CN113720417B - Reagent sucking method based on bottle setting - Google Patents
Reagent sucking method based on bottle setting Download PDFInfo
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- CN113720417B CN113720417B CN202111048244.3A CN202111048244A CN113720417B CN 113720417 B CN113720417 B CN 113720417B CN 202111048244 A CN202111048244 A CN 202111048244A CN 113720417 B CN113720417 B CN 113720417B
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- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F23/00—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm
- G01F23/22—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water
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Abstract
The invention provides reagent sucking logic based on a fast height mode after bottle setting. In the instrument debugging stage, the liquid level positions of different liquid quantities of the reagent bottle are confirmed, and a linear function fitting curve (the functional relation between the liquid quantity of the bottle and the running pulse of the reagent needle) is formed. When the reagent is newly loaded, the quantity information in the bottle is identified by scanning the code, and then the actual liquid quantity in the bottle is confirmed by using the residual quantity detection function. During the main test, the test platform can directly run to a position 1.5mL below the corresponding height of the actual liquid amount, then the liquid level signal is checked, if the liquid level signal is normally triggered, the normal reagent sucking action can be started, otherwise, the test is abandoned, and the reagent air suction abnormality is reported.
Description
Technical Field
The application belongs to the field of medical instruments, is suitable for chemiluminescence equipment, and relates to a reagent sucking method based on bottle setting.
Background
Currently, a chemiluminescence instrument generally sucks a reagent by a liquid level detection mode based on capacitance detection, for the same type of reagent, liquid with the same height is generally injected into each bottle of reagent in actual use so as to be uniformly processed, but in actual situations, due to uncertain factors, liquid in individual bottles may be lacked, for example, in consideration of reagent spill or reagent consumption, a part of reagent is loaded in other instruments for testing, and a traditional reagent sucking mode may cause reagent empty suction due to misdetection, and certain risks exist.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: in order to solve the defects of the reagent sucking method in the prior art, the reagent sucking method based on the bottle setting is provided.
The technical scheme adopted by the invention for solving the technical problems is as follows:
a reagent sucking method based on bottle setting, comprising the following steps:
establishing a relation function of the voltage signal value of the detector and the liquid amount in the bottle;
detecting the residual quantity of the reagent in the reagent bottle;
the logic of the reagent residual quantity detection step in the reagent bottle comprises the following steps:
taking the standard packaging amount in the reagent bottle as X, the preset specific measurement volume as V1 and the reference value of the voltage signal when the sampling needle is at the highest point as AD0;
s3, detecting the liquid level at the standard height: detecting the height of X-V1 by a sampling probe to obtain a voltage signal value AD1; and after S3 is finished, executing a judgment logic: if the difference value between the AD1 and the AD0 does not exceed the set threshold value, performing the step S4, and if the difference value between the AD1 and the AD0 exceeds the set threshold value, taking the standard packaging amount as X as the real liquid amount of the bottle reagent, and performing the step S5;
s4, a first value taking step: controlling the sampling needle to continue to probe downwards, recording the detected voltage signal value H1 after the sampling needle probes the liquid level, starting a plunger pump to pump a reagent, monitoring the pressure state of a pipeline, and judging whether the pipeline is empty-sucked or not;
a second value taking step: detecting the height of the sampling needle to X-V1 to obtain a voltage signal value AD1, controlling the sampling needle to continuously detect downwards, recording a detected voltage signal value H2 after detecting the liquid level, starting a plunger pump to pump a reagent, monitoring the pressure state of a pipeline, and judging whether the pipeline is empty-sucked;
if the difference value of the AD1 and the AD0 in the first value taking step and the difference value of the AD1 and the AD0 in the second value taking step are both larger than or both smaller than the set threshold value, taking the average value of the H1 and the H2, bringing the average value into a relation function of the voltage signal value of the detector and the liquid quantity in the bottle to update the real liquid quantity of the bottle reagent, and carrying out the step S5;
if one of the difference value between the AD1 and the AD0 in the first value taking step and the difference value between the AD1 and the AD0 in the second value taking step is larger than a set threshold value, and the other difference value is smaller than the set threshold value, performing a third value taking step;
a third value taking step: detecting the height of the sampling needle to X-V1 to obtain a voltage signal value AD1, controlling the sampling needle to continuously detect downwards, recording a detected voltage signal value H3 after detecting the liquid level, starting a plunger pump to pump a reagent, monitoring the pressure state of a pipeline, and judging whether the pipeline is empty-sucked;
after the third value taking step is completed, the following three logics are executed:
a. in the third value taking step, if the difference value between AD1 and AD0 does not exceed the set threshold value in the two steps and no air suction is judged to occur, taking the average value of two detected voltage signal values H1, H2 or H3 recorded after the liquid level is detected in the corresponding step, bringing in a relation function of the voltage signal value of the detector and the liquid amount in the bottle to update the real liquid amount of the bottle reagent, and performing the step S5;
b. in the third value taking step, if the difference value between AD1 and AD0 exceeds a set threshold value in the two standard height liquid level detection steps, taking the standard packaging quantity as X as the real liquid quantity of the bottle of reagent, and performing step S5; c. if the logic a or b is not met, determining that the margin detection is abnormal, and performing step S5;
and S5, reporting the detection result and the detected liquid amount H.
Preferably, in the reagent sucking method based on the bottle setting, the residual quantity detection step is preceded by a main test step,
the main test step comprises:
s1, setting a liquid taking amount V2 of a reagent or magnetic beads fixed in a main test each time;
s2, controlling the sampling needle to descend to the position of the liquid amount X-V2 in the reagent bottle, detecting to obtain a voltage signal value AD2, comparing the difference value of AD2 and AD0, if the difference value of AD2 and AD0 exceeds a threshold value, judging that the liquid amount is normal, testing is normally carried out, and in time sequence action, a plunger pump normally sucks the reagent; if the difference value between the AD2 and the AD0 does not exceed the threshold value, the test is abandoned, and the subsequent test is continued; if the difference value between AD2 and AD0 does not exceed the threshold value in two consecutive times, the test is suspended, and the liquid level signal is prompted to be abnormal;
and after all normal tests are finished, carrying out a reagent allowance detection step in the reagent bottle on the abandoned test.
Preferably, the reagent sucking method based on the bottle setting of the invention establishes the relation function of the pulse value of the detector and the liquid amount in the bottle as follows:
taking a plurality of different reagent bottles with known liquid amount, carrying out a liquid level detection step on a sampling needle, and measuring voltage signal values when the sampling needle detects each liquid level; fitting a linear equation between the liquid amount in the reagent bottle and the corresponding measured voltage signal value according to a least square method, and establishing a relation function between the voltage signal value and the liquid amount in the bottle.
Preferably, the reagent sucking method based on the bottle setting of the invention further implements a code scanning identification step before the main test step: set up specific identification code with the reagent bottle of same type on the body, inhale and set up on the reagent equipment and sweep a yard mechanism and sweep the kind of sign indicating number in order to discern the reagent bottle to the identification code.
Preferably, in the reagent sucking method based on the bottle setting of the present invention, in S2, a flag bit is established, an initial value of the flag bit is 0, when a difference value between AD2 and AD0 does not exceed a threshold value, a value of the flag bit is added by 1, and when the value of the flag bit reaches 2, the test is suspended, and an abnormal liquid level signal is prompted.
Preferably, in the reagent sucking method based on the bottle setting, in the three value-taking steps, in the process of pumping the reagent or the magnetic beads by the plunger, the pressure sensor connected in series in the pipeline monitors the pressure signal in the sample sucking process, when the pressure curve accords with the judgment algorithm of normal sample sucking, the test is normally carried out, and the subsequent action of spitting the liquid to the reaction cup is continued in the time sequence action; if the suction condition is triggered, the liquid cannot be spitted, the corresponding test is abandoned, the subsequent test is continued, and if the suction condition is triggered twice continuously, the test is suspended.
Preferably, in the reagent sucking method based on the bottle setting, in the three value-taking steps, a flag bit is established, the initial value of the flag bit is 0, when an empty sucking condition is triggered, the value of the flag bit is increased by 1, and when the value of the flag bit reaches 2, the test is suspended.
The invention has the beneficial effects that: the reagent bottle with part of liquid filled being not standard can be processed, and the possibility of air suction during sampling is reduced;
and when the reagent is spilled, the reagent is loaded to other instruments for testing after being partially consumed, and the experiment can be performed normally through margin updating.
Drawings
The technical solution of the present application is further explained below with reference to the drawings and the embodiments.
FIG. 1 is a flowchart of the main testing steps of the reagent sucking method based on the bottle setting in the embodiment of the application;
fig. 2 is a flow chart of plunger pump suction determination according to the embodiment of the present application.
Detailed Description
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict.
In the description of the present application, it is to be understood that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used in the orientation or positional relationship indicated in the drawings for convenience in describing the present application and for simplicity in description, and are not intended to indicate or imply that the referenced devices or elements must have a particular orientation, be constructed in a particular orientation, and be operated in a particular manner, and are not to be considered limiting of the scope of the present application. Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature. In the description of the invention, the meaning of "a plurality" is two or more unless otherwise specified.
In the description of the present application, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art through specific cases.
The technical solutions of the present application will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.
Examples
The embodiment provides a reagent sucking method based on a bottle setting, which comprises the following steps:
establishing a relation function of the voltage signal value of the detector and the liquid amount in the bottle;
detecting the residual quantity of the reagent in the reagent bottle;
the logic of the reagent residual quantity detection step in the reagent bottle comprises the following steps:
taking the standard packaging amount in the reagent bottle as X, the preset specific measurement volume as V1 (in the embodiment, V1 is 0.5mL of reagent; 0.3mL of magnetic bead liquid), and the reference value of the voltage signal when the sampling needle is at the highest point (namely the highest position of the sampling needle on the driving stroke of the driving device) as AD0;
s3, detecting the liquid level at the standard height: detecting the height of X-V1 by a sampling probe to obtain a voltage signal value AD1; and after S3 is finished, executing a judgment logic: if the difference between AD1 and AD0 does not exceed the set threshold (the threshold is set based on the amount of liquid to be sucked each time in the actual experiment, for example, the in-reagent-bottle package amount in this embodiment is X-10-V1, whereas for the present measurement experiment, the ideal single-time liquid sucking amount is V1, and the acceptable liquid sucking amount is 90-V1 or more; so the voltage signal value AD1' measured when the in-reagent-bottle package amount is X-10-V1 is set as the threshold, and the difference between AD1 and AD0 when a certain reagent bottle is subjected to the standard-height liquid-level detection does not exceed the set threshold indicates that the amount of liquid sucking for the first time has been caused by the reagent package amount is not acceptable), step S4 is performed, and if the difference between AD1 and AD0 exceeds the set threshold, step S5 is performed with the standard package amount as X as the actual liquid amount of the bottle reagent;
s4, a first value taking step: controlling the sampling needle to continue downward probing, recording a detected voltage signal value H1 after the sampling needle probes the liquid level, starting a plunger pump to pump a reagent, monitoring the pressure state of a pipeline, and judging whether the pipeline is empty-sucked or not;
a second value taking step: detecting the height of the sampling needle to X-V1 to obtain a voltage signal value AD1, controlling the sampling needle to continuously detect downwards, recording a detected voltage signal value H2 after detecting the liquid level, starting a plunger pump to pump a reagent, monitoring the pressure state of a pipeline, and judging whether the pipeline is empty-sucked;
if the difference value of the AD1 and the AD0 in the first value taking step and the difference value of the AD1 and the AD0 in the second value taking step are both larger than or both smaller than the set threshold value, averaging the H1 and the H2, bringing the average values into a relation function of the voltage signal value of the detector and the liquid amount in the bottle to update the real liquid amount of the bottle reagent, and carrying out the step S5;
if one of the difference value between the AD1 and the AD0 in the first value taking step and the difference value between the AD1 and the AD0 in the second value taking step is larger than the set threshold value, and the other difference value is smaller than the set threshold value, performing a third value taking step;
a third value taking step: detecting the height of the sampling needle to X-V1 to obtain a voltage signal value AD1, controlling the sampling needle to continuously detect downwards, recording a detected voltage signal value H3 after detecting the liquid level, starting a plunger pump to pump a reagent, monitoring the pressure state of a pipeline, and judging whether the pipeline is empty-sucked;
after the third value taking step is completed, the following three logics are executed:
a. in the third value taking step, if the difference value between AD1 and AD0 does not exceed the set threshold value in the two steps and no air suction is judged to occur, taking the average value of two detected voltage signal values H1, H2 or H3 recorded after the liquid level is detected in the corresponding step, bringing in a relation function of the voltage signal value of the detector and the liquid amount in the bottle to update the real liquid amount of the bottle reagent, and performing the step S5;
b. in the third value taking step, if the difference value between AD1 and AD0 exceeds a set threshold value in the two standard height liquid level detection steps, taking the standard packaging quantity as X as the real liquid quantity of the bottle of reagent, and performing step S5; c. if the logic a or b is not met, determining that the margin detection is abnormal, and performing step S5;
and S5, reporting the detection result and the detected liquid amount H.
Preferably, the reagent sucking method based on the bottle setting of the embodiment, the surplus detecting step is preceded by a main testing step,
as shown in fig. 1, the main test step includes:
s1, setting a liquid taking amount V2 of a reagent or magnetic beads fixed in a main test at each time (in the embodiment, the reagent taking amount V2 is 1.5mL, and the magnetic bead liquid is 0.7 mL);
s2, controlling the sampling needle to descend to the position of the liquid amount X-V2 in the reagent bottle, detecting to obtain a voltage signal value AD2, comparing the difference value of AD2 and AD0, if the difference value of AD2 and AD0 exceeds a threshold value, judging that the liquid amount is normal, testing is normally carried out, and in time sequence action, a plunger pump normally sucks the reagent; if the difference value between the AD2 and the AD0 does not exceed the threshold value, the test is abandoned, and the subsequent test is continued; if the difference value between AD2 and AD0 does not exceed the threshold value in two consecutive times, the test is suspended, and the liquid level signal is prompted to be abnormal;
and after all normal tests are finished, carrying out a reagent allowance detection step in the reagent bottle on the abandoned test.
Preferably, in the reagent sucking method based on the bottle setting of the embodiment, the step of establishing the relation function between the pulse value of the detector and the liquid amount in the bottle is as follows:
taking a plurality of reagent bottles with known liquid amounts and different liquid amounts (reagent: 1.5mL, 15mL, 2022mL, magnetic bead liquid: 1mL, 3mL, 4mL, 5 mL), carrying out a liquid level detection step on a sampling needle, and measuring a voltage signal value when the sampling needle detects each liquid level; fitting a linear equation (for example, taking the volume of the reagent or the magnetic bead liquid as a horizontal coordinate, taking the voltage signal value when the liquid level is detected as a vertical coordinate to establish a plurality of recording points, and then fitting a straight line) according to the least square method by using the liquid amount in the reagent bottle and the correspondingly measured voltage signal value, and establishing a relation function of the voltage signal value and the liquid amount in the bottle.
Preferably, the reagent sucking method based on the bottle setting of the embodiment further performs a code scanning recognition step before the main test step: set up specific identification code with the reagent bottle of same type on the body, inhale and set up on the reagent equipment and sweep a yard mechanism and sweep the kind of sign indicating number in order to discern the reagent bottle to the identification code.
Preferably, in the reagent sucking method based on the bottle setting of this embodiment, in S2, as shown in fig. 1, a flag is established, an initial value of the flag is 0, when a difference between AD2 and AD0 does not exceed a threshold, a value of the flag is added by 1, and when the value of the flag reaches 2, the test is suspended, and a liquid level signal abnormality is indicated.
Preferably, in the reagent sucking method based on the bottle setting of the embodiment, in the three value taking steps, in the process of pumping the reagent or the magnetic beads by the plunger, the pressure sensor connected in series in the pipeline monitors the pressure signal in the sample sucking process, when the pressure curve conforms to the judgment algorithm of normal sample sucking, the test is normally performed, and the subsequent action of spitting the liquid to the reaction cup is continued in the time sequence action; if the air suction condition is triggered, the liquid cannot be spitted, the corresponding test is abandoned, the subsequent test is continued, and if the air suction condition is triggered twice continuously, the test is suspended.
Preferably, in the reagent sucking method based on the bottle setting of the embodiment, as shown in fig. 2, in the three value taking steps, a flag bit is established, an initial value of the flag bit is 0, when an empty sucking condition is triggered, the value of the flag bit is added by 1, and when the value of the flag bit reaches 2, the test is suspended.
In light of the foregoing description of the preferred embodiments according to the present application, it is to be understood that various changes and modifications may be made without departing from the spirit and scope of the invention. The technical scope of the present application is not limited to the content of the specification, and must be determined according to the scope of the claims.
Claims (7)
1. A reagent sucking method based on bottle setting is characterized by comprising the following steps:
establishing a relation function of the voltage signal value of the detector and the liquid amount in the bottle;
detecting the residual quantity of the reagent in the reagent bottle;
the logic of the reagent residual quantity detection step in the reagent bottle comprises the following steps:
the standard packaging amount in the reagent bottle is X, the preset specific measurement volume is V1, and the reference value of the voltage signal when the sampling needle is at the highest point is AD0;
s3, detecting the liquid level at the standard height: detecting the height of X-V1 by a sampling probe to obtain a voltage signal value AD1;
and after S3 is finished, executing a judgment logic: if the difference value between AD1 and AD0 does not exceed the set threshold value, performing step S4, and if the difference value between AD1 and AD0 exceeds the set threshold value, performing step S5 by taking the standard packaging amount as X as the real liquid amount of the reagent bottle;
s4, a first value taking step: controlling the sampling needle to continue to probe downwards, recording the detected voltage signal value H1 after the sampling needle probes the liquid level, starting a plunger pump to pump a reagent, monitoring the pressure state of a pipeline, and judging whether the pipeline is empty-sucked or not;
a second value taking step: detecting the height of the sampling needle to X-V1 to obtain a voltage signal value AD1, controlling the sampling needle to continuously detect downwards, recording a detected voltage signal value H2 after detecting the liquid level, starting a plunger pump to pump a reagent, monitoring the pressure state of a pipeline, and judging whether the pipeline is empty-sucked;
if the difference value of the AD1 and the AD0 in the first value taking step and the difference value of the AD1 and the AD0 in the second value taking step are both larger than or both smaller than the set threshold value, averaging the H1 and the H2, bringing the average values into a relation function of the voltage signal value of the detector and the liquid amount in the bottle to update the real liquid amount of the bottle reagent, and carrying out the step S5;
if one of the difference value between the AD1 and the AD0 in the first value taking step and the difference value between the AD1 and the AD0 in the second value taking step is larger than a set threshold value, and the other difference value is smaller than the set threshold value, performing a third value taking step;
a third value taking step: detecting the height of the sampling needle to X-V1 to obtain a voltage signal value AD1, controlling the sampling needle to continuously detect downwards, recording a detected voltage signal value H3 after detecting the liquid level, starting a plunger pump to pump a reagent, monitoring the pressure state of a pipeline, and judging whether the pipeline is empty-sucked;
after the third value taking step is completed, the following three logics are executed:
a. in the third value taking step, if the difference value between AD1 and AD0 does not exceed the set threshold value in the two steps and no air suction is judged to occur, taking the average value of two detected voltage signal values H1, H2 or H3 recorded after the liquid level is detected in the corresponding step, bringing in a relation function of the voltage signal value of the detector and the liquid amount in the bottle to update the real liquid amount of the bottle reagent, and performing the step S5;
b. in the third value taking step, if the difference value between AD1 and AD0 exceeds a set threshold value in the standard height liquid level detection step twice, taking the standard packaging quantity as X as the real liquid quantity of the bottle reagent, and performing step S5;
c. if the logic a or b is not met, determining that the margin detection is abnormal, and performing step S5;
and S5, reporting the detection result and the detected liquid amount H.
2. The reagent aspirating method according to claim 1, wherein the remaining amount detecting step is preceded by a main testing step,
the main testing step comprises the following steps:
s1, setting a liquid taking amount V2 of a reagent fixed in a main test each time;
s2, controlling the sampling needle to descend to the position of the liquid amount X-V2 in the reagent bottle, detecting to obtain a voltage signal value AD2, comparing the difference value of AD2 and AD0, if the difference value of AD2 and AD0 exceeds a threshold value, judging that the liquid amount is normal, testing is normally carried out, and in time sequence action, a plunger pump normally sucks the reagent; if the difference value between the AD2 and the AD0 does not exceed the threshold value, the test is abandoned, and the subsequent test is continued; if the difference value between the AD2 and the AD0 does not exceed the threshold value continuously twice, the test is suspended, and the liquid level signal is prompted to be abnormal;
and after the normal tests are completely finished, carrying out a reagent allowance detection step in the reagent bottle on the abandoned tests.
3. The reagent sucking method based on the bottle setting as claimed in claim 1, wherein the step of establishing the relation function of the voltage signal value of the detector and the liquid amount in the bottle is as follows:
taking a plurality of different reagent bottles with known liquid amount, carrying out a liquid level detection step on a sampling needle, and measuring voltage signal values when the sampling needle detects each liquid level; fitting a linear equation between the liquid amount in the reagent bottle and the corresponding measured voltage signal value according to a least square method, and establishing a relation function between the voltage signal value and the liquid amount in the bottle.
4. The reagent sucking method based on the bottle setting as claimed in claim 2, characterized in that before the main testing step, a code scanning recognition step is further performed: set up specific identification code with the reagent bottle of same type on the body, inhale and set up on the reagent equipment and sweep a yard mechanism and sweep the kind of sign indicating number in order to discern the reagent bottle to the identification code.
5. The reagent sucking method set according to claim 2 or 4, wherein in S2, a flag is established, the initial value of the flag is 0, when the difference between AD2 and AD0 does not exceed the threshold, the value of the flag is added by 1, and when the value of the flag reaches 2, the test is suspended, and the liquid level signal is abnormal.
6. The reagent sucking method based on the bottle setting according to any one of claims 1 to 4, characterized in that in the three value-taking steps, in the process of reagent sucking by the plunger, a pressure sensor connected in series in the pipeline monitors a pressure signal in the sample sucking process, when a pressure curve conforms to a judgment algorithm of normal sample sucking, a test is normally performed, and the subsequent action of spitting liquid to the reaction cup is continued in a time sequence action; if the air suction condition is triggered, the liquid cannot be spitted, the corresponding test is abandoned, the subsequent test is continued, and if the air suction condition is triggered twice continuously, the test is suspended.
7. The reagent sucking method based on the bottle setting as claimed in claim 6, wherein in the three value taking steps, a flag bit is established, the initial value of the flag bit is 0, when the empty sucking condition is triggered, the value of the flag bit is added by 1, and when the value of the flag bit reaches 2, the test is suspended.
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PCT/CN2022/110211 WO2023035824A1 (en) | 2021-09-08 | 2022-08-04 | Reagent suction method based on bottle setting |
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CN107643699A (en) * | 2017-09-30 | 2018-01-30 | 迈克医疗电子有限公司 | Take hydraulic control method, apparatus and take liquid system |
CN111141919A (en) * | 2019-12-23 | 2020-05-12 | 苏州长光华医生物医学工程有限公司 | Reagent liquid level height detection method and device for chemiluminescence immunoassay analyzer |
CN112414506A (en) * | 2020-11-11 | 2021-02-26 | 苏州长光华医生物医学工程有限公司 | Reagent suction detection device and computer readable storage medium |
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