CN113662904A - Acne-removing patch aerosol and preparation method thereof - Google Patents

Abstract

The invention belongs to the technical field of cosmetics, and particularly discloses an acne-removing patch aerosol and a preparation method thereof. The synergistic effect of the components can effectively prevent the formation of acnes and acnes, remove acnes, diminish inflammation, fade and eliminate acne marks, repair skin, whiten skin and reduce irritation to the skin. The product combines the acne-removing material components with the aerosol package to avoid the pollution of the material components, and in addition, the material is released in a patch form in a unique self-made patch form, so that the advantages of the conventional product are reserved, and the acne-removing effect is enhanced in a form of application.

Description

Acne-removing patch aerosol and preparation method thereof

Technical Field

The invention belongs to the technical field of cosmetics, and particularly relates to an acne-removing patch aerosol and a preparation method thereof.

Background

Acne is also called acne clinically, and is a chronic inflammatory dermatosis of hair follicle sebaceous glands. The main cause of the disease is caused by excessive proliferation of Propionibacterium acnes (p.acnes) on human skin, which is a gram-positive brevibacterium, an intracellular parasitic bacterium belonging to the normal flora of the skin and generally residing in the hair follicles and sebaceous glands of the skin. With the development and maturation of teenagers, the horn plugs at the hair follicle mouths and the secretion function of sebaceous glands are obviously increased, so that sebum of the teenagers contains more fatty acids and other components, and the environment is more suitable for the growth and reproduction of P.acnes, thereby becoming one of the most main causes of acne. Acne has various clinical manifestations, and severe people can leave scars which affect the appearance, resulting in obvious psychological problems and a series of social problems for patients.

With the rapid development of science, technology and economy in modern society, more and more factors causing acne exist, wherein the factors mainly comprise the following aspects: firstly, the immunity is reduced along with the increasing of the life and working pressure of people and irregular daily work and rest, the hormone disorder of the endocrine system, the disturbance of the metabolism of the organism and the like are caused to become a common cause of acne, and the second aspect is that improper diet in daily life, such as frequent eating of spicy, high-calorie and sweet and greasy food, can also cause the aggravation of damp and hot in the body to further aggravate the facial acne. The third aspect is that various pollution in our living environment, such as air pollution, optical pollution and the like, and improper cleaning of daily cosmetics after use can cause the skin to have the conditions of pore blockage, bacterial infection and skin inflammation, which causes the acne in people to be more and more generalized, and meanwhile, the acne has the characteristic of easy recurrence, so more and more consumers begin to pay attention to the problem of acne treatment effect.

A great number of cosmetic and nursing products with acne removing effect emerge in the existing market, but the acne removing products have various acne removing effects and have the following defects: 1. the acne removing effect is not obvious. The acne removing effective components added into the product can not effectively solve the acne removing problem or can be used for a long time to achieve the aim of removing acne. 2. The acne is easy to relapse after removing the acne. The damaged skin can not be effectively repaired and nursed in the acne removing process, so that the acne recurs in the later period. 3. The product is susceptible to contamination after being unsealed. Most of the existing acne-removing products are emulsion, paste and gel, and after the acne-removing products are used by consumers, the residues in the products are easily polluted by bacteria due to storage and other problems. 4. It can not act on pox part for a long time. Therefore, the demand for products which can synergistically bring about acne removal, acne generation prevention, inflammation resistance, acne mark removal, mild skin repair and whitening effects, act on acne parts for a long time, avoid secondary pollution of products and bring about better experience to consumers becomes more urgent.

Patent document CN109381356A discloses a sleep night cream containing oligopeptide-1, nicotinamide, white willow bark extract, centella asiatica extract and scutellaria baicalensis extract, which adopts multiple natural extracts, and has the effects of anti-allergy, anti-inflammation, repairing, whitening, freckle removing, mild astringing, pore shrinking and sebum secretion regulation during use, but the anti-allergy, anti-inflammation and repairing effects are poor, and skin is easily damaged.

Patent document CN110302135A discloses a mild acne cream containing niacinamide, centella asiatica extract, scutellaria baicalensis extract, white willow bark extract and the like, which mostly adopts natural ingredients, greatly reduces irritation to skin, solves the problem from the root, enhances the acne removing effect, can achieve the purpose of repairing acne marks after long-term use, is mild and low in irritation, but has the problems of non-lasting effect and easy recurrence.

Through search, no composition of nicotinamide, a bacillus fermentation product, a SCUTELLARIA ALPINA (scutelaria ALPINA) flower/leaf/stem extract, a centella asiatica extract, oligopeptide-1, salicylic acid and a SALIX ALBA (SALIX ALBA) bark extract and an application of the composition in acne-removing cosmetics are found at present.

Disclosure of Invention

The technology of the invention mainly provides an acne removing patch aerosol which has the effects of preventing acnes, removing acnes, diminishing inflammation, controlling oil, fading acne marks, soothing and repairing skin barriers, whitening and the like.

The invention realizes the aim through the following technical scheme: an acne-removing patch aerosol comprises the following raw materials in parts by weight: 15.0-25.0 parts of water, 1.0-4.0 parts of nicotinamide, 0.1-2.0 parts of bacillus fermentation product, 0.1-1.0 part of SCUTELLARIA ALPINA (Scutellaria ALPINA) flower/leaf/stem extract, 10.1-1.0 part of oligopeptide-10.1-1.0 part of oligopeptide, 0.1-1.0 part of centella asiatica (CENTELLA ASIATICA) extract, 1.0-5.0 parts of dipropylene glycol, 0.1-1.0 part of preservative, 0.1-1.0 part of salicylic acid, 0.1-1.0 part of SALIX ALBA (SALIX ALBA) bark extract, 1.0-5.0 parts of ethanol, 10.0-20.0 parts of film forming agent and 50.0-70.0 parts of propellant.

Preferably, the feed comprises the following raw materials in parts by weight: 15.0 parts of water, 4.0 parts of nicotinamide, 2.0 parts of a bacillus fermentation product, 1.0 part of an extract of flowers/leaves/stems of SCUTELLARIA ALPINA (SCUTELLARIA ALPINIA), 13.0 parts of oligopeptide-13.0 parts of an extract of centella asiatica (CENTELLA ASIATICA), 1.0 part of dipropylene glycol, 1.0 part of a preservative, 1.0 part of salicylic acid, 1.0 part of an extract of bark of SALIX ALBA (SALIX ALBA), 1.0 part of ethanol, 14.0 parts of a film forming agent and 55.0 parts of a propellant.

Preferably, the film former consists of an acrylic/ethylhexyl acrylate copolymer and myristic acid.

Preferably, the weight ratio of the acrylic acid (ester)/ethylhexyl acrylate copolymer to myristic acid is (2-3): 1.

preferably, the propellant is dimethyl ether.

Preferably, the preservative is phenoxyethanol.

In the acne-removing patch aerosol disclosed by the invention, the bacillus fermentation product can effectively reduce the formation of propionibacterium acnes biofilm to prevent the formation of acnes; the salicylic acid and Salix ALBA (Salix ALBA) bark extract has antibacterial and antiinflammatory effects on pox; the centella asiatica (CENTELLA ASIATICA) extract and oligopeptide-1 have the effects of eliminating acne marks and repairing and caring damaged skin in the later stage of acne; the niacinamide has the functions of controlling oil, whitening skin, resisting aging and lightening color spots in the whole using period. Salicylic acid, phenoxyethanol and other substances in the formula are easy to generate irritation on the skin, and the SCUTELLARIA ALPINA (Scutellaria ALPINA) flower/leaf/stem extract is introduced into the invention, so that the irritation of the formula can be effectively relieved, and the formula is suitable for sensitive skin. Therefore, the acne patch aerosol disclosed by the invention has the advantages that the components are synergistic, so that the acne can be effectively prevented, the acne regeneration can be inhibited, the inflamed and red and swollen damaged skin can be conditioned, the acne marks and acne marks can be reduced, the cutin can be removed, the pores can be cleaned, the oil can be controlled, the skin cuticle renewal can be promoted, the skin pigmentation can be reduced, the whitening purpose can be achieved, and the acne patch aerosol is an acne skin patch formula with all-round functions from acne removal to skin barrier repair.

The invention is specifically released in a self-forming patch by combining the body with a propellant. When in use, the aerosol of the acne removing patch is uniformly sprayed back and forth with a distance of about 10-15cm from the palm center, then the two palms are pressed together to form a cotton sheet shape, and then the cotton sheet is uncovered and applied to the required part. The shape and the size of the cotton sheet sprayed by the aerosol can be freely controlled by a user, the use is convenient, and the defect that other acne removing products can not act on acne parts for a long time is overcome.

In addition, the invention also provides a preparation method of the acne removing patch aerosol, which specifically comprises the following steps:

s1, taking water with the formula amount, heating, keeping the temperature for half an hour, and cooling;

s2, cooling, adding nicotinamide, Bacillus subtilis fermentation product, flower/leaf/stem extract of Scutellaria ALPINA (Scutellaria ALPINA), oligopeptide-1, and herba Centellae (CENTELLA ASIATICA), and stirring;

s3, mixing acrylic acid (ester)/ethylhexyl acrylate copolymer, dipropylene glycol, antiseptic, salicylic acid and Salix ALBA (Salix ALBA) bark extract uniformly in advance, adding into the system, and stirring uniformly;

s4, taking ethanol and myristic acid according to the formula amount, mixing uniformly in advance, adding into the system, and stirring uniformly;

s5, filling the agent liquid into an aluminum aerosol can, installing an aerosol valve, sealing, filling propellant, carrying out water bath detection, carrying out tank bottom jet coding, installing a valve actuator, installing a protective cover, and thus obtaining the acne-removing patch aerosol.

Further, the water in the step S1 is heated to 85 ℃.

Further, in the step S2, the temperature is decreased to 45 ℃.

Therefore, compared with the prior art, the invention has the advantages that:

the acne removing and inflammation diminishing agent has the advantages of removing acne, sterilizing and diminishing inflammation, resisting inflammation, preventing acne generation and obviously eliminating acne marks and scars.

The skin care cream has the effects of mildly repairing skin barriers, relieving damaged skin and whitening.

The effects of removing cutin, cleaning pores, tightening skin and shrinking pores can be achieved.

And the patch is in a unique self-made patch form, and can act on the pox part for a long time to enhance the product effect.

Fifthly, the packaging form of the aerosol is adopted, so that the stability of a material system is enhanced, and the secondary pollution of the product to the external environment is effectively avoided.

Detailed Description

The present invention will be further described below by way of specific embodiments, but the present invention is not limited to only the following examples. It will be apparent to those skilled in the art that the invention can be modified and replaced with other components having the same effects without departing from the spirit and scope of the invention, and all such modifications and substitutions are deemed to be within the scope of the invention.

The raw materials used in the invention are all conventional commercial products.

For example, the nicotinamide of the invention is available from imperial groups of netherlands under the trade designation NIACINAMIDE PC;

the Bacillus fermentation product is purchased from Riptat, Spain under the Commodity number Uniclay^TM；

The extract of flower/leaf/stem of Scutellaria ALPINA (Scutellaria ALPINA) is purchased from Imperial group of Netherlands, and has a product number of

SCUTELLARIA AO；

The oligopeptide-1 is purchased from Angel Biotech limited of Shenzhen, and the cargo number is

SOligopeptide-1Plus；

The centella asiatica (CENTELLA ASIATICA) extract is obtained from Ganzhou Gajia leaf Biotech limited, and has a product number of asiaticoside (Renovate ASC);

the salicylic acid is purchased from Merck group of Germany, and the product number is

Salicylic Acid extra pure；

The Salix ALBA (Salix ALBA) bark Extract is obtained from PROVITAL GROUP of Spain under the trade designation Willow Extract GNBN.

Example 1 acne removing patch aerosol of the invention and preparation thereof

The formula is as follows: 15.0kg of water, 4.0kg of nicotinamide, 2.0kg of bacillus fermentation product, 1.0kg of SCUTELLARIA ALPINA (SCUTELLARIA ALPINA) flower/leaf/stem extract, 13.0 kg of oligopeptide-13, 1.0kg of centella asiatica (CENTELLA ASIATICA) extract, 10.0kg of acrylate/ethylhexyl acrylate copolymer, 1.0kg of dipropylene glycol, 1.0kg of phenoxyethanol, 1.0kg of salicylic acid, 1.0kg of SALIX ALBA (SALIX ALBA) bark extract, 1.0kg of ethanol, 4.0kg of myristic acid and 55.0kg of dimethyl ether.

Preparation: s1, taking water with the formula amount, heating to 85 ℃, preserving heat for half an hour, and cooling;

s2, cooling to 45 deg.C, adding nicotinamide, Bacillus fermentation product, Scutellaria ALPINA (Scutellaria ALPINA) flower/leaf/stem extract, oligopeptide-1, and centella asiatica (CENTELLA ASIATICA) extract, and stirring;

s3, mixing acrylic acid (ester)/ethylhexyl acrylate copolymer, dipropylene glycol, antiseptic, salicylic acid and Salix ALBA (Salix ALBA) bark extract uniformly in advance, adding into the system, and stirring uniformly;

s4, taking ethanol and myristic acid according to the formula amount, mixing uniformly in advance, adding into the system, and stirring uniformly;

s5, filling the agent liquid into an aluminum aerosol can, installing an aerosol valve, sealing, filling propellant, carrying out water bath detection, carrying out tank bottom jet coding, installing a valve actuator, installing a protective cover, and thus obtaining the acne-removing patch aerosol.

Example 2 acne removing patch aerosol and preparation thereof

The formula is as follows: 19.0kg of water, 1.0kg of nicotinamide, 0.1kg of bacillus fermentation product, 0.1kg of SCUTELLARIA ALPINA (SCUTELLARIA ALPINA) flower/leaf/stem extract, 10.1 kg of oligopeptide-10.1 kg of centella asiatica (CENTELLA ASIATICA) extract, 12.0kg of acrylate/ethylhexyl acrylate copolymer, 1.0kg of dipropylene glycol, 0.8kg of phenoxyethanol, 0.1kg of salicylic acid, 0.1kg of SALIX ALBA (SALIX ALBA) bark extract, 2.0kg of ethanol, 4.0kg of myristic acid and 60.0kg of dimethyl ether.

The preparation method is the same as example 1.

Example 3 acne removing patch aerosol of the invention and preparation thereof

The formula is as follows: 20.0kg of water, 2.0kg of nicotinamide, 1.0kg of bacillus fermentation product, 1.0kg of SCUTELLARIA ALPINA (SCUTELLARIA ALPINA) flower/leaf/stem extract, 11.0kg of oligopeptide-11.0 kg of centella asiatica (CENTELLA ASIATICA) extract, 10.0kg of acrylic acid (ester)/ethylhexyl acrylate copolymer, 1.0kg of dipropylene glycol, 0.5kg of phenoxyethanol, 0.5kg of salicylic acid, 0.5kg of SALIX ALBA (SALIX ALBA) bark extract, 2.0kg of ethanol, 5.0kg of myristic acid and 55.0kg of dimethyl ether.

The preparation method is the same as example 1.

Example 4 acne removing patch aerosol of the invention and preparation thereof

The formula is as follows: 18.0kg of water, 3.0kg of nicotinamide, 2.0kg of a bacillus fermentation product, 0.5kg of a flower/leaf/stem extract of SCUTELLARIA ALPINA (SCUTELLARIA ALPINA), 12.0kg of oligopeptide-12.0 kg of centella asiatica (CENTELLA ASIATICA) extract, 9.0kg of acrylate/ethylhexyl acrylate copolymer, 1.0kg of dipropylene glycol, 0.5kg of phenoxyethanol, 1.0kg of salicylic acid, 1.0kg of a bark extract of SALIX ALBA (SALIX ALBA), 3.0kg of ethanol, 3.0kg of myristic acid and 55.0kg of dimethyl ether.

The preparation method is the same as example 1.

Example 5 acne removing patch aerosol of the invention and preparation thereof

The formula is as follows: 16.0kg of water, 1.0kg of nicotinamide, 0.5kg of bacillus fermentation product, 0.5kg of SCUTELLARIA ALPINA (SCUTELLARIA ALPINA) flower/leaf/stem extract, 10.5 kg of oligopeptide-10.5 kg of centella asiatica (CENTELLA ASIATICA) extract, 11.0kg of acrylic acid (ester)/ethylhexyl acrylate copolymer, 1.0kg of dipropylene glycol, 0.5kg of phenoxyethanol, 0.5kg of salicylic acid, 1.0kg of SALIX ALBA (SALIX ALBA) bark extract, 3.0kg of ethanol, 4.0kg of myristic acid and 60.0kg of dimethyl ether.

The preparation method is the same as example 1.

Comparative example 1

The comparative example differs from example 1 only in that: does not contain the fermentation product of bacillus, salicylic acid and the bark extract of white willow (Salix ALBA), and correspondingly increases the content of dimethyl ether to 59.0 kg.

The preparation process is referred to example 1.

Comparative example 2

The comparative example differs from example 1 only in that: contains no Bacillus fermentation product, and correspondingly increases the content of Salix ALBA (Salix ALBA) bark extract to 2.0 kg.

The preparation process is referred to example 1.

Comparative example 3

The comparative example differs from example 1 only in that: contains no bark extract of white willow (Salix ALBA), and correspondingly increases the content of flower/leaf/stem extract of Scutellaria ALPINA (Scutellaria ALPINA) to 2.0 kg.

The preparation process is referred to example 1.

Comparative example 4

The comparative example differs from example 1 only in that: does not contain Scutellaria ALPINA (Scutellaria ALPINA) flower/leaf/stem extract, and correspondingly increases the nicotinamide content to 5.0 kg.

The preparation process is referred to example 1.

Experimental example I, in vitro bacteriostasis experiment of acne removing patch aerosol on propionibacterium acnes

Firstly, an experimental article: examples 1 to 5 liquid formulations, comparative examples 1 to 3 liquid formulations, and blank liquid

II, an experimental method: taking a test sample with the same dosage, adding the test sample into quantitative MH agar which is melted and cooled to about 50 ℃ to prepare plates with different test sample concentrations, then inoculating propionibacterium acnes, culturing under the environmental condition suitable for the growth of the bacteria, observing the growth condition of the propionibacterium acnes in a culture dish, counting the colony number in the plates, wherein the experimental data are shown in Table 1.

TABLE 1 antibacterial experimental data of acne removing patch aerosol on Propionibacterium acnes

It can be seen from the data of the bacteria count in table 1 that examples 1 to 5 of the present invention can effectively inhibit the growth of propionibacterium acnes, and example 1 has the least number of colonies, i.e., the best bacteriostatic effect, and comparative examples 1 to 3 have poor bacteriostatic effect due to lack of a certain material composition or a certain material component compared to examples 1 to 5 of the present invention. The experiment proves that the acne removing patch aerosol can effectively inhibit the growth of acnes and achieve the effect of effectively removing acnes.

Experimental example II, anti-inflammatory and detumescent effect experiment of acne removing patch aerosol

The anti-inflammatory effect of the acne removing patch aerosol is observed by adopting a xylene-induced mouse ear swelling model in the experiment.

Firstly, experimental animals: 18-22 g of male Kunming mouse; male SD rats, 200-250 g.

II, medicines and reagents: the acne removing patch aerosol comprises the following components of liquid in an amount of 1-5 in example, liquid in an amount of 3-4 in comparative example, dimethylbenzene and normal saline.

Thirdly, an experimental method: 80 healthy male Kunming mice, half of which are male and female, are randomly divided into 8 groups, and 10 mice are selected. 1.0ml of physiological saline is uniformly coated on the left auricle of a blank group of mice respectively, 1.0ml of acne removing patch aerosol in the embodiment 1-5 and 1.0ml of acne removing patch in the comparative example 3-4. After administration for 30min, the left ear of the mouse is gently wiped clean, 0.1mL of dimethylbenzene is uniformly coated on the upper side and the lower side of the mouse, the right ear is used as a control, and after inflammation is caused for 15min, administration is carried out once according to the method. The mice were sacrificed 30min after the last administration by dislocation of cervical vertebrae, ear pieces were taken from the symmetric part of ears by a 6mm punch, weighed by an electronic balance, and the mass difference between the left and right ear pieces was the swelling degree of inflammation. The data are shown in table 2.

TABLE 2 Effect of acne removing Patch Aerosol on xylene-induced ear swelling in mice

The data in Table 2 show that the liquid of the invention in examples 1-5 has obvious inhibition effect on mouse ear swelling induced by dimethylbenzene, the inhibition effect is enhanced along with the increase of the content percentage of the effective material components, each administration group has obvious anti-inflammatory effect compared with a blank control group, the anti-inflammatory inhibition effect of example 1 is strongest, and the anti-inflammatory inhibition effect of examples 1-5 is better than that of comparative examples 3 and 4. From the experiment, the acne removing patch aerosol can obviously inhibit mouse ear swelling caused by dimethylbenzene, namely the acne removing patch aerosol has an obvious anti-inflammatory effect.

Test example III evaluation of irritation to safety of product

Firstly, experimental animals: 28 adult New Zealand rabbits.

II, medicines and reagents: examples 1 to 5 doses of the solution, comparative example 4 doses of the solution, and physiological saline.

Thirdly, an experimental method: 28 healthy adult New Zealand rabbits meeting the requirements are randomly divided into 7 groups, and 4 rabbits in each group are subjected to the same-body left-right self-comparison method. Depilating two sides of the back of a New Zealand rabbit 24 hours before the experiment, wherein the range is 4cm multiplied by 4cm, and leaving the skin of the depilated area without injury for a complete skin test; the skin in the unhairing zone is cut by a blade with a plurality of # shapes until the degree of blood seepage is reached, and the skin is reserved for a damaged skin test. The depilatory areas of the normal skin and the damaged skin on the left side are coated with 0.5ml of physiological saline as blank control, the depilatory areas of the normal skin and the damaged skin on the right side are coated with 0.5ml of the solutions of the examples 1-5 and the solution of the comparative example 4 respectively, the depilatory areas are covered with 1 layer of gauze and one layer of wax paper, and then fixed by non-woven fabric air-bonding and non-irritant adhesive plaster. After 4h the cover was removed and the remaining test sample was removed with warm water. The same method is applied 1 time per day at the same time for 7 days. The skin was observed and recorded for erythema, edema, bleeding points, etc. and the time of occurrence and regression thereof 1h after each removal of the test article and before reapplication. After the last application, the test site was observed and recorded for erythema and edema 1, 24, 48, 72 hours after removal of the test article.

Skin irritation response scoring criteria: no erythema score 0, mild erythema (barely visible) score 1, moderate erythema (clearly visible) score 2, severe erythema score 3, purplish red erythema to mild eschar score 4; no edema was scored at 0 point, mild edema (barely visible) at 1 point, moderate edema (markedly elevated) at 2 points, severe edema (1 mm of skin with clear contour) at 3 points, and severe edema (1 mm or more of skin with enlargement) at 4 points.

Skin irritation response score mean (total score for erythema and eschar + total score for edema)/total number of experimental animals, with the score for each group being the highest for different observation times. Skin irritation intensity grading criteria: score <0.5, no irritation; score 0.5 to <2.0, mild irritability; scoring for 2.0-6.0, and moderate irritation; score >6.0, strong irritation. The results of the experimental scoring are shown in table 3.

TABLE 3 evaluation results of acne removing patch aerosol skin irritation reaction experiment

As can be seen from the experimental data in Table 3, the skin of the New Zealand rabbits in the embodiments 1 to 5 and the blank control group of the invention have no irritation such as erythema and edema, and the average reaction irritation strength scores are both 0; the liquid of the comparative example 4 shows obvious visible erythema within 1-24 hours after the application, but returns to normal within 48 hours, has a score average of 0.5 and has slight irritation.

Compared with the skin damage group 4, obvious visible erythema edema appears within 1-24 h and completely returns to normal within 48h, and no erythema or edema appears in other groups except dark red scab appearing after the blade scratches the normal skin.

Therefore, it can be seen that the solutions of examples 1 to 5 of the present invention are safe and non-irritating to the skin when used, and the experimental data of examples 1 to 5 and comparative example 4 can prove that the SCUTELLARIA ALPINA (scutelaria ALPINA) flower/leaf/stem extract has the effect of significantly relieving irritation of the material components such as salicylic acid and phenoxyethanol to the skin.

Fourth test example, evaluation of acne mark-removing and skin-repairing effect of acne-removing patch aerosol and experiment of acne recurrence-inhibiting effect

Firstly, a tested sample: examples 1-5 acne removing patch aerosol.

Second, the tested population

Sex number: 85 women; 40 men

Age: between 15 and 40 years of age

Skin condition: the face has obvious acne marks without allergic history of dermatosis, and meets the voluntary selection standard of a subject.

Grouping: divided into 5 groups of 25, 17 women, 8 men.

The test method comprises the following steps: applying the test sample to the cleaned affected part 2 times per day, 1 time in the morning and evening, and trying for 1 month according to the actual condition of the subject; subjects maintained good working and resting time and eating habits during the trial period. The feedback condition of the subjects is counted after 1 month, and the subjects are followed up half a year after the experiment, and the pox recurrence condition of the subjects in the examples 1 to 5 is counted, and the results are shown in the following tables 4 to 8.

Table 4 example 1 test results of acne removal patch aerosol

Table 5 example 2 test results for anti-acne patch aerosol

Table 6 example 3 test results of acne removal patch aerosol

Table 7 example 4 test results of acne removal patch aerosol

Table 8 example 5 test results for acne removal patch aerosol

As can be seen from tables 4 to 8, the acne removal patch aerosol of embodiments 1 to 5 of the present invention is approved by most of the subjects, has a good acne mark removal effect, and can repair acne muscle, i.e., improve the conditions of skin allergy, vigorous oil secretion, roughness, etc., wherein the acne removal patch aerosol of embodiment 1 has the highest acceptance.

The data of the acne recurrence rate of the subjects after the follow-up visit for half a year in the table show that the acne removing patch aerosol has obvious effect on reducing the recurrence and regeneration of the acne. In the test of various items, no one in all the subjects has allergy or produces skin prick, red and swollen, pruritus and other conditions.

The experiments show that the synergistic effect of the components in the technology can effectively prevent the formation of the acne, remove the acne, diminish inflammation, remove red swelling, eliminate acne marks, repair and care and whiten skin. Meanwhile, the effectiveness and the durability of the acne treatment effect of the product are enhanced in a special aerosol patch mode.

The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.

Claims (9)

1. The acne-removing patch aerosol is characterized by comprising the following raw materials in parts by weight: 15.0-25.0 parts of water, 1.0-4.0 parts of nicotinamide, 0.1-2.0 parts of bacillus fermentation product, 0.1-1.0 part of SCUTELLARIA ALPINA (Scutellaria ALPINA) flower/leaf/stem extract, 10.1-1.0 part of oligopeptide-10.1-1.0 part of oligopeptide, 0.1-1.0 part of centella asiatica (CENTELLA ASIATICA) extract, 1.0-5.0 parts of dipropylene glycol, 0.1-1.0 part of preservative, 0.1-1.0 part of salicylic acid, 0.1-1.0 part of SALIX ALBA (SALIX ALBA) bark extract, 1.0-5.0 parts of ethanol, 10.0-20.0 parts of film forming agent and 50.0-70.0 parts of propellant.

2. The acne-removing patch aerosol as claimed in claim 1, which comprises the following raw materials in parts by weight: 15.0 parts of water, 4.0 parts of nicotinamide, 2.0 parts of a bacillus fermentation product, 1.0 part of an extract of flowers/leaves/stems of SCUTELLARIA ALPINA (SCUTELLARIA ALPINIA), 13.0 parts of oligopeptide-13.0 parts of an extract of centella asiatica (CENTELLA ASIATICA), 1.0 part of dipropylene glycol, 1.0 part of a preservative, 1.0 part of salicylic acid, 1.0 part of an extract of bark of SALIX ALBA (SALIX ALBA), 1.0 part of ethanol, 14.0 parts of a film forming agent and 55.0 parts of a propellant.

3. The aerosol for acne removal patch according to claim 1 or 2, wherein the film-forming agent consists of (ester) acrylate/ethylhexyl acrylate copolymer and myristic acid.

4. The acne removal patch aerosol according to claim 3, wherein the weight ratio of the (ester) acrylate/ethylhexyl acrylate copolymer to the myristic acid is (2-3): 1.

5. the aerosol for acne removal patch according to claim 1 or 2, wherein the propellant is dimethyl ether.

6. The aerosol for acne removal patch according to claim 1 or 2, wherein the preservative is phenoxyethanol.

7. The preparation method of the acne-removing patch aerosol according to claim 3, which comprises the following steps:

s1, taking water with the formula amount, heating, keeping the temperature for half an hour, and cooling;

s2, cooling, adding nicotinamide, Bacillus subtilis fermentation product, flower/leaf/stem extract of Scutellaria ALPINA (Scutellaria ALPINA), oligopeptide-1, and herba Centellae (CENTELLA ASIATICA), and stirring;

s3, mixing acrylic acid (ester)/ethylhexyl acrylate copolymer, dipropylene glycol, antiseptic, salicylic acid and Salix ALBA (Salix ALBA) bark extract uniformly in advance, adding into the system, and stirring uniformly;

s4, taking ethanol and myristic acid according to the formula amount, mixing uniformly in advance, adding into the system, and stirring uniformly;

s5, filling the agent liquid into an aluminum aerosol can, installing an aerosol valve, sealing, filling propellant, carrying out water bath detection, carrying out tank bottom jet coding, installing a valve actuator, installing a protective cover, and thus obtaining the acne-removing patch aerosol.

8. The method for preparing the acne-removing patch aerosol according to claim 7, wherein the water in the step S1 is heated to 85 ℃.

9. The preparation method of the acne-removing patch aerosol according to claim 7, wherein the temperature is reduced to 45 ℃ in the step S2.