CN113712559A - Human stress load measuring method and application thereof - Google Patents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
Abstract
The application provides a non-diagnosis method for measuring human stress load, which comprises measuring physiological dimension indexes, measuring psychological dimension indexes, measuring marker dimension indexes, measuring operation capacity dimension indexes and calculating stress load; the method measures and evaluates the four-dimensional mode of the stress load from four levels of physiology, psychology, markers and operation capacity, and can more completely reflect the comprehensive characteristics of stress compared with single hormone measurement and single physiological biochemical measurement; the method has potential guiding significance for optimizing stress control strategies, planning implementation opportunities of stress management measures and promoting national health level.
Description
Technical Field
The invention belongs to the field of biotechnology and human physiology, and particularly provides a human stress load measuring method and potential application thereof in prevention and treatment of stress-related diseases.
Background
Stress response is a non-specific physiological psychological response of a human body to internal and external adverse stimuli, and is expressed by changes in stress hormone levels and changes in functions of organs of the whole body caused by the changes, and even psychological behavior changes caused by differences in perception and cognitive evaluation of internal and external environments. With the acceleration of the rhythm of life and the aggravation of social competition in modern society, most people are in stress response of different degrees. Although stress is critical to the survival and adaptation of the body in adverse environments, long-term or high-intensity stress can overwhelm the body's potential, inducing damage and disease. Epidemiological investigation shows that about 70 percent of human diseases are related to the activation of stress injury mechanism of the body, and stress is also known as risk factors of cardiovascular and cerebrovascular diseases, cognitive dysfunction, immune dysfunction and other diseases.
Stress load is a term used to measure the degree of negative effects of a stress response, and refers to the magnitude of deviation from homeostasis of the body from the challenge of adapting to an adverse factor under the action of a stressor, and the cost of reestablishing and maintaining a non-homeostatic balance outside of the body's original homeostasis. Although it is acknowledged that the measurement and monitoring of stress load is a key link for early warning of stress injury and has important significance for prevention and treatment of stress-related diseases, the definition of stress load is quite abstract, and stress response is a complex process involving almost all systems of an organism, so that quantitative evaluation of stress load is quite difficult, and an effective measurement method is always lacked.
Glucocorticoid or norepinephrine have long been commonly used to assess stress load, but they have rhythmic changes and complex detection techniques, i.e., inaccuracy and inability to fully describe the psychological and behavioral effects of stress. The American stress biology specialist McEwen proposed a set of stress load assessment methods in 1997 and adjusted the measurement indexes involved in the methods many times in the following ten years. The method is used for realizing the quantification of the stress load by measuring ten indexes such as systolic pressure, diastolic pressure, serum total cholesterol, serum high-density lipoprotein, serum glycosylated hemoglobin, serum dehydroepiandrosterone, urine cortisol, urine adrenaline, urine noradrenaline, waist-hip ratio and the like. The method plays an important role in stress evaluation and early warning, but systematic organization and classification among indexes of the method are lacked, and only the change of physiological and biochemical indexes is considered, so that the influence of stress on psychology, behavior and operation capability is ignored.
Disclosure of Invention
Aiming at the problems, the applicant follows the characteristics of multilevel and comprehensive stress response, provides a four-dimensional mode for measuring and evaluating the stress load from four levels of physiology, psychology, biomarkers and operation capacity, and establishes a human stress load measuring method. According to the method, the stress load of a human body is effectively measured by measuring eight stress related indexes and calculating the stress load index in a weighted manner, so that a basis is provided for early warning and protection of stress injury and stress related diseases, and self management and promotion of national health are facilitated.
In one aspect, the present application provides a non-diagnostic method for human stress load measurement, comprising physiological dimension index measurement, psychological dimension index measurement, marker dimension index measurement, performance dimension index measurement, and stress load measurement calculation.
Further, the physiological dimension index measurement comprises heart rate variation rate total power and respiratory rate measurement.
Further, the total power of the heart rate variability rate is measured by a commercially available electrocardiogram heart rate variability analyzer or other devices capable of measuring the heart rate variability rate; collecting 5min electrocardiosignals, recording heart rate variability rate total power data with frequency band less than 0.4Hz, and recording as P1The unit: ms is2(ii) a According to the formula: t is1＝19.6(3466–P1) The standard score for this index was calculated 1018+ 50.
The population mean value of the parameter is 3466ms2Standard deviation of 1018ms2。
Further, the respiratory rate is measured by using a commercial respiratory belt or other devices capable of measuring the respiratory rate or by manually observing the thoracic fluctuation of the measured person; during measurement, a user avoids speaking and suggesting to the measured person so as to avoid influencing the result; count continuously for 1 minute, or count for 30 seconds times 2 to obtain the respiratory rate, which is denoted as P2The unit: the times are/min; calculating according to the formula: t is2＝19.6(P2-16)/2 +50 standard score of the index.
The population mean value of the parameter is 16 times/min, and the standard deviation is 2 times/min.
Further, the psychometric dimension measure includes a psychometric stress scale score and a selection reaction time measure.
Further, the psychological stress scale score is measured using the following psychological stress self-rating scale; the sum of the scores of the items of the scale is an original score which is marked as P3(ii) a . According to the formula: t is3＝19.6(P3-16)/2.85 +50 calculating the standard score of the index;
psychological stress self-rating scale
The population mean for this parameter was 16 with a standard deviation of 2.85.
Further, the selective reaction is measured by a commercially available selective reaction tester or other device having a selective reaction detection function; test twice, and take the best result as the selection reaction, and mark it as P4The unit: s; according to the formula: t is4＝19.6(P4-0.6)/0.19 +50 the standard score of the index is calculated.
The population mean of the parameter was 0.6s and the standard deviation was 0.19 s.
Further, marker dimension index measurements include salivary amylase level, plasma homocysteine level measurements.
Further, the level of salivary amylase is measured by using a commercial dry chemical test paper/salivary amylase detector or other devices with salivary amylase detection function; the testee fasts, forbids drinking and forbids smoking 15min before sucking the test strip, the saliva amylase detector reads the saliva amylase level and marks the level as P5The unit: kIU/L; according to the formula: t is5＝19.6(P5-19)/21.5 +50 the standard score for this index was calculated.
The mean value of the parameter population is 19kIU/L, and the standard deviation is 21.5 kIU/L.
Plasma homocysteine levels: measuring by adopting a commercially available homocysteine fluorescence POCT detector or a biochemical instrument containing a kit or clinical test; the measured person draws venous blood and separates plasma, the detection is carried out according to the requirement of the detection kit, the reading of the instrument is the plasma homocysteine level, and the plasma homocysteine level is recorded as P6The unit: mu mol/L; according to the formula: t is6＝19.6(P6-9.8)/3 +50 the standard score of the index is calculated.
The population mean value of the parameter is 9.8 mu mol/L, and the standard deviation is 3 mu mol/L.
Further, the performance dimension index measurements include a maximum oxygen uptake and a digital memory breadth measurement.
Furthermore, the maximum oxygen uptake is measured by adopting a stepping experiment specified by national military standard soldier physical ability evaluation (GJB1337-1992) or a commercially available intelligent device with the maximum oxygen uptake detection function; maximum oxygen uptake is noted as P7The unit: ml/kg. min; according to the formula: t is7＝19.6(46.5–P7) The standard score of the index was calculated as/5.5 + 50.
The population mean value of the parameter is 46.5 ml/kg.min, and the standard deviation is 5.5 ml/kg.min.
Further, the digital memory width is measured by a commercial digital memory width detector or other devices with digital memory width detection functions; the digital memory breadth is marked as P8(ii) a According to the formula: t is8＝19.6(7–P8) The standard score for this index was calculated 2+ 50.
The population mean of this parameter was 7 and the standard deviation was 2.
Further, according to the formula: SL ═ 0.15 (T)1+T3+T5+T7)+0.1(T2+T4+T6+T8) Calculating stress load, and recording as SL; the stress load SL is approximately normally distributed by taking 50 as the center, the smaller the numerical value is, the smaller the stress load is, and the larger the numerical value is, the larger the stress load is; SL ≥ 70 indicates that the stress load is higher and should appearAn increased risk of stress injury or of suffering from stress related diseases.
The methods of the present application may be diagnostic or non-diagnostic methods including, but not limited to, human physiological studies, psychological studies, census of population and screening of specific populations such as soldiers, operators of specialty equipment, and the like.
Advantageous effects
The invention provides a four-dimensional mode for measuring and evaluating stress load from four levels of physiology, psychology, markers and operation capability, and can more completely reflect the comprehensive characteristics of stress compared with single hormone measurement and single physiological biochemical measurement. The indexes selected by the method are derived from the stress high association table group and the stress load marker obtained by the research of the inventor, and the measurement accuracy of the stress load is high. The stress load measurement index combination related to the method can also be applicable to other species except human beings through necessary reference value adjustment. The stress load measuring method provided by the invention can define whether the stress load exceeds a reasonable range, and when the stress load SL is more than or equal to 70, the stress load is higher, the stress load measuring method prompts that the risk of stress injury or stress related diseases of a measured person is increased. The method has potential guiding significance for optimizing stress control strategies, planning implementation opportunities of stress management measures and promoting national health level.
Drawings
FIG. 1 is a graph showing the distribution of stress load test results of students and naval officers in examples 3 and 4.
Detailed Description
In the following examples, the total heart rate variability rate was measured using DLP6000 heart rate variability analyzer from shenzhen hennari medical instruments incorporated, ltd; the respiratory rate is obtained by observing the number of thoracic fluctuation times of a measured person when the measured person measures the total power of the heart rate variability; the psychological stress scale score is measured by adopting a psychological stress self-rating scale compiled by Liquan et al (Zhang Shu. behavioral medicine scale handbook [ M ]. Beijing: China medical electronic audio and video publisher, 2005: 258-:
psychological stress self-rating scale
Example 1
The person to be measured is a student in some university in Beijing. The total power of the heart rate variability rate is measured to be 4767ms2Standard score T124.95; respiratory rate of 17 times/min, standard score T259.8; psychological stress scale Total score 12, Standard score T322.49; selection of 0.50s, standard score T at the time of reaction439.33; salivary amylase level 3.5kIU/L, Standard score T535.87; plasma homocysteine level 9.56. mu. mol/L, Standard score T648.4; maximum oxygen uptake of 51.2 ml/kg-min, standard score T733.24; digital memory breadth 7, standard score T850. The stress load SL is calculated to be 37.24, the stress load is normal, and the risk of stress injury or stress-related diseases is low.
Example 2
The person being measured is a soldier in the navy. The work task of the part is heavy, and the working environment has the characteristics of high temperature and high noise. The people need to participate in the shift during the maritime task, and the work and rest cannot be matched with the natural rhythm. The total power of the heart rate variation rate is measured to be 2009ms2Standard score T178.05; respiratory rate 19 times/min, standard score T279.4; mental stress scale Total score 26, Standard score T3118.8; selection of 0.62s for reaction, Standard score T451.84; salivary amylase level 53.5kIU/L, Standard score T581.45; plasma homocysteine level 11.36. mu. mol/L, Standard score T660.22; maximum oxygen uptake of 44.18 ml/kg.min, standard score T758.26; digital memory breadth 7, standard score T850. The stress load SL is calculated to be 74.63, the stress load is higher, and the risk of stress injury or stress-related diseases is increased.
Example 3
The measured persons were 51 students in Beijing in colleges and universities. The stress load SL mean value is 41.71 and is lower than the population mean value, wherein the lowest is 11.68, the highest is 71.60, and the stress load SL of only 1 student is more than or equal to 70 and accounts for 1.96 percent of the measured personnel. After the measurement, the student found a failure in his home within 3 months before the measurement. The measurements suggest that the population is under a lower stress load and has a low risk of developing stress injury or suffering from stress related diseases (figure 1).
Example 4
The measured person is officer and soldier of a certain part of the navy, and the number of the officer and soldier is 45. The work task of the part is heavy, and the working environment has the characteristics of high temperature and high noise. The people need to participate in the shift during the maritime task, and the work and rest cannot be matched with the natural rhythm. The measurement process is completed during the offshore mission. The measurement result shows that the stress load SL of the rescue workers is 57.64 on average, which is higher than the population average, wherein the lowest one is 17.08, the highest one is 98.21, and the stress load SL of 9 rescue workers is more than or equal to 70 and accounts for 20 percent of the measured personnel. The measurement results show that the stress load can be increased during the execution of the maritime mission, the risk of stress injury or stress-related diseases is increased (figure 1), and corresponding medical service support measures are required to be adopted by the army for matching.
Finally, it should be noted that: the present invention has been described in terms of specific examples, which are provided to aid understanding of the invention and are not intended to be limiting. For those skilled in the art to which the invention pertains, numerous and varied variations and substitutions may be made in accordance with the spirit of the invention, and these simple variations and combinations should also be considered as within the scope of the invention disclosed herein.
Claims (10)
1. A non-diagnosis method for measuring human stress load comprises measuring physiological dimension index, measuring psychological dimension index, measuring marker dimension index, measuring operation ability dimension index and calculating stress load; preferably, the method is used for human physiological studies, psychological studies, census demographics or specific population screening.
2. The method of claim 1, wherein the physiological dimension indicator measure comprises a heart rate variability rate total power, respiratory rate measure.
3. The method of claim 2, wherein the total heart rate variability rate is measured using a commercially available cardioelectric heart rate variability analyzer or other device capable of measuring heart rate variability; collecting 5min electrocardiosignals, recording heart rate variability rate total power data with frequency band less than 0.4Hz, and recording as P1The unit: ms is2(ii) a According to the formula: t is1＝19.6(3466–P1) Calculating the standard score of the index by 1018+ 50; and/or the respiratory rate is measured by using a commercial respiratory belt or other devices capable of measuring the respiratory rate or by manually observing the thoracic fluctuation of the measured person; during measurement, a user avoids speaking and suggesting to the measured person so as to avoid influencing the result; count continuously for 1 minute, or count for 30 seconds times 2 to obtain the respiratory rate, which is denoted as P2The unit: the times are/min; calculating according to the formula: t is2＝19.6(P2-16)/2 +50 standard score of the index.
4. The method of claim 1, wherein the psychometric dimension index measures comprise psychometric stress scale scores and selection reaction time measures.
5. The method of claim 4, wherein psychological stressThe scale score is measured by using the following psychological stress self-rating scale; the sum of the scores of the items of the scale is an original score which is marked as P3(ii) a . According to the formula: t is3＝19.6(P3-16)/2.85 +50 calculating the standard score of the index;
psychological stress self-rating scale
And/or the selective reaction is measured by a commercial selective reaction tester or other devices with selective reaction detection function; test twice, and take the best result as the selection reaction, and mark it as P4The unit: s; according to the formula: t is4＝19.6(P4-0.6)/0.19 +50 the standard score of the index is calculated.
6. The method of claim 1, wherein marker dimension index measurements comprise salivary amylase level, plasma homocysteine level measurements.
7. The method of claim 6, wherein salivary amylase levels are measured using a commercially available dry chemistry dipstick/salivary amylase detector or other device with salivary amylase detection capability; the testee fasts, forbids drinking and forbids smoking 15min before sucking the test strip, the saliva amylase detector reads the saliva amylase level and marks the level as P5The unit: kIU/L; according to the formula: t is5＝19.6(P5-19)/21.5 +50 calculating the standard score of the index; and/or plasma homocysteine levels: measuring by adopting a commercially available homocysteine fluorescence POCT detector or a biochemical instrument containing a kit or clinical test; the measured person draws venous blood and separates plasma, detects according to the requirement of detection kit, the reading of the instrument is the plasma homocysteine level, and the blood is taken outIs denoted by P6The unit: mu mol/L; according to the formula: t is6＝19.6(P6-9.8)/3 +50 the standard score of the index is calculated.
8. The method of claim 1, wherein the performance dimension indicator measure comprises a maximum oxygen uptake and a digital memory breadth measure.
9. The method of claim 8, wherein the maximum oxygen uptake is measured using a stepping experiment specified in national military Standard "physical assessment of soldiers" (GJB1337-1992) or a commercially available intelligent device with maximum oxygen uptake detection; maximum oxygen uptake is noted as P7The unit: ml/kg. min; according to the formula: t is7＝19.6(46.5–P7) 5.5+50 calculating the standard score of the index; and/or the digital memory width is measured by a commercial digital memory width detector or other devices with digital memory width detection functions; the digital memory breadth is marked as P8(ii) a According to the formula: t is8＝19.6(7–P8) The standard score for this index was calculated 2+ 50.
10. The method of any of claims 1-9, wherein according to the formula: SL ═ 0.15 (T)1+T3+T5+T7)+0.1(T2+T4+T6+T8) Calculating stress load, and recording as SL; the stress load SL is approximately normally distributed by taking 50 as the center, the smaller the numerical value is, the smaller the stress load is, and the larger the numerical value is, the larger the stress load is; SL ≧ 70 indicates a higher stress load and an increased risk of developing stress injury or suffering stress-related disease.
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