CN113677667B - 用于rar激活的合成的类视黄醇 - Google Patents

用于rar激活的合成的类视黄醇 Download PDF

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CN113677667B
CN113677667B CN202080018638.1A CN202080018638A CN113677667B CN 113677667 B CN113677667 B CN 113677667B CN 202080018638 A CN202080018638 A CN 202080018638A CN 113677667 B CN113677667 B CN 113677667B
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disease
compound
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alzheimer
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CN113677667A (zh
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安德鲁·怀廷
大卫·奇泽姆
伊恩·格雷格
塔巴特·哈提卜
彼得·麦卡弗里
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University of Durham
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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