CN113712559B - Human stress load measuring method and application thereof - Google Patents
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Abstract
The application provides a non-diagnostic method for measuring human stress load, which comprises physiological dimension index measurement, psychological dimension index measurement, marker dimension index measurement, operation capacity dimension index measurement and stress load measurement calculation; the method of the application measures and evaluates the four-dimensional mode of stress load from four layers of physiology, psychology, markers and operation capacity, and can more completely reflect the comprehensive characteristics of stress compared with single hormone measurement and single physiological and biochemical measurement; the method has potential guiding significance for optimizing stress control strategies, planning implementation time of pressure management measures and promoting national health level.
Description
Technical Field
The invention belongs to the field of biotechnology and human physiology, and particularly provides a human stress load measurement method and potential application thereof in stress related disease prevention and treatment.
Background
Stress response is a non-specific physiological psychological response of the human body to the generation of internal and external adverse stimulus, and is expressed by the change of stress hormone level and the change of functions of organs of the whole body caused by the stress hormone level, and even comprises psychological behavior change caused by the difference of perception and cognitive evaluation of internal and external environments. With the acceleration of the life rhythm of modern society and the aggravation of social competition, most people are in stress reactions of different degrees. Although stress is critical to the survival and adaptation of the body in adverse environments, prolonged or intense stress can overstretch the body's potential, inducing injury and disease. Epidemiological investigation shows that about 70% of human diseases are related to the activation of the stress injury mechanism of the organism, and the stress is also recognized as a risk factor for cardiovascular and cerebrovascular diseases, cognitive dysfunction, immune dysfunction and other diseases.
Stress load is a term that measures the degree of adverse effects of stress, and refers to the cost of the body's deviation from homeostasis under the influence of a stress source to accommodate adverse factors challenges, and the reconstruction and maintenance of homeostasis beyond the body's original homeostasis. Although the measurement and monitoring of the stress load are the key links of early warning of the stress injury, the method has important significance for the prevention and treatment of stress related diseases, the definition of the stress load is very abstract, and the stress response is a complex process involving almost all systems of an organism, so the method has quite difficulty in quantitative evaluation of the stress load, and an effective measurement method is always lacking.
For a long time, people have generally used glucocorticoids or norepinephrine to assess stress load, but they have rhythmic changes and detection techniques are complex, i.e. inaccuracy does not fully describe the psychological and behavioral effects of stress. The american stress biology expert McEwen proposed a suite of stress load assessment methods in 1997 and had several adjustments over the next ten years to the measurement index involved in the method. The quantification of stress load is realized by measuring ten indexes of systolic pressure, diastolic pressure, serum total cholesterol, serum high density lipoprotein, serum glycosylated hemoglobin, serum dehydroepiandrosterone, urocortisol, uroepinephrine, uronorepinephrine, waist-hip ratio and the like. The method plays an important role in stress evaluation early warning, but the indexes of the method lack systematic organization and classification, only changes of physiological and biochemical indexes are considered, and influences of stress on psychological, behavioral and operation capacity are ignored.
Disclosure of Invention
Aiming at the problems, the applicant follows the characteristic of multi-level comprehensiveness of stress response, proposes a four-dimensional mode for measuring and evaluating stress load from four layers of physiology, psychology, biomarker and operation capacity, and establishes a human stress load measuring method. According to the method, the eight stress related indexes are measured, the stress load indexes are weighted and calculated, and effective measurement of the stress load of a human body is achieved, so that basis is provided for early warning and protection of stress injury and stress related diseases, and self-management and promotion of national health are facilitated.
In one aspect, the present application provides a non-diagnostic method for human stress load measurement, including physiological dimension index measurement, psychological dimension index measurement, marker dimension index measurement, working capacity dimension index measurement, and stress load measurement calculation.
Further, the physiological dimension index measurement includes a heart rate variability total power, a respiratory rate measurement.
Further, the total heart rate variability is measured by using a commercially available electrocardiographic heart rate variability analyzer or other devices capable of measuring heart rate variability; collecting electrocardiosignal for 5min, recording heart rate variability total power data with frequency band less than 0.4Hz, and recording as P 1 Units: ms of 2 The method comprises the steps of carrying out a first treatment on the surface of the According to the formula: t (T) 1 ＝19.6(3466–P 1 ) The standard score of the index was calculated at/1018+50.
The average value of the parameter crowd is 3466ms 2 Standard deviation was 1018ms 2 。
Further, the respiratory rate is measured by using a commercially available respiratory belt or other devices capable of measuring respiratory rate or by manually observing the thoracic relief of the measured person; during measurement, speech implications for a measured person are avoided, so that the result is not influenced; the respiration rate is obtained by multiplying the count for 1 minute continuously or for 30 seconds by 2, and is denoted as P 2 Units: secondary/min; the method comprises the following steps of: t (T) 2 ＝19.6(P 2 -16)/2+50 standard fractions of the index.
The average value of the parameter population is 16 times/min, and the standard deviation is 2 times/min.
Further, the psychological dimension index measurement includes a psychological stress scale score and a measurement at the time of selecting a response.
Further, the psychological stress scale score was measured using the following psychological stress self-scale; the sum of the scores of the entries of the table is the original score, which is recorded as P 3 The method comprises the steps of carrying out a first treatment on the surface of the . According to the formula: t (T) 3 ＝19.6(P 3 -16)/2.85+50 calculate the standard score of the index;
psychological stress self-rating scale
The population mean of the parameter is 16, and the standard deviation is 2.85.
Further, the selection reaction is measured by a commercially available selection reaction tester or other devices with detection function during the selection reaction; testing twice, and marking the best result as P when the best result is taken as the selective reaction 4 Units: s; according to the formula: t (T) 4 ＝19.6(P 4 -0.6)/0.19+50 calculate the standard score for the index.
The mean value of the parameter population is 0.6s, and the standard deviation is 0.19s.
Further, the marker dimension index measurement includes a salivary amylase level, a plasma homocysteine level measurement.
Further, the level of salivary amylase is measured using a commercially available dry chemical test strip/salivary amylase detector or other device with salivary amylase detection function; the test paper strip is taken by the person to be measured, and is fasted, prohibited from drinking and prohibited from smoking 15min before the test paper strip is taken by the person to be measured, and the saliva amylase detector reads the saliva amylase level and marks the saliva amylase level as P 5 Units: kIU/L; according to the formula: t (T) 5 ＝19.6(P 5 -19)/21.5+50 calculate the standard score for the index.
The average value of the parameter population is 19kIU/L, and the standard deviation is 21.5kIU/L.
Plasma of bloodHomocysteine level: the homocysteine fluorescence POCT detector or kit or clinical examination biochemical instrument are adopted for measurement; the measured person draws venous blood and separates blood plasma, the blood plasma is detected according to the requirement of a detection kit, the instrument reads the blood plasma homocysteine level, and the blood plasma homocysteine level is marked as P 6 Units: mu mol/L; according to the formula: t (T) 6 ＝19.6(P 6 -9.8)/3+50 calculate the standard score for the index.
The average value of the parameter population is 9.8 mu mol/L, and the standard deviation is 3 mu mol/L.
Further, the work capacity dimension index measurement includes a maximum oxygen uptake and a digital memory breadth measurement.
Further, the maximum oxygen uptake is measured by a stepping experiment specified in the national military standard soldier physical ability evaluation (GJB 1337-1992) or an intelligent device with the maximum oxygen uptake detection function on the market; the maximum oxygen uptake is denoted as P 7 Units: ml/kg.min; according to the formula: t (T) 7 ＝19.6(46.5–P 7 ) 5.5+50 calculate the standard score for the index.
The average value of the parameter population is 46.5 ml/kg.min, and the standard deviation is 5.5 ml/kg.min.
Further, the digital memory breadth is measured by a commercial digital memory breadth detector or other devices with digital memory breadth detecting functions; the digital memory breadth is denoted as P 8 The method comprises the steps of carrying out a first treatment on the surface of the According to the formula: t (T) 8 ＝19.6(7–P 8 ) And (2) calculating the standard score of the index by using the method of (2+50).
The population mean value of the parameter is 7, and the standard deviation is 2.
Further, according to the formula: sl=0.15 (T 1 +T 3 +T 5 +T 7 )+0.1(T 2 +T 4 +T 6 +T 8 ) Calculating stress load, which is marked as SL; the stress load SL is approximately normally distributed with 50 as a center, and the smaller the value is, the smaller the stress load is, and the larger the value is, the larger the stress load is; SL.gtoreq.70 indicates a higher stress load and an increased risk of developing stress injury or stress related diseases.
The methods of the present application may be diagnostic or non-diagnostic methods including, but not limited to, physiological studies of humans, psychological studies, census of population conditions and screening of specific populations such as soldiers, specialty equipment operators, and the like.
Advantageous effects
The invention provides a four-dimensional mode for measuring and evaluating stress load from four layers of physiology, psychology, markers and operation capacity, which can more completely reflect the comprehensive characteristics of stress compared with single hormone measurement and single physiological and biochemical measurement. The index selected by the method is derived from the stress high-association characterization group and the stress load marker obtained by the research of the inventor, and the measurement accuracy of the stress load is high. The stress load measurement index combination related to the method can be also applicable to other species except human beings after necessary reference value adjustment. The stress load measuring method provided by the invention can make a definition whether the stress load exceeds a reasonable range, and when the stress load SL is more than or equal to 70, the stress load is higher, the risk of the measured person for generating stress injury or suffering from stress related diseases is prompted to be increased. The method has potential guiding significance for optimizing stress control strategies, planning implementation time of pressure management measures and promoting national health level.
Drawings
FIG. 1 is a graph showing the results of the test for stress load of students and naval officials in examples 3 and 4.
Detailed Description
In the following examples, the total heart rate variability is measured by using a DLP6000 heart rate variability analyzer of Shenzhen Jie Nari medical instruments Co., ltd; the respiratory rate is obtained by observing the times of the thoracic cavity fluctuation of the measured person when the measured person measures the total power of the heart rate variability; the psychological stress scale score was measured by using a Li Quan oversubscribed psychological stress self-rating scale (Zhang Zuoji. Handbook of behavioural medical scale [ M ]. Beijing: china medical electronic audio-visual Press 2005:258-259), the scale contents are as follows:
psychological stress self-rating scale
；
The selection reaction is obtained by measuring BD-II-511 visual reaction time measuring instrument of North big green birds; the salivary amylase level was measured using a 59-010 salivary amylase test strip of Nippro corporation, japan; plasma homocysteine level is measured and obtained by adopting a plasma Homocysteine (HCY) detection kit developed by the military medical institute; the maximum oxygen uptake is measured by a JS-2209A dynamometer of Aureotide body building industry Co., ltd; the digital memory breadth was measured using BD-II-407 of North Dahong bird and a breadth measuring instrument. The measuring device used in the examples is not limiting to the invention, and other devices having similar measuring functions are also suitable for the measuring method provided by the invention.
Example 1
The measured person is a student in Beijing certain college. Total power of heart rate variability of 4767ms 2 Standard score T 1 =24.95; respiratory rate of 17 times/min, standard score T 2 =59.8; psychological stress scale total score 12, standard score T 3 =22.49; 0.50s at the time of selective reaction, standard fraction T 4 = 39.33; salivary amylase level 3.5kIU/L, standard score T 5 = 35.87; plasma homocysteine level 9.56 mu mol/L, standard fraction T 6 =48.4; maximum oxygen uptake of 51.2 ml/kg.min, standard score T 7 =33.24; digital memory breadth 7, standard division T 8 =50. The stress load SL is calculated to be 37.24, the stress load is normal, and the risk of stress injury or stress related diseases is low.
Example 2
The person to be measured is a soldier in a navy department. The work task of the part is heavy, and the work environment has the characteristics of high temperature and high noise. The need to participate in the turn-over values during offshore tasks is greater and the work and rest cannot be matched with the natural rhythms. Total heart rate variability of 2009ms was measured 2 Standard score T 1 = 78.05; respiratory rate 19 times/min, standard score T 2 =79.4; psychological stress scale total score 26, standard score T 3 =118.8; 0.62s at the time of selective reaction, standard fraction T 4 =51.84; salivary amylase level 53.5kIU/L, standard score T 5 =81.45; plasma homocysteine level 11.36 mu mol/L, standard fraction T 6 =60.22; maximum oxygen uptake 44.18 ml/kg.min, standard score T 7 =58.26; digital memory breadth 7, standard division T 8 =50. The stress load SL was calculated to be 74.63, and the stress load was higher, and the risk of stress injury or the risk of developing stress-related diseases was increased.
Example 3
The measured person is 51 students in Beijing college and university. The stress load SL average value is 41.71 and is lower than the population overall average value, wherein the lowest stress load SL average value is 11.68, the highest stress load SL average value is 71.60, and the stress load SL of only 1 student is more than or equal to 70 and accounts for 1.96% of the measured person. After the measurement, the investigation found that the birth became a cause in the home within 3 months before the measurement. The measurement results indicate that the population has lower stress load and low risk of developing stress injury or stress-related diseases (figure 1).
Example 4
The measured person is 45 officials and soldiers in the navy. The work task of the part is heavy, and the work environment has the characteristics of high temperature and high noise. The need to participate in the turn-over values during offshore tasks is greater and the work and rest cannot be matched with the natural rhythms. The measurement process is completed during the offshore mission. The measurement result shows that the average value of the stress load SL of the rescue workers is 57.64, which is higher than the overall average value of the people, wherein the lowest value is 17.08, the highest value is 98.21, and the stress load SL of 9 rescue workers is more than or equal to 70, which accounts for 20% of the measured workers. Measurement results show that the stress load can be increased in the process of executing the offshore tasks, the risk of generating stress injury or stress related diseases is increased (figure 1), and the requirement of the army to take corresponding health care measures for matching is indicated.
Finally, it should be noted that: the foregoing description of the invention has been presented for purposes of illustration and description, and is not intended to be limiting. It will be apparent to those skilled in the art that several simple deductions, modifications or substitutions can be made according to the idea of the invention, and these simple modifications and combinations should also be regarded as the disclosure of the invention, which falls within the scope of the invention.
Claims (1)
1. A non-diagnostic method for measuring human stress load comprises physiological dimension index measurement, psychological dimension index measurement, marker dimension index measurement, operation capability dimension index measurement and stress load measurement calculation; the method is used for human physiological research, psychological research, population screening or specific crowd screening; wherein:
the physiological dimension index measurement comprises heart rate variability total power and respiratory rate measurement; the total heart rate variability is measured by a commercial electrocardiograph type heart rate variability analyzer or other devices capable of measuring heart rate variability; collecting electrocardiosignal for 5min, recording heart rate variability total power data with frequency band less than 0.4Hz, and recording as P 1 Units: ms of 2 The method comprises the steps of carrying out a first treatment on the surface of the According to the formula: t (T) 1 ＝19.6(3466–P 1 ) Calculating a standard score of the index by using/1018+50; the respiratory rate is measured by using a commercially available respiratory belt or other devices capable of measuring the respiratory rate or by manually observing the thoracic cavity fluctuation of a measured person; during measurement, speech implications for a measured person are avoided, so that the result is not influenced; the respiration rate is obtained by multiplying the count for 1 minute continuously or for 30 seconds by 2, and is denoted as P 2 Units: secondary/min; the method comprises the following steps of: t (T) 2 ＝19.6(P 2 -16)/2+50 standard fractions of the index;
psychological dimension index measurement includes psychological stress scale score and measurement in response to selection; the psychological stress scale score was measured using the following psychological stress self-scale; the sum of the scores of the entries of the table is the original score, which is recorded as P 3 The method comprises the steps of carrying out a first treatment on the surface of the According to the formula: t (T) 3 ＝19.6(P 3 -16)/2.85+50 calculate the standard score of the index;
psychological stress self-rating scale
；
The reaction is carried out by adopting the commercial selectionA reaction time tester or other devices with a detection function for selecting reaction time for measurement; testing twice, and marking the best result as P when the best result is taken as the selective reaction 4 Units: s; according to the formula: t (T) 4 ＝19.6(P 4 -0.6)/0.19+50 calculate the standard score of the index;
marker dimension index measurements include salivary amylase levels, plasma homocysteine level measurements; the level of the salivary amylase is measured by a commercially available dry chemical test strip/salivary amylase detector or other devices with salivary amylase detection function; the test paper strip is taken by the person to be measured, and is fasted, prohibited from drinking and prohibited from smoking 15min before the test paper strip is taken by the person to be measured, and the saliva amylase detector reads the saliva amylase level and marks the saliva amylase level as P 5 Units: kIU/L; according to the formula: t (T) 5 ＝19.6(P 5 -19)/21.5+50 calculate the standard score of the index; plasma homocysteine levels: the homocysteine fluorescence POCT detector or kit or clinical examination biochemical instrument are adopted for measurement; the measured person draws venous blood and separates blood plasma, the blood plasma is detected according to the requirement of a detection kit, the instrument reads the blood plasma homocysteine level, and the blood plasma homocysteine level is marked as P 6 Units: mu mol/L; according to the formula: t (T) 6 ＝19.6(P 6 -9.8)/3+50 calculate the standard score of the index;
the operation capability dimension index measurement comprises maximum oxygen uptake and digital memory breadth measurement; the maximum oxygen uptake is measured by a stepping experiment specified in the national military standard soldier physical ability evaluation (GJB 1337-1992) or an intelligent device with the maximum oxygen uptake detection function on the market; the maximum oxygen uptake is denoted as P 7 Units: ml/kg.min; according to the formula: t (T) 7 ＝19.6(46.5–P 7 ) 5.5+50 calculating a standard score for the index; and/or the digital memory breadth is measured by a commercial digital memory breadth detector or other devices with digital memory breadth detecting functions; the digital memory breadth is denoted as P 8 The method comprises the steps of carrying out a first treatment on the surface of the According to the formula: t (T) 8 ＝19.6(7–P 8 ) 2+50 calculating a standard score of the index;
the stress load measurement calculation is based on the formula: sl=0.15 (T 1 +T 3 +T 5 +T 7 )+0.1(T 2 +T 4 +T 6 +T 8 ) Calculating stress load, which is marked as SL; the stress load SL is approximately normally distributed with 50 as a center, and the smaller the value is, the smaller the stress load is, and the larger the value is, the larger the stress load is; SL.gtoreq.70 indicates a higher stress load and an increased risk of developing stress injury or stress related diseases.
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