CN113727720A - 用于治疗表达cldn6的癌症的嵌合抗原受体修饰的细胞 - Google Patents

用于治疗表达cldn6的癌症的嵌合抗原受体修饰的细胞 Download PDF

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CN113727720A
CN113727720A CN202080026088.8A CN202080026088A CN113727720A CN 113727720 A CN113727720 A CN 113727720A CN 202080026088 A CN202080026088 A CN 202080026088A CN 113727720 A CN113727720 A CN 113727720A
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cells
cell
car
cldn6
immune effector
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Chinese (zh)
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U·沙欣
P·厄姆
B·伦斯特尔
K·赖因哈德
K·米歇尔
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Biontech Cell and Gene Therapies GmbH
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CN202080026088.8A 2019-02-08 2020-02-05 用于治疗表达cldn6的癌症的嵌合抗原受体修饰的细胞 Pending CN113727720A (zh)

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Application Number Priority Date Filing Date Title
EPPCT/EP2019/053156 2019-02-08
EP2019053156 2019-02-08
PCT/EP2020/052867 WO2020161186A1 (en) 2019-02-08 2020-02-05 Chimeric antigen receptor-modified cells for the treatment of cldn6-expressing cancers

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CN113727720A true CN113727720A (zh) 2021-11-30

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US (1) US20220184119A1 (enExample)
EP (2) EP3920939B1 (enExample)
JP (2) JP7663500B2 (enExample)
KR (1) KR20210124237A (enExample)
CN (1) CN113727720A (enExample)
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114478802A (zh) * 2022-01-28 2022-05-13 郑州大学 一种嵌合抗原受体及其应用
WO2024022512A1 (en) * 2022-07-29 2024-02-01 Nanjing Legend Biotech Co., Ltd. Claudin-6 binding moieties and uses thereof
WO2024088325A1 (zh) * 2022-10-25 2024-05-02 科济生物医药（上海）有限公司 抗体及其应用
CN120484126A (zh) * 2022-07-28 2025-08-15 乐普创一生物科技（上海）有限公司 抗MerTK抗体及其用途

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021129927A1 (en) * 2019-12-23 2021-07-01 Biontech Cell & Gene Therapies Gmbh Treatment with immune effector cells engineered to express an antigen receptor
KR20240133791A (ko) * 2021-12-09 2024-09-04 비온테크 에스이 Cldn6를 발현하는 암을 치료하기 위한 키메라 항원 수용체 변형 세포
WO2024046572A1 (en) * 2022-09-01 2024-03-07 BioNTech SE Chimeric antigen receptor-modified cells for the treatment of cldn6 expressing cancer
CN114410588B (zh) * 2022-01-29 2022-11-04 西安电子科技大学 一种α1β1整合素依赖增强型CAR巨噬细胞及其制备方法和应用
WO2025184170A1 (en) 2024-02-27 2025-09-04 Overt Bio, Inc. Methods and compositions for improving t cell function in an immunosuppressive environment

Family Cites Families (11)

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HK1047109A1 (zh) 1999-10-15 2003-02-07 University Of Massachusetts 作为指定基因干预工具的rna干预轨迹基因
US6326193B1 (en) 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
WO2001096584A2 (en) 2000-06-12 2001-12-20 Akkadix Corporation Materials and methods for the control of nematodes
WO2013143555A1 (en) 2012-03-26 2013-10-03 Biontech Ag Rna formulation for immunotherapy
EP4026909A1 (en) * 2013-12-19 2022-07-13 Novartis AG Human mesothelin chimeric antigen receptors and uses thereof
DK3126381T4 (da) * 2014-04-01 2022-04-04 Biontech Cell&Gene Therapies Gmbh Claudin-6-specifikke immunoreceptorer og t-celleepitoper
MA40921A (fr) * 2014-11-05 2017-09-12 Abbvie Stemcentrx Llc Récepteurs antigéniques chimériques anti-cldn et procédés d'utilisation
CN106146666B (zh) * 2015-03-26 2019-09-06 科济生物医药（上海）有限公司 靶向cldn6的免疫效应细胞及其制备方法和应用
WO2016180467A1 (en) 2015-05-11 2016-11-17 Biontech Cell & Gene Therapies Gmbh Enhancing the effect of car-engineered t cells by means of nucleic acid vaccination
JP7654240B2 (ja) * 2017-09-19 2025-04-01 マサチューセッツ インスティテュート オブ テクノロジー キメラ抗原受容体ｔ細胞治療のための組成物およびその使用
CN109206524B (zh) * 2018-09-25 2022-04-05 山东兴瑞生物科技有限公司 抗Claudin18A2嵌合抗原受体、其修饰的T细胞及T细胞制备方法和用途

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114478802A (zh) * 2022-01-28 2022-05-13 郑州大学 一种嵌合抗原受体及其应用
CN114478802B (zh) * 2022-01-28 2023-05-26 郑州大学 一种嵌合抗原受体及其应用
CN120484126A (zh) * 2022-07-28 2025-08-15 乐普创一生物科技（上海）有限公司 抗MerTK抗体及其用途
WO2024022512A1 (en) * 2022-07-29 2024-02-01 Nanjing Legend Biotech Co., Ltd. Claudin-6 binding moieties and uses thereof
WO2024088325A1 (zh) * 2022-10-25 2024-05-02 科济生物医药（上海）有限公司 抗体及其应用

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AU2020217868A1 (en) 2021-08-12
JP2025060882A (ja) 2025-04-10
ES3002958T3 (en) 2025-03-10
PT3920939T (pt) 2025-01-08
RS66364B1 (sr) 2025-01-31
LT3920939T (lt) 2025-01-10
EP3920939B1 (en) 2024-11-13
CU20210067A7 (es) 2022-03-07
EP4501351A3 (en) 2025-05-07
CO2021010347A2 (es) 2022-01-17
MX2021009507A (es) 2021-09-08
FI3920939T3 (fi) 2025-01-03
PL3920939T3 (pl) 2025-02-17
CA3129140A1 (en) 2020-08-13
CL2021002067A1 (es) 2022-03-11
DK3920939T3 (da) 2025-01-13
HUE070174T2 (hu) 2025-05-28
SI3920939T1 (sl) 2025-03-31
SG11202108339TA (en) 2021-08-30
WO2020161186A1 (en) 2020-08-13
SMT202500012T1 (it) 2025-03-12
BR112021015429A2 (pt) 2021-10-05
KR20210124237A (ko) 2021-10-14
EP3920939A1 (en) 2021-12-15
US20220184119A1 (en) 2022-06-16
JP7663500B2 (ja) 2025-04-16
IL285122A (en) 2021-09-30
EP4501351A2 (en) 2025-02-05
JP2022520059A (ja) 2022-03-28
HRP20250016T1 (hr) 2025-03-14

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