CN113710687A - 环肽抗生素 - Google Patents

环肽抗生素 Download PDF

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Publication number
CN113710687A
CN113710687A CN202080027001.9A CN202080027001A CN113710687A CN 113710687 A CN113710687 A CN 113710687A CN 202080027001 A CN202080027001 A CN 202080027001A CN 113710687 A CN113710687 A CN 113710687A
Authority
CN
China
Prior art keywords
optionally substituted
alkyl
compound
heterocycloalkyl
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080027001.9A
Other languages
English (en)
Chinese (zh)
Inventor
吴国胜
E·J·哈南
M-G·布劳恩
S·拉巴迪
K·加兰德
R·M·帕斯托尔
P·吉本斯
付玉红
程云行
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN113710687A publication Critical patent/CN113710687A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202080027001.9A 2019-03-14 2020-03-12 环肽抗生素 Pending CN113710687A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2019078189 2019-03-14
CNPCT/CN2019/078189 2019-03-14
PCT/US2020/022272 WO2020185999A1 (en) 2019-03-14 2020-03-12 Cyclic peptide antibiotics

Publications (1)

Publication Number Publication Date
CN113710687A true CN113710687A (zh) 2021-11-26

Family

ID=70190176

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080027001.9A Pending CN113710687A (zh) 2019-03-14 2020-03-12 环肽抗生素

Country Status (5)

Country Link
US (1) US12358951B2 (https=)
EP (1) EP3938377A1 (https=)
JP (2) JP7670618B2 (https=)
CN (1) CN113710687A (https=)
WO (1) WO2020185999A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025209164A1 (zh) * 2024-04-03 2025-10-09 上海科技大学 β氨基酯、聚β氨基酯化合物及其制备方法及应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7670618B2 (ja) * 2019-03-14 2025-04-30 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 環状ペプチド抗生物質
WO2022009212A1 (en) * 2020-07-09 2022-01-13 Technion Research And Development Foundation Ltd. TYROSINE, TRYPTOPHAN AND PHENYLALANINE AS mTOR AGONISTS MEDIATING PROTEASOME DYNAMICS, COMPOSITIONS, METHODS AND USES THEREOF IN THERAPY, AND PROGNOSTIC METHODS FOR DRUG-RESISTANCE

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS594990B2 (ja) 1977-05-13 1984-02-02 三共株式会社 抗生物質グロボマイシン
JPS5547644A (en) 1978-10-02 1980-04-04 Meiji Seika Kaisha Ltd New antibiotics sf-1902 a2, a3, a4 and a5 and their preparation
US5384309A (en) 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
US10787490B2 (en) 2015-07-15 2020-09-29 Protaganist Therapeutics, Inc. Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases
US11072616B2 (en) 2015-11-11 2021-07-27 Universite De Montreal Cyclic peptides targeting alpha-4-beta-7 integrin
JP2020533374A (ja) 2017-09-15 2020-11-19 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 環状ペプチド抗生物質
JP7670618B2 (ja) * 2019-03-14 2025-04-30 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 環状ペプチド抗生物質

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025209164A1 (zh) * 2024-04-03 2025-10-09 上海科技大学 β氨基酯、聚β氨基酯化合物及其制备方法及应用

Also Published As

Publication number Publication date
JP2022524151A (ja) 2022-04-27
WO2020185999A1 (en) 2020-09-17
US12358951B2 (en) 2025-07-15
JP2025037920A (ja) 2025-03-18
JP7670618B2 (ja) 2025-04-30
EP3938377A1 (en) 2022-01-19
US20230025834A1 (en) 2023-01-26

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