation is smooth.
10. A certain Panzhi, a free occupational and a female are 53 years old, and have long-term gastritis, gastrectasia and stomachache and inappetence, and after the medicine is taken for 1 month, the gastrectasia and the stomachache disappear and are continuously taken without pain.
11. Zhangzhi, technical staff, men and people of 57 years old suffer from inappetence for a long time, emaciation and easy cold, and after taking the medicine for 3 months, the appetite is greatly increased, the meal amount is more than one time of the previous meal amount, and the cold is obviously reduced.
In conclusion, the composition for promoting diuresis and tonifying spleen provided by the invention is low in cost, simple to prepare, excellent in effect and good in popularization and application values.
Claims (10)
1. The composition for promoting diuresis and tonifying spleen is characterized by being prepared from the following components in parts by weight:
10-30 parts of Chinese yam, 5-15 parts of poria cocos, 5-15 parts of white hyacinth bean, 5-15 parts of black bean, 30-50 parts of gordon euryale seed, 10-30 parts of coix seed, 5-15 parts of dried orange peel and 5-15 parts of phaseolus calcaratus.
2. The composition of claim 1, wherein the composition is prepared from the following components in parts by weight:
15-25 parts of Chinese yam, 8-13 parts of poria cocos, 8-13 parts of white hyacinth bean, 8-13 parts of black bean, 35-45 parts of gordon euryale seed, 15-25 parts of coix seed, 7-12 parts of dried orange peel and 8-13 parts of phaseolus calcaratus.
3. The composition of claim 2, wherein the composition is prepared from the following components in parts by weight:
20 parts of Chinese yam, 10 parts of tuckahoe, 10 parts of white hyacinth bean, 10 parts of black bean, 40 parts of gordon euryale seed, 20 parts of coix seed, 7.5 parts of dried orange peel and 10 parts of phaseolus calcaratus.
4. The composition according to any one of claims 1 to 3, which is a food or health product prepared by uniformly mixing the components, or extracting with water or an organic solvent, and adding food auxiliary materials.
5. The composition according to any one of claims 1 to 3, which is a pharmaceutical preparation prepared by uniformly mixing the components, or extracting the components by adding water or an organic solvent, and adding pharmaceutically acceptable auxiliary materials.
6. Use of the composition of any one of claims 1 to 4 in the preparation of a food or health product for promoting diuresis and invigorating spleen.
7. The use according to claim 6, wherein the health product for promoting diuresis and strengthening spleen is a health product for improving immunity.
8. Use of the composition of any one of claims 1 to 3 or 5 for preparing a medicament for promoting diuresis and invigorating spleen.
9. The use according to claim 8, wherein the medicament is a medicament for ameliorating the symptoms of splenic asthenia and/or lung-splenic qi deficiency.
10. The use according to claim 8, wherein the medicament for promoting diuresis and strengthening the spleen is a medicament for improving inappetence, loose stools, stomach ache and bloating, poor immunity, dyspepsia, and poor sleep quality.
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