CN113640512B - 用于多路测定的解码方法及相关流体设备、试剂盒和固体支持物 - Google Patents
用于多路测定的解码方法及相关流体设备、试剂盒和固体支持物 Download PDFInfo
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- CN113640512B CN113640512B CN202110961051.0A CN202110961051A CN113640512B CN 113640512 B CN113640512 B CN 113640512B CN 202110961051 A CN202110961051 A CN 202110961051A CN 113640512 B CN113640512 B CN 113640512B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
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- Health & Medical Sciences (AREA)
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- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
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- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Optical Measuring Cells (AREA)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562237324P | 2015-10-05 | 2015-10-05 | |
| US62/237,324 | 2015-10-05 | ||
| CN201680058434.4A CN108351352B (zh) | 2015-10-05 | 2016-10-05 | 用于多路测定的解码方法及相关流体设备、试剂盒和固体支持物 |
| PCT/US2016/055407 WO2017112025A2 (en) | 2015-10-05 | 2016-10-05 | Decoding methods for multiplexing assays and associated fluidic devices, kits, and solid supports |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680058434.4A Division CN108351352B (zh) | 2015-10-05 | 2016-10-05 | 用于多路测定的解码方法及相关流体设备、试剂盒和固体支持物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113640512A CN113640512A (zh) | 2021-11-12 |
| CN113640512B true CN113640512B (zh) | 2024-12-31 |
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110961051.0A Active CN113640512B (zh) | 2015-10-05 | 2016-10-05 | 用于多路测定的解码方法及相关流体设备、试剂盒和固体支持物 |
| CN201680058434.4A Active CN108351352B (zh) | 2015-10-05 | 2016-10-05 | 用于多路测定的解码方法及相关流体设备、试剂盒和固体支持物 |
| CN202411937836.4A Pending CN119846200A (zh) | 2015-10-05 | 2016-10-05 | 用于多路测定的解码方法及相关流体设备、试剂盒和固体支持物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680058434.4A Active CN108351352B (zh) | 2015-10-05 | 2016-10-05 | 用于多路测定的解码方法及相关流体设备、试剂盒和固体支持物 |
| CN202411937836.4A Pending CN119846200A (zh) | 2015-10-05 | 2016-10-05 | 用于多路测定的解码方法及相关流体设备、试剂盒和固体支持物 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US11016084B2 (enExample) |
| EP (2) | EP3957996B1 (enExample) |
| JP (1) | JP6847934B2 (enExample) |
| CN (3) | CN113640512B (enExample) |
| WO (1) | WO2017112025A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104508492B (zh) | 2012-05-25 | 2018-07-27 | 北卡罗来纳-查佩尔山大学 | 微流体装置、用于试剂的固体支持体和相关方法 |
| CN113640512B (zh) | 2015-10-05 | 2024-12-31 | 北卡罗来纳-查佩尔山大学 | 用于多路测定的解码方法及相关流体设备、试剂盒和固体支持物 |
| WO2019089996A1 (en) | 2017-11-03 | 2019-05-09 | University Of Washington | Digital nucleic acid amplification using encoded particles |
| CN112154190A (zh) | 2018-05-18 | 2020-12-29 | 北卡罗来纳-查佩尔山大学 | 用于改善基材的表面性质的组合物、装置和方法 |
| EP3880364B1 (en) | 2018-11-13 | 2024-04-17 | The University of North Carolina at Chapel Hill | Analysis system for microfluidic devices |
| DE102019220017A1 (de) * | 2019-12-18 | 2021-06-24 | Robert Bosch Gesellschaft mit beschränkter Haftung | Aufnahmeeinheit zum Aufnehmen eines Fluids, Verfahren und Vorrichtung zum Herstellen einer Aufnahmeeinheit, Verfahren und Vorrichtung zum Betreiben einer Aufnahmeeinheit und Aufnahmeeinrichtung |
| CA3199746A1 (en) * | 2020-10-27 | 2022-05-05 | Quantum-Si Incorporated | Single molecule detection system using photobleaching information |
| EP4341670A1 (en) * | 2021-05-19 | 2024-03-27 | Leica Microsystems CMS GmbH | Method and device for analyzing a biological sample |
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| DK171161B1 (da) * | 1985-03-28 | 1996-07-08 | Hoffmann La Roche | Fremgangsmåde til påvisning af forekomst eller fravær af mindst én specifik nukleinsyresekvens i en prøve eller til skelnen mellem to forskellige nukleinsyresekvenser i denne prøve |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US6387707B1 (en) * | 1996-04-25 | 2002-05-14 | Bioarray Solutions | Array Cytometry |
| US6074827A (en) | 1996-07-30 | 2000-06-13 | Aclara Biosciences, Inc. | Microfluidic method for nucleic acid purification and processing |
| US6023540A (en) * | 1997-03-14 | 2000-02-08 | Trustees Of Tufts College | Fiber optic sensor with encoded microspheres |
| US7622294B2 (en) | 1997-03-14 | 2009-11-24 | Trustees Of Tufts College | Methods for detecting target analytes and enzymatic reactions |
| US20030027126A1 (en) * | 1997-03-14 | 2003-02-06 | Walt David R. | Methods for detecting target analytes and enzymatic reactions |
| US6327410B1 (en) * | 1997-03-14 | 2001-12-04 | The Trustees Of Tufts College | Target analyte sensors utilizing Microspheres |
| US6143496A (en) | 1997-04-17 | 2000-11-07 | Cytonix Corporation | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly |
| US7115884B1 (en) * | 1997-10-06 | 2006-10-03 | Trustees Of Tufts College | Self-encoding fiber optic sensor |
| US7348181B2 (en) * | 1997-10-06 | 2008-03-25 | Trustees Of Tufts College | Self-encoding sensor with microspheres |
| WO1999067641A2 (en) * | 1998-06-24 | 1999-12-29 | Illumina, Inc. | Decoding of array sensors with microspheres |
| WO2000047996A2 (en) | 1999-02-09 | 2000-08-17 | Illumina, Inc. | Arrays comprising a fiducial and automated information processing in randomly ordered arrays |
| ATE412184T1 (de) * | 1999-08-17 | 2008-11-15 | Luminex Corp | Verfahren zur analyse einer mehrzahl von proben verschiedenen ursprungs auf einen analyten |
| WO2004034012A2 (en) * | 2001-10-18 | 2004-04-22 | Virtual Arrays, Inc. | Coded particles for multiplexed analysis of biological samples |
| EP1311270B1 (en) | 2000-07-26 | 2008-01-09 | Taro Pharmaceutical Industries Limited | Non-sedating barbiturate compounds as neuroprotective agents |
| WO2002099982A2 (en) * | 2001-03-01 | 2002-12-12 | Illumina, Inc. | Methods for improving signal detection from an array |
| WO2002081729A2 (en) | 2001-04-06 | 2002-10-17 | California Institute Of Technology | Nucleic acid amplification utilizing microfluidic devices |
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| DE602004021569D1 (de) * | 2003-03-07 | 2009-07-30 | Univ New Jersey Med | Optisch dekodierbare mikroträger, arrays und verfahren |
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| EP1963531B1 (en) * | 2005-12-23 | 2011-09-21 | Nanostring Technologies, Inc. | Nanoreporters and methods of manufacturing and use thereof |
| EP2664916B1 (en) * | 2007-04-02 | 2017-02-08 | Acoustic Cytometry Systems, Inc. | Method for manipulating a fluid medium within a flow cell using acoustic focusing |
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| EP2017354A1 (en) * | 2007-07-20 | 2009-01-21 | Eppendorf Ag | Detection and/or quantification of target molecules on a solid support |
| US8222047B2 (en) | 2008-09-23 | 2012-07-17 | Quanterix Corporation | Ultra-sensitive detection of molecules on single molecule arrays |
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| EP2542890B1 (en) | 2010-03-01 | 2015-05-06 | Quanterix Corporation | Methods for extending dynamic range in assays for the detection of molecules or particles |
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| US20120088691A1 (en) * | 2010-10-08 | 2012-04-12 | Gao Chen | Highly multiplexed real-time pcr using encoded microbeads |
| EP4361607A3 (en) * | 2012-02-03 | 2024-07-17 | California Institute of Technology | Signal encoding and decoding in multiplexed biochemical assays |
| CN104508492B (zh) * | 2012-05-25 | 2018-07-27 | 北卡罗来纳-查佩尔山大学 | 微流体装置、用于试剂的固体支持体和相关方法 |
| CN104641233B (zh) | 2012-06-22 | 2018-01-09 | 麦考瑞大学 | 采用寿命编码的复合悬液分析/阵列 |
| US8921277B2 (en) * | 2012-09-26 | 2014-12-30 | Palo Alto Research Center Incorporated | Multiplexed flow assay based on absorption-encoded micro beads |
| NZ711033A (en) | 2013-03-13 | 2020-03-27 | Univ North Carolina Chapel Hill | Nanofluidic devices for the rapid mapping of whole genomes and related systems and methods of analysis |
| CN114272964B (zh) | 2013-06-25 | 2024-04-23 | 华盛顿大学商业中心 | 样品体积的自数字化 |
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| CN114272966B (zh) | 2015-07-22 | 2023-11-07 | 北卡罗来纳-查佩尔山大学 | 含有具有空间分离的珠保留和信号检测段的珠孔几何结构的流体装置和相关方法 |
| WO2017015529A1 (en) | 2015-07-22 | 2017-01-26 | The University Of North Carolina At Chapel Hill | Fluidic devices with freeze-thaw valves with ice-nucleating agents and related methods of operation and analysis |
| CN113640512B (zh) | 2015-10-05 | 2024-12-31 | 北卡罗来纳-查佩尔山大学 | 用于多路测定的解码方法及相关流体设备、试剂盒和固体支持物 |
| JP6965272B2 (ja) | 2016-04-22 | 2021-11-10 | パーデュー・リサーチ・ファウンデーションPurdue Research Foundation | 高スループット粒子捕捉および分析 |
| CN112154190A (zh) | 2018-05-18 | 2020-12-29 | 北卡罗来纳-查佩尔山大学 | 用于改善基材的表面性质的组合物、装置和方法 |
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2016
- 2016-10-05 CN CN202110961051.0A patent/CN113640512B/zh active Active
- 2016-10-05 US US15/765,749 patent/US11016084B2/en active Active
- 2016-10-05 CN CN201680058434.4A patent/CN108351352B/zh active Active
- 2016-10-05 JP JP2018517432A patent/JP6847934B2/ja active Active
- 2016-10-05 EP EP21183583.0A patent/EP3957996B1/en active Active
- 2016-10-05 CN CN202411937836.4A patent/CN119846200A/zh active Pending
- 2016-10-05 WO PCT/US2016/055407 patent/WO2017112025A2/en not_active Ceased
- 2016-10-05 EP EP16858484.5A patent/EP3329279B1/en active Active
-
2021
- 2021-04-29 US US17/244,257 patent/US12146876B2/en active Active
-
2024
- 2024-10-04 US US18/906,315 patent/US20250027934A1/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| Photobleaching kitnetics-based bead encoding for multiplexed bioassays;Thomas H LINZ 等;Lab on a chip;20170101;第17卷(第6期);1076-1082 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20190094212A1 (en) | 2019-03-28 |
| US11016084B2 (en) | 2021-05-25 |
| WO2017112025A2 (en) | 2017-06-29 |
| EP3329279B1 (en) | 2021-07-07 |
| CN119846200A (zh) | 2025-04-18 |
| CN108351352B (zh) | 2021-09-10 |
| JP6847934B2 (ja) | 2021-03-24 |
| CN108351352A (zh) | 2018-07-31 |
| EP3957996B1 (en) | 2025-09-17 |
| WO2017112025A3 (en) | 2017-09-08 |
| US20220011300A1 (en) | 2022-01-13 |
| JP2018538514A (ja) | 2018-12-27 |
| US20250027934A1 (en) | 2025-01-23 |
| EP3329279A2 (en) | 2018-06-06 |
| CN113640512A (zh) | 2021-11-12 |
| EP3957996A1 (en) | 2022-02-23 |
| US12146876B2 (en) | 2024-11-19 |
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