CN113712871A

CN113712871A - Essence emulsion composition containing liposome with comedones removing effect and preparation method thereof

Info

Publication number: CN113712871A
Application number: CN202111126540.0A
Authority: CN
Inventors: 周紫燕; 杨帆; 李沫; 郭苗; 周正; 郭阳
Original assignee: Hubei Maishite Biotechnology Co Ltd
Current assignee: Hubei Maishite Biotechnology Co Ltd
Priority date: 2021-09-26
Filing date: 2021-09-26
Publication date: 2021-11-30
Anticipated expiration: 2041-09-26
Also published as: CN113712871B

Abstract

The invention discloses an essential milk composition containing liposome with an effect of removing blackheads and a preparation method thereof. The essence milk composition comprises: 0.5-30% of liposome with the effect of removing blackheads, 1-40% of emollient, 0.1-20% of emulsifier, 0.5-30% of filler, 0.1-10% of thickener, 0.1-4% of preservative, 0.01-4% of pH regulator, 0.005-1% of daily essence and the balance of deionized water. The liposome with the effect of removing blackheads comprises the following main effective components: white willow bark extract, marrubium vulgare extract, lentil seed extract, and Fucus serrata extract. The essential emulsion composition can solve the problems of poor stability of active ingredients and slow skin absorption by wrapping each functional component in the liposome, and the reasonable matching of various functional components can reduce the generation of skin grease, recover the normal keratinization process of skin, soften the blackheads in pores, reduce the blackheads, achieve the aim of deeply cleaning the skin and enable the skin to look cleaner and finer.

Description

Essence emulsion composition containing liposome with comedones removing effect and preparation method thereof

Technical Field

The invention relates to a skin care product and a preparation method thereof, belongs to the technical field of daily chemicals, and particularly relates to an essence emulsion composition containing liposome with a blackhead removing effect and a preparation method thereof.

Background

In the age of rapid development of skin care products, people want to have clean and smooth facial eggs, but many people suffer from troubles of skin blackheads. In daily life, a plurality of young people can grow blackheads on the nose, which affects aesthetic feeling, however, the blackheads are difficult to eradicate, the recurrence is fast, and how to effectively clean the blackheads of the skin is one of skin problems which are concerned by people.

The blackheads are mainly formed by the fact that oil and fat secreted by the skin, old cutin and bacteria are mixed and blocked at the openings of pores, and when the blackheads are contacted with pollutants in the air, the pollutants are oxidized, so that sebum mixture at the openings of the pores is blackened and hardened to form the blackheads. Due to the recurrent outbreak of blackheads and the difficulty in eradicating, the single component makes it difficult to effectively inhibit the formation of blackheads.

Therefore, how to scientifically select effective components capable of removing blackheads so that the synergistic effect of the effective components can reduce blackheads to the maximum extent from all dimensions generated by the blackheads and clean skin pores is a technical problem which needs to be solved by technical personnel in the field.

Disclosure of Invention

The invention aims to provide an essence emulsion composition containing liposome with the effect of removing blackheads, which has the effects of reducing skin grease, cleaning pores and reducing blackheads and is popular among a plurality of consumers suffering from blackheads.

The invention also aims to provide a preparation method of the essence emulsion composition containing the liposome with the comedones removing effect.

An essential emulsion composition containing liposome having comedones removing effect, which comprises, based on the total weight of the composition:

0.5-30% of liposome with the effect of removing blackheads, which comprises the following main functional components: 0.1-10% white willow bark extract, 0.1-8% marrubium vulgare extract, 0.1-8% lentil seed extract, 0.1-10% fucus serratus extract;

1-40% of emollient;

0.1-20% of emulsifier;

0.5-30% of a filler;

0.1-10% of a thickening agent; 0.1-4% of preservative; 0.01-4% of pH regulator; 0.005-1% of daily essence; the balance being deionized water.

Preferably, the composition comprises, by total weight of the composition: 1-10% of the liposome with the effect of removing blackheads, which comprises the following main effective components: 0.1-3% white willow bark extract, 0.1-3% marrubium vulgare extract, 0.1-2% lentil seed extract, 0.1-2% fucus serratus extract;

5-25% of an emollient; 0.5-15% of emulsifier; 0.5-15% of a filler; 1-8% of a thickening agent; 0.2-2% of preservative; 0.1-3% of pH regulator; 0.01-1% of daily essence; the balance being deionized water.

Preferably, the composition comprises, by total weight of the composition: 4-6% of the liposome with the effect of removing blackheads, which comprises the following main effective components: 0.1-3% white willow bark extract, 0.1-3% marrubium vulgare extract, 0.1-2% lentil seed extract, 0.1-2% fucus serratus extract;

8-15% of an emollient; 2-4% of an emulsifier; 5-10% of a filler; 5-8% of a thickening agent; 0.2-1% of preservative; 0.5-2% of pH regulator; 0.01-0.5% of daily essence; the balance being deionized water.

Specifically, the components with the effect of removing blackheads comprise: the composition comprises a lentil seed extract, an fucus serratus extract, a white willow bark extract and an eriocaulon europaea extract, wherein the mass ratio of the lentil seed extract to the fucus serratus extract to the white willow bark extract to the eriocaulon europaea extract is 1: 1: 2: 2.

specifically, the preparation method of the liposome with the effect of removing blackheads comprises the following process steps:

1) dissolving phospholipid and cholesterol in anhydrous ethanol to obtain phase A; dissolving lentil seed extract, Fucus serratus extract, white willow bark extract and marrubium vulgare extract in phosphate buffer solution, and stirring to obtain phase B;

2) placing the phase B into a constant-temperature water bath at 50 ℃, slowly injecting the phase A while stirring, stirring and hydrating for half an hour, and transferring to a rotary evaporator to remove ethanol to obtain a suspension;

3) treating the suspension obtained in the step 2) by a high-pressure homogenizer to obtain the liposome with small and uniform particle size.

Preferably, in the step 1), the phospholipid comprises: one of lecithin, cephalin, soybean phospholipid and synthetic phospholipid; the mass ratio of the phospholipid to the cholesterol is (2-5): 1.

the speed of injecting the phase A into the phase B in the step 2) is 1 mL/min.

Specifically, the particle size of the liposome with the effect of removing the blackhead acne is 50-200 nm.

Preferably, the emollient is selected from one or more of glycerol, butylene glycol, phytosterol, polyethylene glycol-8, isohexadecane, panthenol, lauryl alcohol, squalane, olive oil, avocado oil, octyldodecanol lauroyl glutamate, caprylic acid, capric acid triglyceride.

The emulsifier is one or more selected from polysorbate-20, polysorbate-80, and sorbitan oleate.

The filler is selected from one or more of boron nitride, kaolin and talcum powder.

The thickening agent is one or more selected from xanthan gum, carbomer, acrylate/C10-30 alkyl acrylate cross-linked polymer.

The preservative is selected from one or more of phenoxyethanol, aroyl, ethylhexyl glycerol, sodium benzoate, triclosan and chlorphenesin.

The pH regulator is one or more of lactic acid or arginine.

Specifically, the emollient is selected from the mixture of phytosterol, octyl dodecanol lauroyl glutamate and panthenol, and the mass ratio of the phytosterol to the octyl dodecanol lauroyl glutamate to the panthenol is 1: (0.5-1): (0.2 to 1).

Specifically, the filler is selected from a mixture of boron nitride and kaolin, and the mass ratio of the boron nitride to the kaolin is 1: (1-2).

Specifically, the thickening agent is selected from xanthan gum, carbomer and a mixture of acrylate/C10-30 alkyl acrylate cross-linked polymer, and the mass ratio of the xanthan gum to the carbomer to the acrylate/C10-30 alkyl acrylate cross-linked polymer is 1: (0.2-0.5): (0.5 to 1).

Specifically, the preservative is selected from the mixture of phenoxyethanol and ethylhexyl glycerin, and the mass ratio of the phenoxyethanol to the ethylhexyl glycerin is 1: (0.05-0.2).

Specifically, the pH regulator is a mixture of lactic acid and arginine, and the mass ratio of the lactic acid to the arginine is 1: (1-3).

The preparation method of the essence emulsion composition containing the liposome with the acne removing effect comprises the following process steps:

1) wetting and completely dispersing the thickening agent in water to obtain a mixed solution;

2) adding liposome with the effect of removing comedones, an emollient, a filler, a preservative and a pH regulator into the mixed solution obtained in the step 1), heating to 65 ℃, and homogenizing at 3000r/min for 3 minutes to completely disperse the liposome;

3) adding an emulsifier and a daily essence into the step 2), homogenizing at 3000r/min for 3 minutes to completely emulsify the mixture, and heating to 65 ℃ to obtain the essence emulsion composition of the liposome with the effect of removing the comedones.

Specifically, the essential emulsion composition of the liposome with the comedones removing effect is in a solvent dispersion or suspension mode, or in an emulsified particle mode, or in a polymer-coated mode.

Specifically, the essential milk composition containing liposome with comedones removing effect of the present invention has a pH in the range of 4 to 10, preferably a pH in the range of 5 to 8, and most preferably a pH in the range of 5 to 7.

Specifically, the essential milk composition containing the liposome having the comedoneremoving effect according to the present invention is a skin care product, and is mainly used for essential milk.

Specifically, the essential milk composition containing the liposome with the acne removing effect comprises the following main components: lentil seed extract, Fucus serrata extract, white willow bark extract, and marrubium vulgare extract.

Extract of lentil seed

The oligosaccharide component in the lentil seed extract can inhibit excessive secretion of skin oil, and the excessive oil level can cause the growth of blackheads too fast, especially the forehead and nose of the skin, thereby reducing the possibility of blackhead generation from the source. In addition, the skin-care product can restore the normal keratinization process of the skin, eliminate nucleated cells around pores which harden the pore walls and enable the pores to be clean and fine.

② Fucus serrata extract

The Fucus serratus extract contains various nutrient components required by the skin, is a brand new energy source for the skin, can improve the activity of mitochondria, can accelerate the metabolism of the skin, and can prevent old cutin from blocking the opening of a hair space and being oxidized into blackheads by air after being mixed with sebum.

③ white willow bark extract

The white willow bark extract can effectively condition cutin, pour into the deep of pores, fully soften and loosen the cutin, guide stubborn black heads and old waste cutin accumulated in the pores for a long time, and reduce the black heads existing on the skin.

Extract of marrubium vulgare

The marrubium vulgare extract can protect skin from being invaded by pollutants, strengthen skin barrier, promote natural antioxidation of the skin, and in addition, the extract can also destroy lipid structures in pores and prevent the lipid from being oxidized by air to form blackheads after being excessively secreted.

By means of the technical scheme, the invention has the following beneficial technical effects:

1) when the black head removing component is used by compounding the bean extract, the fucus extract, the salix bark extract and the marrubium vulgare extract, the skin oil can be inhibited from being generated from the source, the normal keratinization of the skin is recovered, the pore is prevented from being blocked, the existing stubborn black head can be reduced, or the existing black head is prevented from being generated by the oxidation of the sebum or the contact with external pollutants, the pore is purified from multiple dimensions, and the black head is reduced.

2) The invention discloses innovative functional components for removing blackheads, which comprise the following components: the lentil seed extract, the fucus extract, the white willow bark extract and the marrubium vulgare extract are compounded and used at the same time, and the liposome is used as a carrier, so that the stability of the active substance can be improved, the transdermal absorption efficiency of the active substance can be improved, the active substance can be slowly released at the pore blackheads, and the synergistic effect of inhibiting the blackheads is achieved.

Drawings

FIG. 1 is a graph showing the degree of skin keratinization at the site around pores after 28 days using the anti-blackhead acne effect composition;

fig. 2 is a graph showing the average area change rate of skin blackheads after 56 days using the essence cream composition product of example 1;

fig. 3 is a graph showing the change rate of the average area ratio of skin blackheads after 56 days using the essence cream composition product of example 1;

FIG. 4 is a result of clinical evaluation by a dermatologist;

fig. 5 is a graph showing the average area change rate of skin blackheads after 56 days using the serum dairy composition products of example 1 and comparative examples 1 to 15;

fig. 6 is a graph showing the average area-specific change rate of skin blackheads after 56 days using the serum dairy composition products of example 1 and comparative examples 1 to 15.

Detailed Description

The invention discloses an essence emulsion composition containing liposome with an effect of removing comedones. The essential milk composition mainly comprises the following components for removing comedones: lentil seed extract, Fucus serrata extract, white willow bark extract, and marrubium vulgare extract. It has effects of reducing skin oil, cleaning pores, and reducing blackhead. By the preferred combination and efficacy test, it was found that the most preferred composition ratios, synergistic comedones removal efficacy can be achieved.

The invention can inhibit sebum level, strengthen skin barrier, restore normal keratinization of skin, clean pores and remove blackheads. The four components of the swertia bean extract, the fucus serratus extract, the salix alba bark extract and the marrubium vulgare extract are compounded and used at the same time, so that the acne removing tea has the function of synergistically removing the acne, and the problem of blackheads is solved from multiple dimensions.

The present invention is illustrated by the following examples, which are provided for the purpose of further illustration only and are not intended to limit the scope of the present invention. Other insubstantial modifications and adaptations of the present invention can be made without departing from the scope of the present invention.

Unless otherwise specified, the following percentages (%) are mass percentages. All the raw material components are commercially available products.

Examples 1 to 3

An essential milk composition containing liposome with the effect of removing comedones is prepared into the essential milk for removing the comedones, and the raw material components of the essential milk comprise the following components in percentage by weight as shown in table 1.

TABLE 1 raw material component ratios (% by mass) of examples 1 to 3

The preparation method of the essential milk composition containing liposome having the comedones removal effect of example 1 comprises the following steps:

1) preparing the liposome with the effect of removing blackheads:

accurately weighing 900mg of lecithin and 300mg of cholesterol, adding 10mL of 95% ethanol into a beaker, and fully dissolving; dissolving 33mg of lentil seed extract, 33mg of fucus extract, 66mg of white willow bark extract and 66mg of marrubium vulgare extract in 20mL of phosphate buffer, placing in a water bath kettle at 50 ℃, and stirring for later use; injecting the liposome solution into buffer solution at a speed of 1mL/min, stirring for hydrating for 1h, performing rotary evaporation to remove ethanol to obtain suspension containing liposome, treating with high pressure homogenizer to obtain liposome with small and uniform particle size, and further centrifuging and drying to obtain liposome with effect of removing comedones; the particle size of the liposome is 50-150 nm;

2) wetting and completely dispersing the thickening agent in water to obtain a mixed solution;

3) adding liposome with the effect of removing comedones, an emollient, a filler, a preservative and a pH regulator into the mixed solution obtained in the step 1), heating to 65 ℃, and homogenizing at 3000r/min for 3 minutes to completely disperse the liposome;

4) adding an emulsifier and a daily essence into the step 2), homogenizing at 3000r/min for 3 minutes to completely emulsify the mixture, and heating to 65 ℃ to obtain the essence emulsion composition containing the liposome with the effect of removing the comedones. The pH value is 5.5-6.5.

The essential milk composition containing liposome having comedones removal effect of example 2 comprises the following steps:

1) preparing the liposome with the effect of removing blackheads:

accurately weighing 1000mg of cephalin and 500mg of cholesterol, adding 12mL of 95% ethanol into a beaker, and fully dissolving; dissolving 35mg of lentil seed extract, 35mg of fucus extract, 70mg of white willow bark extract and 70mg of marrubium vulgare extract in 25mL of phosphate buffer solution, placing in a water bath kettle at 50 ℃, and stirring for later use; injecting the liposome solution into buffer solution at a speed of 1mL/min, stirring for hydrating for 1h, performing rotary evaporation to remove ethanol to obtain suspension containing liposome, treating with high pressure homogenizer to obtain liposome with small and uniform particle size, and further centrifuging and drying to obtain liposome with effect of removing comedones; the particle size of the liposome is 50-200 nm;

The essential milk composition containing liposome having comedones removal effect of example 3 comprises the following steps:

1) preparing the liposome with the effect of removing blackheads:

accurately weighing 2000mg of soybean phospholipid and 400mg of cholesterol, adding 15mL of 95% ethanol into a beaker, and fully dissolving; dissolving 45mg of lentil seed extract, 45mg of fucus extract, 90mg of white willow bark extract and 90mg of marrubium vulgare extract in 30mL of phosphate buffer solution, placing in a water bath kettle at 50 ℃, and stirring for later use; injecting the liposome solution into buffer solution at a speed of 1mL/min, stirring for hydrating for 1h, performing rotary evaporation to remove ethanol to obtain suspension containing liposome, treating with high pressure homogenizer to obtain liposome with small and uniform particle size, and further centrifuging and drying to obtain liposome with effect of removing comedones; the particle size of the liposome is 50-150 nm;

Test example for Effect verification

1. Safety test

Test samples: example 1;

the test method comprises the following steps: and (4) testing the safety by adopting a third-party detection mechanism. The selection area is not more than 50mm²And a suitable patch device having a depth of about 1mm, wherein about 0.02 to about 0.025ml (g) of the test substance is applied to the patch device in a closed patch test. Applying the spot tester to the curved side of forearm of subject, removing the test substance 24H later, observing skin reaction at 0.5H, 24H and 48H after removal, respectively, and observing<<Cosmetic safety regulations 2015>>The results were recorded using the medium skin response grading standard.

TABLE 2 Patch test results

Remarking: grading standard of skin reaction.

Level 0: negative reaction;

level 1: carrying out suspicious reaction; only faint erythema;

and 2, stage: weak positive reaction (erythema reaction); erythema, infiltration, edema, and possibly papules;

and 3, level: strong positive reaction (herpes reaction); erythema, infiltration, edema, pimples, herpes; the reaction may be beyond the test area;

4, level: very strong response (fusional herpes response); erythema, severe infiltration, edema, fusional herpes, and response beyond the test area.

The results in table 2 show no irritation as a safety pass.

2. Stability test

Test samples: example 1;

the test method comprises the following steps: and (5) observing the appearance color, viscosity and pH value for three months according to internal control standard.

Table 3 stability test results

Time

45℃

40℃

37℃

25℃

5℃

-15℃

CYCLE

Illumination of light

1W

√

2W

√

3W

√

4W

√

2M

√

3M

√

3. Efficacy test of blackhead removing component

Test samples: the comedoneremoving efficacy liposome of example 1;

the test method comprises the following steps: samples were used twice daily, morning and evening, and tried for 12 weeks. Volunteers applied the appropriate amount of test sample to their entire face and daily applied the entire face in the morning with a sunscreen product. The results were tested at the following time periods, respectively: before use of the sample (D0), after use of the sample for 28 days (D28).

And (3) testing results:

fig. 1 shows the effect of the blackhead-removing component on the keratinization process, and the results of in vivo tests on human skin show that the blackhead-removing component can reduce the number of nucleated cells around cheek pores by 20.8%, which indicates that the blackhead-removing component can restore the normal keratinization process and stimulate the differentiation of keratinocyte, thereby promoting the replacement of nucleated cells around large pores, preventing the cuticle near the pores from peeling off to block the pores to form blackheads, and enabling the pores to be clean and fine.

4. Evaluation of blackhead removing Effect

Test samples: example 1;

the test method comprises the following steps: samples were used twice daily, morning and evening, for 8 weeks, for a total of 56 days. The appropriate amount of test sample was applied to the entire face, using the sunscreen product to apply to the entire face every morning.

The results were tested at the following 4 time periods, respectively: before use of the sample (D0), after use of the sample for 14 days (D14), after use of the sample for 28 days (D28) and after use of the sample for 56 days (D56).

The detection items are as follows:

VISIA-CR is used for facial image acquisition and blackhead analysis;

clinical evaluation by dermatologist.

And (3) testing results:

TABLE 4 average area Change Rate of skin comedones

Number of days	After 14 days of use	After 28 days of use	After 56 days of use
				Rate of change	-1.42％	-3.40％	-6.80％

TABLE 5 rate of change of average area to area ratio of skin blackheads

Number of days	After 14 days of use	After 28 days of use	After 56 days of use
				Rate of change	-2.15％	-3.120％	-6.90％

As shown in fig. 2 to 3 and tables 4 to 5, which are the results of clinical efficacy test experiments for removing blackheads, the reduction in analysis values, which were obtained and analyzed from the face images of the subjects 56 days after the use of the samples, indicates the improvement in blackheads. As can be seen from fig. 2-3, the average area of comedones in the nasal tip region was significantly reduced by 6.80% after the 56 th day of using the sample; the average area of comedones in the nose tip area is remarkably reduced by 6.90 percent.

TABLE 6 clinical evaluation results of dermatologists (blackheads number)

Number of days	After 14 days of use	After 28 days of use	After 56 days of use
				Rate of change	-53.13％	-77.01％	-99.10％

As shown in fig. 4 and table 6, which are clinical evaluation results of dermatologists, the number of blackheads was significantly reduced by 99.10% after 56 days of using the sample.

5. Synergistic experiment of composition for removing blackhead

Essential milk prepared from essential milk composition containing components with comedones removal effect in control examples 1-15 according to the raw material component ratio shown in tables 7-8

TABLE 7 proportion of essential cream for removing blackhead in comparative examples 1 to 7 (unit: mass%)

TABLE 8 proportion of essential cream for removing blackhead in comparative examples 8 to 15 (unit: mass%)

The effects of example 1 and comparative examples 1 to 15 of the synergy test of the blackhead removing component were verified, and the test procedures and results were as follows:

1) the tester: 170 healthy women (25-45 years old) divided into 17 groups of 10 persons each; each group used the same formulation;

2) test area: a face;

3) use of: twice a day in the morning and evening for 8 weeks;

4) testing an instrument: VISIA-CR;

5) the effect indexes are as follows: VISIA-CR is used for facial image acquisition and blackhead analysis;

6) the test results are shown in table 9.

TABLE 9 test group Effect

From table 9, the results of fig. 5 to 6 show that, when the four components of soyabean extract, fucus serratus extract, willow bark extract and marrubium vulgare extract are added to the serum together with the liposome as the carrier, i.e., example 1, they have the greatest blackhead removing ability, while the blackhead removing effect is not as significant as that of the addition of the four components by adding only one component or two or three components, i.e., blackhead removing effect example 1 > comparative example 15> comparative examples 11 to 14 > comparative examples 5 to 10 > comparative examples 1 to 4 > blank.

The reason is that only one or two or three components are used for treating blackheads from one dimension, and the four components are used simultaneously to remove blackheads from all aspects, such as controlling from the source of blackheads generation, namely reducing sebum secretion, recovering normal keratinization of skin to avoid blocking pores, controlling from the process of blackheads generation, namely strengthening skin barrier to avoid oxidation, finally loosening stubborn blackheads in skin and cleaning the existing blackheads.

In addition, the liposome is a carrier, so that the stability of the active substance can be increased, the transdermal absorption efficiency of the active substance can be increased, the active substance can slowly release the effective components in pores and blackheads, and the effect of inhibiting the blackheads in a synergistic manner is achieved.

The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, so that any simple modification, equivalent change and modification made to the above embodiment according to the technical spirit of the present invention are within the scope of the technical solution of the present invention.

Claims

1. The essence emulsion composition containing the liposome with the effect of removing the comedones is characterized by comprising the following components in percentage by weight of the total composition:

1-40% of emollient; 0.1-20% of emulsifier; 0.5-30% of a filler; 0.1-10% of a thickening agent; 0.1-4% of preservative; 0.01-4% of pH regulator; 0.005-1% of daily essence; the balance being deionized water.

2. The essential milk composition containing liposome having an acne removing effect according to claim 1, wherein: the essence milk composition comprises the following components in percentage by weight:

1-10% of liposome with the effect of removing blackheads, which comprises the following main functional components: 0.1-3% white willow bark extract, 0.1-3% marrubium vulgare extract, 0.1-2% lentil seed extract, 0.1-2% fucus serratus extract; 5-25% of an emollient; 0.5-15% of emulsifier; 0.5-15% of a filler; 1-8% of a thickening agent; 0.2-2% of preservative; 0.1-3% of pH regulator; 0.01-1% of daily essence; the balance being deionized water.

3. The essential milk composition containing liposome having comedones-removing effect according to claim 2, wherein: the main functional components for removing the blackheads are as follows according to the total weight of the composition: the mass ratio of the lentil seed extract, the fucus serratus extract, the white willow bark extract and the marrubium vulgare extract is 1: 1: 2: 2.

4. the essential milk composition containing liposome having an acne removing effect according to claim 1, wherein: the preparation method of the liposome with the effect of removing blackheads comprises the following process steps:

5. The essential milk composition containing liposome having the comedones-removing effect according to claim 4, wherein:

in the step 1), the phospholipid is selected from one of lecithin, cephalin, soybean phospholipid and synthetic phospholipid; the mass ratio of the phospholipid to the cholesterol is (2-5): 1.

6. the essential milk composition containing liposome having the comedones-removing effect according to claim 4, wherein: in the step 2), the speed of injecting the phase A into the phase B is 1 mL/min.

7. The essential milk composition containing liposome having the comedones-removing effect according to claim 4, wherein: the particle size of the liposome is 50-200 nm.

8. The essential milk composition containing liposome having an acne removing effect according to claim 1, wherein:

the emollient is one or more selected from glycerol, butanediol, phytosterol, polyethylene glycol-8, isohexadecane, panthenol, lauryl alcohol, squalane, olive oil, avocado oil, octyldodecanol lauroyl glutamate, caprylic acid, and capric acid triglyceride;

the emulsifier is selected from one or more of polysorbate-20, polysorbate-80 and sorbitan oleate;

the filler is selected from one or more of boron nitride, kaolin and talcum powder;

the thickening agent is selected from one or more of xanthan gum, carbomer, acrylate/C10-30 alkyl acrylate cross-linked polymer;

the preservative is selected from one or more of phenoxyethanol, jasmonic acid, ethylhexyl glycerol, sodium benzoate, triclosan and chlorphenesin;

the pH regulator is one or more of lactic acid or arginine.

9. The essential cream composition containing liposome having an acne removing effect according to claim 8, wherein:

the emollient is selected from the mixture of phytosterol, octyl dodecanol lauroyl glutamate and panthenol, and the mass ratio of the phytosterol to the octyl dodecanol lauroyl glutamate to the panthenol is 1: (0.5-1): (0.2 to 1);

the filler is selected from the mixture of boron nitride and kaolin, and the mass ratio of the boron nitride to the kaolin is 1: (1-2);

the thickening agent is selected from xanthan gum, carbomer and a mixture of acrylate/C10-30 alkyl acrylate cross-linked polymer, and the mass ratio of the xanthan gum to the carbomer to the acrylate/C10-30 alkyl acrylate cross-linked polymer is 1: (0.2-0.5): (0.5 to 1);

the preservative is selected from the mixture of phenoxyethanol and ethylhexyl glycerin, and the mass ratio of the phenoxyethanol to the ethylhexyl glycerin is 1: (0.05-0.2);

the pH regulator is a mixture of lactic acid and arginine, and the mass ratio of the lactic acid to the arginine is 1: (1-3).

10. The method for preparing the essential milk composition containing the liposome with the comedones removal effect according to any one of claims 1 to 9, which comprises the following process steps:

3) adding an emulsifier and a daily essence into the step 2), homogenizing at 3000r/min for 3 minutes to completely emulsify the mixture, and heating to 65 ℃ to obtain the essence emulsion composition containing the liposome with the effect of removing the comedones.