CN113648044A - High-voltage transmitting circuit for catheter and ablation tool - Google Patents

High-voltage transmitting circuit for catheter and ablation tool Download PDF

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CN113648044A
CN113648044A CN202110875450.5A CN202110875450A CN113648044A CN 113648044 A CN113648044 A CN 113648044A CN 202110875450 A CN202110875450 A CN 202110875450A CN 113648044 A CN113648044 A CN 113648044A
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electrode
voltage
high voltage
transmitting circuit
switching tube
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赵成刚
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Suzhou Aikemai Medical Technology Co ltd
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Suzhou Aikemai Medical Technology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00345—Vascular system
    • A61B2018/00351—Heart
    • A61B2018/00375—Ostium, e.g. ostium of pulmonary vein or artery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00613—Irreversible electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00696—Controlled or regulated parameters
    • A61B2018/00767—Voltage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/0091—Handpieces of the surgical instrument or device

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Abstract

The invention discloses a high-voltage transmitting circuit and an ablation tool for a catheter, wherein a first electrode and a second electrode are arranged on the catheter, and the high-voltage transmitting circuit comprises: the device comprises a first transmitting circuit, a second transmitting circuit and a control circuit, wherein the transmitting end of the first transmitting circuit is connected with a first electrode and is used for outputting positive high voltage, negative high voltage or zero voltage to the first electrode; the transmitting end of the second transmitting circuit is connected with the second electrode and is used for outputting positive high voltage, negative high voltage or zero voltage to the second electrode; the control circuit is respectively connected with the first transmitting circuit and the second transmitting circuit and used for controlling the first transmitting circuit and the second transmitting circuit so as to form positive high voltage, negative high voltage, double high voltage or zero voltage between the first electrode and the second electrode. Therefore, the precise control and flexible adjustment of the pulse voltage of the catheter are realized, the treatment requirements in various pulsed electric field ablation operations are met, and the application prospect of the pulsed electric field ablation technology in arrhythmia treatment is improved to a great extent.

Description

High-voltage transmitting circuit for catheter and ablation tool
Technical Field
The invention relates to the technical field of pulsed electric field ablation, in particular to a high-voltage transmitting circuit for a catheter and an ablation tool.
Background
The ablation energy in the catheter ablation technology adopted for treating arrhythmia at present is mainly radio frequency energy and is assisted by freezing energy, and the two ablation modes have certain superiority in treating arrhythmia and have corresponding limitations, for example, the ablation energy has no selectivity for damaging tissues in an ablation area, and certain damage can be caused to adjacent esophagus, coronary artery, phrenic nerve and the like depending on the adhesion force of a catheter, so that the related technology of finding a quick, safe and efficient ablation energy to complete and achieve persistent pulmonary vein isolation without damaging adjacent tissues becomes a hotspot of research.
Pulsed electric field ablation is a new type of ablation using pulsed electric field as energy, and is gaining attention as a non-thermal ablation technique in clinical application. The pulsed electric field ablation technology is mainly characterized in that a high-voltage pulsed electric field with the pulse width of millisecond, microsecond or even nanosecond is generated, extremely high energy is released in a short time, and a cell membrane, even intracellular organelles such as endoplasmic reticulum, mitochondria, cell nucleus and the like can generate a large number of irreversible micropores, so that apoptosis of pathological cells is caused, and the expected treatment purpose is achieved. However, as a novel energy ablation technology, pulsed electric field ablation has the defects of inaccurate pulse voltage control, inflexible pulse voltage adjustment and the like, so that the application of the pulsed electric field ablation technology in clinic is limited.
Disclosure of Invention
The present invention is directed to solving, at least to some extent, one of the technical problems in the related art. Therefore, the first objective of the present invention is to provide a high voltage transmitting circuit for a catheter, which realizes precise control and flexible adjustment of the pulse voltage of the catheter, meets the treatment requirements in various pulsed electric field ablation operations, and greatly improves the application prospect of the pulsed electric field ablation technology in arrhythmia treatment.
A second object of the invention is to propose an ablation instrument.
In order to achieve the above object, a first embodiment of the present invention provides a high voltage transmitting circuit for a catheter, the catheter having a first electrode and a second electrode, the high voltage transmitting circuit comprising: the first end of the first transmitting circuit is connected with the high-voltage anode, the second end of the first transmitting circuit is connected with the high-voltage ground, the third end of the first transmitting circuit is connected with the high-voltage cathode, and the transmitting end of the first transmitting circuit is connected with the first electrode and used for outputting positive high voltage, negative high voltage or zero voltage to the first electrode; the first end of the second transmitting circuit is connected with the high-voltage anode, the second end of the second transmitting circuit is connected with a high-voltage ground, the third end of the second transmitting circuit is connected with the high-voltage cathode, and the transmitting end of the second transmitting circuit is connected with the second electrode and used for outputting positive high voltage, negative high voltage or zero voltage to the second electrode; and the control circuit is respectively connected with the first transmitting circuit and the second transmitting circuit and is used for controlling the first transmitting circuit and the second transmitting circuit so as to form positive high voltage, negative high voltage, double high voltage or zero voltage between the first electrode and the second electrode.
According to the high-voltage transmitting circuit for the catheter, disclosed by the embodiment of the invention, the first transmitting circuit is connected with the first electrode and used for outputting positive high voltage, negative high voltage or zero voltage to the first electrode, the second transmitting circuit is connected with the second electrode and used for outputting positive high voltage, negative high voltage or zero voltage to the second electrode, and the first transmitting circuit and the second transmitting circuit are respectively controlled through the control circuit so that positive high voltage, negative high voltage, double high voltage or zero voltage is formed between the first electrode and the second electrode. Therefore, the precise control and flexible adjustment of the pulse voltage of the catheter are realized, the treatment requirements in various pulsed electric field ablation operations are met, and the application prospect of the pulsed electric field ablation technology in arrhythmia treatment is improved to a great extent.
According to one embodiment of the present invention, a first transmission circuit includes: the first end of the first switch tube is connected with the high-voltage positive electrode, the second end of the first switch tube, the first end of the second switch tube and the first end of the third switch tube are connected with the first electrode, the second end of the second switch tube is connected with the high-voltage ground, the second end of the third switch tube is connected with the high-voltage negative electrode, and the control end of the first switch tube, the control end of the second switch tube and the control end of the third switch tube are respectively connected with the control circuit.
According to one embodiment of the present invention, the second transmission circuit includes: the first end of the fourth switch tube is connected with the high-voltage positive electrode, the second end of the fourth switch tube, the first end of the fifth switch tube and the first end of the sixth switch tube are connected with the second electrode, the second end of the fifth switch tube is connected with the high-voltage ground, the second end of the sixth switch tube is connected with the high-voltage negative electrode, and the control end of the fourth switch tube, the control end of the fifth switch tube and the control end of the sixth switch tube are connected with the control circuit respectively.
According to an embodiment of the present invention, when the second electrode is used as a reference electrode, wherein when the first switching tube and the fifth switching tube are in a conducting state, a positive high voltage with the second electrode as the reference electrode is formed between the first electrode and the second electrode; when the third switching tube and the fifth switching tube are in a conducting state, a negative high voltage with the second electrode as a reference electrode is formed between the first electrode and the second electrode; when the second switching tube and the fifth switching tube are in a conducting state, zero voltage with the second electrode as a reference electrode is formed between the first electrode and the second electrode; when the first switching tube and the sixth switching tube are in a conducting state, a high voltage which is multiplied by the second electrode as a reference electrode is formed between the first electrode and the second electrode.
According to an embodiment of the present invention, when the first electrode is used as a reference electrode, wherein when the fourth switching tube and the second switching tube are in a conducting state, a positive high voltage with the first electrode as the reference electrode is formed between the first electrode and the second electrode; when the sixth switching tube and the second switching tube are in a conducting state, a negative high voltage taking the first electrode as a reference electrode is formed between the first electrode and the second electrode; when the fifth switching tube and the second switching tube are in a conducting state, zero voltage with the first electrode as a reference electrode is formed between the first electrode and the second electrode; when the fourth switching tube and the third switching tube are in a conducting state, a high voltage which is multiplied by the first electrode as a reference electrode is formed between the first electrode and the second electrode.
According to one embodiment of the invention, the first switch tube to the sixth switch tube have the same structure and are respectively composed of a plurality of switch tubes which are reversely connected.
According to an embodiment of the present invention, the first transmitting circuit further includes: the first resistor is connected between the first end of the first switching tube and the high-voltage positive electrode in series, and the second resistor is connected between the second end of the third switching tube and the high-voltage negative electrode in series.
According to an embodiment of the present invention, the second transmission circuit further includes: the third resistor is connected between the first end of the fourth switching tube and the high-voltage positive electrode in series, and the fourth resistor is connected between the second end of the sixth switching tube and the high-voltage negative electrode in series.
According to an embodiment of the present invention, the high voltage transmitting circuit further includes: and one end of the sampling resistor is connected with the second end of the first transmitting circuit and the second end of the second transmitting circuit respectively, and the other end of the sampling resistor is connected with a high-voltage ground.
According to one embodiment of the present invention, each of the first electrodes and the second electrodes includes a plurality of electrodes, each of the first electrodes is provided with a first transmitting circuit, and each of the second electrodes is provided with a second transmitting circuit.
In order to achieve the above object, a second aspect of the present invention provides an ablation instrument, which includes a catheter and a high voltage transmitting circuit for the catheter as in the first aspect.
According to the ablation tool provided by the embodiment of the invention, through the high-voltage transmitting circuit for the catheter, the precise control and flexible adjustment of the pulse voltage of the catheter are realized, the treatment requirements in various pulsed electric field ablation operations are met, and the application prospect of the pulsed electric field ablation technology in arrhythmia treatment is improved to a great extent.
Additional aspects and advantages of the invention will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention.
Drawings
FIG. 1 is a schematic diagram of a high voltage transmit circuit for a catheter according to a first embodiment of the present invention;
FIG. 2 is a schematic diagram of a high voltage transmitting circuit for a catheter according to a second embodiment of the present invention;
FIG. 3 is a pulse voltage waveform diagram for a high voltage transmit circuit for a conduit according to one embodiment of the present invention;
FIG. 4 is a schematic diagram of a high voltage transmitting circuit for a catheter according to a third embodiment of the present invention;
FIG. 5 is a schematic diagram of a high voltage transmitting circuit for a catheter according to a fourth embodiment of the present invention;
FIG. 6 is a schematic diagram of a high voltage transmitting circuit for a catheter according to a fifth embodiment of the present invention;
fig. 7 is a schematic structural view of an ablation instrument in accordance with an embodiment of the invention.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are illustrative and intended to be illustrative of the invention and are not to be construed as limiting the invention.
The high voltage transmitting circuit for a catheter and an ablation instrument according to embodiments of the present invention will be described with reference to the accompanying drawings.
Fig. 1 is a schematic structural view of a high voltage transmitting circuit for a catheter according to a first embodiment of the present invention, and referring to fig. 1, the catheter is provided with a first electrode P1 and a second electrode P2, and the high voltage transmitting circuit includes: a first transmitting circuit 110, a second transmitting circuit 120, and a control circuit 130.
The first end of the first transmitting circuit 110 is connected with the high-voltage positive electrode + HV, the second end of the first transmitting circuit 110 is connected with the high-voltage ground GND, the third end of the first transmitting circuit 110 is connected with the high-voltage negative electrode-HV, and the transmitting end of the first transmitting circuit 110 is connected with the first electrode P1 and used for outputting positive high voltage, negative high voltage or zero voltage to the first electrode P1; the first end of the second transmitting circuit 120 is connected to the high-voltage positive electrode + HV, the second end of the second transmitting circuit 120 is connected to the high-voltage ground GND, the third end of the second transmitting circuit 120 is connected to the high-voltage negative electrode-HV, and the transmitting end of the second transmitting circuit 120 is connected to the second electrode P2, so as to output a positive high voltage, a negative high voltage or a zero voltage to the second electrode P2; the control circuit 130 is connected to the first and second transmitting circuits 110 and 120, respectively, and is configured to control the first and second transmitting circuits 110 and 120 to form a positive high voltage, a negative high voltage, a double high voltage, or a zero voltage between the first electrode P1 and the second electrode P2.
The method is characterized in that a high-voltage pulse electric field with the pulse width of millisecond, microsecond or even nanosecond is generated, extremely high energy is released in a short time, and cell membranes and even intracellular organelles such as endoplasmic reticulum, mitochondria and cell nucleus can generate a large number of irreversible micropores under the action of the high-voltage pulse electric field, so that apoptosis of pathological cells is caused, and the aim of treating rapid arrhythmia is fulfilled.
In practical application, firstly, the electrophysiology examination is carried out on the heart through the puncture subclavian vein and the bicuspid vein to clearly diagnose the position of the lesion to be ablated, then the heart is inserted into the lesion position along the blood vessel through a special catheter, and a high-voltage pulse electric field is emitted to the lesion position in a short time through the first electrode P1 and the second electrode P2 arranged on the catheter, so that the function of accurately treating the myocardial cells is achieved, and other non-target cell tissues are not necessarily affected. In operation, under normal conditions, the control circuit 130 in the high voltage transmitting circuit respectively sends control signals to the first transmitting circuit 110 and the second transmitting circuit 120 to control the first transmitting circuit 110 to output a positive high voltage, a negative high voltage or a zero voltage through the first electrode P1, and control the second transmitting circuit 120 to output a positive high voltage, a negative high voltage or a zero voltage through the second electrode P2, and no matter the first electrode P1 or the second electrode P2 is used as a reference electrode, a positive high voltage, a negative high voltage, a double high voltage or a zero voltage can be formed between the first electrode P1 and the second electrode P2, so that flexible control of the catheter output pulse voltage is realized, various requirements in pulsed electric field ablation surgery can be met, and due to generation of the double high voltage, the high voltage + HV and the high voltage negative-HV can be reduced under the condition that the pulse voltage requirement is small, and all maximum pulse voltages can be reached only depending on the formed double high voltage, therefore, the accurate control of the high-voltage pulse signal can be realized.
According to the high-voltage transmitting circuit for the catheter, disclosed by the embodiment of the invention, the first transmitting circuit is connected with the first electrode and used for outputting positive high voltage, negative high voltage or zero voltage to the first electrode, the second transmitting circuit is connected with the second electrode and used for outputting positive high voltage, negative high voltage or zero voltage to the second electrode, and the first transmitting circuit and the second transmitting circuit are respectively controlled through the control circuit so that positive high voltage, negative high voltage, double high voltage or zero voltage is formed between the first electrode and the second electrode. Therefore, the precise control and flexible adjustment of the pulse voltage of the catheter are realized, the treatment requirements in various pulsed electric field ablation operations are met, and the application prospect of the pulsed electric field ablation technology in arrhythmia treatment is improved to a great extent.
In some embodiments, as shown in fig. 2, the first transmitting circuit 110 includes: the high-voltage switch comprises a first switch tube Q1, a second switch tube Q2 and a third switch tube Q3, wherein a first end of the first switch tube Q1 is connected with a high-voltage positive electrode + HV, a second end of the first switch tube Q1, a first end of the second switch tube Q2 and a first end of the third switch tube Q3 are connected with a first electrode P1, a second end of the second switch tube Q2 is connected with a high-voltage ground GND, a second end of the third switch tube Q3 is connected with a high-voltage negative electrode-HV, and a control end of the first switch tube Q1, a control end of the second switch tube Q2 and a control end of the third switch tube Q3 are respectively connected with the control circuit 130.
Further, the second transmitting circuit 120 includes: a fourth switching tube Q4, a fifth switching tube Q5 and a sixth switching tube Q6, wherein the first end of the fourth switching tube Q4 is connected to the high-voltage positive electrode + HV, the second end of the fourth switching tube Q4, the first end of the fifth switching tube Q5 and the first end of the sixth switching tube Q6 are all connected to the second electrode P2, the second end of the fifth switching tube Q5 is connected to the high-voltage ground GND, the second end of the sixth switching tube Q6 is connected to the high-voltage negative electrode-HV, and the control end of the fourth switching tube Q4, the control end of the fifth switching tube Q5 and the control end of the sixth switching tube Q6 are respectively connected to the control circuit 130.
Specifically, as shown in fig. 2, the control terminals of the first switch Q1, the second switch Q2 and the third switch Q3 in the first transmitting circuit 110 are respectively connected to the control circuit 130, and when the control circuit 130 controls the conduction of the first switch Q1 through the control terminal of the first switch Q1, the first electrode P1 is directly connected to the positive high voltage + HV through the first switch Q1 to obtain an absolute positive high voltage; when the control circuit 130 controls the second switch tube Q2 to be turned on through the control terminal of the second switch tube Q2, the first electrode P1 is directly connected to the high voltage ground GND through the second switch tube Q2 to obtain an absolute zero voltage; when the control circuit 130 controls the third switching tube Q3 to be conducted through the control terminal of the third switching tube Q3, the first electrode P1 is directly connected to the high voltage negative-HV through the third switching tube Q3 to obtain an absolute negative high voltage.
Further, the control terminals of the fourth switching tube Q4, the fifth switching tube Q5 and the sixth switching tube Q6 in the second transmitting circuit 120 are respectively connected to the control circuit 130, and when the control circuit 130 controls the fourth switching tube Q4 to be turned on through the control terminal of the fourth switching tube Q4, the second electrode P2 is directly connected to the positive high voltage + HV through the fourth switching tube Q4 so as to obtain an absolute positive high voltage; when the control circuit 130 controls the fifth switching tube Q5 to be turned on through the control terminal of the fifth switching tube Q5, the second electrode P2 is directly connected to the high voltage ground GND through the fifth switching tube Q5 to obtain an absolute zero voltage; when the control circuit 130 controls the sixth switching tube Q6 to be turned on through the control terminal of the sixth switching tube Q6, the second electrode P2 is directly connected to the high voltage negative-HV through the sixth switching tube Q6 to obtain an absolute negative high voltage.
It should be noted that the first to sixth switching tubes Q1 to Q6 are ideal switching models, and in practical applications, some or all of the first to sixth switching tubes Q1 to Q6 may be implemented by one or more non-ideal switching tubes and some auxiliary components to implement the functions of the ideal switching models, and all of these modifications and alternatives are within the scope of the present application, and are not limited herein.
In some embodiments, when the second electrode P2 is used as a reference electrode, wherein when the first switching tube Q1 and the fifth switching tube Q5 are in a conducting state, a positive high voltage with the second electrode P2 as a reference electrode is formed between the first electrode P1 and the second electrode P2; when the third switching tube Q3 and the fifth switching tube Q5 are in a conducting state, a negative high voltage with the second electrode P2 as a reference electrode is formed between the first electrode P1 and the second electrode P2; when the second switching tube Q2 and the fifth switching tube Q5 are in a conducting state, a zero voltage with the second electrode P2 as a reference electrode is formed between the first electrode P1 and the second electrode P2; when the first switch tube Q1 and the sixth switch tube Q6 are in a conducting state, a high voltage which is twice as high as that of the second electrode P2 serving as a reference electrode is formed between the first electrode P1 and the second electrode P2.
Further, in some embodiments, when the first electrode P1 is used as a reference electrode, wherein when the fourth switching tube Q4 and the second switching tube Q2 are in a conducting state, a positive high voltage with the first electrode P1 as a reference electrode is formed between the first electrode P1 and the second electrode P2; when the sixth switch tube Q6 and the second switch tube Q2 are in a conducting state, a negative high voltage with the first electrode as a reference electrode is formed between the first electrode P1 and the second electrode P2; when the fifth switch tube Q5 and the second switch tube Q2 are in a conducting state, a zero voltage with the first electrode P1 as a reference electrode is formed between the first electrode P1 and the second electrode P2; when the fourth switching tube Q4 and the third switching tube Q3 are in a conducting state, a high voltage which is twice as high as that of the first electrode P1 serving as a reference electrode is formed between the first electrode P1 and the second electrode P2.
Specifically, as shown in fig. 2, the control circuit 130 may control the first and second transmitting circuits 110 and 120 to form a positive high voltage, a negative high voltage, a zero voltage, and a double high voltage between the first and second electrodes P1 and P2.
For example, first, the second electrode P2 is used as a reference electrode, the control circuit 130 can control the fifth switch tube Q5 and the first switch tube Q1 to be in a conducting state, and control the other switch tubes to be in an off state, at this time, the voltage of the first electrode P1 relative to the second electrode P2 is + HV, a positive high voltage + HV is formed between the first electrode P1 and the second electrode P2, and the voltage is also an absolute positive high voltage; the control circuit 130 can control the third switching tube Q3 and the fifth switching tube Q5 to be in a conducting state, and control the other switching tubes to be in an off state, at this time, the voltage of the first electrode P1 relative to the second electrode P2 is-HV, and a negative high voltage-HV is formed between the first electrode P1 and the second electrode P2, and the voltage is also an absolute negative high voltage; the control circuit 130 can control the second switch tube Q2 and the fifth switch tube Q5 to be in a conducting state, and control the other switch tubes to be in a disconnected state, at this time, the voltage of the first electrode P1 relative to the second electrode P2 is 0, and zero voltage is formed between the first electrode P1 and the second electrode P2, and the voltage is also absolute zero voltage; the control circuit 130 can control the first switch tube Q1 and the sixth switch tube Q6 to be in a conducting state, and control the other switch tubes to be in an off state, when the voltage of the first electrode P1 relative to the second electrode P2 is +2HV, a double high voltage +2HV is formed between the first electrode P1 and the second electrode P2.
Similarly, with the first electrode P1 as a reference electrode, the control circuit 130 can control the second switch tube Q2 and the fourth switch tube Q4 to be in an on state, and control the remaining switch tubes to be in an off state, where the voltage of the second electrode P2 relative to the first electrode P1 is + HV, and a positive high voltage + HV is formed between the first electrode P1 and the second electrode P2, and the voltage is also an absolute positive high voltage; the control circuit 130 can control the sixth switching tube Q6 and the second switching tube Q2 to be in a conducting state, and control the other switching tubes to be in a disconnected state, at this time, the voltage of the second electrode P2 relative to the first electrode P1 is-HV, and a negative high voltage-HV is formed between the first electrode P1 and the second electrode P2, and the voltage is also an absolute negative high voltage; the control circuit 130 can control the fifth switching tube Q5 and the second switching tube Q2 to be in a conducting state, and control the other switching tubes to be in a disconnected state, at this time, the voltage of the second electrode P2 relative to the first electrode P1 is 0, and zero voltage is formed between the first electrode P1 and the second electrode P2, and the voltage is also absolute zero voltage; the control circuit 130 can control the third switching tube Q3 and the fourth switching tube Q4 to be in a conducting state, and control the other switching tubes to be in an off state, at this time, the voltage of the second electrode P2 relative to the first electrode P1 is +2HV, and a double high voltage +2HV is formed between the first electrode P1 and the second electrode P2.
Further, the first transmitting circuit 110 and the second transmitting circuit 120 may be controlled by the control circuit 130 to form different pulse voltage waveforms, for example, a plurality of different pulse voltage waveforms as shown in fig. 3 may be formed, based on the capability of forming a positive high voltage, a negative high voltage, a zero voltage, and a double high voltage between the first electrode P1 and the second electrode P2.
Specifically, as shown in fig. 2-3, the second electrode P2 is used as a reference electrode, when the fifth switch tube Q5 is in a conducting state, and the first switch tube Q1 is turned on, and the other switch tubes are turned off, the voltage of the first electrode P1 relative to the second electrode P2 is + HV, and when the first switch tube Q1 is turned off, the second switch tube Q2 is turned on, and the other switch tubes are kept in a turned-off state, the voltage of the first electrode P1 relative to the second electrode P2 is 0, and the control circuit 130 controls the on/off of the first switch tube Q1 and the second switch tube Q2 cyclically, so as to obtain the pulse voltage waveform shown in fig. 3 (a).
When the fifth switching tube Q5 is in a conducting state, if the third switching tube Q3 is turned on and the remaining switching tubes are turned off, the voltage of the first electrode P1 with respect to the second electrode P2 is-HV, and when the third switching tube Q3 is turned off, the second switching tube Q2 is turned on and the remaining switching tubes are kept in a disconnected state, the voltage of the first electrode P1 with respect to the second electrode P2 is 0, and the control circuit 130 controls the third switching tube Q3 and the second switching tube Q2 to be turned on and off in a circulating manner, so that a pulse voltage waveform as shown in fig. 3(b) can be obtained.
When the sixth switching tube Q6 is in the on state, if the first switching tube Q1 is turned on and the remaining switching tubes are turned off, the voltage of the first electrode P1 with respect to the second electrode P2 becomes +2HV, and when the first switching tube Q1 is turned off, the third switching tube Q3 is turned on and the remaining switching tubes are kept in the off state, the voltage of the first electrode P1 with respect to the second electrode P2 becomes 0, and the on/off of the first switching tube Q1 and the third switching tube Q3 is cyclically controlled by the control circuit 130, so that a pulse voltage waveform as shown in fig. 3(c) can be obtained.
When the fifth switching tube Q5 is in a conducting state, if the first switching tube Q1 is turned on and the remaining switching tubes are turned off, the voltage of the first electrode P1 with respect to the second electrode P2 is + HV, and when the first switching tube Q1 is turned off, the second switching tube Q2 is turned on and the remaining switching tubes are kept in a disconnected state, the voltage of the first electrode P1 with respect to the second electrode P2 is 0, and then when the second switching tube Q2 is turned off, the third switching tube Q3 is turned on and the remaining switching tubes are kept in a disconnected state, the voltage of the first electrode P1 with respect to the second electrode P2 is-HV, and the on/off of the first switching tube Q1, the second switching tube Q2 and the third switching tube Q3 is controlled cyclically by the control circuit 130 in order, so that a pulse voltage waveform as shown in fig. 3(d) can be obtained.
When the fifth switching tube Q5 is in a conducting state, if the first switching tube Q1 is conducting and the other switching tubes are off, the voltage of the first electrode P1 with respect to the second electrode P2 is + HV, and when the first switching tube Q1 is off, the third switching tube Q3 is conducting and the other switching tubes are kept in a disconnected state, the voltage of the first electrode P1 with respect to the second electrode P2 is-HV, and then when the third switching tube Q3 is off, the second switching tube Q2 is conducting and the other switching tubes are kept in a disconnected state, the voltage of the first electrode P1 with respect to the second electrode P2 is 0, and the on/off of the first switching tube Q1, the third switching tube Q3 and the second switching tube Q2 is controlled by the control circuit 130 in a circulating manner in order, so that a pulse voltage waveform as shown in fig. 3(e) can be obtained.
When the fifth switching tube Q5 is in a conducting state, if the third switching tube Q3 is conducting and the other switching tubes are off, the voltage of the first electrode P1 with respect to the second electrode P2 is-HV, and when the third switching tube Q3 is off, the first switching tube Q1 is conducting and the other switching tubes are kept in a disconnected state, the voltage of the first electrode P1 with respect to the second electrode P2 is + HV, and then when the first switching tube Q1 is off, the second switching tube Q2 is conducting and the other switching tubes are kept in a disconnected state, the voltage of the first electrode P1 with respect to the second electrode P2 is 0, and the on/off of the third switching tube Q3, the first switching tube Q1 and the second switching tube Q2 is controlled by the control circuit 130 in a circulating manner in order, so that a pulse voltage waveform as shown in fig. 3(f) can be obtained.
In practical applications, the control circuit 130 can flexibly control different switching tubes as required to obtain a suitable pulse voltage waveform, for example, when a pulse voltage needs to be increased in the process of treating arrhythmia, the control circuit 130 can control the corresponding switching tubes to adjust the voltage pulse waveform shown in fig. 3(a) to the voltage pulse waveform shown in fig. 3(c), so that the voltage pulse can be adjusted at any time, and the flexibility of controlling and adjusting the pulse voltage is improved.
It should be noted that, when the first electrode P1 is used as a reference electrode, the pulse voltage shown in fig. 3 can be obtained by controlling the corresponding fourth switching tube Q4, fifth switching tube Q5 and sixth switching tube Q6 in the second transmitting circuit 120, and detailed steps are not repeated. And the foregoing is illustrative only and is not to be taken as a specific limitation of the present application.
In some embodiments, referring to fig. 4, the first to sixth switching tubes Q1 to Q6 have the same structure and are each composed of a plurality of oppositely connected switching tubes. Here, two reversely connected switching tubes are taken as an example, and the specific working process refers to the foregoing description, which is not described herein again.
In some embodiments, as illustrated with continued reference to fig. 2, the first transmit circuit 110 further comprises: a first resistor R1 and a second resistor R2, wherein the first resistor R1 is connected in series between the first end of the first switch tube Q1 and the high voltage positive electrode + HV, and the second resistor R2 is connected in series between the second end of the third switch tube Q3 and the high voltage negative electrode-HV. Further, the second transmitting circuit 120 further includes: a third resistor R3 and a fourth resistor R4, wherein the third resistor R3 is connected in series between the first end of the fourth switching tube Q4 and the high voltage positive electrode + HV, and the fourth resistor R4 is connected in series between the second end of the sixth switching tube Q6 and the high voltage negative electrode-HV. It should be noted that the first resistor R1, the second resistor R2, the third resistor R3, and the fourth resistor R4 are current-limiting resistors or current-surge-preventing resistors, and are used to reduce or prevent transient large current and circuit oscillation caused by parasitic inductance or parasitic capacitance when the system discharges.
In some embodiments, as shown in fig. 5, the high voltage transmitting circuit further comprises: and one end of the sampling resistor R is connected to the second end of the first transmitting circuit 110 and the second end of the second transmitting circuit 120 respectively, and the other end of the sampling resistor R is connected to the high-voltage ground GND for detecting high-voltage discharge during use.
Optionally, referring to fig. 6, the first electrode and the second electrode each include a plurality of electrodes, each first electrode is provided with a first transmitting circuit correspondingly, and each second electrode is provided with a second transmitting circuit correspondingly.
That is, the high voltage transmitting circuit in the present application may be configured by a plurality of first transmitting circuits and second transmitting circuits connected in parallel to output voltages to the plurality of first electrodes and second electrodes so as to form a desired pulse voltage between the plurality of first electrodes and second electrodes. In the using process, any electrode can be selected as a reference electrode according to the requirement, for example, P1 can be selected as the reference electrode, P2, Pn and the like can also be selected as the reference electrode, and similarly, any electrode can be selected as a working electrode in a series of electrodes, so that the output polarity can be interchanged, the current loop can be flexibly adjusted, that is, two electrodes can be matched and used at will. In addition, because the electrodes are arranged at different positions of the catheter, the working electrode can be adjusted at will according to the position of a focus in the pulse voltage ablation treatment process without moving the catheter in a large range to enable the electrode to be aligned with the focus, the operability of the pulse voltage ablation technology is improved, and the operation difficulty is reduced.
In summary, the first transmitting circuit is connected to the first electrode for outputting a positive high voltage, a negative high voltage or a zero voltage to the first electrode, the second transmitting circuit is connected to the second electrode for outputting a positive high voltage, a negative high voltage or a zero voltage to the second electrode, and the control circuit controls the first transmitting circuit and the second transmitting circuit respectively to form a positive high voltage, a negative high voltage, a double high voltage or a zero voltage between the first electrode and the second electrode. Therefore, the precise control and flexible adjustment of the pulse voltage of the catheter are realized, the treatment requirements in various pulsed electric field ablation operations are met, and the application prospect of the pulsed electric field ablation technology in arrhythmia treatment is improved to a great extent.
Fig. 7 is a schematic structural view of an ablation instrument according to an embodiment of the present invention, and referring to fig. 7, the ablation instrument 1000 includes the high voltage transmitting circuit 100 for a catheter and the catheter 200 described above.
According to the ablation tool provided by the embodiment of the invention, through the accurate control of the catheter pulse voltage, the accurate control and flexible adjustment of the catheter pulse voltage are realized, the treatment requirements in various pulsed electric field ablation operations are met, and the application prospect of the pulsed electric field ablation technology in arrhythmia treatment is improved to a great extent.
It should be noted that the logic and/or steps represented in the flowcharts or otherwise described herein, such as an ordered listing of executable instructions that can be considered to implement logical functions, can be embodied in any computer-readable medium for use by or in connection with an instruction execution system, apparatus, or device, such as a computer-based system, processor-containing system, or other system that can fetch the instructions from the instruction execution system, apparatus, or device and execute the instructions. For the purposes of this description, a "computer-readable medium" can be any means that can contain, store, communicate, propagate, or transport the program for use by or in connection with the instruction execution system, apparatus, or device. More specific examples (a non-exhaustive list) of the computer-readable medium would include the following: an electrical connection (electronic device) having one or more wires, a portable computer diskette (magnetic device), a Random Access Memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber device, and a portable compact disc read-only memory (CDROM). Additionally, the computer-readable medium could even be paper or another suitable medium upon which the program is printed, as the program can be electronically captured, via for instance optical scanning of the paper or other medium, then compiled, interpreted or otherwise processed in a suitable manner if necessary, and then stored in a computer memory.
It should be understood that portions of the present invention may be implemented in hardware, software, firmware, or a combination thereof. In the above embodiments, the various steps or methods may be implemented in software or firmware stored in memory and executed by a suitable instruction execution system. For example, if implemented in hardware, as in another embodiment, any one or combination of the following techniques, which are known in the art, may be used: a discrete logic circuit having a logic gate circuit for implementing a logic function on a data signal, an application specific integrated circuit having a suitable combinational logic gate circuit, a Programmable Gate Array (PGA), a Field Programmable Gate Array (FPGA), an MCU, a DSP, and the like.
In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.
In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can, for example, be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be connected internally or in any other suitable relationship, unless expressly stated otherwise. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and that variations, modifications, substitutions and alterations can be made to the above embodiments by those of ordinary skill in the art within the scope of the present invention.

Claims (10)

1. A high voltage transmitting circuit for a catheter, wherein a first electrode and a second electrode are disposed on the catheter, the high voltage transmitting circuit comprising:
the first end of the first transmitting circuit is connected with a high-voltage anode, the second end of the first transmitting circuit is connected with a high-voltage ground, the third end of the first transmitting circuit is connected with a high-voltage cathode, and the transmitting end of the first transmitting circuit is connected with the first electrode and used for outputting positive high voltage, negative high voltage or zero voltage to the first electrode;
a first end of the second transmitting circuit is connected with the high-voltage anode, a second end of the second transmitting circuit is connected with the high-voltage ground, a third end of the second transmitting circuit is connected with the high-voltage cathode, and a transmitting end of the second transmitting circuit is connected with the second electrode and used for outputting positive high voltage, negative high voltage or zero voltage to the second electrode;
and the control circuit is respectively connected with the first transmitting circuit and the second transmitting circuit and is used for controlling the first transmitting circuit and the second transmitting circuit so as to form positive high voltage, negative high voltage, double high voltage or zero voltage between the first electrode and the second electrode.
2. The high voltage transmit circuit for a catheter of claim 1, wherein the first transmit circuit comprises: the high-voltage switch comprises a first switch tube, a second switch tube and a third switch tube, wherein the first end of the first switch tube is connected with the high-voltage positive electrode, the second end of the first switch tube, the first end of the second switch tube and the first end of the third switch tube are connected with the first electrode, the second end of the second switch tube is connected with the high-voltage ground, the second end of the third switch tube is connected with the high-voltage negative electrode, and the control end of the first switch tube, the control end of the second switch tube and the control end of the third switch tube are respectively connected with the control circuit.
3. The high voltage transmit circuit for a catheter of claim 2, wherein the second transmit circuit comprises: fourth switch tube, fifth switch tube and sixth switch tube, wherein, the first end of fourth switch tube with the high-pressure positive pole links to each other, the second end of fourth switch tube the first end of fifth switch tube with the first end of sixth switch tube all with the second electrode links to each other, the second end of fifth switch tube with link to each other high-voltage ground, the second end of sixth switch tube with the high-pressure negative pole links to each other, the control end of fourth switch tube the control end of fifth switch tube with the control end of sixth switch tube respectively with control circuit links to each other.
4. The high voltage transmit circuit for a catheter of claim 3, wherein when the second electrode is used as a reference electrode, wherein,
when the first switching tube and the fifth switching tube are in a conducting state, a positive high voltage with the second electrode as a reference electrode is formed between the first electrode and the second electrode;
when the third switching tube and the fifth switching tube are in a conducting state, a negative high voltage with the second electrode as a reference electrode is formed between the first electrode and the second electrode;
when the second switching tube and the fifth switching tube are in a conducting state, a zero voltage with the second electrode as a reference electrode is formed between the first electrode and the second electrode;
when the first switching tube and the sixth switching tube are in a conducting state, a high voltage which is multiplied by the second electrode as a reference electrode is formed between the first electrode and the second electrode.
5. The high voltage transmit circuit for a catheter of claim 3, wherein when the first electrode is a reference electrode, wherein,
when the fourth switching tube and the second switching tube are in a conducting state, a positive high voltage with the first electrode as a reference electrode is formed between the first electrode and the second electrode;
when the sixth switching tube and the second switching tube are in a conducting state, a negative high voltage with the first electrode as a reference electrode is formed between the first electrode and the second electrode;
when the fifth switching tube and the second switching tube are in a conducting state, a zero voltage with the first electrode as a reference electrode is formed between the first electrode and the second electrode;
when the fourth switching tube and the third switching tube are in a conducting state, a high voltage which is multiplied by the first electrode as a reference electrode is formed between the first electrode and the second electrode.
6. The high voltage transmitting circuit for the conduit according to claim 3, wherein the first switch tube to the sixth switch tube have the same structure and are each composed of a plurality of switch tubes connected in opposite directions.
7. The high voltage transmit circuit for a conduit of any one of claims 2-6,
the first transmission circuit further includes: the first resistor is connected between the first end of the first switching tube and the high-voltage positive electrode in series, and the second resistor is connected between the second end of the third switching tube and the high-voltage negative electrode in series;
the second transmitting circuit further includes: the third resistor is connected between the first end of the fourth switching tube and the high-voltage positive electrode in series, and the fourth resistor is connected between the second end of the sixth switching tube and the high-voltage negative electrode in series.
8. The high voltage transmit circuit for a catheter of claim 1, further comprising: and one end of the sampling resistor is connected with the second end of the first transmitting circuit and the second end of the second transmitting circuit respectively, and the other end of the sampling resistor is connected with the high-voltage ground.
9. The high voltage transmit circuit for a catheter of any of claims 1-6, wherein the first electrode and the second electrode each comprise a plurality, each of the first electrodes is provided with the first transmit circuit and each of the second electrodes is provided with the second transmit circuit.
10. An ablation instrument comprising a catheter and a high voltage firing circuit for a catheter according to any one of claims 1 to 9.
CN202110875450.5A 2021-07-30 2021-07-30 High-voltage transmitting circuit for catheter and ablation tool Withdrawn CN113648044A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110875450.5A CN113648044A (en) 2021-07-30 2021-07-30 High-voltage transmitting circuit for catheter and ablation tool

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202110875450.5A CN113648044A (en) 2021-07-30 2021-07-30 High-voltage transmitting circuit for catheter and ablation tool

Publications (1)

Publication Number Publication Date
CN113648044A true CN113648044A (en) 2021-11-16

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN202110875450.5A Withdrawn CN113648044A (en) 2021-07-30 2021-07-30 High-voltage transmitting circuit for catheter and ablation tool

Country Status (1)

Country Link
CN (1) CN113648044A (en)

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