CN113648340A - Substitutional tea with functions of relieving allergy and improving immunity and preparation method - Google Patents

Substitutional tea with functions of relieving allergy and improving immunity and preparation method Download PDF

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Publication number
CN113648340A
CN113648340A CN202111147112.6A CN202111147112A CN113648340A CN 113648340 A CN113648340 A CN 113648340A CN 202111147112 A CN202111147112 A CN 202111147112A CN 113648340 A CN113648340 A CN 113648340A
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parts
hericium erinaceus
improving immunity
raw material
freeze
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Inventor
陈晓明
张东星
陈颖
宋兆伟
崔瀚元
张越
李淑芳
丁舒
陈龙
张晓�
张峻
张志军
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Tianjin Academy of Agricultural Sciences
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Priority to ZA2022/10551A priority patent/ZA202210551B/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F3/00—Tea; Tea substitutes; Preparations thereof
    • A23F3/34—Tea substitutes, e.g. matè; Extracts or infusions thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
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  • Immunology (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Experiments show that the substituted tea formula provided by the invention has double effects of relieving allergy and improving immunity, the effective rate can reach 83% or more, and the substituted tea also has the effect of inhibiting the growth of human liver cancer tumor cells (Bel7402) and human lung cancer tumor cells (A549), and is more beneficial to comprehensively conditioning the health after being taken for a long time. The invention has the advantages of relatively low preparation cost, simple process, no solvent residue and safe eating, and can be used for developing health-care functional foods and medicines, thereby having good popularization value and market potential.

Description

Substitutional tea with functions of relieving allergy and improving immunity and preparation method
Technical Field
The invention provides substitutional tea capable of relieving allergy and improving immunity and a preparation method thereof, belonging to the technical field of agricultural product processing.
Background
Due to the influence of climate and environment, people with anaphylactic reaction are more and more, and particularly when seasons and living environments change, people are more prone to anaphylactic reaction due to external stimulation and changes of self organisms. The new coronavirus pneumonia spread worldwide recently also makes people experience the importance of immunity. Therefore, in recent years, the concept of 'major health' is deeply popular, and the major health is a global concept proposed according to the change of times development, social needs and disease spectrum. The health management system is provided under the guidance of an idea of comprehensively caring the whole life process, focuses on various dangerous factors and error regions influencing health around the clothes and the eating and housing of people and the life, and advocates self health management. It pursues not only the physical health of an individual but also the complete health in terms of mental, psychological, physiological, social, environmental, ethical, etc. The advocated method not only has scientific healthy life, but also has correct healthy consumption and the like. Its scope relates to all types of health-related information, products and services, and to the actions taken by all types of organizations to meet the health needs of society. Under the background of a big health idea, the application of the invention is researched by combining with the major and achievement bases, and the purpose is to create the substitutional tea with the double functions of relieving allergy and improving immunity. The food intake is used for relieving the symptoms and improving immunity, is convenient and safe, and does not cause more psychological burden to people.
The products for preventing allergy and improving immunity are also available in the market at present, and the published data shows that CN201710911506.1, an extraction method of hericium erinaceus antiallergic activity polysaccharide, has an obvious inhibition effect on hyaluronidase and has antiallergic activity. The invention discloses a gordon europaea substitutional tea and a preparation method thereof, and relates to the technical field of tea drink processing, wherein the gordon europaea substitutional tea comprises the following raw material components in parts by weight: 35-50 parts of gorse flabellatus, 10-30 parts of wolfberry fruit, 10-20 parts of rhizoma polygonati, 10-20 parts of poria cocos and 10-20 parts of raspberry. The disclosed material has relevant researches on allergy and immunity improvement, but does not research the combined effect of the allergy and the immunity improvement, but the invention has double effects of allergy relief and immunity improvement, and the substitute tea of the invention also has the effect of inhibiting the growth of human liver cancer tumor cells (Bel7402) and human lung cancer tumor cells (A549).
Disclosure of Invention
The invention aims to provide substitutional tea with the functions of relieving allergy and improving immunity and a preparation method thereof.
The substitutional tea for relieving allergy and improving immunity and the preparation method thereof comprise the following components in parts by weight: 20-100 parts of hericium erinaceus, 20-100 parts of sparrow's canary, 1-10 parts of liquorice and 1-10 parts of momordica grosvenori.
Preferably, the composition comprises the following components in parts by weight: 20-80 parts of hericium erinaceus, 30-100 parts of sparrow's canary, 1-8 parts of liquorice and 1-8 parts of momordica grosvenori.
Further preferably, the composition comprises the following components in parts by weight: 20-30 parts of hericium erinaceus, 60-70 parts of sparrow's canary, 1-5 parts of liquorice and 1-5 parts of momordica grosvenori.
As a preferred embodiment of the present invention, the composition comprises the following components in parts by weight: 20-30 parts of hericium erinaceus, 60-70 parts of sparrow's canary, 1-3 parts of liquorice and 1-3 parts of momordica grosvenori.
In the above composition:
the weight parts can be the weight units known in the medical field such as mu g, mg, g, kg, and the like, and can also be multiples thereof such as 1/10, 1/100, 10, 100, and the like.
The Hericium erinaceus, the broom cypress, the liquorice and the momordica grosvenori can be obtained from markets.
The composition of the invention can be broken by a conventional method mastered by a person skilled in the art, and made into substitutional tea according to actual requirements.
The invention discloses substitutional tea with the functions of relieving allergy and improving immunity and a preparation method thereof, wherein the substitutional tea comprises the following steps:
1) freeze thawing Hericium Erinaceus, drying, mixing with flos Caraganae Sinicae, Glycyrrhrizae radix, and fructus Siraitiae Grosvenorii at a certain proportion, pulverizing, sieving, selecting 20-60 mesh granules, weighing the above raw materials at a certain proportion, and mixing well. Wherein the freeze-thaw conditions of the hericium erinaceus are as follows: spraying a certain amount of water into the raw material of the dried hericium erinaceus to enable the water content to reach 20-25%, and then placing the raw material in a closed environment at the temperature of-18-70 ℃ for 18-24 hours;
2) And subpackaging the mixed mixture into small packages of 3-5g, and filling into food-grade filter paper bags to obtain the product.
The method comprises the following steps:
the composition provided by the invention has the following advantages:
1. the hericium erinaceus, the gorgon euryale seed, the liquorice and the momordica grosvenori are used as main raw materials, various components are reasonably combined and matched, the functions of relieving allergy and improving immunity are achieved in multiple ways and in multiple levels, and the hericium erinaceus-momordica grosvenori-fructus-momordica-containing oral liquid is suitable for the common problems of allergy and low immunity in daily life.
2. The substitute tea provided by the invention has coordinated color after being brewed, and has the special fragrance of mushroom and plants.
3. Experiments show that the problems of allergy and low immunity of volunteers taking the composition and the preparation provided by the invention can be improved, and the effective rate is more than 83%.
4. Through in vitro cell activity screening, the substitute tea product disclosed by the invention is found to have an inhibition rate of 14% or more on human liver cancer tumor cells (Bel7402) and an inhibition rate of 20% or more on human lung cancer tumor cells (A549) when the final concentration is 5 mug/ml.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
The processing method of the present invention will be described below with reference to specific examples, but the present invention is not limited thereto. The methods described in the following examples are conventional methods unless otherwise specified; the reagents and materials and equipment are commercially available, unless otherwise specified. In the following examples:
The hericium erinaceus is a dry product and is provided by agricultural product fresh-keeping and processing technology research institute of agricultural academy of agricultural sciences in Tianjin;
the used sparrow flowers are imported from south Africa and purchased from Tianjin Yibeiyuan Natural products technology GmbH;
the liquorice and the momordica grosvenori meet the 2015 pharmacopoeia standard and are purchased from Tianjin Yibeiyuan natural product technology limited company.
Example 1:
the formula is as follows: 65 parts of gorse flabellifolia, 20 parts of hericium erinaceus, 1.5 parts of liquorice and 1.5 parts of momordica grosvenori.
The invention discloses substitutional tea with the functions of relieving allergy and improving immunity and a preparation method thereof, wherein the substitutional tea comprises the following steps:
1) freeze thawing Hericium erinaceus, drying, mixing with broom cypress, licorice and Momordica grosvenori in proportion, pulverizing, sieving, selecting 40 mesh granules, weighing the above raw materials according to a ratio, and mixing uniformly. Wherein the freeze-thaw conditions of the hericium erinaceus are as follows: spraying a certain amount of water into the raw material of the dried hericium erinaceus to enable the water content to reach 20%, and then placing the raw material in a closed environment at the temperature of-18 ℃ for 24 hours;
2) and subpackaging the mixed mixture into small packages of 3g, and filling into food-grade filter paper bags to obtain the product.
The results of screening for the in vitro growth inhibitory activity of tumor cells using tea substitutes prepared in this example are shown in Table 1.
TABLE 1 results of tumor cell growth inhibition in vitro (SRB method)
Figure BDA0003285764790000031
Example 2:
the formula is as follows: 70 parts of sparrow's broom, 30 parts of hericium erinaceus, 1.8 parts of liquorice and 1.8 parts of momordica grosvenori.
The invention discloses substitutional tea with the functions of relieving allergy and improving immunity and a preparation method thereof, wherein the substitutional tea comprises the following steps:
1) freeze thawing Hericium erinaceus, drying, mixing with flos Caraganae Sinicae, Glycyrrhrizae radix, and fructus Siraitiae Grosvenorii at a certain proportion, pulverizing, sieving, selecting 20 mesh granules, weighing the above raw materials at a certain ratio, and mixing. Wherein the freeze-thaw conditions of the hericium erinaceus are as follows: spraying a certain amount of water into the raw material of the dried hericium erinaceus to enable the water content to reach 22%, and then placing the raw material in a closed environment at the temperature of 28 ℃ below zero for 19 hours;
2) and subpackaging the mixed mixture into small packages of 3g, and filling into food-grade filter paper bags to obtain the product.
The results of screening for the in vitro growth inhibitory activity of tumor cells using tea substitutes prepared in this example are shown in Table 2.
TABLE 2 results of tumor cell growth inhibition in vitro (SRB method)
Figure BDA0003285764790000041
Example 3:
the formula is as follows: 67 parts of gorse flabellifolia, 28 parts of hericium erinaceus, 2 parts of liquorice and 2 parts of momordica grosvenori.
The invention discloses substitutional tea with the functions of relieving allergy and improving immunity and a preparation method thereof, wherein the substitutional tea comprises the following steps:
1) Freeze thawing Hericium erinaceus, drying, mixing with broom cypress, licorice and Momordica grosvenori in proportion, pulverizing, sieving, selecting 60 mesh granules, weighing the above raw materials according to a ratio, and mixing uniformly. Wherein the freeze-thaw conditions of the hericium erinaceus are as follows: spraying a certain amount of water into the raw material of the dried hericium erinaceus to enable the water content to reach 25%, and then placing the raw material in a closed environment at the temperature of-70 ℃ for 18 hours;
2) and subpackaging the mixed mixture into small packages of 3g, and filling into food-grade filter paper bags to obtain the product.
The results of screening for the in vitro growth inhibitory activity of tumor cells using tea substitutes prepared in this example are shown in Table 3.
TABLE 3 results of tumor cell growth inhibition in vitro (SRB method)
Figure BDA0003285764790000042
Comparative example 1:
the formula of the published document CN 201810347146.1: 40 parts of gorse flabellatus, 15 parts of medlar, 15 parts of rhizoma polygonati, 15 parts of tuckahoe and 10 parts of raspberry.
Comparative example 2:
the formula is as follows: 67 parts of gorse canary, 2 parts of liquorice and 2 parts of momordica grosvenori.
Comparative example 3:
the formula is as follows: 28 parts of hericium erinaceus, 2 parts of liquorice and 2 parts of momordica grosvenori
Teabags containing the compositions of examples 1-3 and comparative examples 1-3 were prepared in a manner conventional in the art.
Experimental example: experiments for proving that the invention has the functions of relieving allergy and improving immunity
1. Selecting a crowd:
selecting the population 20-60 years old, which is easy to cause skin allergy, allergic rhinitis symptom and cold (1-2 cold per month)
2. Experiment grouping
180 of 210 volunteers took the products provided in examples 1-3 and comparative examples 1-3, respectively, and 30 volunteers did not take any product, as a blank control group, wherein:
3. the experimental method comprises the following steps: the composition is taken three times a day after three meals according to the taking dosage, and is brewed with 3g of hot water for 3 times each time and is continuously taken for 2 months.
4. The result of the allergy alleviation experiment is as follows: see table 4.
TABLE 4 allergy relief test results
Figure BDA0003285764790000051
Figure BDA0003285764790000061
Table 4 the results show:
after 2-month test, the allergic symptoms of the volunteers taking the blank control group are not obviously relieved; the effective rate of allergy relief of the product prepared by the formula of the invention can reach 83 percent.
5. The experimental result for improving the immunity is as follows: see Table 5
Table 5: experimental conditions for improving immunity
Figure BDA0003285764790000062
Table 5 the results show:
after 2-month test, the immunity of the volunteers taking the blank control group is not obviously improved; the product prepared by the formula of the invention has the effective rate of improving immunity (reducing the number of cold) up to 80 percent.
Although the invention has been described in detail hereinabove with respect to a general description and specific embodiments thereof, it will be apparent to those skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.

Claims (3)

1. The invention provides substitutional tea with the functions of relieving allergy and improving immunity and a preparation method thereof, and is characterized by comprising the following components in parts by weight: 20-100 parts of hericium erinaceus, 20-100 parts of sparrow's canary, 1-10 parts of liquorice and 1-10 parts of momordica grosvenori.
2. The invention discloses substitutional tea with the functions of relieving allergy and improving immunity and a preparation method thereof, wherein the substitutional tea comprises the following steps:
1) freeze thawing Hericium Erinaceus, drying, mixing with flos Caraganae Sinicae, Glycyrrhrizae radix, and fructus Siraitiae Grosvenorii at a certain proportion, pulverizing, sieving, selecting 20-60 mesh granules, weighing the above raw materials at a certain proportion, and mixing well. Wherein the freeze-thaw conditions of the hericium erinaceus are as follows: spraying a certain amount of water into the raw material of the dried hericium erinaceus to enable the water content to reach 20-25%, and then placing the raw material in a closed environment at the temperature of-18-70 ℃ for 18-24 hours;
2) and subpackaging the mixed mixture into small packages of 3-5g, and filling into food-grade filter paper bags to obtain the product.
3. The method according to any one of claims 1 or 2, wherein in step 1) of claim 2, the hericium erinaceus is freeze-thawed and dried, then the hericium erinaceus is mixed with the broom cypress, the liquorice and the momordica grosvenori in proportion, then the mixture is crushed and sieved, particles of 20-60 meshes are selected, the raw materials are weighed according to the proportion, and the mixture is uniformly mixed. Wherein the freeze-thaw conditions of the hericium erinaceus are as follows: spraying a certain amount of water into the raw material of the dried hericium erinaceus to enable the water content to reach 20-25%, and then placing the raw material into a closed environment at the temperature of-18-70 ℃ for 18-24 hours.
CN202111147112.6A 2021-09-29 2021-09-29 Substitutional tea with functions of relieving allergy and improving immunity and preparation method Pending CN113648340A (en)

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CN111328898A (en) * 2020-03-03 2020-06-26 上海蒂歌科技有限公司 Genistis sinica flower substitutional tea and preparation method thereof

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张扬，等: "响应面分析法在食用菌领域的应用", 《中国食用菌》 *
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Application publication date: 20211116