GB201903242D0 - Synthetic retinoids for use in rar activation - Google Patents

Synthetic retinoids for use in rar activation

Info

Publication number
GB201903242D0
GB201903242D0 GBGB1903242.4A GB201903242A GB201903242D0 GB 201903242 D0 GB201903242 D0 GB 201903242D0 GB 201903242 A GB201903242 A GB 201903242A GB 201903242 D0 GB201903242 D0 GB 201903242D0
Authority
GB
United Kingdom
Prior art keywords
synthetic retinoids
rar activation
rar
activation
retinoids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1903242.4A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Durham
Original Assignee
University of Durham
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Durham filed Critical University of Durham
Priority to GBGB1903242.4A priority Critical patent/GB201903242D0/en
Publication of GB201903242D0 publication Critical patent/GB201903242D0/en
Priority to MX2021011028A priority patent/MX2021011028A/es
Priority to PCT/GB2020/050607 priority patent/WO2020183173A2/en
Priority to KR1020247035311A priority patent/KR20240159014A/ko
Priority to EP24184646.8A priority patent/EP4414355A3/en
Priority to BR112021017045A priority patent/BR112021017045A2/pt
Priority to AU2020235464A priority patent/AU2020235464B2/en
Priority to SG11202109075WA priority patent/SG11202109075WA/en
Priority to EP20715434.5A priority patent/EP3937923B1/en
Priority to PL20715434.5T priority patent/PL3937923T3/pl
Priority to ES20715434T priority patent/ES2985674T3/es
Priority to NZ779699A priority patent/NZ779699B2/en
Priority to US17/435,939 priority patent/US12344587B2/en
Priority to CA3131108A priority patent/CA3131108A1/en
Priority to CN202080018638.1A priority patent/CN113677667B/zh
Priority to JP2021553136A priority patent/JP7566765B2/ja
Priority to KR1020217032599A priority patent/KR102722925B1/ko
Priority to CN202510439129.0A priority patent/CN120271434A/zh
Priority to JP2024173169A priority patent/JP2025016465A/ja
Priority to US19/231,208 priority patent/US20260000631A1/en
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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GBGB1903242.4A 2019-03-11 2019-03-11 Synthetic retinoids for use in rar activation Ceased GB201903242D0 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
GBGB1903242.4A GB201903242D0 (en) 2019-03-11 2019-03-11 Synthetic retinoids for use in rar activation
CN202510439129.0A CN120271434A (zh) 2019-03-11 2020-03-11 用于rar激活的合成的类视黄醇
EP20715434.5A EP3937923B1 (en) 2019-03-11 2020-03-11 Synthetic retinoids for use in rar activation
ES20715434T ES2985674T3 (es) 2019-03-11 2020-03-11 Retinoides sintéticos para su uso en la activación de RAR
KR1020247035311A KR20240159014A (ko) 2019-03-11 2020-03-11 Rar 활성화에 사용하기 위한 합성 레티노이드
EP24184646.8A EP4414355A3 (en) 2019-03-11 2020-03-11 Synthetic retinoids for use in rar activation
BR112021017045A BR112021017045A2 (pt) 2019-03-11 2020-03-11 Retinoides sintéticos para uso na ativação de rar
AU2020235464A AU2020235464B2 (en) 2019-03-11 2020-03-11 Synthetic retinoids for use in RAR activation
SG11202109075WA SG11202109075WA (en) 2019-03-11 2020-03-11 Synthetic retinoids for use in rar activation
MX2021011028A MX2021011028A (es) 2019-03-11 2020-03-11 Retinoides sinteticos para usarse en la activacion de receptores de acido retinoico.
PL20715434.5T PL3937923T3 (pl) 2019-03-11 2020-03-11 Syntetyczne retinoidy do stosowania w aktywacji rar
PCT/GB2020/050607 WO2020183173A2 (en) 2019-03-11 2020-03-11 Synthetic retinoids for use in rar activation
NZ779699A NZ779699B2 (en) 2020-03-11 Synthetic retinoids for use in rar activation
US17/435,939 US12344587B2 (en) 2019-03-11 2020-03-11 Synthetic retinoids for use in RAR activation
CA3131108A CA3131108A1 (en) 2019-03-11 2020-03-11 Synthetic retinoids for use in rar activation
CN202080018638.1A CN113677667B (zh) 2019-03-11 2020-03-11 用于rar激活的合成的类视黄醇
JP2021553136A JP7566765B2 (ja) 2019-03-11 2020-03-11 Ｒａｒ活性化のための合成レチノイド
KR1020217032599A KR102722925B1 (ko) 2019-03-11 2020-03-11 Rar 활성화에 사용하기 위한 합성 레티노이드
JP2024173169A JP2025016465A (ja) 2019-03-11 2024-10-02 Ｒａｒ活性化のための合成レチノイド
US19/231,208 US20260000631A1 (en) 2019-03-11 2025-06-06 Synthetic retinoids for use in rar activation

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GB201903242D0 (en) * 2019-03-11 2019-04-24 Univ Durham Synthetic retinoids for use in rar activation
CN115974860B (zh) * 2022-12-15 2024-09-24 复旦大学附属中山医院 维甲酸类化合物及其制备方法和用途、含该化合物的药物组合物
GB2638262A (en) 2024-02-16 2025-08-20 Univ Durham Synthetic retinoids for use in RAR activation
GB2642547A (en) * 2024-07-12 2026-01-14 Univ Durham Compounds for use in senotherapy

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US5149705A (en) 1987-03-13 1992-09-22 Allergan, Inc. Acetylenes disubstituted with a heteroaromatic group and a tetralin group and having retinoid like activity
ATE68486T1 (de) * 1988-07-28 1991-11-15 Uriach & Cia Sa J 1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl - 1h-imidazol.
JP2003081834A (ja) * 2001-09-10 2003-03-19 Shiseido Co Ltd ざ瘡治療剤、及びざ瘡治療用皮膚外用剤
RU2010136954A (ru) * 2008-02-06 2012-03-20 Носсира С.А. (Es) Фенилпрениловые производные морского и синтетического происхождения для лечения нарушения познавательной способности, нейродегенеративных или нервных заболеваний или нарушений
CN107176945B (zh) 2016-03-11 2021-06-08 中国科学院上海有机化学研究所 一种视黄酸类化合物、其制备方法、中间体及应用
WO2017152725A1 (zh) * 2016-03-11 2017-09-14 中国科学院上海有机化学研究所 一种视黄酸类化合物、其制备方法、中间体及应用
WO2017174999A1 (en) * 2016-04-07 2017-10-12 High Force Research Limited Synthetic retinoids for use in rar mediated conditions
GB201903242D0 (en) * 2019-03-11 2019-04-24 Univ Durham Synthetic retinoids for use in rar activation

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KR20210150406A (ko) 2021-12-10
CA3131108A1 (en) 2020-09-17
WO2020183173A3 (en) 2020-12-03
ES2985674T3 (es) 2024-11-06
CN113677667A (zh) 2021-11-19
PL3937923T3 (pl) 2024-11-25
WO2020183173A2 (en) 2020-09-17
JP2025016465A (ja) 2025-02-04
AU2020235464A1 (en) 2021-09-30
EP3937923A2 (en) 2022-01-19
EP3937923B1 (en) 2024-07-24
EP3937923C0 (en) 2024-07-24
KR20240159014A (ko) 2024-11-05
CN113677667B (zh) 2025-04-29
AU2020235464B2 (en) 2024-01-25
US20220144783A1 (en) 2022-05-12
MX2021011028A (es) 2021-12-10
JP7566765B2 (ja) 2024-10-15
EP4414355A3 (en) 2024-10-23
KR102722925B1 (ko) 2024-10-25
US20260000631A1 (en) 2026-01-01
NZ779699A (en) 2024-05-31
CN120271434A (zh) 2025-07-08
SG11202109075WA (en) 2021-09-29
BR112021017045A2 (pt) 2021-11-16
US12344587B2 (en) 2025-07-01
EP4414355A2 (en) 2024-08-14
JP2022524111A (ja) 2022-04-27

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